Cardiovascular Risk Associated With Social Determinants of Health at Individual and Area Levels
CONCLUSIONS AND RELEVANCE: In this cohort study, both individual- and area-level SDOH were associated with ASCVD risk; adding both individual- and area-level SDOH to the PCEs modestly improved discrimination and calibration for estimating ASCVD risk for Black individuals, and adding individual-level SDOH to PREVENT plus SDI also modestly improved calibration. These findings suggest that both individual- and area-level SDOH may be considered in future development of ASCVD risk assessment tools, particularly among Black individuals.PMID:38669015 | DOI:10.1001/jamanetworkopen.2024.8584 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Mengying Xia Jaejin An Monika M Safford Lisandro D Colantonio Mario Sims Kristi Reynolds Andrew E Moran Yiyi Zhang Source Type: research
Unravelling the role of cathepsins in cardiovascular diseases
Mol Biol Rep. 2024 Apr 26;51(1):579. doi: 10.1007/s11033-024-09518-1.ABSTRACTLysosomal cathepsins as a regulatory medium have been assessed as potential therapeutic targets for the treatment of various cardiac diseases such as abdominal aortic aneurysm, hypertension, cardiomyopathy, coronary heart disease, atherosclerosis, etc. They are ubiquitous lysosomal proteases with papain-like folded protein structures that are involved in a variety of physiological processes, such as the digestion of proteins, activation of pro-inflammatory molecules, degradation of extracellular matrix components, and maturation of peptide hormone...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Sonali Maheshwari Bhoomika M Patel Source Type: research
A Novel Artificial Coronary Plaque to Model Coronary Heart Disease
CONCLUSION: This artificial atherosclerotic plaque model works as a simulating tool for future medical testing and could be crucial for further specified research on coronary artery disease and is going to help to provide information about the optimal interventional and surgical care of the disease.PMID:38667208 | PMC:PMC11048636 | DOI:10.3390/biomimetics9040197 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Philipp Lindenhahn Jannik Richter Iliyana Pepelanova Bettina Seeger Holger A Volk Rabea Hinkel Bernhard Hiebl Thomas Scheper Jan B Hinrichs Lena S Becker Axel Haverich Tim Kaufeld Source Type: research
Unravelling the role of cathepsins in cardiovascular diseases
Mol Biol Rep. 2024 Apr 26;51(1):579. doi: 10.1007/s11033-024-09518-1.ABSTRACTLysosomal cathepsins as a regulatory medium have been assessed as potential therapeutic targets for the treatment of various cardiac diseases such as abdominal aortic aneurysm, hypertension, cardiomyopathy, coronary heart disease, atherosclerosis, etc. They are ubiquitous lysosomal proteases with papain-like folded protein structures that are involved in a variety of physiological processes, such as the digestion of proteins, activation of pro-inflammatory molecules, degradation of extracellular matrix components, and maturation of peptide hormone...
Source: Molecular Biology Reports - April 26, 2024 Category: Molecular Biology Authors: Sonali Maheshwari Bhoomika M Patel Source Type: research
The relationship between atherosclerosis and dementia
CONCLUSION: Cognitively impaired individuals, in particular those with vascular cognitive impairment, have poorer quality of life and shorter survival. Risk factors contributing to such impairment are similar to those for ischaemic or haemorrhagic stroke. It may be concluded that most of the analysed risk factors play a role in the development of both atherosclerosis and dementia.PMID:38669152 | DOI:10.21101/cejph.a7848 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Jana Janoutov á Ond řej Machaczka Martina Kovalov á Anna Zatloukalov á Petr Ambroz Veronika Koutn á Eva Mr ázková Michal Bar Martin Roubec Petra B ártová Richard Novobilsk ý Martin Sabela Pavl ína Kušnierová David Stejskal Lucie Faldynov á S Source Type: research
Transportation-Related Carbon Footprint of Coronary Heart Disease Ambulatory Care in the United States
Circ Res. 2024 Apr 26;134(9):1218-1220. doi: 10.1161/CIRCRESAHA.124.324330. Epub 2024 Apr 25.NO ABSTRACTPMID:38662867 | DOI:10.1161/CIRCRESAHA.124.324330 (Source: Circulation Research)
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Pedro R V O Salerno Zhuo Chen Brendan Bourges-Sevenier Alice Qian Salil Deo Khurram Nasir Sanjay Rajagopalan Sadeer Al-Kindi Source Type: research
