Mendelian randomization of chronic hepatitis B and cardiovascular disease
CONCLUSION: Our research indicates that chronic hepatitis B has a correlation with an elevated risk of developing atherosclerosis and coronary heart disease, while it is associated with a decreased risk of experiencing an ischemic stroke.PMID:38559670 | PMC:PMC10978653 | DOI:10.3389/fcvm.2024.1332557 (Source: Atherosclerosis)
Source: Atherosclerosis - April 1, 2024 Category: Cardiology Authors: Dongjie Wu Feiyang Xiong Qingzhi Ran Jing Liu Qingjuan Wu Liang Wang Wenliang Lv Source Type: research
Type 2 diabetes mellitus and cardiometabolic outcomes in metabolic dysfunction-associated steatotic liver disease population
The metabolic syndrome is a constellation of epidemics, involving type 2 diabetes mellitus (T2DM), hypertension, hyperlipidemia, and obesity, that share common biological and societal pathways.[1 –4] This pathological metabolic milieu collectively increases the individual’s risk of cardiovascular diseases, including coronary heart disease and heart failure.[3,5,6] More recently, metabolic dysfunction-associated steatotic liver disease (MASLD) has been increasingly recognized as a key man ifestation of this systemic metabolic disease. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 1, 2024 Category: Endocrinology Authors: Nicholas W.S. Chew, Xin Hui Pan, Bryan Chong, Chanchal Chandramouli, Mark Muthiah, Carolyn S.P. Lam Source Type: research
Trends of LDL/HDL cholesterol ratio levels among US 6-80: National Health and Nutrition Examination Survey (NHANES) 2005-2020
This study aimed to examine the trends and differences in serum low-density lipoprotein cholesterol-to-high density lipoprotein cholesterol (LDL/HDL-C) ratio among U.S. residents by survey years, selected demographic, and socioeconomic variables. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - April 1, 2024 Category: Rehabilitation Authors: Inga Wang, Mohammad Rahman, Sheng-Che Yen, Xiaoyan Li, Stephen Hou, Chiung-ju Liu Tags: Research Poster 2372738 Source Type: research
Miscarriage and stillbirth in relation to risk of cardiovascular diseases: A systematic review and meta-analysis
CONCLUSION: This meta-analysis indicates that both miscarriages and stillbirths are related to a higher risk of total CVDs, CHD, stroke, and total CVD deaths. The risk of total CVDs and CHD increased with the number of miscarriages or stillbirths.PMID:38554480 | DOI:10.1016/j.ejogrb.2024.03.035 (Source: Reproductive Biology)
Source: Reproductive Biology - March 30, 2024 Category: Reproduction Medicine Authors: Mengmeng Wang Jinli Zhang Lijun Yuan Huifang Hu Tianze Li Yifei Feng Yang Zhao Yuying Wu Xueru Fu Yamin Ke Yajuan Gao Yaobing Chen Weifeng Huo Longkang Wang Wenkai Zhang Xi Li Jiong Liu Zelin Huang Fulan Hu Ming Zhang Liang Sun Dongsheng Hu Yang Zhao Source Type: research
Role of inflammatory signaling pathways involving the CD40-CD40L-TRAF cascade in diabetes and hypertension-insights from animal and human studies
Basic Res Cardiol. 2024 Mar 30. doi: 10.1007/s00395-024-01045-1. Online ahead of print.ABSTRACTCD40L-CD40-TRAF signaling plays a role in atherosclerosis progression and affects the pathogenesis of coronary heart disease (CHD). We tested the hypothesis that CD40L-CD40-TRAF signaling is a potential therapeutic target in hyperlipidemia, diabetes, and hypertension. In mouse models of hyperlipidemia plus diabetes (db/db mice) or hypertension (1 mg/kg/d angiotensin-II for 7 days), TRAF6 inhibitor treatment (2.5 mg/kg/d for 7 or 14 days) normalized markers of oxidative stress and inflammation. As diabetes and hypertension are imp...
Source: Atherosclerosis - March 30, 2024 Category: Cardiology Authors: Lea Strohm Andreas Daiber Henning Ubbens Roopesh Krishnankutty Matthias Oelze Marin Kuntic Omar Hahad Veronique Klein Imo E Hoefer Alex von Kriegsheim Hartmut Kleinert Dorothee Atzler Philipp Lurz Christian Weber Philipp S Wild Thomas M ünzel Christoph K Source Type: research
Miscarriage and stillbirth in relation to risk of cardiovascular diseases: A systematic review and meta-analysis
CONCLUSION: This meta-analysis indicates that both miscarriages and stillbirths are related to a higher risk of total CVDs, CHD, stroke, and total CVD deaths. The risk of total CVDs and CHD increased with the number of miscarriages or stillbirths.PMID:38554480 | DOI:10.1016/j.ejogrb.2024.03.035 (Source: Reproductive Biology)
Source: Reproductive Biology - March 30, 2024 Category: Reproduction Medicine Authors: Mengmeng Wang Jinli Zhang Lijun Yuan Huifang Hu Tianze Li Yifei Feng Yang Zhao Yuying Wu Xueru Fu Yamin Ke Yajuan Gao Yaobing Chen Weifeng Huo Longkang Wang Wenkai Zhang Xi Li Jiong Liu Zelin Huang Fulan Hu Ming Zhang Liang Sun Dongsheng Hu Yang Zhao Source Type: research
Role of inflammatory signaling pathways involving the CD40 –CD40L–TRAF cascade in diabetes and hypertension—insights from animal and human studies
AbstractCD40L –CD40–TRAF signaling plays a role in atherosclerosis progression and affects the pathogenesis of coronary heart disease (CHD). We tested the hypothesis that CD40L–CD40–TRAF signaling is a potential therapeutic target in hyperlipidemia, diabetes, and hypertension. In mouse models of hyperlipi demia plus diabetes (db/db mice) or hypertension (1 mg/kg/d angiotensin-II for 7 days), TRAF6 inhibitor treatment (2.5 mg/kg/d for 7 or 14 days) normalized markers of oxidative stress and inflammation. As diabetes and hypertension are important comorbidities aggravating CHD, we explored whether the CD40L–CD4...
