Caffeoylquinic acids with potential biological activity from plant in vitro cultures as alternative sources of valuable natural products.
CONCLUSION: The results indicate that the various in vitro cultures of different plant species can be profitable approach for production of CQAs. In particular an efficient production of these valuable compounds is possible by Lonicera macranthoides and Eucomia ulmoides cell suspension cultures, Leonurus sibiricus transformed roots and AtPAP1 transgenic roots, Echinacea angustifolia adventitious shoots, Rhaponticum carthamoides transformed plants, Lavandula viridis shoots, Sausera involucrata cell suspension and Cichorium intybus transformed roots.
PMID: 32048962 [PubMed - as supplied by publisher] (Source: Current...
Source: Current Pharmaceutical Design - February 10, 2020 Category: Drugs & Pharmacology Authors: Skała E, Makowczyńska J, Wieczfinska J, Kowalczyk T, Sitarek P Tags: Curr Pharm Des Source Type: research
Polysaccharide from Echinacea purpurea reduce the oxidant stress in vitro and in vivo.
Abstract
Echinacea purpurea polysaccharides (EPPS) were extracted through water extract and alcohol precipitate method. Three polysaccharides were purified by DEAE cellulose, named EPPS-1, EPPS-2 and EPPS-3. The antioxidant activities in three polysaccharides were screened by free radical scavenging test and EPPS-3 possessed the best antioxidant function. Then the antioxidant activities of EPPS-3 were further explored in oxidative damage model in vitro and in vivo for the first time. The results showed that the antioxidases and the metabolism content were significantly improved in EPPS-3 group. EPPS-3 coul...
Source: International Journal of Biological Macromolecules - January 13, 2020 Category: Biochemistry Authors: Hou R, Xu T, Li Q, Yang F, Wang C, Huang T, Hao Z Tags: Int J Biol Macromol Source Type: research
A strategy for test article selection and phytochemical characterization of Echinacea purpurea extract for safety testing.
Abstract
Botanical dietary supplements (BDS) are used around the world for many purported therapeutic properties. The selection of an authentic product and it's phytochemical characterization is critical to generate robust safety data. Because botanicals are complex mixtures with variable quality, identification of a representative product for testing has been challenging. Echinacea is used for its purported immune stimulant properties and was listed as the 2nd top-selling BDS in 2018. However, there are limited safety data for Echinacea. Hence, the National Toxicology Program (NTP) has selected Echinacea ...
Source: Food and Chemical Toxicology - January 9, 2020 Category: Food Science Authors: Waidyanatha S, Pierfelice J, Cristy T, Mutlu E, Burback B, Rider CV, Ryan K Tags: Food Chem Toxicol Source Type: research
Ginger and echinacea extracts improve the quality and fertility potential of frozen-thawed ram epididymal spermatozoa.
Abstract
The current study examined the impact of the supplementation of ginger and echinacea extract, as natural antioxidant agents, in freezing extender on the quality and fertility potential of ram epididymal spermatozoa after cryopreservation. Epididymal spermatozoa isolated from Forty testicles, obtained from 20 rams, with motility >80% and total morphological abnormalities <10% were pooled, divided into 7 aliquots and used for cryopreservation. The semen samples were re-suspended with basic Tris egg yolk diluent containing ginger and echinacea extracts (5, 10 and 20 mg/l). The control diluent...
Source: Cryobiology - December 25, 2019 Category: Biology Authors: Merati Z, Farshad A Tags: Cryobiology Source Type: research
Impact of dietary supplementation with Echinacea purpurea on growth performance, immunological, biochemical, and pathological finding in broiler chickens infected by pathogenic E. coli
This study is aimed to appraise the impact of dietary supplementation withEchinacea purpurea (EP) in broiler chickens infected by pathogenicE. coli. Eighty-one-day-old chicks of both sexes, commercial Hubbard chicks, were divided into 4 groups. The first was kept as normal control, the second was supplemented by EP (5 mg/kg feed) from the first day to the end, where the third was infected orally by 1 mlE. coli O78 at 107 CFU intra-crop at 7 days old, while the last group was supplemented by EP and infected by theE. coli O78 as previously described .E. coli-infected chicks disclosed severe symptoms with mort...
Source: Tropical Animal Health and Production - December 10, 2019 Category: Veterinary Research Source Type: research
Herbal Interaction With Chemotherapeutic Drugs —A Focus on Clinically Significant Findings
This study reviews relevant literature and identified six herbal products namely echinacea, garlic, ginseng, grapefruit juice, milk thistle, and St John's wort, which have shown interactions with chemotherapeutic agents in humans. This focus on clinically significant herb-drug interaction, should be of interest to the public including practitioners, researchers, and consumers of cancer chemotherapy. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - December 2, 2019 Category: Cancer & Oncology Source Type: research
Effect of Immunomodulatory Supplements Based on Echinacea Angustifolia and Echinacea Purpurea on the Posttreatment Relapse Incidence of Genital Condylomatosis: A Prospective Randomized Study.
Conclusions. In conclusion, the presence of a latent infection causes condylomatosis relapse; in order to reduce the relapse risk an induction of a protective immune response seems to be essential to allow rapid viral clearance from genital areas surrounding lesion and treatment zones. Echinacea promotes this process. EP and EA dry root extracts seem to be a valid adjuvant therapy in reducing relapse incidence of lesions in patients treated for genital condylomatosis.
