Belzutifan for von Hippel-Lindau Disease: Pancreatic Lesion Population of the Phase 2 LITESPARK-004 Study
CONCLUSIONS: Belzutifan continued to show robust activity and manageable safety in VHL disease-associated pNETs.PMID:38393723 | DOI:10.1158/1078-0432.CCR-23-2592 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - February 23, 2024 Category: Cancer & Oncology Authors: Tobias Else Eric Jonasch Othon Lliopoulos Kathryn E Beckermann Vivek Narayan Benjamin L Maughan Stephane Oudard Jodi K Maranchie Ane B Iversen Cynthia Muller Goldberg Wei Fu Rodolfo F Perini Yanfang Liu W Marston Linehan Ramaprasad Srinivasan Source Type: research
CK7+/CK20+/CDX2+ mucinous carcinoma, arising in a mature cystic teratoma of ovary, presenting with disseminated metastasis and pseudomyxoma peritonei
In this report, we have described a case of a well-differentiated mucinous carcinoma arising within a mature cystic teratoma. The mucinous carcinoma showed a spectrum of morphological patterns, including cystadenoma-like areas, proliferative/borderline areas, villous adenoma-like areas, and areas of invasive carcinoma. In addition, our case showed some unusual findings, namely, diffuse CK7 positivity, associated pseudomyxoma peritonei, and metastasis to lungs. These features were not demonstrated in any of the previously reported cases. Our case shows that the teratomatous mucinous neoplasm of the ovary may show CK7+/CK20+...
Source: Indian Journal of Pathology and Microbiology - February 23, 2024 Category: Pathology Authors: Amit K Adhya Abhitesh Singh Dillip K Muduly Biswajit Sahoo Source Type: research
CK7+/CK20+/CDX2+ mucinous carcinoma, arising in a mature cystic teratoma of ovary, presenting with disseminated metastasis and pseudomyxoma peritonei
In this report, we have described a case of a well-differentiated mucinous carcinoma arising within a mature cystic teratoma. The mucinous carcinoma showed a spectrum of morphological patterns, including cystadenoma-like areas, proliferative/borderline areas, villous adenoma-like areas, and areas of invasive carcinoma. In addition, our case showed some unusual findings, namely, diffuse CK7 positivity, associated pseudomyxoma peritonei, and metastasis to lungs. These features were not demonstrated in any of the previously reported cases. Our case shows that the teratomatous mucinous neoplasm of the ovary may show CK7+/CK20+...
Source: Indian Journal of Pathology and Microbiology - February 23, 2024 Category: Pathology Authors: Amit K Adhya Abhitesh Singh Dillip K Muduly Biswajit Sahoo Source Type: research
CK7+/CK20+/CDX2+ mucinous carcinoma, arising in a mature cystic teratoma of ovary, presenting with disseminated metastasis and pseudomyxoma peritonei
In this report, we have described a case of a well-differentiated mucinous carcinoma arising within a mature cystic teratoma. The mucinous carcinoma showed a spectrum of morphological patterns, including cystadenoma-like areas, proliferative/borderline areas, villous adenoma-like areas, and areas of invasive carcinoma. In addition, our case showed some unusual findings, namely, diffuse CK7 positivity, associated pseudomyxoma peritonei, and metastasis to lungs. These features were not demonstrated in any of the previously reported cases. Our case shows that the teratomatous mucinous neoplasm of the ovary may show CK7+/CK20+...
