The Impact of the COVID-19 Pandemic on Bell's Palsy and Ramsay-Hunt Syndrome: A Multicenter Retrospective Study
CONCLUSION: This study highlights the impact of the COVID-19 pandemic on the presentation and management of facial palsy, and suggests potential associations with COVID-19. Notably, the observed increase in Bell's palsy cases among elderly individuals with diabetes emphasizes the impact of the pandemic. Identifying the epidemiological changes in facial palsy during the COVID-19 pandemic has important implications for assessing its etiology and pathological mechanisms of facial palsy disease.PMID:38685888 | DOI:10.3346/jkms.2024.39.e140 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 30, 2024 Category: General Medicine Authors: Min Young Kwak Ho Yun Lee Se A Lee Junhui Jeong Jae Ho Chung Jin Kim Beom Cho Jun Seung-Geun Yeo Sang Hoon Kim Jong Dae Lee Source Type: research
The Impact of the COVID-19 Pandemic on Bell's Palsy and Ramsay-Hunt Syndrome: A Multicenter Retrospective Study
CONCLUSION: This study highlights the impact of the COVID-19 pandemic on the presentation and management of facial palsy, and suggests potential associations with COVID-19. Notably, the observed increase in Bell's palsy cases among elderly individuals with diabetes emphasizes the impact of the pandemic. Identifying the epidemiological changes in facial palsy during the COVID-19 pandemic has important implications for assessing its etiology and pathological mechanisms of facial palsy disease.PMID:38685888 | DOI:10.3346/jkms.2024.39.e140 (Source: Herpes)
Source: Herpes - April 30, 2024 Category: Infectious Diseases Authors: Min Young Kwak Ho Yun Lee Se A Lee Junhui Jeong Jae Ho Chung Jin Kim Beom Cho Jun Seung-Geun Yeo Sang Hoon Kim Jong Dae Lee Source Type: research
Radiologic Abnormalities in Prolonged SARS-CoV-2 Infection: A Systematic Review
Korean J Radiol. 2024 May;25(5):473-480. doi: 10.3348/kjr.2023.1149.ABSTRACTWe systematically reviewed radiological abnormalities in patients with prolonged SARS-CoV-2 infection, defined as persistently positive polymerase chain reaction (PCR) results for SARS-CoV-2 for > 21 days, with either persistent or relapsed symptoms. We extracted data from 24 patients (median age, 54.5 [interquartile range, 44-64 years]) reported in the literature and analyzed their representative CT images based on the timing of the CT scan relative to the initial PCR positivity. Our analysis focused on the patterns and distribution of CT findi...
Source: Korean Journal of Radiology - April 30, 2024 Category: Radiology Authors: Kyongmin Sarah Beck Jeong-Hwa Yoon Soon Ho Yoon Source Type: research
Efficacy of a Single Day Extracorporeal Membrane Oxygenation Training Course for Critical Care Air Transport Team Eligible Personnel
CONCLUSIONS: An abbreviated 1-day lecture and hands-on task-trainer-based ECMO course resulted in a high rate of successful skill demonstration and improvement of physicians' and nurses' knowledge assessments and confidence levels, similar to our previous live-tissue training program. When compared to our previous studies, the addition of telemedicine and patient transportation to this study did not affect the duration or performance of procedures.PMID:38687647 | DOI:10.1093/milmed/usae138 (Source: Military Medicine)
Source: Military Medicine - April 30, 2024 Category: International Medicine & Public Health Authors: R Madelaine Paredes Brannon Inman William T Davis Maria Castaneda Allyson A Mireles Darren S Baldwin Dylan C Rodriguez Kimberly L Medellin Patrick C Ng Joseph K Maddry Source Type: research
Ayurvedic and Chinese Herbs against Coronaviruses
Curr Pharm Des. 2024 Apr 29. doi: 10.2174/0113816128269864231112094917. Online ahead of print.ABSTRACTCOVID-19 is a viral disease that infects the lower airways, causing severe acute respiratory syndrome (SARS) and fatal pneumonia. The ripple effect of the COVID-19 outbreak has created serious problems in the healthcare systems of many countries and had far-reaching consequences for the global economy. Thus, effective control measures should be implemented for this coronavirus infection in the future. The ongoing episode of the SARS-CoV-2 sickness, COVID-19, in China, and the subsequent irregular spread of contamination to...
