Fight Aging! Newsletter, January 15th 2024
In conclusion, FMD cycles have high potential to be effective in increasing the toxicity of a range of therapies against ALL and other blood cancers and should be tested in randomized clinical trials, especially in combination with immunotherapy and low toxicity cancer therapies.
In summary, we present a new strategy for improving leukemia treatment by combining FMD with chemotherapy to promote the killing of ALL cells in part by an immune-dependent mechanism. Fasting/FMD has been shown to reduce chemotherapy-associated toxicity in pre-clinical and clinical studies and thus represents a safe and potentially effectiv...
Source: Fight Aging! - January 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Effects of LDLR Variants on Longevity via Lowered Cardiovascular Disease
This study suggests that LDLR is a promising genetic target for human longevity. Lipid-related gene targets, such as PCSK9, CETP, and APOC3, might potentially regulate human lifespan, thus offering promising prospects for developing newer nonstatin therapies.
Link: https://doi.org/10.1186/s12944-023-01983-0 (Source: Fight Aging!)
Source: Fight Aging! - January 12, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 20th 2023
In this study, we attempted to further explain the role, exact mechanism and target of ICA in treating AD from the ferroptosis perspective. We found that ICA could improve the neurobehavioral, memory, and motor abilities of AD mice. It could lower the ferroptosis level and enhance the resistance to oxidative stress. After inhibition of MDM2, ICA could no longer improve the cognitive ability of AD mice, nor could it further inhibit ferroptosis. Network pharmacological analysis revealed that MDM2 might be the target of ICA action.
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Particulate Air Pollution and Its Effects on the Mechan...
Source: Fight Aging! - November 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Endothelial Cell Senescence in Atherosclerosis
Senescent cells accumulate throughout the body with age. They are created constantly due to stresses placed upon cells, and when somatic cells reach the Hayflick limit on replication, and are cleared by the immune system. This process of clearance slows down with age, unfortunately, and so a burden of lingering senescent cells begins to build up. Senescent cells are disruptive to tissue structure and function, even when present in comparatively small numbers relative to other cells in a tissue, as a result of the pro-growth, pro-inflammatory signals that they generate.
Atherosclerosis involves the generation of fatt...
Source: Fight Aging! - November 16, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Study: High Blood Pressure While Lying Down Linked To Greater Heart Risks
Conclusion
The findings of this recent study are nothing short of a game-changer in how we understand and manage blood pressure. It’s clear that simply taking blood pressure readings while seated might not give the full picture.
High blood pressure while lying down has been linked to a heightened risk of serious heart health complications, including heart attack, stroke, and even premature death.
Therefore, a more comprehensive approach to blood pressure monitoring is crucial. One that considers different body positions could offer deeper insights into an individual’s cardiovascular health.
This n...
Source: The EMT Spot - September 9, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
How To Live Longer: 8 Delicious Foods That Add Years To Your Life
Foods rich in this type of omega-3 fatty acid found to reduce risk of death, especially from coronary heart disease. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - August 20, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Heart Disease Source Type: blogs
Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer'...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Longevity-Associated FLT1 Variant May Protect Against Hypertension Consequences
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Link: https://doi.org/10.18632/aging.204722 (Source: Fight Aging!)
Source: Fight Aging! - July 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Processed Foods Linked To Increased Blood Pressure, Study Finds
Conclusions
This groundbreaking study highlights the link between high consumption of processed foods and increased blood pressure variability, particularly at night.
The findings emphasize the crucial role of diet and lifestyle in cardiovascular health.
Interestingly, researchers noted an unexpected association: higher consumption of ultra-processed foods was linked to less variation in night-time blood pressure.
This puzzling finding suggests a need for further investigation into the effects of ultra-processed foods on our health.
In conclusion, the study underscores the importance of prioritizing unproc...
Source: The EMT Spot - July 4, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
Fight Aging! Newsletter, May 15th 2023
In this study, we examined the average telomere length and telomerase activity, as well as the formation of telomere associated foci (TAFs) and the mRNA expression levels of the shelterin components in cultured primary cells of Spalax, a long-lived, hypoxia-tolerant, and cancer-resistant blind mole-rat species.
We showed that with cell passages, Spalax fibroblasts demonstrated significant shortening in telomere length, similar to rat cells, and in line with the processes observed earlier in tissues. We also demonstrated that the average telomere length in Spalax fibroblasts was significantly higher than the average ...
Source: Fight Aging! - May 14, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Athletes Exhibit Half the Incidence of Hypertension in the General Population
Cardiovascular aging is greatly influenced by exercise and physical fitness, to the point at which one can point to physically active hunter-gatherer populations that exhibit very few of the common cardiovascular issues present in wealthier first world populations. Researchers here report on a study of cardiovascular aging in competitive athletic individuals, noting that they exhibit less than half of the risk of hypertension observed in the general population. This is one of many examples of the way in which athletes tend to be healthier than the average.
Master athlete is a term applied to individuals typically ...
Source: Fight Aging! - May 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 8th 2023
In conclusion, NAT mitigated age-associated cerebral injury in mice through gut-brain axis. The findings provide novel evidence for the effect of NAT on anti-aging, and highlight the potential application of NAT as an effective intervention against age-related diseases.
Retinal Cell Reprogramming Restores Vision in Non-Human Primate Study
https://www.fightaging.org/archives/2023/05/retinal-cell-reprogramming-restores-vision-in-non-human-primate-study/
Early applications of in vivo cellular reprogramming to medicine are cautiously focused on retinal regeneration. The eye is as close to an isolated system...
Source: Fight Aging! - May 7, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Extending the GrimAge Epigenetic Clock with Physical Fitness Measures
An aging clock can be built from near any collection of data that changes with age. The first epigenetic clocks used DNA methylation status for many different locations on the genome, but just about any biochemical or physiological measure can be incorporated into a clock algorithm. Since early epigenetic clocks were insensitive to physical fitness, it is interesting to see an attempt to extend a later epigenetic clock by adding assessments of physical fitness. Can there be a hypothetical best clock, one that accurately reflects the result of any intervention in aging, or will it always be the case that clocks will only ap...
Source: Fight Aging! - May 3, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Nutrition: Major Government Fail?
Chris EdwardsAmericans are getting used to failures by government experts. Government economists have a dismal forecasting record. Government actions and advice during the pandemic were often misguided. And dozens of former government intelligence experts got the Hunter Biden laptop storywrong.A less recognized but also important failure may be in nutrition. Federal experts appear to have issued faulty advice for decades, even as American obesityexploded from 15 percent in the 1970s to 42 percent today. Federal guidance on nutrition has a large influence on health practice across society. Some researchers argue that Am...
Source: Cato-at-liberty - April 26, 2023 Category: American Health Authors: Chris Edwards Source Type: blogs
Fight Aging! Newsletter, December 19th 2022
In conclusion, p16 deletion or p16 positive cell clearance could be a novel strategy preventing long term HFD-induced skin aging.
Association of LDL-Cholesterol with Mortality
https://www.fightaging.org/archives/2022/12/association-of-ldl-cholesterol-with-mortality/
Researchers here report on a study of LDL-cholesterol and mortality risk in older people. As they note, data on this topic is conflicted once one moves beyond the matter of cardiovascular disease. Over a lifetime, higher LDL-cholesterol makes it easier to reach the tipping point at which cholesterol deposited in blood vessel walls produces e...
Source: Fight Aging! - December 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
