Neutrophilic dermatoses as a manifestation of a systemic lupus erythematosus flare
We describe a case of neutrophilic dermatoses as a manifestation of a SLE flare.PMID:38235694 | DOI:10.1177/09612033231226350 (Source: Lupus)
Source: Lupus - January 18, 2024 Category: Rheumatology Authors: Yingxue Wang Eugenia Chen Priyanka Iyer Source Type: research
Safety and tolerability of intravenous immunoglobulin in patients with active dermatomyositis: results from the randomised, placebo-controlled ProDERM study
Dermatomyositis is an idiopathic inflammatory myopathy characterised by rashes and progressive muscle weakness. The recent ProDERM (Progress in DERMatomyositis) study is the first large randomised, placebo-con... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - January 17, 2024 Category: Rheumatology Authors: Rohit Aggarwal, Joachim Schessl, Christina Charles-Schoeman, Zsuzsanna Bata-Cs örgő, Mazen M. Dimachkie, Zoltan Griger, Sergey Moiseev, Chester V. Oddis, Elena Schiopu, Jiri Vencovský, Irene Beckmann, Elisabeth Clodi and Todd Levine Tags: Research Source Type: research
Hypouricemia as a novel predictor of mortality in anti-MDA5 positive dermatomyositis patients with ILD: A retrospective cohort study
Anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis (MDA5+ DM) is a unique subtype of idiopathic inflammatory myopathy (IIM) that is associated with rapidly progressive interstitial lung disease (RPILD) and high mortality. This retrospective study aimed to identify predictors of mortality and discover novel easily detectable indicators. (Source: Respiratory Medicine)
Source: Respiratory Medicine - January 14, 2024 Category: Respiratory Medicine Authors: Hongjiang Liu, Bo Chen, Yixue Guo, Huan Liu, Jingjing Ran, Ruiting Liu, Geng Yin, Qibing Xie Tags: Original Research Source Type: research
Case report: Checkpoint inhibitor pneumonitis with positive anti-melanoma differentiation-associated gene 5 antibodies in a patient with lung cancer
We present the case of a 74-year-old man with lung adenocarcinoma who developed RP-ILD after treatment with immune checkpoint inhibitors. Further investigation revealed multiple autoantibodies, including anti-MDA5 antibodies. He initially responded to systemic glucocorticoids, immunosuppressants, and tocilizumab but eventually died from worsening pneumomediastinum. This case is the first one to suggest that checkpoint inhibitor pneumonitis can present as RP-ILD with positive anti-MDA5 antibodies, which may be predictive of a poor prognosis. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - January 12, 2024 Category: Allergy & Immunology Source Type: research
Clinical features of macrophage activation syndrome in adult dermatomyositis: A single‐center retrospective case‐control study
ConclusionMAS was a common and fatal complication of dermatomyositis in our cohort. MAS is closely related to RP-ILD in patients with dermatomyositis. When RP-ILD is present in dermatomyositis patients with abnormal laboratory findings, such as cytopenia and hyperferritinemia, the presence of MAS should be considered. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - January 10, 2024 Category: Allergy & Immunology Authors: Dingxian Zhu,
Shuni Ying,
Changyi Yang,
Sheng Li,
Shunli Tang,
Chuanyin Sun,
Hong Fang,
Jianjun Qiao Tags: ORIGINAL ARTICLE Source Type: research
Causes and Clinical Presentation of Drug-Induced Dermatomyositis
This systematic review characterizes causes and clinical presentation of drug-induced dermatomyositis based on the current literature. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 10, 2024 Category: Dermatology Source Type: research
Global trends in research of melanoma differentiation-associated gene 5: a bibliometric analysis from 2002 to 2022
ConclusionThis study comprehensively demonstrated the research frontiers of MDA5 and will provide a useful resource for scholars to conduct future decisions.Key PointsWe conducted the first in-depth survey of the research frontiers on melanoma differentiation-associated gene 5 (MDA5) over the past two decades via bibliometric analysis.We found that many early breakthroughs have been made in the mechanism of MDA5-mediated antiviral immune responses, and the role of MDA5 in autoimmune and autoinflammatory diseases has raised the recent concern.We identified that the virus infection-associated pathogenesis and effective thera...
Source: Clinical Rheumatology - January 6, 2024 Category: Rheumatology Source Type: research
Clinicopathological Reclassification of Idiopathic Inflammatory Myopathy to Match the Serological Results of Myositis-Specific Antibodies
CONCLUSIONS: This new clinicopathological classification for IIM in combination with serological test results could be applied to our previous case series. Adoption of the new criteria will lead to a better understanding of the disease and hence new therapeutic insights.PMID:38179634 | DOI:10.3988/jcn.2022.0432 (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 5, 2024 Category: Neurology Authors: Young-Eun Park Dae-Seong Kim Minsung Kang Jin-Hong Shin Source Type: research
Clinicopathological Reclassification of Idiopathic Inflammatory Myopathy to Match the Serological Results of Myositis-Specific Antibodies
CONCLUSIONS: This new clinicopathological classification for IIM in combination with serological test results could be applied to our previous case series. Adoption of the new criteria will lead to a better understanding of the disease and hence new therapeutic insights.PMID:38179634 | PMC:PMC10782087 | DOI:10.3988/jcn.2022.0432 (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 5, 2024 Category: Neurology Authors: Young-Eun Park Dae-Seong Kim Minsung Kang Jin-Hong Shin Source Type: research
Adverse cutaneous reaction to hydroxychloroquine in a patient with anti-SAE-1-positive dermatomyositis and a history of diffuse large B-cell lymphoma
This report highlights the utility of the myositis-specific antibody panel to guide diagnosis and management, as well as the potential for developing dermatomyositis years after a lymphoma diagnosis.PMID:38174019 | PMC:PMC10761009 | DOI:10.1080/08998280.2023.2274231 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - January 4, 2024 Category: Universities & Medical Training Authors: Corley Pruneda Soumya A Reddy Hannah Buckingham Michelle Tarbox Source Type: research
Adverse cutaneous reaction to hydroxychloroquine in a patient with anti-SAE-1-positive dermatomyositis and a history of diffuse large B-cell lymphoma
This report highlights the utility of the myositis-specific antibody panel to guide diagnosis and management, as well as the potential for developing dermatomyositis years after a lymphoma diagnosis.PMID:38174019 | PMC:PMC10761009 | DOI:10.1080/08998280.2023.2274231 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - January 4, 2024 Category: Universities & Medical Training Authors: Corley Pruneda Soumya A Reddy Hannah Buckingham Michelle Tarbox Source Type: research