PMID: 31111049 [PubMed - indexed for MEDLINE] (Source: Biomed Res)
Source: Biomed Res - November 24, 2019 Category: Research Authors: De Rosa N, Giampaolino P, Lavitola G, Morra I, Formisano C, Nappi C, Bifulco G Tags: Biomed Res Int Source Type: research
Echinacea can help with Azithromycin in prevention of recurrent tonsillitis in children
ConclusionThe combined use of Echinacea with Azithromycin produced favorable outcome than Azithromycin alone in pediatric patients with recurrent tonsillitis. (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - November 14, 2019 Category: Endocrinology Source Type: research
Combined extracts of Echinacea angustifolia DC. and Zingiber officinale Roscoe in softgel capsules: Pharmacokinetics and immunomodulatory effects assessed by gene expression profiling
ConclusionsThese data demonstrated that the bioactive ingredients are highly and rapidly absorbed from softgel capsules containing the combination of the above-mentioned lipophilic extracts, providing evidence to support their immunomodulatory and anti-inflammatory properties. These data also help in defining the mechanistic pathways underlying the health benefits of these plant-derived bioactive compounds.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - September 17, 2019 Category: Drugs & Pharmacology Source Type: research
Echinacea-induced amyopathic dermatomyositis exacerbation in a patient well controlled on naltrexone: A case report
We report the successful use of oral low-dose naltrexone (LDN) to manage CADM. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research
The immunoregulatory effect of sulfated Echinacea purpurea polysaccharide on chicken bone marrow-derived dendritic cells.
Abstract
Echinacea purpurea polysaccharide (EPP) was obtained by modern separation technology and sulfated EPP (sEPP) was prepared by sulfation modification. The immunological effects of EPP and sEPP were compared on chicken bone marrow-derived dendritic cells (chBM-DCs). The results showed that the surface marker expression of CD11c and CD80 was increased after chBM-DCs were cultured with three dosage of sEPP, especially in sEPPM group. Three dosage of sEPP, EPPL and LPS could significantly enhance the effects of chBM-DCs on the proliferation of allogenic mixed lymphocytes. After chBM-DCs treatment with E...
Source: International Journal of Biological Macromolecules - August 4, 2019 Category: Biochemistry Authors: Yao L, Bai L, Tan Y, Sun J, Qu Q, Shi D, Guo S, Liu C Tags: Int J Biol Macromol Source Type: research
Comparative immune response and pathogenicity of the H9N2 avian influenza virus after administration of Immulant ®, based on Echinacea and Nigella sativa, in stressed chickens.
In conclusion, oral administration of 1% IMU for six weeks can enhance the immune response after AI-H9N2 vaccination and reduce the pathogenicity of infection in stressed chickens.
PMID: 31300109 [PubMed - in process] (Source: Comparative immunology, microbiology and infectious diseases.)
Source: Comparative immunology, microbiology and infectious diseases. - July 15, 2019 Category: Allergy & Immunology Authors: Eladl AH, Arafat N, El-Shafei RA, Farag VM, Saleh RM, Awadin WF Tags: Comp Immunol Microbiol Infect Dis Source Type: research
Echinacea purpurea Root Extract Increases Tumor Necrosis Factor Production by Concanavalin A-Activated Murine Splenocytes
Journal of Medicinal Food, Ahead of Print. (Source: Journal of Medicinal Food)
Source: Journal of Medicinal Food - July 6, 2019 Category: Nutrition Authors: Mikaela P. Cadiz Mackenzie R. Schara Bailey H. Kemp Rachel M. Gibbons Johnson Source Type: research
Tissue specificity and differential effects on in vitro plant growth of single bacterial endophytes isolated from the roots, leaves and rhizospheric soil of Echinacea purpurea
Echinacea-endophyte interaction might affect plant secondary metabolites content and influence bacterial colonization specificity and plant growth, but the underlying mechanisms need deepening. An in vitro model,... (Source: BMC Plant Biology)
Source: BMC Plant Biology - June 28, 2019 Category: Biology Authors: Valentina Maggini, Alessio Mengoni, Eugenia Rosaria Gallo, Sauro Biffi, Renato Fani, Fabio Firenzuoli and Patrizia Bogani Tags: Research article Source Type: research
Echinacea for the prevention and treatment of upper respiratory tract infections: A systematic review and meta-analysis.
CONCLUSIONS: Our review presents evidence that echinacea might have a preventative effect on the incidence of upper respiratory tract infections but whether this effect is clinically meaningful is debatable. We did not find any evidence for an effect on the duration of upper respiratory tract infections. Regarding the safety of echinacea no risk is apparent in the short term at least. The strength of these conclusions is limited by the risk of selective reporting and methodological heterogeneity.
IMPLICATIONS OF KEY FINDINGS: Based on the results of this review users of echinacea can be assured that echinacea prepa...
Source: Complementary Therapies in Medicine - May 29, 2019 Category: Complementary Medicine Authors: David S, Cunningham R Tags: Complement Ther Med Source Type: research
