Oncocytic variant of mucoepidermoid carcinoma – A report of two cases and review of histopathology, immunohistochemistry, and molecular profiling
Oncocytic changes have been described in approximately 10% of salivary gland tumors. It has been associated with a variety of benign and malignant tumors such as Warthin tumor, cystadenoma, pleomorphic adenoma, polymorphous adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma (MEC), among others. MEC is the most common salivary gland malignancy and exhibits various histological patterns. Oncocytic MEC (OMEC) is a rare variant characterized by a predominant oncocytic cell population. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 15, 2022 Category: ENT & OMF Authors: Dr. Madhu Shrestha, Dr. Haiying Zhang, Dr. Daniel A Gehlbach, Dr. Victoria Woo Source Type: research
Endocrine cell micronests in an ovarian mucinous borderline tumor: a potential diagnostic pitfall for microinvasion
The occurrence of endocrine cell micronests in ovarian tumors is rarely reported. To our knowledge, there are only three prior cases reported to date: one occurring in an ovarian mucinous cystadenoma, one in a... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 14, 2022 Category: Pathology Authors: Katrina Collins, Sheila Segura and Michael Hwang Tags: Case Report Source Type: research
Recurrent Acromegaly in a Patient With a < em > CHEK2 < /em > Mutation
CONCLUSION: Our data raise the possibility that CHEK2 mutations may be involved in the development of acromegaly. Additional studies are needed to elucidate the potential role of CHEK2 mutations in the pathogenesis of somatotroph adenomas.PMID:35415223 | PMC:PMC8984513 | DOI:10.1016/j.aace.2021.10.006 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 13, 2022 Category: Cancer & Oncology Authors: Milica Perosevic Maria Martinez-Lage Brooke Swearingen Nicholas A Tritos Source Type: research
Recurrent Acromegaly in a Patient With a < em > CHEK2 < /em > Mutation
CONCLUSION: Our data raise the possibility that CHEK2 mutations may be involved in the development of acromegaly. Additional studies are needed to elucidate the potential role of CHEK2 mutations in the pathogenesis of somatotroph adenomas.PMID:35415223 | PMC:PMC8984513 | DOI:10.1016/j.aace.2021.10.006 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 13, 2022 Category: Cancer & Oncology Authors: Milica Perosevic Maria Martinez-Lage Brooke Swearingen Nicholas A Tritos Source Type: research
Recurrent Acromegaly in a Patient With a < em > CHEK2 < /em > Mutation
CONCLUSION: Our data raise the possibility that CHEK2 mutations may be involved in the development of acromegaly. Additional studies are needed to elucidate the potential role of CHEK2 mutations in the pathogenesis of somatotroph adenomas.PMID:35415223 | PMC:PMC8984513 | DOI:10.1016/j.aace.2021.10.006 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 13, 2022 Category: Cancer & Oncology Authors: Milica Perosevic Maria Martinez-Lage Brooke Swearingen Nicholas A Tritos Source Type: research
Recurrent Acromegaly in a Patient With a < em > CHEK2 < /em > Mutation
CONCLUSION: Our data raise the possibility that CHEK2 mutations may be involved in the development of acromegaly. Additional studies are needed to elucidate the potential role of CHEK2 mutations in the pathogenesis of somatotroph adenomas.PMID:35415223 | PMC:PMC8984513 | DOI:10.1016/j.aace.2021.10.006 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 13, 2022 Category: Cancer & Oncology Authors: Milica Perosevic Maria Martinez-Lage Brooke Swearingen Nicholas A Tritos Source Type: research
Recurrent Acromegaly in a Patient With a < em > CHEK2 < /em > Mutation
CONCLUSION: Our data raise the possibility that CHEK2 mutations may be involved in the development of acromegaly. Additional studies are needed to elucidate the potential role of CHEK2 mutations in the pathogenesis of somatotroph adenomas.PMID:35415223 | PMC:PMC8984513 | DOI:10.1016/j.aace.2021.10.006 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 13, 2022 Category: Cancer & Oncology Authors: Milica Perosevic Maria Martinez-Lage Brooke Swearingen Nicholas A Tritos Source Type: research
Recurrent Acromegaly in a Patient With a < em > CHEK2 < /em > Mutation
