A 30-year-old female with dermatomyositis without high elevation of muscle enzymes: a rare case report from Syria
CONCLUSION: Even if test findings are not conclusive, dermatomyositis should always be considered when muscular weakness manifests. It's important to distinguish the disorder from connective tissue diseases like lupus erythematosus. In fact, to correctly diagnose DM, if there are any doubts, a muscle biopsy is required.PMID:38576947 | PMC:PMC10990297 | DOI:10.1097/MS9.0000000000001682 (Source: Hand Surgery)
Source: Hand Surgery - April 5, 2024 Category: Surgery Authors: Suaad Hamsho Bilal Sleiay Mouhammed Sleiay Obeda Batrash Hadi Alabdullah Majed Aboud Source Type: research
A 30-year-old female with dermatomyositis without high elevation of muscle enzymes: a rare case report from Syria
CONCLUSION: Even if test findings are not conclusive, dermatomyositis should always be considered when muscular weakness manifests. It's important to distinguish the disorder from connective tissue diseases like lupus erythematosus. In fact, to correctly diagnose DM, if there are any doubts, a muscle biopsy is required.PMID:38576947 | PMC:PMC10990297 | DOI:10.1097/MS9.0000000000001682 (Source: Annals of Medicine)
Source: Annals of Medicine - April 5, 2024 Category: Internal Medicine Authors: Suaad Hamsho Bilal Sleiay Mouhammed Sleiay Obeda Batrash Hadi Alabdullah Majed Aboud Source Type: research
Pembrolizumab-associated anti-MDA5 dermatomyositis in a patient with lung cancer: a first case report
We report the first case of anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis as a systemic immune-related adverse event in a 64-year-old man receiving pembrolizumab to treat advanced lung cancer. The patient experienced hypothyroidism, myalgia, skin involvement, dyspnoea and diarrhoea. Laboratory tests revealed raised inflammatory markers, hypercreatinekinasemia and anti-MDA5 autoantibodies. Electroneuromyography and pathognomonic signs on physical examination confirmed the diagnosis of pauci-myopathic dermatomyositis. Pembrolizumab was discontinued and immunosuppressive therapy led to rapid ...
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Antonino Marcello Pilia Lorenzo Salvati Alessia Guidolin Francesca Mazzoni Lorenzo Antonuzzo Paola Parronchi Francesco Liotta Source Type: research
Pembrolizumab-associated anti-MDA5 dermatomyositis in a patient with lung cancer: a first case report
We report the first case of anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis as a systemic immune-related adverse event in a 64-year-old man receiving pembrolizumab to treat advanced lung cancer. The patient experienced hypothyroidism, myalgia, skin involvement, dyspnoea and diarrhoea. Laboratory tests revealed raised inflammatory markers, hypercreatinekinasemia and anti-MDA5 autoantibodies. Electroneuromyography and pathognomonic signs on physical examination confirmed the diagnosis of pauci-myopathic dermatomyositis. Pembrolizumab was discontinued and immunosuppressive therapy led to rapid ...