Source: Basic Research in Cardiology - March 30, 2024 Category: Cardiology Source Type: research
Risk analysis of the association between different hemoglobin glycation index and poor prognosis in critical patients with coronary heart disease-A study based on the MIMIC-IV database
The hemoglobin glycation index (HGI) is the difference between the observed and predicted values of glycosylated hemoglobin (HbA1c), which is closely associated with a variety of poor prognoses. However, there... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 30, 2024 Category: Cardiology Authors: Xing Wei, Xinghua Chen, Zhipeng Zhang, Jing Wei, Ben Hu, Nv Long, Jun Feng and Chunmiao Luo Tags: Research Source Type: research
Retracted: The Protective Effects of miR-21-Mediated Fibroblast Growth Factor 1 in Rats with Coronary Heart Disease
Biomed Res Int. 2024 Mar 20;2024:9867070. doi: 10.1155/2024/9867070. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.1155/2021/3621259.].PMID:38550207 | PMC:PMC10977212 | DOI:10.1155/2024/9867070 (Source: Biomed Res)
Source: Biomed Res - March 29, 2024 Category: Research Authors: BioMed Research International Source Type: research
Meta-analysis of Risk Factors for Venous Thromboembolism in Patients with Gynecologic Malignant Tumors
CONCLUSION: Age, tumor staging, body mass index, hypertension, and surgery time emerge as significant risk factors for VTE in gynecologic malignant tumor surgery patients. Monitoring these risk factors can effectively facilitate risk assessment and prevention of VTE. These findings have important clinical implications. Firstly, they emphasize the importance of considering these risk factors during the assessment of VTE risk in patients with gynecologic malignancies. Healthcare professionals can use this information to identify high-risk patients and implement appropriate preventive measures. For example, older patients, th...
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Jiewei Pan Gang Zhao Source Type: research
Subclinical vascular composites predict clinical cardiovascular disease, stroke, and dementia: The Multi-Ethnic Study of Atherosclerosis (MESA)
CONCLUSIONS: Subclinical vascular composites of atherosclerosis and arteriosclerosis may be useful biomarkers to inform the vascular pathways contributing to events of CVD, CHD, stroke, and dementia.PMID:38552474 | DOI:10.1016/j.atherosclerosis.2024.117521 (Source: Atherosclerosis)
Source: Atherosclerosis - March 29, 2024 Category: Cardiology Authors: Timothy M Hughes Jordan Tanley Haiying Chen Christopher L Schaich Joseph Yeboah Mark A Espeland Joao A C Lima Bharath Ambale-Venkatesh Erin D Michos Jingzhong Ding Kathleen Hayden Ramon Casanova Suzanne Craft Stephen R Rapp Jos é A Luchsinger Annette L F Source Type: research
Retracted: The Protective Effects of miR-21-Mediated Fibroblast Growth Factor 1 in Rats with Coronary Heart Disease
Biomed Res Int. 2024 Mar 20;2024:9867070. doi: 10.1155/2024/9867070. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.1155/2021/3621259.].PMID:38550207 | PMC:PMC10977212 | DOI:10.1155/2024/9867070 (Source: Biomed Res)
Source: Biomed Res - March 29, 2024 Category: Research Authors: BioMed Research International Source Type: research
Deciphering the role of SMARCA4 in cardiac disorders: Insights from single-cell studies on dilated cardiomyopathy and coronary heart disease
CONCLUSION: This study provides a clearer understanding of cell-type dynamics in heart diseases, emphasizing the role of fibroblasts and the significance of SMARCA4 in their function. Our results offer insights into the cellular mechanisms underlying DCM and CHD, potentially guiding future therapeutic strategies.PMID:38552892 | DOI:10.1016/j.cellsig.2024.111150 (Source: Cellular Signalling)
Source: Cellular Signalling - March 29, 2024 Category: Cytology Authors: Li Liu Chengban Li Linxing Yu Yubo Wang Xingshou Pan Jianjun Huang Source Type: research
Meta-analysis of Risk Factors for Venous Thromboembolism in Patients with Gynecologic Malignant Tumors
CONCLUSION: Age, tumor staging, body mass index, hypertension, and surgery time emerge as significant risk factors for VTE in gynecologic malignant tumor surgery patients. Monitoring these risk factors can effectively facilitate risk assessment and prevention of VTE. These findings have important clinical implications. Firstly, they emphasize the importance of considering these risk factors during the assessment of VTE risk in patients with gynecologic malignancies. Healthcare professionals can use this information to identify high-risk patients and implement appropriate preventive measures. For example, older patients, th...
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Jiewei Pan Gang Zhao Source Type: research
Deciphering the role of SMARCA4 in cardiac disorders: Insights from single-cell studies on dilated cardiomyopathy and coronary heart disease
CONCLUSION: This study provides a clearer understanding of cell-type dynamics in heart diseases, emphasizing the role of fibroblasts and the significance of SMARCA4 in their function. Our results offer insights into the cellular mechanisms underlying DCM and CHD, potentially guiding future therapeutic strategies.PMID:38552892 | DOI:10.1016/j.cellsig.2024.111150 (Source: Cellular Signalling)
Source: Cellular Signalling - March 29, 2024 Category: Cytology Authors: Li Liu Chengban Li Linxing Yu Yubo Wang Xingshou Pan Jianjun Huang Source Type: research