CONCLUSION: Our data raise the possibility that CHEK2 mutations may be involved in the development of acromegaly. Additional studies are needed to elucidate the potential role of CHEK2 mutations in the pathogenesis of somatotroph adenomas.PMID:35415223 | PMC:PMC8984513 | DOI:10.1016/j.aace.2021.10.006 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 13, 2022 Category: Cancer & Oncology Authors: Milica Perosevic Maria Martinez-Lage Brooke Swearingen Nicholas A Tritos Source Type: research
Pancreatic Cyst Surveillance
Pancreatic cysts (PC) are an increasingly common problem facing general gastroenterologists and generalists. They can be divided into 3 groups. First, those that have no risk of developing into pancreatic cancer, such as a pseudocyst or serous cystadenomas (SCAs). Second, mucinous cystic neoplasms (MCNs) and intraductal papillary mucinous neoplasms (IPMNs), which are precursor lesions to high-grade dysplasia and pancreatic cancer. Third, solid cancers of the pancreas, such as neuroendocrine tumors and pancreatic adenocarcinomas, which have undergone cystic degeneration. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - April 6, 2022 Category: Gastroenterology Authors: Anne Marie Lennon, Santhi Swaroop Vege Tags: Here and Now: Clinical Practice Source Type: research
When prolapse cannot be reduced: incarcerated procidentia due to pelvic mass
ConclusionIncarcerated procidentia is an uncommon occurrence, which in rare cases may be due to a pelvic mass. Surgical management may be required with colpotomy for removal of the pelvic mass in order to reduce the prolapse and resolve the case. (Source: International Urogynecology Journal)
Source: International Urogynecology Journal - April 4, 2022 Category: OBGYN Source Type: research
When prolapse cannot be reduced: incarcerated procidentia due to pelvic mass
ConclusionIncarcerated procidentia is an uncommon occurrence, which in rare cases may be due to a pelvic mass. Surgical management may be required with colpotomy for removal of the pelvic mass in order to reduce the prolapse and resolve the case. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - April 4, 2022 Category: OBGYN Source Type: research
Cancers, Vol. 14, Pages 1506: Development of Low-Grade Serous Ovarian Carcinoma from Benign Ovarian Serous Cystadenoma Cells
Kiyono
Satoru Kyo
Despite the knowledge about numerous genetic mutations essential for the progression of low-grade serous ovarian carcinoma (LGSOC), the specific combination of mutations required remains unclear. Here, we aimed to recognize the oncogenic mutations responsible for the stepwise development of LGSOC using immortalized HOVs-cyst-1 cells, developed from ovarian serous cystadenoma cells, and immortalized via cyclin D1, CDK4R24C, and hTERT gene transfection. Furthermore, oncogenic mutations, KRAS and PIK3CA, were individually and simultaneously introduced in immortalized HOV-cyst-1 cells. Cell functions we...
Source: Cancers - March 15, 2022 Category: Cancer & Oncology Authors: Puja Dey Kentaro Nakayama Sultana Razia Masako Ishikawa Tomoka Ishibashi Hitomi Yamashita Kosuke Kanno Seiya Sato Tohru Kiyono Satoru Kyo Tags: Article Source Type: research
Intestinal-type mucinous ovarian carcinoma arising from a seromucinous precursor lesion
CONCLUSIONS: Our case may represent the ovarian counterpart of endometrial gastrointestinal-type carcinoma, which is an aggressive entity developing from gastrointestinal metaplasia of the endometrial epithelium. Acknowledging the existence of such entity might be relevant in terms of diagnosis and patient management.PMID:35253183 | DOI:10.26355/eurrev_202202_28119 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 7, 2022 Category: Drugs & Pharmacology Authors: A Santoro N D'Alessandris A Travaglino D Arciuolo F Inzani G Angelico G Scaglione M Valente A Raffone G F Zannoni Source Type: research
Intestinal-type mucinous ovarian carcinoma arising from a seromucinous precursor lesion
CONCLUSIONS: Our case may represent the ovarian counterpart of endometrial gastrointestinal-type carcinoma, which is an aggressive entity developing from gastrointestinal metaplasia of the endometrial epithelium. Acknowledging the existence of such entity might be relevant in terms of diagnosis and patient management.PMID:35253183 | DOI:10.26355/eurrev_202202_28119 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 7, 2022 Category: Drugs & Pharmacology Authors: A Santoro N D'Alessandris A Travaglino D Arciuolo F Inzani G Angelico G Scaglione M Valente A Raffone G F Zannoni Source Type: research
