TWiV 1065: Cat coronavirus gains function in Cyprus
TWiV reviews ban on gain-of-function research by the House, chronic wasting disease in Tennessee deer, nOPV2 causing paralysis in children, and an outbreak of feline infectious peritonitis in Cyprus caused by a new recombinant coronavirus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Di...
Source: This Week in Virology - MP3 Edition - November 26, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 1064: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses progress toward measles elimination, risk of severe coronavirus disease 2019 despite vaccination in patients requiring treatment with immune-suppressive drugs, symptoms, viral loads, and rebound among COVID-19 outpatients treated with nirmatrelvir/ritonavir compared to propensity score matched untreated individuals, late administration and corticosteroid usage explain inefficacy in COVID-19 convalescent plasma trial, higher-dose fluvoxamine and time to sustained recovery in outpatients with COVID-19, recombinant C1 inhibitor in the prevention of severe COVID-19, and Epst...
Source: This Week in Virology - MP3 Edition - November 25, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 1061: Seasonal COVID and a niche for cervical cancer
TWiV reveals a prediction of the expected endemic seasonality of COVID-19, based on circulation of human coronaviruses, and ecological clearance of vaccine-targeted human papillomaviruses and an increase in circulation of non-targeted virus types. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommi...
Source: This Week in Virology - MP3 Edition - November 12, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 1060: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses CDC expanding testing of international air traveler samples to include flu, RSV, and other respiratory viruses, missed opportunities for preventing congenital syphilis, intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and omicron BA.2 variant in Hong Kong, T-cell immunity against severe acute respiratory syndrome coronavirus 2 measured by an interferon-γ release assay is strongly associated with patient outcomes in vaccinated persons hospitalized with delta or omicron variants, masks during pandemics caused by respiratory pathogens, ...
Source: This Week in Virology - MP3 Edition - November 11, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 1028: Asymptomatic SARS-CoV-2 infection and T cells
TWiV reviews approvals of the first gene therapy for severe hemophilia A in adults and a monoclonal antibody to prevent RSV respiratory disease in babies and toddlers, and a common allele of HLA that mediates asymptomatic SARS-CoV-2 infection through pre-existing T cell immunity due to previous exposure to common cold coronaviruses. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server First gene therapy for hemophilia A approved (FDA) Lux...
Source: This Week in Virology - MP3 Edition - July 23, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 1008: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses variant specific clinical performance of a SARS-CoV-2 rapid antigen test with focus on omicron VOC, ventilation in buildings, COVID-19 mortality among selective serotonin reuptake inhibitor users, risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses, trajectories of the evolution of post COVID-19 condition, and efficacy of cognitive behavioral therapy targeting severe fatigue following COVID-19. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for t...
Source: This Week in Virology - MP3 Edition - May 20, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 1006: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses immunogenicity and tolerability of a bivalent virus-like particle norovirus vaccine candidate in children from 6 months up to 4 years of age, influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults, COVID-19 surveillance after expiration of the public health emergency declaration, provisional mortality data, targeted vaccine messaging to promote COVID-19 vaccines for children and youth, vaccines and related biological products advisory committee meeting June 15, 2023 announcement, how to overhaul the CDC, impact o...
Source: This Week in Virology - MP3 Edition - May 13, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 984: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants, yes masks reduce the risk of spreading infection, despite a review saying they don’t, COVID-19 and airborne transmission: science rejected,...
Source: This Week in Virology - MP3 Edition - February 18, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 964: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses Dr. Griffin discusses progress toward poliomyelitis eradication in Afghanistan, reduced risk for Mpox after receipt of 1 or 2 doses of JYNNEOS vaccine compared with risk among unvaccinated persons, reduced airborne transmission of SARS-CoV-2 BA.1 Omicron virus in Syrian hamsters, authorized updated (Bivalent) COVID-19 vaccines for children down to 6 months of age, low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by parental mRNA vaccine or a BA.5-bivalent booster, efficacy of antiviral agents against omicron subvariants BQ.1.1 and XBB, incide...