Source: Current Pharmaceutical Design - April 30, 2024 Category: Drugs & Pharmacology Authors: Amin Gasmi Sonia Kanwal Petro Oliinyk Roman Lysiuk Mariia Shanaida Asma Gasmi Benahmed Walallawita Kankanamge Tharindu Dushmantha Maria Arshad Ivanna Kernychna Larysa Lenchyk Taras Upyr Volodymyr Shanaida Geir Bj ørklund Source Type: research
The Impact of the COVID-19 Pandemic on Bell's Palsy and Ramsay-Hunt Syndrome: A Multicenter Retrospective Study
CONCLUSION: This study highlights the impact of the COVID-19 pandemic on the presentation and management of facial palsy, and suggests potential associations with COVID-19. Notably, the observed increase in Bell's palsy cases among elderly individuals with diabetes emphasizes the impact of the pandemic. Identifying the epidemiological changes in facial palsy during the COVID-19 pandemic has important implications for assessing its etiology and pathological mechanisms of facial palsy disease.PMID:38685888 | DOI:10.3346/jkms.2024.39.e140 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 30, 2024 Category: Biomedical Science Authors: Min Young Kwak Ho Yun Lee Se A Lee Junhui Jeong Jae Ho Chung Jin Kim Beom Cho Jun Seung-Geun Yeo Sang Hoon Kim Jong Dae Lee Source Type: research
Polyoxometalate exerts broad-spectrum activity against human respiratory viruses hampering viral entry
Antiviral Res. 2024 Apr 27:105897. doi: 10.1016/j.antiviral.2024.105897. Online ahead of print.ABSTRACTHuman respiratory viruses have an enormous impact on national health systems, societies, and economy due to the rapid airborne transmission and epidemic spread of such pathogens, while effective specific antiviral drugs to counteract infections are still lacking. Here, we identified two Keggin-type polyoxometalates (POMs), [TiW11CoO40]8- (TiW11Co) and [Ti2PW10O40]7- (Ti2PW10), endowed with broad-spectrum activity against enveloped and non-enveloped human respiratory viruses, i.e., coronavirus (HCoV-OC43), rhinovirus (HRV-...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Irene Arduino Rachele Francese Andrea Civra Elisa Feyles Monica Argenziano Marco Volante Roberta Cavalli Ali M Mougharbel Ulrich Kortz Manuela Donalisio David Lembo Source Type: research
Polyoxometalate exerts broad-spectrum activity against human respiratory viruses hampering viral entry
Antiviral Res. 2024 Apr 27:105897. doi: 10.1016/j.antiviral.2024.105897. Online ahead of print.ABSTRACTHuman respiratory viruses have an enormous impact on national health systems, societies, and economy due to the rapid airborne transmission and epidemic spread of such pathogens, while effective specific antiviral drugs to counteract infections are still lacking. Here, we identified two Keggin-type polyoxometalates (POMs), [TiW11CoO40]8- (TiW11Co) and [Ti2PW10O40]7- (Ti2PW10), endowed with broad-spectrum activity against enveloped and non-enveloped human respiratory viruses, i.e., coronavirus (HCoV-OC43), rhinovirus (HRV-...
Source: Antiviral Research - April 30, 2024 Category: Virology Authors: Irene Arduino Rachele Francese Andrea Civra Elisa Feyles Monica Argenziano Marco Volante Roberta Cavalli Ali M Mougharbel Ulrich Kortz Manuela Donalisio David Lembo Source Type: research
An Outbreak of Home Distillation Methanol Poisoning in Turkey During the COVID-19 Pandemic: A Single Center Experience
CONCLUSION: In methanol poisoning due to home brewing, low blood pressure, oxygen saturation, and impaired consciousness at the time of admission were clinical findings associated with mortality. In terms of laboratory findings, especially severe metabolic acidosis and lactate elevation were observed in the group that was mortal despite treatment.PMID:38685840 | DOI:10.34172/aim.2024.23 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 30, 2024 Category: Middle East Health Authors: Serta ç Güler Dilber Üçöz Kocaşaban Source Type: research
Viruses, Vol. 16, Pages 718: Nirmatrelvir Resistance in an Immunocompromised Patient with Persistent Coronavirus Disease 2019
We present a patient who independently acquired a T21I mutation in the 3CL protease after nirmatrelvir exposure. The T21I mutation in the 3CL protease is one of the most frequent mutations responsible for nirmatrelvir resistance. However, limited reports exist on actual cases of SARS-CoV-2 with T21I and other mutations in the 3CL protease. The patient, a 55 year-old male, had COVID-19 during chemotherapy for multiple myeloma. He was treated with nirmatrelvir early in the course of the disease but relapsed, and SARS-CoV-2 with a T21I mutation in the 3CL protease was detected in nasopharyngeal swab fluid. The patient had tem...
