LDL-C and TC mediate the risk of PNPLA3 inhibition on cardiovascular diseases
CONCLUSION: This study suggests that PNPLA3 inhibition increases the risk of major CVDs. Moreover, blood LDL-C and TC may mediate a significant proportion of the associations between PNPLA3 inhibition and coronary atherosclerosis, coronary heart disease, or myocardial infarction.PMID:38636099 | DOI:10.1210/clinem/dgae264 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 18, 2024 Category: Endocrinology Authors: Genshan Zhang Wei Jiang Fangxun He Jie Fu Xiangshang Xu Xuelai Luo Zhixin Cao Source Type: research
Lipoprotein(a) and Long-Term Cardiovascular Risk in a Multi-Ethnic Pooled Prospective Cohort
CONCLUSIONS: The study shows, in a large U.S. pooled cohort, that higher Lp(a) levels are associated with an increased ASCVD risk, including in patients with diabetes.PMID:38631771 | DOI:10.1016/j.jacc.2024.02.031 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Nathan D Wong Wenjun Fan Xingdi Hu Christie Ballantyne Ron C Hoodgeveen Michael Y Tsai Auris Browne Matthew J Budoff Source Type: research
Lipoprotein(a) and Long-Term Cardiovascular Risk in a Multi-Ethnic Pooled Prospective Cohort
CONCLUSIONS: The study shows, in a large U.S. pooled cohort, that higher Lp(a) levels are associated with an increased ASCVD risk, including in patients with diabetes.PMID:38631771 | DOI:10.1016/j.jacc.2024.02.031 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Nathan D Wong Wenjun Fan Xingdi Hu Christie Ballantyne Ron C Hoodgeveen Michael Y Tsai Auris Browne Matthew J Budoff Source Type: research
Immune Homeostasis Maintenance Through Advanced Immune Therapeutics to Target Atherosclerosis
Methods Mol Biol. 2024;2782:25-37. doi: 10.1007/978-1-0716-3754-8_2.ABSTRACTAtherosclerosis remains the leading cause of coronary heart disease (CHD) with enormous health and societal tolls. Traditional drug development approaches have been focused on small molecule-based compounds that aim to lower plasma lipids and reduce systemic inflammation, two primary causes of atherosclerosis. However, despite the widely available lipid-lowering and anti-inflammatory small compounds and biologic agents, CHD prevalence still remains high. Based on recent advances revealing disrupted immune homeostasis during atherosclerosis pathogen...
Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Shuo Geng Yajun Wu Liwu Li Source Type: research
A Chinese classical prescription Xuefu Zhuyu decoction in the treatment of coronary heart disease: An overview
CONCLUSION: Through this study, we found that XFZYD has a significant therapeutic effect in the clinical treatment of coronary heart disease, which can play a role in the treatment of CHD by inhibiting atherosclerosis, inhibiting cardiovascular remodeling, improving oxidative stress damage, improving hemorheology, improving myocardial fibrosis and other mechanisms. Through computer simulation, it was found that the main effective components of XFZYD treatment for CHD were quercetin, kaempferol and luteolin, and the key core targets were IL6, VEGFA and P53, and each component had a high VEGFA libdock score. It is speculated...
Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Xuezhen Wang Xunyan Xing Peifeng Huang Zhibin Zhang Zehua Zhou Leiqin Liang Rongmei Yao Xuerun Wu Long Yang Source Type: research
Does shortage of GPs matter? A cross-sectional study of practice population life expectancy
CONCLUSION: The number of GPs, continuity of care, and access in England are declining, and it is worrying that these features of general practice were positively associated with life expectancy.PMID:38621806 | DOI:10.3399/BJGP.2023.0195 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - April 15, 2024 Category: Primary Care Authors: Richard Baker Louis S Levene Christopher Newby George K Freeman Source Type: research
Immune Homeostasis Maintenance Through Advanced Immune Therapeutics to Target Atherosclerosis
Methods Mol Biol. 2024;2782:25-37. doi: 10.1007/978-1-0716-3754-8_2.ABSTRACTAtherosclerosis remains the leading cause of coronary heart disease (CHD) with enormous health and societal tolls. Traditional drug development approaches have been focused on small molecule-based compounds that aim to lower plasma lipids and reduce systemic inflammation, two primary causes of atherosclerosis. However, despite the widely available lipid-lowering and anti-inflammatory small compounds and biologic agents, CHD prevalence still remains high. Based on recent advances revealing disrupted immune homeostasis during atherosclerosis pathogen...