Source: This Week in Virology - MP3 Edition - December 17, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 963: Feline coronavirus with Gary Whittaker
Vincent travels to Cornell University to speak with Gary Whittaker about regulation by proteolytic processing of the fusion activity of the spike protein of SARS-CoV-2, and feline coronavirus transmission, replication and disease. Hosts: Vincent Racaniello Guest: Gary Whittaker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 spike and its furin cleavage site (Lancet Microbe) TMPRSS2 inhibitor blocks SARS-CoV-2 reproduction (Nature) Distinct spike proteins of feline coronaviruses (Viruses) Feline coronavirus and feline infectious peritonitis (J...
Source: This Week in Virology - MP3 Edition - December 14, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 948: Breathless with David Quammen
David Quammen returns to TWiV to discuss how he wrote his new book ‘Breathless’, a story about the science and the scientists behind the race to understand the pandemic coronavirus SARS-CoV-2. Hosts: Vincent Racaniello, Rich Condit,  Kathy Spindler, and Brianne Barker Guest: David Quammen Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Boston Quammens (TWiV 408) Breathless by David Quammen Spillover by David Quammen Song of the Dodo by David Quammen Timestamps by Jolene. Thanks! Weekly Picks David – Shepherd Brianne – Adventure Aquarium Kathy â€...
Source: This Week in Virology - MP3 Edition - October 23, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 940: Eddie Holmes in on viral origins
Eddie Holmes joins TWiV to discuss his role in the first release of the SARS-CoV-2 genome sequence, what really happened during the infamous Fauci teleconference, and evidence that the virus came from Nature and not from a lab. Hosts: Vincent Racaniello and Dickson Despommier Guest: Eddie Holmes Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position at FDA (pdf) Support MicrobeTV with a Spike t-shirt (Vaccinated.us) Novel 2019 coronavirus genome (Virological) Proximal origins of SARS-CoV-2 (Virological and Nature versions) Original p...
Source: This Week in Virology - MP3 Edition - September 28, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 932: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses vaccine effectiveness against influenza illness in children, clinical manifestations of infection with poliovirus, spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice, concordance of SARS-CoV-2 results in self-collected nasal swabs vs swabs collected by health care workers in children and adolescents, probable animal-to-human transmission of SARS-CoV-2 causing a pet shop-related outbreak, laboratory-confirmed COVID-19–associated hospitalizations among adults during BA.2 variant, SARS-CoV-2 specific T-cells and antibodies, Nirmatr...
Source: This Week in Virology - MP3 Edition - September 3, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

Coronapod: 'viral ghosts' support idea that SARS-CoV-2 reservoirs could be behind long COVID
Millions of people around the world have been left managing the complex and amorphous syndrome that is long COVID. But the underlying cause of this myriad of symptoms is not clear. One hypothesis is that the virus is able to find a safe haven in the body from which it can bide its time and potentially re-emerge - a viral reservoir. Now researchers studying long COVID have found evidence of SARS-CoV-2 in a series of organs around the body, most notably the gut, months after the infection appears to have been cleared from the respiratory system. While there is still a long way to go before the reservoir hypothesis can be con...
Source: Nature Podcast - May 13, 2022 Category: Science Authors: Springer Nature Limited Source Type: podcasts

Milky Way's origin story revealed by 250,000 stars
In this episode:00:45 Accurately ageing stars reveals the Milky Way’s historyTo understand when, and how, the Milky Way formed, researchers need to know when its stars were born. This week, a team of astronomers have precisely aged nearly a quarter of a million stars, revealing more about the sequence of events that took place as our galaxy formed.Research article: Xiang and RixNews and Views: A stellar clock reveals the assembly history of the Milky Way09:53 Research HighlightsArchaeologists reveal an ancient lake was actually a ritual pool, and how the Moon’s phase affects some birds' altitude.Research Highlight: Anc...
Source: Nature Podcast - March 23, 2022 Category: Science Authors: Springer Nature Limited Source Type: podcasts