Herb-drug interactions in neuropsychiatric pharmacotherapy - a review of clinically relevant findings
This study reviewed the relevant literature and identified 13 commonly used herbal products - celery, echinacea, ginkgo, ginseng, hydroxycut, kava, kratom, moringa, piperine, rhodiola, St John's wort, terminalia/commiphora ayurvedic mixture and valerian - which have shown clinically relevant interactions with prescription drugs used in the management of neuropsychiatric disorders. The clinical focus is aimed to provide easily accessible information that will be of interest to clinicians, researchers, and the drug-consuming public.PMID:34370637 | DOI:10.2174/1570159X19666210809100357 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - August 9, 2021 Category: Drugs & Pharmacology Authors: Tram T Le Sarah R McGrath Pius S Fasinu Source Type: research
Herb-drug interactions in neuropsychiatric pharmacotherapy - a review of clinically relevant findings
This study reviewed the relevant literature and identified 13 commonly used herbal products - celery, echinacea, ginkgo, ginseng, hydroxycut, kava, kratom, moringa, piperine, rhodiola, St John's wort, terminalia/commiphora ayurvedic mixture and valerian - which have shown clinically relevant interactions with prescription drugs used in the management of neuropsychiatric disorders. The clinical focus is aimed to provide easily accessible information that will be of interest to clinicians, researchers, and the drug-consuming public.PMID:34370637 | DOI:10.2174/1570159X19666210809100357 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - August 9, 2021 Category: Drugs & Pharmacology Authors: Tram T Le Sarah R McGrath Pius S Fasinu Source Type: research
Echinacea purpurea polysaccharide prepared by fractional precipitation prevents alcoholic liver injury in mice by protecting the intestinal barrier and regulating liver-related pathways
This study aimed to examine the protective effects of Echinacea purpurea polysaccharides (EPPs) against ALD and explore the underlying mechanisms based on hepatic oxidative stress, inflammation, and intestinal barrier function. Three polysaccharide fractions, namely, EPP40, EPP60, and EPP80, were obtained by stepwise ethanol precipitation, and their antioxidant activity in vitro was investigated. The results showed that EPP80 with Mw 11.82 kDa had the strongest radical-scavenging capacity against DPPH, ABTS, and •OH radicals. Besides, EPP80 comprised arabinose, galactose, glucose, mannose, galacturonic acid, and glucuron...
Source: International Journal of Biological Macromolecules - July 22, 2021 Category: Biochemistry Authors: Wenhao Jiang Hongkang Zhu Wenqian Xu Chang Liu Bin Hu Yahui Guo Yuliang Cheng He Qian Source Type: research
Multi-protective role of Echinacea purpurea L. water extract in Allium cepa L. against mercury(II) chloride
In this study, multi-protective role of Echinacea purpurea L. extract against toxicity caused by mercury(II) chloride (HgCI2) on Allium cepa L. investigated in a multifaceted way. As a consequence of 100 mgL-1 HgCI2 administration, root elongation, weight increase, germination rate, and mitotic index were reduced, whereas micronucleus frequency, chromosomal abnormalities frequency, meristematic cell injuries severity, malondialdehyde level, catalase, and superoxide dismutase activity were increased. On the other hand, co-administration of increasing doses of E. purpurea extract (265 mgL-1 and 530 mgL-1) and HgCI2 gradually...
Source: Cell Research - July 4, 2021 Category: Cytology Authors: Emine Yal çın Oksal Macar Tu ğçe Kalefetoğlu Macar Dilek Çavuşoğlu K ültiğin Çavuşoğlu Source Type: research
Multi-protective role of Echinacea purpurea L. water extract in Allium cepa L. against mercury(II) chloride
In this study, multi-protective role of Echinacea purpurea L. extract against toxicity caused by mercury(II) chloride (HgCI2) on Allium cepa L. investigated in a multifaceted way. As a consequence of 100 mgL-1 HgCI2 administration, root elongation, weight increase, germination rate, and mitotic index were reduced, whereas micronucleus frequency, chromosomal abnormalities frequency, meristematic cell injuries severity, malondialdehyde level, catalase, and superoxide dismutase activity were increased. On the other hand, co-administration of increasing doses of E. purpurea extract (265 mgL-1 and 530 mgL-1) and HgCI2 gradually...