Source: Mol Biol Cell - April 15, 2024 Category: Molecular Biology Authors: Shuo Geng Yajun Wu Liwu Li Source Type: research
Does shortage of GPs matter? A cross-sectional study of practice population life expectancy
CONCLUSION: The number of GPs, continuity of care, and access in England are declining, and it is worrying that these features of general practice were positively associated with life expectancy.PMID:38621806 | DOI:10.3399/BJGP.2023.0195 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - April 15, 2024 Category: Primary Care Authors: Richard Baker Louis S Levene Christopher Newby George K Freeman Source Type: research
Does shortage of GPs matter? A cross-sectional study of practice population life expectancy
CONCLUSION: The number of GPs, continuity of care, and access in England are declining, and it is worrying that these features of general practice were positively associated with life expectancy.PMID:38621806 | DOI:10.3399/BJGP.2023.0195 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - April 15, 2024 Category: Primary Care Authors: Richard Baker Louis S Levene Christopher Newby George K Freeman Source Type: research
Does shortage of GPs matter? A cross-sectional study of practice population life expectancy
CONCLUSION: The number of GPs, continuity of care, and access in England are declining, and it is worrying that these features of general practice were positively associated with life expectancy.PMID:38621806 | PMC:PMC11044019 | DOI:10.3399/BJGP.2023.0195 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - April 15, 2024 Category: Primary Care Authors: Richard Baker Louis S Levene Christopher Newby George K Freeman Source Type: research
The overall fractions of coronary heart diseases and depression attributable to multiple dependent psychosocial work factors in Europe
ConclusionOur study showed that the overall fractions attributable to all studied psychosocial work factors were substantial especially for depression. These overall attributable fractions may be particularly useful to evaluate the burden and costs attributable to psychosocial work factors, and also to inform policies makers at European level. (Source: International Archives of Occupational and Environmental Health)
Source: International Archives of Occupational and Environmental Health - April 15, 2024 Category: Occupational Health Source Type: research
Treatment patterns and adherence to lipid-lowering drugs during eight-year follow-up after a coronary heart disease event
Proper prescription and high adherence to intensive lipid lowering drugs (LLD) in patients with coronary heart disease (CHD) is crucial and strongly recommended. The aim of this study is to investigate long-term treatment patterns and adherence to LLD following hospitalization for a CHD event. (Source: Atherosclerosis)
Source: Atherosclerosis - April 14, 2024 Category: Cardiology Authors: Ingrid Engebretsen, Christoffer Bugge, Henrik St øvring, Einar Husebye, Elise Sverre, Toril Dammen, Sigrun Halvorsen, John Munkhaugen Source Type: research
Mediterranean diet for cardiovascular disease: an evidence mapping study
CONCLUSION: This study indicates that although recognizing the potential efficacy of MD in managing CVD, the quality of the methodology and the evidence for the outcome indicators remain unsatisfactory. To establish the true benefits of MD for CVD patients, future research should not only adhere to rigorous methodological requirements but also prioritize enhancing the quality of primary studies and conducting patient-centered meta-analyses.PMID:38600858 | DOI:10.1017/S1368980024000776 (Source: Public Health Nutrition)
Source: Public Health Nutrition - April 11, 2024 Category: International Medicine & Public Health Authors: Zi-Ling Cai Liao-Yao Wang Bing-Yue Zhang Ai-Song Zhu Source Type: research
Mediterranean diet for cardiovascular disease: an evidence mapping study
CONCLUSION: This study indicates that although recognizing the potential efficacy of MD in managing CVD, the quality of the methodology and the evidence for the outcome indicators remain unsatisfactory. To establish the true benefits of MD for CVD patients, future research should not only adhere to rigorous methodological requirements but also prioritize enhancing the quality of primary studies and conducting patient-centered meta-analyses.PMID:38600858 | DOI:10.1017/S1368980024000776 (Source: Public Health Nutrition)
Source: Public Health Nutrition - April 11, 2024 Category: International Medicine & Public Health Authors: Zi-Ling Cai Liao-Yao Wang Bing-Yue Zhang Ai-Song Zhu Source Type: research
The current position of β-blockers in hypertension: guidelines and clinical practice
Curr Med Res Opin. 2024;40(sup1):25-32. doi: 10.1080/03007995.2024.2318003. Epub 2024 Apr 10.ABSTRACTThe benefits of improved clinical outcomes through blood pressure (BP) reduction have been proven in multiple clinical trials and meta-analyses. The new (2023) guideline from the European Society of Hypertension (ESH) includes β-blockers within five main classes of antihypertensive agents suitable for initiation of antihypertensive pharmacotherapy and for combination with other antihypertensive agents. This is in contrast to the 2018 edition of ESH guidelines that recommended β-blockers for use primarily in patients with ...
Source: Current Medical Research and Opinion - April 10, 2024 Category: Research Authors: Felix Mahfoud Jiguang Wang Saumitra Ray Source Type: research
