SARS-CoV-2 infection induces thymic atrophy mediated by IFN- γ in hACE2 transgenic mice
Eur J Immunol. 2024 Apr 24:e2350624. doi: 10.1002/eji.202350624. Online ahead of print.ABSTRACTPathogenic infections cause thymic atrophy, perturb thymic T-cell development, and alter immunological response. Previous studies reported dysregulated T-cell function and lymphopenia in coronavirus disease-19 (COVID-19). However, immunopathological changes in the thymus associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection have not been elucidated. Here, we report that SARS-CoV-2 infects thymocytes, and induces CD4+CD8+ (double positive; DP) T-cell apoptosis leading to thymic atrophy and loss of ...
Source: European Journal of Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Zaigham Abbas Rizvi Srikanth Sadhu Jyotsna Dandotiya Puja Sharma Akshay Binayke Virendra Singh Vinayaka Das Ritika Khatri Rajesh Kumar Sweety Samal Manjula Kalia Amit Awasthi Source Type: research
Impact of Anti-angiogenic Drugs on Severity of COVID-19 in Patients with Non-Small Cell Lung Cancer
Conclusion: Our data suggests that the use of anti-angiogenic drugs may not exacerbate COVID-19 severity in NSCLC patients, indicating their potential safe application even during the pandemic period.PMID:38656242 | DOI:10.1177/15330338241248573 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 24, 2024 Category: Cancer & Oncology Authors: Sujuan Peng Hongxiang Huang Jinhong Chen Xinjing Ding Xie Zhu Yangyang Liu Li Chen Zhihui Lu Source Type: research
Impact of Anti-angiogenic Drugs on Severity of COVID-19 in Patients with Non-Small Cell Lung Cancer
Conclusion: Our data suggests that the use of anti-angiogenic drugs may not exacerbate COVID-19 severity in NSCLC patients, indicating their potential safe application even during the pandemic period.PMID:38656242 | DOI:10.1177/15330338241248573 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Sujuan Peng Hongxiang Huang Jinhong Chen Xinjing Ding Xie Zhu Yangyang Liu Li Chen Zhihui Lu Source Type: research
Coronavirus Anxiety, COVID Anxiety Syndrome and Mental Health: A Test Among Six Countries During March 2021
Clin Psychol Psychother. 2024 Mar-Apr;31(2):e2988. doi: 10.1002/cpp.2988.ABSTRACTThe negative impact of the COVID-19 pandemic on mental health outcomes is widely documented. Specifically, individuals experiencing greater degrees of severity in coronavirus anxiety have demonstrated higher levels of generalized anxiety, depression and psychological distress. Yet the pathways in which coronavirus anxiety confers vulnerability are not well known. The present investigation sought to address this gap in the scientific literature by testing the indirect effect of the COVID-19 anxiety syndrome, which centres on the function of det...
Source: Clinical Psychology and Psychotherapy - April 24, 2024 Category: Psychiatry Authors: Michael J Zvolensky Jafar Bakhshaie Brooke Y Redmond Tanya Smit Ana V Nik čević Marcantonio M Spada Walter Distaso Source Type: research
Impact of SARS-CoV-2 vaccines on Covid-19 incidence and mortality in the United States
ConclusionsAssociations between complete vaccination rates and COVID-19 incidence and mortality appeared to vary with shifts in the dominant variant, perhaps due to variations in vaccine efficacy by variant or to waning vaccine immunity over time. Vaccine boosters were associated with notable protection against Omicron disease and mortality. (Source: PLoS One)
Source: PLoS One - April 24, 2024 Category: Biomedical Science Authors: Fang Fang Source Type: research
Use of Respiratory and Contact Precautions to Decrease the Spread of SARS-CoV-2 Infection Was Not Associated with a Decrease in Endometritis –Intra-Amniotic Infection
Conclusion The use of respiratory and contact precautions to limit the spread of SARS-CoV-2 was not associated with risk of endometritis/IAI.
Key Points
[...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - April 24, 2024 Category: Perinatology & Neonatology Authors: Roig, Jacqueline DeBolt, Chelsea A. Cabrera, Mariela Spiera, Emily Goldberger, Cody Bianco, Angela Stone, Joanne A. Factor, Stephanie H. Tags: Original Article Source Type: research
Exogenous Insulin Antibody Syndrome (EIAS) Presenting in an Elderly, Long-Term Patient with Type 1 Diabetes Mellitus that Resolved with Low-Cost Outpatient Therapy with Mycophenolate Mofetil and Regular Insulin by Pump
AbstractExogenous insulin antibody syndrome (EIAS) has until recently been a rarely described complication of exogenous insulin therapy. EIAS results not only in hyperglycemia, but also in hypoglycemia and occasionally in ketoacidosis (DKA). The incidence of EIAS is increasing probably due to an overall increase in autoimmunity associated with the coronavirus disease 2019 (Covid-19) epidemic resulting in increasing binding of insulin by antibodies. Herein, we describe a case of EIAS occurring in an elderly patient with longstanding type 1 diabetes mellitus (T1DM) who had progressive loss of glycemic control. It responded p...
