WALS- George Khoury Lecture: Coronavirus Activation and Antagonism of Interferon Signaling Pathways: from MHV to SARS-CoV-2
Coronavirus interactions with the interferon signaling response are crucial for antiviral defense especially at the early stages of infection. Murine coronavirus, MHV, has taught us a lot about the basic biology of this family of viruses as well as antagonism of innate immune response, a hallmark of coronavirus infection. Building on our MHV data, we have more recently worked with human coronaviruses. We have optimized methods for comparing human coronaviruses in a primary nasal cell air liquid interface (ALI) culture system, which models the initial site of respiratory virus infection. Common cold coronaviruses as well as...
Source: Videocast - All Events - March 6, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS- George Khoury Lecture: Coronavirus Activation and Antagonism of Innate Immune Pathways
Our lab studies murine and human coronavirus pathogenesis, including MHV, MERS-CoV and SARS-CoV. We use MHV infection of mice as a model system for the study of:acute viral encephalitischronic demyelinating diseases such as Multiple Sclerosisvirus-induced hepatitissevere acute respiratory diseases.We have the important tools of a well-developed animal model system and reverse genetic systems with which to manipulate the viral genome. We also investigate pathogenesis of human coronaviruses both the lethal MERS-CoV and SARS-CoV-2 as well as the common cold viruses OC43 and 229E and NL63. We are investigating these both in ep...
Source: Videocast - All Events - October 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Active Living Conference (Day 2)
The 2023 Active Living Conference theme, Expanding Active Living Applications beyond Chronic Diseases to Synergistic Epidemics, or “ syndemics ” , focuses attention on the role of active living in addressing multiple intersecting crises, such as coronavirus disease (COVID-19), mental health, climate change, and structural racism. The Active Living Conference highlights research, policies, and practices based on a multilevel perspective. Physically active behaviors have been well documented to prevent, intercept, and treat several common chronic diseases, including multiple cancers, heart disease, diabetes, and obesity....
Source: Videocast - All Events - March 14, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Active Living Conference [Day 2]
The 2023 Active Living Conference theme, Expanding Active Living Applications beyond Chronic Diseases to Synergistic Epidemics, or “ syndemics ” , focuses attention on the role of active living in addressing multiple intersecting crises, such as coronavirus disease (COVID-19), mental health, climate change, and structural racism. The Active Living Conference highlights research, policies, and practices based on a multilevel perspective. Physically active behaviors have been well documented to prevent, intercept, and treat several common chronic diseases, including multiple cancers, heart disease, diabetes, and obesity....
Source: Videocast - All Events - March 6, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Active Living Conference [Day 1]
The 2023 Active Living Conference theme, Expanding Active Living Applications beyond Chronic Diseases to Synergistic Epidemics, or “ syndemics ” , focuses attention on the role of active living in addressing multiple intersecting crises, such as coronavirus disease (COVID-19), mental health, climate change, and structural racism. The Active Living Conference highlights research, policies, and practices based on a multilevel perspective. Physically active behaviors have been well documented to prevent, intercept, and treat several common chronic diseases, including multiple cancers, heart disease, diabetes, and obesity....
Source: Videocast - All Events - March 6, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Cornelia Bergmann
The Bergmann lab researches innate and adaptive immune responses to viral infection of the central nervous system (CNS), with an emphasis on mechanisms contributing to viral persistence and demyelinating disease, similar to multiple sclerosis in human. Control of viral encephalomyelitis or latent/persisting viruses in the central nervous system (CNS) poses a challenge to provide protection while minimizing immune-mediated damage to neurons and glia. Dr. Bergmann ’ s research interests reside in two broad areas of neuroinflammation and central nervous system (CNS) pathology: one investigates innate and adaptive immune res...
Source: Videocast - All Events - February 15, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH – FDA COVID SIG Lecture with Malik Peiris
In 2003, Professor Peiris and his research team discovered SARS-CoV, a novel coronavirus, as the etiological agent for SARS. He joined The University of Hong Kong in 1995, and is now Chair of Virology at the School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China. He co-directs the WHO H5 Reference Laboratory and the WHO SARS-CoV-2 reference laboratory at The University of Hong Kong. Currently, he serves on many Hong Kong and WHO advisory committees, including the WHO International Health Regulations Emergency Committee on COVID-19.
He is a clinical and public health virologis...