Source: Indian Journal of Pathology and Microbiology - February 23, 2024 Category: Pathology Authors: Amit K Adhya Abhitesh Singh Dillip K Muduly Biswajit Sahoo Source Type: research
Utilization of texture features of volumetric ADC maps in differentiating between serous cystadenoma and intraductal papillary neoplasms
ConclusionA support vector machine model trained and validated on volumetric texture features extracted from ADC maps showed the possible beneficence of these features in differentiating IPMNs from SCAs. These results are in line with previous regarding the role of ADC maps in classifying cystic lesions and offers new evidence regarding the role of texture features in differentiation of potentially neoplastic and benign lesions. (Source: Abdominal Imaging)
Source: Abdominal Imaging - February 20, 2024 Category: Radiology Source Type: research
A Rare Case of Ovarian Abscess Secondary to Salmonella typhi Infection in Women with MRKH: A Case Report and Review of Literature
We report a case of a 32 yr old woman with fever of unknown origin unresponsive to medical management. During her fever work up, her blood tests suggested typhoid infection while her MRI suggested right sided ovarian mass with high suspicion of mucinous cystadenoma. On staging laparotomy, huge right sided ovarian abscess was found. Right salpingo-oopherectomy was performed. Pus culture suggestedSalmonella typhi infection and histopathology suggested infected ovarian endometrioma. (Source: The Journal of Obstetrics and Gynecology of India)
Source: The Journal of Obstetrics and Gynecology of India - February 16, 2024 Category: OBGYN Source Type: research
Case report: Obstructive azoospermia as the first presentation of Von Hippel-Lindau disease
We report the case of a 38-year-old man whose diagnostic workup for primary infertility led to the discovery of obstructive azoospermia due to bilateral papillary cystadenoma of the epididymis (PCE). Given the rarity of this finding and because PCE could be a manifestation of Von Hippel-Lindau disease (VHL), although the patient had no family or personal history of VHL, the VHL gene was tested, and a known pathogenetic variant (c.464-1G>A; p.)? was found. Screening for other Von Hippel-Lindau disease-associated neoplasms revealed bilateral retinal capillary hemangioblastomas, clear cell renal cell carcinoma, and multipl...
Source: Frontiers in Oncology - December 12, 2023 Category: Cancer & Oncology Source Type: research
An algorithm for the pre-operative differentiation of benign ovarian tumours based on magnetic resonance imaging interpretation in a regional core hospital: A retrospective study
CONCLUSIONS: Among four types of OTs (OEC, OMCT, OEA and OCCA), MRI interpretation was able to differentiate between Be-OTs and Bo/Ma-OTs almost perfectly. Additionally, to mitigate the difficulty in differentiating SM-OTs, OT size may be useful in combination with MRI findings, although further accumulation and analysis of OT cases is needed.PMID:38058586 | PMC:PMC10696378 | DOI:10.1016/j.eurox.2023.100260 (Source: Reproductive Biology)
Source: Reproductive Biology - December 7, 2023 Category: Reproduction Medicine Authors: Wataru Isono Hiroko Tsuchiya Reiko Matsuyama Akihisa Fujimoto Osamu Nishii Source Type: research
An algorithm for the pre-operative differentiation of benign ovarian tumours based on magnetic resonance imaging interpretation in a regional core hospital: A retrospective study
CONCLUSIONS: Among four types of OTs (OEC, OMCT, OEA and OCCA), MRI interpretation was able to differentiate between Be-OTs and Bo/Ma-OTs almost perfectly. Additionally, to mitigate the difficulty in differentiating SM-OTs, OT size may be useful in combination with MRI findings, although further accumulation and analysis of OT cases is needed.PMID:38058586 | PMC:PMC10696378 | DOI:10.1016/j.eurox.2023.100260 (Source: Reproductive Biology)
Source: Reproductive Biology - December 7, 2023 Category: Reproduction Medicine Authors: Wataru Isono Hiroko Tsuchiya Reiko Matsuyama Akihisa Fujimoto Osamu Nishii Source Type: research
An algorithm for the pre-operative differentiation of benign ovarian tumours based on magnetic resonance imaging interpretation in a regional core hospital: A retrospective study