Source: Viruses - April 30, 2024 Category: Virology Authors: Chie Yamamoto Masashi Taniguchi Keitaro Furukawa Toru Inaba Yui Niiyama Daisuke Ide Shinsuke Mizutani Junya Kuroda Yoko Tanino Keisuke Nishioka Yohei Watanabe Koichi Takayama Takaaki Nakaya Yoko Nukui Tags: Brief Report Source Type: research
Viruses, Vol. 16, Pages 712: Research Progress on Spike-Dependent SARS-CoV-2 Fusion Inhibitors and Small Molecules Targeting the S2 Subunit of Spike
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Since the beginning of the COVID-19 pandemic, extensive drug repurposing efforts have sought to identify small-molecule antivirals with various mechanisms of action. Here, we aim to review research progress on small-molecule viral entry and fusion inhibitors that directly bind to the SARS-CoV-2 Spike protein. Early in the pandemic, numerous small molecules were identified in drug repurposing screens and reported to be effective in in vitro SARS-CoV-2 viral entry or fusion inhibitors. However, given minimal experimental information regarding the exact location of small-molecule binding sites on Spike, it was unclear...
Source: Viruses - April 30, 2024 Category: Virology Authors: Matthew R. Freidel Roger S. Armen Tags: Review Source Type: research
Causal Associations between Posttraumatic Stress Disorder and COVID-19
CONCLUSIONS: Our study suggests that PTSD was associated with increased risks for COVID-19 susceptibility and severity. Early diagnosis and effective treatment of PTSD in individuals infected with the coronavirus may improve the management of the outcomes of COVID-19.PMID:38682223 | DOI:10.31083/j.jin2304068 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Ancha Baranova Li Fu Yuqing Song Hongbao Cao Fuquan Zhang Source Type: research
Anti-SARS-CoV-2 nucleocapsid antibody positivity 3 years after COVID-19
This study aimed to comprehensively assess anti-nucleocapsid antibody positivity using diverse commercial and in-house immunoassays among individuals who contracted COVID-19 more than 3 years ago. We enrolled 44 participants with laboratory-confirmed COVID-19 between January and May 2020 from Seoul National University Hospital and its community treatment centers. The results showed anti-nucleocapsid antibody positivities ranged from 45.5% to 87.9% depending upon the immunoassay used. The study highlights the importance of considering the limited anti-nucleocapsid antibody positivity in participants with a distant COVID-19 ...
Source: Japanese Journal of Infectious Diseases - April 29, 2024 Category: Infectious Diseases Authors: Chang Kyung Kang Youngju Kim Hyeon Jae Jo Chan Mi Lee Nam Joong Kim Chang-Han Lee Pyoeng Gyun Choe Wan Beom Park Myoung-Don Oh Source Type: research
Early and Long-Term Morbidity and Mortality Following Pancreaticoduodenectomy for Periampullary Tumors in Elderly Patients
CONCLUSION: PD can be performed effectively in selected elderly patients with tolerable morbidity and mortality rates.PMID:38684489 | DOI:10.62713/aic.3380 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Mehmet Aziret Feyza A şıkuzunoğlu Fatih Alt ıntoprak Mukaddes Tozlu Ay şe Demirci Metin Ercan Do ğukan Saydan Ali İmran Küçük Source Type: research
Causal Associations between Posttraumatic Stress Disorder and COVID-19
CONCLUSIONS: Our study suggests that PTSD was associated with increased risks for COVID-19 susceptibility and severity. Early diagnosis and effective treatment of PTSD in individuals infected with the coronavirus may improve the management of the outcomes of COVID-19.PMID:38682223 | DOI:10.31083/j.jin2304068 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Ancha Baranova Li Fu Yuqing Song Hongbao Cao Fuquan Zhang Source Type: research