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Antonino Marcello Pilia Lorenzo Salvati Alessia Guidolin Francesca Mazzoni Lorenzo Antonuzzo Paola Parronchi Francesco Liotta Source Type: research
Characteristics of chest high-resolution computed tomography in patients with anti-aminoacyl-tRNA synthetase antibody-positive interstitial lung disease
CONCLUSIONS: This retrospective study demonstrated that ARS-ILD patients, regardless of myositis symptoms, most often showed the NSIP pattern on HRCT, as previously reported. However, unlike previous reports, the UIP pattern on HRCT was not rare.PMID:38567566 | DOI:10.36141/svdld.v41i1.14144 (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 3, 2024 Category: Respiratory Medicine Authors: Masato Mima Seidai Sato Takayoshi Shinya Nobuhito Naito Takatoshi Shoji Saki Harada Ryoko Suzue Kojin Murakami Kazuya Koyama Yasuhiko Nishioka Source Type: research
Tension Pneumomediastinum in Anti-MDA5 Antibody-positive Dermatomyositis-associated Interstitial Lung Disease: A Case Report and Literature Review
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.3418-23. Online ahead of print.ABSTRACTAnti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM)-associated interstitial lung disease (ILD) can sometimes be complicated by pneumomediastinum, although tension pneumomediastinum is extremely rare. We herein report a case of anti-MDA5 antibody-positive DM-ILD that worsened subcutaneous and mediastinal emphysema during treatment. Hypotension and worsening respiratory failure were observed on day 20 of treatment. Mediastinal drainage under video-assisted thoracoscopic surgery promptly impro...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Hiroko Okabayashi Seiya Nakashima Kosuke Fujino Miyu Imai Shohei Hamada Aiko Masunaga Hidenori Ichiyasu Makoto Suzuki Takuro Sakagami Source Type: research
Characteristics of chest high-resolution computed tomography in patients with anti-aminoacyl-tRNA synthetase antibody-positive interstitial lung disease
CONCLUSIONS: This retrospective study demonstrated that ARS-ILD patients, regardless of myositis symptoms, most often showed the NSIP pattern on HRCT, as previously reported. However, unlike previous reports, the UIP pattern on HRCT was not rare.PMID:38567566 | DOI:10.36141/svdld.v41i1.14144 (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 3, 2024 Category: Respiratory Medicine Authors: Masato Mima Seidai Sato Takayoshi Shinya Nobuhito Naito Takatoshi Shoji Saki Harada Ryoko Suzue Kojin Murakami Kazuya Koyama Yasuhiko Nishioka Source Type: research
Tension Pneumomediastinum in Anti-MDA5 Antibody-positive Dermatomyositis-associated Interstitial Lung Disease: A Case Report and Literature Review
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.3418-23. Online ahead of print.ABSTRACTAnti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM)-associated interstitial lung disease (ILD) can sometimes be complicated by pneumomediastinum, although tension pneumomediastinum is extremely rare. We herein report a case of anti-MDA5 antibody-positive DM-ILD that worsened subcutaneous and mediastinal emphysema during treatment. Hypotension and worsening respiratory failure were observed on day 20 of treatment. Mediastinal drainage under video-assisted thoracoscopic surgery promptly impro...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Hiroko Okabayashi Seiya Nakashima Kosuke Fujino Miyu Imai Shohei Hamada Aiko Masunaga Hidenori Ichiyasu Makoto Suzuki Takuro Sakagami Source Type: research
Characteristics of chest high-resolution computed tomography in patients with anti-aminoacyl-tRNA synthetase antibody-positive interstitial lung disease
CONCLUSIONS: This retrospective study demonstrated that ARS-ILD patients, regardless of myositis symptoms, most often showed the NSIP pattern on HRCT, as previously reported. However, unlike previous reports, the UIP pattern on HRCT was not rare.PMID:38567566 | DOI:10.36141/svdld.v41i1.14144 (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 3, 2024 Category: Respiratory Medicine Authors: Masato Mima Seidai Sato Takayoshi Shinya Nobuhito Naito Takatoshi Shoji Saki Harada Ryoko Suzue Kojin Murakami Kazuya Koyama Yasuhiko Nishioka Source Type: research
Tension Pneumomediastinum in Anti-MDA5 Antibody-positive Dermatomyositis-associated Interstitial Lung Disease: A Case Report and Literature Review