CONCLUSIONS: Among four types of OTs (OEC, OMCT, OEA and OCCA), MRI interpretation was able to differentiate between Be-OTs and Bo/Ma-OTs almost perfectly. Additionally, to mitigate the difficulty in differentiating SM-OTs, OT size may be useful in combination with MRI findings, although further accumulation and analysis of OT cases is needed.PMID:38058586 | PMC:PMC10696378 | DOI:10.1016/j.eurox.2023.100260 (Source: Reproductive Biology)
Source: Reproductive Biology - December 7, 2023 Category: Reproduction Medicine Authors: Wataru Isono Hiroko Tsuchiya Reiko Matsuyama Akihisa Fujimoto Osamu Nishii Source Type: research
Analysis of the clinical efficacy of laparoscopic middle pancreatectomy in the treatment of benign or low-grade malignant tumors of the pancreas
ConclusionLaparoscopic middle pancreatectomy is safe and feasible in the treatment of benign or low-grade malignant tumors in the body of the pancreatic neck and is not accompanied by increased risk of intraoperative and postoperative complications and endocrine dysfunction of the pancreas. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - November 2, 2023 Category: Cancer & Oncology Source Type: research
Biliary cystadenoma in a child: A rare entity
We report a rare case of hepatic biliary cystadenoma in a 3-year-old girl, with a gradually increasing lump in the right upper abdomen. Complete excision with a healthy liver margin was done. (Source: Journal of Indian Association of Pediatric Surgeons)
Source: Journal of Indian Association of Pediatric Surgeons - November 2, 2023 Category: Surgery Authors: Sohail Ahmad Subrat Kumar Sahoo Aditya Arvind Manekar Janjala Narahari Bikasha Bihary Tripathy Mukund Sable Manoj Kumar Mohanty Source Type: research
Papillary cystadenoma of the major salivary gland: A case report and review of literature
We report a case of papillary cystadenoma of the parotid gland in a 44-years-old female. The patient presented with painful nodular swelling in the right parotid region for two months. Ultrasonography revealed a well marginated oval lesion with altered signal intensity involving the superficial lobe. The excision specimen showed a neoplasm with multicystic spaces having papillary projections lined by benign low-grade epithelium and supported by fibrovascular cores. No significant cytological atypia or mitosis was observed. The cells were immunoreactive for Keratin, Keratin 7, and were negative for Keratin 20, AR, HeR2/neu,...
Source: Pathology, Research and Practice - November 1, 2023 Category: Pathology Authors: Vipra Malik Mallika Dixit Shivani Sharma Asheesh Jain Adesh Dhankad Sambit K Mohanty Source Type: research
Papillary cystadenoma of the major salivary gland: A case report and review of literature
We report a case of papillary cystadenoma of the parotid gland in a 44-years-old female. The patient presented with painful nodular swelling in the right parotid region for two months. Ultrasonography revealed a well marginated oval lesion with altered signal intensity involving the superficial lobe. The excision specimen showed a neoplasm with multicystic spaces having papillary projections lined by benign low-grade epithelium and supported by fibrovascular cores. No significant cytological atypia or mitosis was observed. The cells were immunoreactive for Keratin, Keratin 7, and were negative for Keratin 20, AR, HeR2/neu,...
Source: Pathology, Research and Practice - November 1, 2023 Category: Pathology Authors: Vipra Malik Mallika Dixit Shivani Sharma Asheesh Jain Adesh Dhankad Sambit K Mohanty Source Type: research
Coexisting ovarian serous cystadenoma with fibroma: A very unusual combination
J Cancer Res Ther. 2023 Jul-Sep;19(5):1474-1476. doi: 10.4103/jcrt.jcrt_2319_21.ABSTRACTSurface epithelial neoplasms are the most common ovarian tumors, constituting around 60% of all ovarian malignancies. They are classified as benign, borderline, and malignant. Ovarian cystadenomas are common benign epithelial neoplasms which carry an excellent prognosis. Ovarian thecoma-fibroma groups are uncommon sex cord-stromal neoplasms, constituting 1.0%-4.0% of all ovarian tumors. Most of them are benign and often found in postmenopausal patients. Combination tumors in the ovary are known. The most common combination is mucinous c...
Source: Cell Research - October 3, 2023 Category: Cytology Authors: Kirti Balhara Varuna Mallya Nita Khurana Anjali Tempe Source Type: research