Source: Videocast - All Events - February 10, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH/FDA IIG Seminar - Cornelia Bergmann
The Bergmann lab researches innate and adaptive immune responses to viral infection of the central nervous system (CNS), with an emphasis on mechanisms contributing to viral persistence and demyelinating disease, similar to multiple sclerosis in human. Control of viral encephalomyelitis or latent/persisting viruses in the central nervous system (CNS) poses a challenge to provide protection while minimizing immune-mediated damage to neurons and glia. Dr. Bergmann ’ s research interests reside in two broad areas of neuroinflammation and central nervous system (CNS) pathology: one investigates innate and adaptive immune res...
Source: Videocast - All Events - February 6, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Pandemic Preparedness and Response: Lessons from COVID
In less than three years, the novel coronavirusSARS-CoV-2 has caused more than half a billion cases of COVID-19 and nearly six and a half million deaths globally. Through longstanding investments in basic research and well-developed clinical trial networks, NIAID made major contributions to the development of safe and effective COVID-19 vaccines and therapeutics, in record time. However, a combination of waning vaccine immunity and the repeated emergence and spread of SARS-CoV-2 variants with enhanced transmissibility and immune evasiveness have led to the need for booster shots and updated vaccines more closely aligned wi...
Source: Videocast - All Events - August 26, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar Series: The ecology of emerging coronaviruses, from host reservoir to disease
In the past two decades, three coronaviruses have emerged and caused widespread outbreaks in humans. The origin of these zoonotic viruses has been traced back to bats as natural reservoir. Since the SARS epidemic in 2002 – 2003, the appreciation of bats as key hosts of zoonotic coronaviruses has advanced rapidly, but data underlying key drivers of the epidemic and pandemic emergence of these viruses remain limited. Here we discuss the emergence of MERS-CoV and SARS-CoV-2. Highlighting the origin, genetic diversity, pandemic potential, transmission dynamics, pathogenicity, and development of countermeasure against these b...
Source: Videocast - All Events - July 6, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
COVID Lecture: SARS-CoV-2: What We Have Learned So Far
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for COVID-19, continues to spread around the world and has caused millions of deaths to date. In an effort to develop therapeutics and preventive measures, we are performing numerous research projects with this virus and its variants. In this presentation, I will discuss our findings regarding animal models and their value as tools for evaluating countermeasures against SARS-CoV-2.For more information go tohttps://www.niaid.nih.gov/research/covid-19-sig-lecture-seriesAir date: 5/26/2022 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - May 23, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Town Hall - April 2022
10th Virtual Town Hall
Participants:• Larry Tabak, Acting Director, NIH• Tara Schwetz, Acting Principal Deputy Director, NIH• Alfred Johnson, NIH Deputy Director for Management• Julie Berko, NIH Chief People Officer
Topics: Update on efforts to return staff to the physical workplace, workplace flexibilities, and impact of COVID-19 community levels on NIH safety guidance, meetings, and travel
Please visit:
https://employees.nih.gov/pages/coronavirus/events.aspxAir date: 4/5/2022 11:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - March 24, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
¿ Odias las agujas? Una nueva vacuna contra el coronavirus podr í a inhalarse.
Científicos financiados por la NSF están desarrollando dos métodos alternativos para administrar la vacuna contra el coronavirus. Estos métodos podrían ayudar a prepararnos durante posibles pandemias futuras. Los científicos están tratando de crear una vacuna en forma de aerosol inhalable que pueda ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - October 22, 2021 Category: Science Source Type: video
COVID-19 Scientific Interest Group: Human Antibody Response to SARS-CoV-2 Infection and Vaccination
COVID-19 Scientific Interest Group
Michel C. Nussenzweig is the Zanvil A. Cohn and Ralph M. Steinman Professor and Investigator, Howard Hughes Medical Institute. The Nussenzweig ’ s laboratory studies the molecular aspects of the immune system ’ s innate and adaptive responses using a combination of biochemistry, molecular biology, and genetics. For work on adaptive immunity, he focuses on B lymphocytes and antibodies to HIV-1, while his studies of innate immunity focus on dendritic cells. His work is leading to new antibody-based therapies for infections by HIV and the novel SARS-CoV-2 coronavirus, among other viruses...
Source: Videocast - All Events - September 23, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Strategies for Development of Coronavirus Vaccines That Induce Broadly Reactive Neutralizing Antibodies
Speaker Barton Ford Haynes is Professor of Medicine Frederic M. Hanes Distinguished Professor of Medicine at Duke University. The Haynes lab is studying host innate and adaptive immune responses to the human immunodeficiency virus (HIV), tuberculosis (TB), and influenza in order to find the enabling technology to make preventive vaccines against these three major infectious diseases.For more information go tohttps://www.niaid.nih.gov/research/covid-19-sigAir date: 11/18/2021 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 21, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