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.3418-23. Online ahead of print.ABSTRACTAnti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM)-associated interstitial lung disease (ILD) can sometimes be complicated by pneumomediastinum, although tension pneumomediastinum is extremely rare. We herein report a case of anti-MDA5 antibody-positive DM-ILD that worsened subcutaneous and mediastinal emphysema during treatment. Hypotension and worsening respiratory failure were observed on day 20 of treatment. Mediastinal drainage under video-assisted thoracoscopic surgery promptly impro...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Hiroko Okabayashi Seiya Nakashima Kosuke Fujino Miyu Imai Shohei Hamada Aiko Masunaga Hidenori Ichiyasu Makoto Suzuki Takuro Sakagami Source Type: research
Characteristics of chest high-resolution computed tomography in patients with anti-aminoacyl-tRNA synthetase antibody-positive interstitial lung disease
CONCLUSIONS: This retrospective study demonstrated that ARS-ILD patients, regardless of myositis symptoms, most often showed the NSIP pattern on HRCT, as previously reported. However, unlike previous reports, the UIP pattern on HRCT was not rare.PMID:38567566 | DOI:10.36141/svdld.v41i1.14144 (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 3, 2024 Category: Respiratory Medicine Authors: Masato Mima Seidai Sato Takayoshi Shinya Nobuhito Naito Takatoshi Shoji Saki Harada Ryoko Suzue Kojin Murakami Kazuya Koyama Yasuhiko Nishioka Source Type: research
Tension Pneumomediastinum in Anti-MDA5 Antibody-positive Dermatomyositis-associated Interstitial Lung Disease: A Case Report and Literature Review
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.3418-23. Online ahead of print.ABSTRACTAnti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM)-associated interstitial lung disease (ILD) can sometimes be complicated by pneumomediastinum, although tension pneumomediastinum is extremely rare. We herein report a case of anti-MDA5 antibody-positive DM-ILD that worsened subcutaneous and mediastinal emphysema during treatment. Hypotension and worsening respiratory failure were observed on day 20 of treatment. Mediastinal drainage under video-assisted thoracoscopic surgery promptly impro...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Hiroko Okabayashi Seiya Nakashima Kosuke Fujino Miyu Imai Shohei Hamada Aiko Masunaga Hidenori Ichiyasu Makoto Suzuki Takuro Sakagami Source Type: research
Characteristics of chest high-resolution computed tomography in patients with anti-aminoacyl-tRNA synthetase antibody-positive interstitial lung disease
CONCLUSIONS: This retrospective study demonstrated that ARS-ILD patients, regardless of myositis symptoms, most often showed the NSIP pattern on HRCT, as previously reported. However, unlike previous reports, the UIP pattern on HRCT was not rare.PMID:38567566 | DOI:10.36141/svdld.v41i1.14144 (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 3, 2024 Category: Respiratory Medicine Authors: Masato Mima Seidai Sato Takayoshi Shinya Nobuhito Naito Takatoshi Shoji Saki Harada Ryoko Suzue Kojin Murakami Kazuya Koyama Yasuhiko Nishioka Source Type: research
Tension Pneumomediastinum in Anti-MDA5 Antibody-positive Dermatomyositis-associated Interstitial Lung Disease: A Case Report and Literature Review
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.3418-23. Online ahead of print.ABSTRACTAnti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM)-associated interstitial lung disease (ILD) can sometimes be complicated by pneumomediastinum, although tension pneumomediastinum is extremely rare. We herein report a case of anti-MDA5 antibody-positive DM-ILD that worsened subcutaneous and mediastinal emphysema during treatment. Hypotension and worsening respiratory failure were observed on day 20 of treatment. Mediastinal drainage under video-assisted thoracoscopic surgery promptly impro...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Hiroko Okabayashi Seiya Nakashima Kosuke Fujino Miyu Imai Shohei Hamada Aiko Masunaga Hidenori Ichiyasu Makoto Suzuki Takuro Sakagami Source Type: research
Characteristics of chest high-resolution computed tomography in patients with anti-aminoacyl-tRNA synthetase antibody-positive interstitial lung disease
CONCLUSIONS: This retrospective study demonstrated that ARS-ILD patients, regardless of myositis symptoms, most often showed the NSIP pattern on HRCT, as previously reported. However, unlike previous reports, the UIP pattern on HRCT was not rare.PMID:38567566 | DOI:10.36141/svdld.v41i1.14144 (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - April 3, 2024 Category: Respiratory Medicine Authors: Masato Mima Seidai Sato Takayoshi Shinya Nobuhito Naito Takatoshi Shoji Saki Harada Ryoko Suzue Kojin Murakami Kazuya Koyama Yasuhiko Nishioka Source Type: research