Source: Diabetes Therapy - April 24, 2024 Category: Endocrinology Source Type: research
The contributions of vaccination and natural infection to the production of neutralizing antibodies against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) prototype strain and variants
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a novel coronavirus responsible for the coronavirus disease 2019 (COVID-19) global pandemic [1-3]. As the pandemic progressed, new, more transmissible but less virulent variants, like the Omicron variant, emerged and became more dominant, further reducing the mortality rate [4-8]. The World Health Organization (WHO) eventually declared that the COVID-19 pandemic no longer constitutes a public health emergency of international concern on May 2023 [9]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 24, 2024 Category: Infectious Diseases Authors: Hui Xie, Junnan Zhang, Shuang Bai, Min Lv, Juan Li, Weixin Chen, Luodan Suo, Meng Chen, Wei Zhao, Shanshan Zhou, Jian Wang, Ao Zhang, Jianxin Ma, Fengshuang Wang, Le Yan, Dongmei Li, Jiang Wu Source Type: research
Post-COVID Trajectory of Pentraxin 3 Plasma Levels Over 6 Months and Their Association with the Risk of Developing Post-Acute Depression and Anxiety
ConclusionsA lower reduction of plasma PTX3 after acute COVID-19 associates with the presence of depression and anxiety, suggesting an involvement of inflammation in post-COVID-19 psychopathology and a potential role of PTX3 as a biomarker. (Source: CNS Drugs)
Source: CNS Drugs - April 24, 2024 Category: Neurology Source Type: research
Viruses, Vol. 16, Pages 665: Exploring the Antiviral Potential of Esters of Cinnamic Acids with Quercetin
o Manzin
Giuseppina Sanna
Severe acute respiratory syndrome-related Coronavirus 2 (SARS-CoV-2) has infected more than 762 million people to date and has caused approximately 7 million deaths all around the world, involving more than 187 countries. Although currently available vaccines show high efficacy in preventing severe respiratory complications in infected patients, the high number of mutations in the S proteins of the current variants is responsible for the high level of immune evasion and transmissibility of the virus and the reduced effectiveness of acquired immunity. In this scenario, the development of safe...
Source: Viruses - April 24, 2024 Category: Virology Authors: Valeria Manca Annalisa Chianese Vanessa Palmas Federica Etzi Carla Zannella Davide Moi Francesco Secci Gabriele Serreli Giorgia Sarais Maria Vittoria Morone Massimiliano Galdiero Valentina Onnis Aldo Manzin Giuseppina Sanna Tags: Article Source Type: research
Viruses, Vol. 16, Pages 659: Design and Application of Biosafe Coronavirus Engineering Systems without Virulence
ingxin Ma
In the last twenty years, three deadly zoonotic coronaviruses (CoVs)—namely, severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and SARS-CoV-2—have emerged. They are considered highly pathogenic for humans, particularly SARS-CoV-2, which caused the 2019 CoV disease pandemic (COVID-19), endangering the lives and health of people globally and causing unpredictable economic losses. Experiments on wild-type viruses require biosafety level 3 or 4 laboratories (BSL-3 or BSL-4), which significantly hinders basic virological r...
Source: Viruses - April 24, 2024 Category: Virology Authors: Guoqiang Wu Qiaoyu Li Junbiao Dai Guobin Mao Yingxin Ma Tags: Review Source Type: research
Neuropsychiatric complications of coronavirus disease 2019: Mount Sinai Health System cohort study
ConclusionNeuropsychiatric complications of COVID-19, especially AMS, were common, varied, and associated with in-hospital mortality in a diverse multicenter cohort at an epicenter of the COVID-19 pandemic. (Source: Journal of Neurology)
Source: Journal of Neurology - April 24, 2024 Category: Neurology Source Type: research
Comparison of effectiveness and safety of molnupiravir versus sotrovimab for COVID ‐19: A systematic review and meta‐analysis
ConclusionThe current findings indicate that sotrovimab may be more effective than molnupiravir in reducing the mortality rate in COVID-19 patients. However, no statistical difference was observed between the two treatments for other effectiveness outcomes. The certainty of evidence for these findings was rated as low or moderate. Further research is required to provide a better comparison of these interventions in treating COVID-19 patients. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 23, 2024 Category: Allergy & Immunology Authors: Bahman Amani,
Behnam Amani Tags: REVIEW ARTICLE Source Type: research
Perinatal mental health and Covid-19-related distress: the role of personality traits
CONCLUSION: Our study highlights the importance of considering the personality vulnerability factors that can worsen psychopathological symptoms of women in the perinatal period, especially in periods of high psychological stress.PMID:38651775 | DOI:10.1708/4259.42360 (Source: Rivista di Psichiatria)
Source: Rivista di Psichiatria - April 23, 2024 Category: Psychiatry Authors: Melania Martucci Matteo Panfili Nicoletta Giacchetti Francesco Saverio Bersani Paola Ciolli Alessandra Forte Carla Sogos Franca Aceti Source Type: research
Retention of En Route Cricothyroidotomy Skills in Novice Providers Following a Simulation-Based Mastery Learning Curriculum
CONCLUSIONS: This study showed that the skill required to perform a SC after initial mastery training does decay significantly. A brief refresher course can help increase retention of skills. Based on our findings SC skills should be refreshed at a minimum of every 6 months to assure optimal proficiency.PMID:38651572 | DOI:10.1093/milmed/usae107 (Source: Military Medicine)
Source: Military Medicine - April 23, 2024 Category: International Medicine & Public Health Authors: Laura S Kraemer Joseph Lopreiato Haana McMurray Theepica Jeyarajah Rachel Dampman Sorana Raiciulescu Gerardo Capo Dosal Edward Jaffe Julia Switzer Mark Bowyer Source Type: research