Gene expression profiling in elderly patients with familial hypercholesterolemia with and without coronary heart disease
CONCLUSIONS: Elderly event-free FH patients displayed a different PBMC gene expression profile compared to FH patients with CHD. Differences in gene expression compared to healthy controls were more pronounced in the CHD group, indicating a less atherogenic gene expression profile in event-free individuals. Overall, identification of cardioprotective factors could lead to future therapeutic targets.PMID:38663317 | DOI:10.1016/j.atherosclerosis.2024.117507 (Source: Atherosclerosis)
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Torunn Melnes Martin P Bogsrud Jacob J Christensen Amanda Rundblad Ingunn Narverud Kjetil Retterst øl P ål Aukrust Bente Halvorsen Stine M Ulven Kirsten B Holven Source Type: research
The Role of Pyroptosis in Coronary Heart Disease
Anatol J Cardiol. 2024 Apr 25. doi: 10.14744/AnatolJCardiol.2024.4001. Online ahead of print.ABSTRACTThe incidence and mortality of cardiovascular diseases, of which coronary heart disease (CHD) is a significant cardiovascular burden, are on the rise. Pyroptosis as an incipient programmed cell death mediated by inflammasomes can sense cytoplasmic contamination or interference and is typically marked by intracellular swelling, plasma membrane blistering and intense inflammatory cytokine release. As research on pyroptosis continues to progress, there is mounting evidence that pyroptosis is a vital participant in the pathophy...
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Yinyin Qiu Liping Meng Yangbo Xing Jiahao Peng Yan Zhou Zhangjie Yu Hanxuan Liu Fang Peng Source Type: research
Asthma and cardiovascular disease: embracing disease heterogeneity is required
Extract
We read with interest the recent original research investigation by Valencia-Hernández et al. [1]. This observational study used two approaches to investigate the association of asthma and coronary heart disease (CHD): medical records and Mendelian randomisation (MR). Their results differ compared to many other prior studies investigating the association of asthma and CHD [2]. We applaud the authors for the thoroughness of the investigation; however, we have identified key methodological considerations in this study which may account for differences in the conclusions, compared to prior studies. (Source: Eur...
Source: European Respiratory Journal - April 25, 2024 Category: Respiratory Medicine Authors: Tattersall, M. C., Gangnon, R. E., Jarjour, N. N. Tags: Correspondence Source Type: research
The Use of Precision Epigenetic Methods for the Diagnosis and Care of Stable Coronary Heart Disease Reduces Healthcare Costs
ConclusionThese analyses support the use of precision epigenetic methods as part of the initial diagnosis and care of stable CHD and can meaningfully reduce cost. Real-world pilots to test the reliability of these analyses are indicated. (Source: Advances in Therapy)
Source: Advances in Therapy - April 25, 2024 Category: Drugs & Pharmacology Source Type: research
Predictive model and risk analysis for coronary heart disease in people living with HIV using machine learning
This study aimed to construct a coronary heart disease (CHD) risk-prediction model in people living with human immunodeficiency virus (PLHIV) with the help of machine learning (ML) per electronic medical recor... (Source: BMC Medical Informatics and Decision Making)
Source: BMC Medical Informatics and Decision Making - April 25, 2024 Category: Information Technology Authors: Zengjing Liu, Zhihao Meng, Di Wei, Yuan Qin, Yu Lv, Luman Xie, Hong Qiu, Bo Xie, Lanxiang Li, Xihua Wei, Die Zhang, Boying Liang, Wen Li, Shanfang Qin, Tengyue Yan, Qiuxia Meng & hellip; Tags: Research Source Type: research
Treatment patterns and adherence to lipid-lowering drugs during eight-year follow-up after a coronary heart disease event
CONCLUSIONS: In this long-term follow-up of patients with CHD, less than 70 % used high-intensity statin therapy with only small changes over time, and only 25 % used additional treatment with ezetimibe. We identified factors associated with reduced statin adherence that may be target for interventions.PMID:38657552 | DOI:10.1016/j.atherosclerosis.2024.117550 (Source: Atherosclerosis)
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Ingrid Engebretsen Christoffer Bugge Henrik St øvring Einar Husebye Elise Sverre Toril Dammen Sigrun Halvorsen John Munkhaugen Source Type: research