Source: Environmental Science and Pollution Research International - July 4, 2021 Category: Environmental Health Authors: Emine Yal çın Oksal Macar Tu ğçe Kalefetoğlu Macar Dilek Çavuşoğlu K ültiğin Çavuşoğlu Source Type: research
Effects of an oral hydro-ethanolic purple coneflower extract on performance, clinical health and immune parameters in calves
Publication date: Available online 2 June 2021Source: Research in Veterinary ScienceAuthor(s): Hannah Ayrle, Meike Mevissen, Rupert M. Bruckmaier, Olga Wellnitz, Martin Kaske, Anna Bieber, Andrea Vögtlin, Raffael Fricker, Michael Walkenhorst (Source: Research in Veterinary Science)
Source: Research in Veterinary Science - June 3, 2021 Category: Veterinary Research Source Type: research
Herbal Extracts as Potential Antioxidant, Anti-Aging, Anti-Inflammatory, and Whitening Cosmeceutical Ingredients
Chem Biodivers. 2021 May 14. doi: 10.1002/cbdv.202100245. Online ahead of print.ABSTRACTThe aim of this research was to investigate and compare the antioxidant, anti-tyrosinase, anti-aging, and anti-inflammatory activities of 16 herbal extracts for topical application in cosmetic/cosmeceutical products. Herbal plant materials were extracted by infusion in boiled water for 15 min. The total phenolic content and total flavonoid content of each extract were investigated by the Folin-Ciocalteu and aluminum chloride methods, respectively. Antioxidant activities were investigated using 2,2'-diphenyl-1-picrylhydrazyl and a ferric...
Source: Chemistry and Biodiversity - May 14, 2021 Category: Biochemistry Authors: Wantida Chaiyana Wannaree Charoensup Suwannee Sriyab Chanun Punyoyai Waranya Neimkhum Source Type: research
Echinacea purpurea (L.) Moench treatment of monocytes promotes tonic interferon signaling, increased innate immunity gene expression and DNA repeat hypermethylated silencing of endogenous retroviral sequences
Herbal remedies of Echinacea purpurea tinctures are widely used today to reduce common cold respiratory tract infections. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - May 12, 2021 Category: Complementary Medicine Authors: Ken Declerck, Claudina Perez Novo, Lisa Grielens, Guy Van Camp, Andreas Suter and Wim Vanden Berghe Tags: Research article Source Type: research
Echinacea in hepatopathy: A review of its phytochemistry, pharmacology, and safety
Publication date: Available online 26 April 2021Source: PhytomedicineAuthor(s): Wenqian Xu, Hongkang Zhu, Bin Hu, Yuliang Cheng, Yahui Guo, Weirong Yao, He Qian (Source: Phytomedicine)
Source: Phytomedicine - April 27, 2021 Category: Drugs & Pharmacology Source Type: research
Interactions of Echinacea spp. Root Extracts and Alkylamides With the Endocannabinoid System and Peripheral Inflammatory Pain
This study demonstrates that in vitro effects of crude echinacea root extracts on CB receptors is predicted by phytochemistry. In vivo, echinacea has potential applications for peripheral inflammatory pain such as arthritis and burns, reflecting the traditional uses of Indigenous North Americans. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 27, 2021 Category: Drugs & Pharmacology Source Type: research
429 Spirulina use and its temporal association with dermatomyositis exacerbation
The immunostimulatory effects of complementary and alternative medicine (CAM) may lead to the exacerbation of autoimmunity. As a result, there is a need to characterize the temporal association between immunostimulatory CAM use and autoimmune skin diseases. We performed a nested retrospective study of prospectively-collected CAM usage data at UPenn. Patients with dermatomyositis (DM), cutaneous lupus erythematosus (CLE), autoimmune blistering disease (AIBD), and healthy controls (HC) without autoimmune disease were surveyed for history of immunostimulatory CAM usage (Spirulina, Chlorella, Alfalfa, Green Algae, Echinacea) a...
Source: Journal of Investigative Dermatology - April 19, 2021 Category: Dermatology Authors: A. Ravishankar, C. Bax, M. Grinnell, D. Yan, R. Feng, J. Okawa, V.P. Werth Tags: Patient-Targeted Research Source Type: research
Molecules, Vol. 26, Pages 2381: Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels
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Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin. First, an aqueous extract of Echinacea purpurea was prepared using a Soxhlet apparatus. Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, addit...
Source: Molecules - April 19, 2021 Category: Chemistry Authors: Bialik-W ąs Kr ólicka Malina Tags: Article Source Type: research
Echinacea reduces antibiotic usage in children through respiratory tract infection prevention: a randomized, blinded, controlled clinical trial
ConclusionsOur results support the use of Echinacea for the prevention of RTIs and reduction of associated antibiotic usage in children.Trial registration clinicaltrials.gov, NCT02971384, 23th Nov 2016. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 8, 2021 Category: Research Source Type: research
Anticancer and biological properties of leaf and flower extracts of Echinacea purpurea (L.) Moench
Publication date: June 2021Source: Food Bioscience, Volume 41Author(s): Khawla Omran Mohamed Sharif, Enis Fuat Tufekci, Buket Ustaoglu, Yasemin Celik Altunoglu, Gokhan Zengin, E.J. Llorent-Martínez, Kerim Guney, Mehmet Cengiz Baloglu (Source: Food Bioscience)
Source: Food Bioscience - March 31, 2021 Category: Food Science Source Type: research
[ASAP] Interaction of Phytocompounds of < italic toggle="yes" > Echinacea purpurea < /italic > with ABCB1 and ABCG2 Efflux Transporters
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.0c01075 (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - March 17, 2021 Category: Drugs & Pharmacology Authors: Charles Awortwe, Henrike Bruckmueller, Meike Kaehler, and Ingolf Cascorbi Source Type: research
