Paraneoplastic Syndromes in Neuroendocrine Prostate Cancer: A Systematic Review
Curr Oncol. 2024 Mar 21;31(3):1618-1632. doi: 10.3390/curroncol31030123.ABSTRACTNeuroendocrine prostate cancer (NEPC) is a rare subtype of prostate cancer (PCa) that usually results in poor clinical outcomes and may be accompanied by paraneoplastic syndromes (PNS). NEPC is becoming more frequent. It can initially manifest as PNS, complicating diagnosis. Therefore, we reviewed the literature on the different PNS associated with NEPC. We systematically reviewed English-language articles from January 2017 to September 2023, identifying 17 studies meeting PRISMA guidelines for NEPC and associated PNS. A total of 17 articles we...
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Mohammad Abufaraj Raghad Ramadan Amro Alkhatib Source Type: research

Asymmetric darkened knuckles with subclinical myopathy revealed anti-Mi2b positive dermatomyositis
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research

Clinical Image: Nasal rim sign: A clinical manifestation of dermatomyositis
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - March 26, 2024 Category: Rheumatology Authors: Sweta Subhadarshani, Madeline Hunt, Kerith Spicknall Tags: Clinical Image Source Type: research

A less common case of anti ‐MDA5 and anti‐Ro52 antibody‐positive juvenile dermatomyositis complicated with macrophage activation syndrome
(Source: Clinical Case Reports)
Source: Clinical Case Reports - March 21, 2024 Category: General Medicine Authors: Li Zhang, Haiqing Zhang, Shanshan Liu, Ning Zhang, Yun Wang Tags: CASE IMAGE Source Type: research

Therapeutic efficacy and safety of JAK inhibitors in treating polymyositis/dermatomyositis: a single-arm systemic meta-analysis
DiscussionIn summary, this meta-analysis demonstrated that JAK inhibitors can potentially treat DM/PM without severe adverse reactions.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42023416493, identifier CRD42023416493. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 21, 2024 Category: Allergy & Immunology Source Type: research

Case report: A case of resistant anti ‐SAE1 dermatomyositis with severe periorbital edema after hydroxychloroquine that responded to adalimumab
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 20, 2024 Category: Rheumatology Authors: Maria Farhat, Boutros Soutou Tags: LETTER TO THE EDITOR Source Type: research

Asymmetric darkened knuckles with subclinical myopathy revealed anti-Mi2b positive dermatomyositis
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - March 18, 2024 Category: Rheumatology Source Type: research

Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement
ConclusionThis study extends to NK cells an altered profile of TRAIL, Bcl-2, TNFR1, Fas, FasL, Bax, Bim, and caspase-3 proteins in patients with jSLE, particularly in those with active disease, positive anti-dsDNA, nephritis, and without neuropsychiatric involvement. This change in apoptosis-related protein expressions may contribute to the defective functions of NK cells and, consequently, to lupus development. The full clarification of the role of NK cells in jSLE pathogenesis may pave the way for new therapies like those of NK cell–based. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 18, 2024 Category: Allergy & Immunology Source Type: research

Anti-SAE dermatomyositis: clinical and histologic characteristics from a monocentric Italian cohort
CONCLUSIONS: Anti-SAE DM represents a disease subset characterised by classic cutaneous involvement often associated with itching, less severe muscle involvement, but potential pulmonary involvement that should always be investigated in these patients.PMID:38488098 | DOI:10.55563/clinexprheumatol/110r0p (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Marco Fornaro Laura Coladonato Margherita Giannini Angelica Napoletano Francesco Girolamo Dario D'Abbicco Maddalena Ruggieri Daniele Vito Andrea Sabella Florenzo Iannone Source Type: research

Cancer-associated myositis before and after the COVID-19 pandemic onset: a changing trend
CONCLUSIONS: There was a significant increase in the incidence of CAM after the COVID-19 pandemic. IIM diagnosis after the COVID-19 pandemic was an independent predictor of CAM.PMID:38488097 | DOI:10.55563/clinexprheumatol/jv9ey8 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Filipa M Costa Raquel Campanilho-Marques Eduardo Dourado Matilde Bandeira Bianca Correia Ana Teresa Melo Fernando Saraiva Sofia C Barreira Jo ão Eurico Fonseca Source Type: research

Polymyositis is a rare and favourable outcome subtype of idiopathic inflammatory myopathy in Chinese patients
CONCLUSIONS: Strictly defined typical PM is a rare clinical subtype in Chinese IIM patients. Typical PM patients with classical pathology were MSA-negative and responded well to treatment and had a favourable prognosis. It is crucial for clinicians to combine clinical, serological, and pathological features to properly distinguish PM from other IIM subtypes.PMID:38488095 | DOI:10.55563/clinexprheumatol/7v9d2x (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Chao Sun Xiaolan Tian Hongxia Yang Hanbo Yang Shanshan Li Wei Jiang Qinglin Peng Guochun Wang Xin Lu Source Type: research

Mental health in paediatric and adult myositis-related diseases: current state of research, interventions, and future steps from the MIHRA Psychological Impact Scientific Working Group
Clin Exp Rheumatol. 2024 Feb;42(2):413-424. doi: 10.55563/clinexprheumatol/cngdfn. Epub 2024 Mar 14.ABSTRACTPsychological and emotional well-being are critical aspects of overall health for individuals with chronic rheumatologic conditions. Mental health-related literature, however, predominantly focuses on systemic lupus erythematosus or rheumatoid arthritis, with limited emphasis on idiopathic inflammatory myopathies (IIMs). High proportions of those with juvenile myositis report psychological distress at levels warranting mental health referral. Adults with dermatomyositis diagnosed with depression or anxiety do not rec...
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Aviya Lanis Helene Alexanderson Kaveh Ardalan Suzanne Edison Christopher D Graham Ingrid de Groot Latika Gupta Susan Kim Andrea M Knight Linda Kobert Polly Livermore Christian Lood Clarissa Pilkington Malin Regardt Tamar B Rubinstein Susan Shenoi Luke Tur Source Type: research

Nailfold capillaroscopy findings of a multicentric multi-ethnic cohort of patients with idiopathic inflammatory myopathies
CONCLUSIONS: NVC abnormalities are related to the diagnosis, clinical features, disease activity, and autoantibodies of patients with IIM.PMID:38488092 | DOI:10.55563/clinexprheumatol/l9gudh (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Jiram Torres-Ruiz Iago Pinal-Fernandez Albert Selva-O'Callaghan Bianca Campbell Sandra Mu ñoz-Braceras Nancy R Mej ía-Domínguez Carlos N úñez-Álvarez Jos é Milisenda Maria Casal-Dom ínguez Katherine Pak Alfredo Guill én-Del-Castillo Ernesto Trall Source Type: research

Clinical, histologic and prognostic features of clinically amyopathic dermatomyositis
CONCLUSIONS: CADM patients differ in disease onset, autoantibody profiles, joint and lung involvement. While laboratory and instrumental tests have not shown muscle involvement in CADM, many muscle biopsies have shown MHC-I overexpression.PMID:38488091 | DOI:10.55563/clinexprheumatol/kgpnbq (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Marco Fornaro Francesco Girolamo Margherita Giannini Laura Coladonato Adriana Capuano Marco Capodiferro Dario D'Abbicco Maddalena Ruggieri Mariangela Mastrapasqua Florenzo Iannone Source Type: research

Clinical, histologic and prognostic features of clinically amyopathic dermatomyositis
CONCLUSIONS: CADM patients differ in disease onset, autoantibody profiles, joint and lung involvement. While laboratory and instrumental tests have not shown muscle involvement in CADM, many muscle biopsies have shown MHC-I overexpression.PMID:38488091 | DOI:10.55563/clinexprheumatol/kgpnbq (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Marco Fornaro Francesco Girolamo Margherita Giannini Laura Coladonato Adriana Capuano Marco Capodiferro Dario D'Abbicco Maddalena Ruggieri Mariangela Mastrapasqua Florenzo Iannone Source Type: research