Hydrogen Sulfide Influences Cellular Senescence via Splicing Mechanisms
In this open access paper, researchers report that compounds delivering hydrogen sulfide into cells slow the pace at which those cells become senescent in culture. The mechanisms involved are not fully explored but involve splicing factors, proteins that have a strong influence over gene expression. As the biochemistry of cellular senescence is explored, and researchers find ways to potentially hold back the transition of cells into the senescent state, we might ask whether or not this is a good idea. Lingering cellular senescence is a cause of aging, but most cells become senescent for a good reason - they are damaged, po...
Source: Fight Aging! - August 8, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
No Scientific Proof That Multivitamins Promote Heart Health
https://www.medscape.com/viewarticle/899130No Scientific Proof That Multivitamins Promote Heart HealthTaking multivitamin/mineral (MVM) supplements does not prevent myocardial infarction, stroke, or death from a cardiovascular cause, according to a comprehensive meta-analytic review of relevant research." The take-home message is simple: there is no scientific evidence that MVM supplements promote cardiovascular health. We hope that our paper helps to settle the controversy on MVM use for CVD prevention, " lead author Joonseok Kim, MD, University of Alabama at Birmingham, toldtheheart.org | Medscape Cardiology.The study wa...
Source: Dr Portnay - July 25, 2018 Category: Cardiology Authors: Dr Portnay Source Type: blogs
Omega-3 supplements don't help prevent disease - Business Insider
@media print { body { margin: 2mm 9mm; } .original-url { display: none; } #article .float.left { float: left !important; } #article .float.right { float: right !important; } #article .float { margin-top: 0 !important; margin-bottom: 0 !important; } }Omega-3 supplements don ' t help prevent disease - Business Insiderhttp://www.businessinsider.com/omega-3-supplements-dont-help-prevent-disease-2018-7Omega-3 supplements are essentially useless for preventing diseases, according to a new studyLindsay DodgsonBaoyan...
Source: Dr Portnay - July 18, 2018 Category: Cardiology Authors: Dr Portnay Source Type: blogs
Fight Aging! Newsletter, June 18th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - June 17, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Reminder that Excess Visceral Fat is Harmful
This popular science article takes a high level look at the vast array of research data showing that excess visceral fat causes great harm to long term health. One of the more important mediating mechanisms is an increase in chronic inflammation, a state of dysfunction in the operation of the immune system that disrupts organ function and tissue maintenance, and accelerates the development of all of the common age-related diseases. There are numerous other connections between the pace of aging and the activities of visceral fat tissue, however. Becoming overweight is the path to a shorter life expectancy, greater incidence...
Source: Fight Aging! - June 13, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A New Target Mechanism for Lowering Blood Pressure in Cases of Hypertension
Hypertension, high blood pressure, is caused by arterial stiffness, which is in turn caused by a combination of mechanisms such as the accumulation of persistent cross-links that alter the structural properties of tissue, and chronic inflammation produced by senescent cells that alters the behavior of cells in blood vessel walls. Hypertension damages fragile tissues, causes the muscle of the heart to become larger and weaker, and ultimately interacts with the corrosive effects of atherosclerosis on blood vessel walls to produce a fatal rupture, leading to a stroke or heart attack.
The work noted here is representati...
Source: Fight Aging! - June 1, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 21st 2018
In conclusion, the connection between DNA damage and aging is emphasized by the secretion of senescence-associated proteins during cellular senescence, a phenotype which is activated by DNA damage and is common for both human and mice. Though much progress has been achieved, full understanding of these mechanisms has still a long way to go.
XPO1 as a Novel Target for Therapies to Enhance Autophagy
https://www.fightaging.org/archives/2018/05/xpo1-as-a-novel-target-for-therapies-to-enhance-autophagy/
Autophagy is the name given to a collection of cellular housekeeping processes that recycle damaged and u...
Source: Fight Aging! - May 20, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Is Lipid Level or Inflammation the Critical Factor for Cardiovascular Disease Risk?
No orthodoxy lacks accompanying heretics; it often seems that science is a business of proceeding abruptly and messily from one steady state consensus to another via the mechanism of heresy. It is of course worth bearing in mind that most heretics do turn out to be wrong, and are consequently forgotten by all but the most painstaking of scientific historians. In the paper I'll point out today, the orthodoxy of blood lipid levels as a cause of cardiovascular disease is challenged. The heresy is to suggest that it isn't the lipids at all, but all down to a matter of chronic inflammation.
This is a tough topic to arbit...
Source: Fight Aging! - May 17, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Explore How Exercises Boost Your Health and Fitness & Help Extend Your Lifespan
Conclusion
Exercise and some sort of a physical activity are certainly effective ways of having great fun and boosting your health. You could consider doing 150 minutes of moderate-intensity workouts per week or opt for 75 minutes of vigorous exercise every week as per your preference and convenience. You must necessarily fit in some exercises in your daily routine.You've read Explore How Exercises Boost Your Health and Fitness & Help Extend Your Lifespan, originally posted on Pick the Brain | Motivation and Self Improvement. If you've enjoyed this, please visit our site for more inspirational articles. (Source: PickT...
Source: PickTheBrain | Motivation and Self Improvement - May 17, 2018 Category: Consumer Health News Authors: matteid78 Tags: health and fitness health tips the importance of exercise Source Type: blogs
Death by donut
I don’t mean that you will be struck down by simply stepping into a Dunkin’ Donuts. I mean that donuts and others things wheat and grains will substantially abbreviate your life, or at least make your time on earth a lot more miserable.
I’ve been accused of exaggeration to get the no-wheat, no-grain message through. But if you see what I see every day, I think that you would agree: The consumption of wheat and grains is entirely inappropriate for humans; we exchange near-term calories for deterioration of long-term health that takes numerous forms. And when you see lives completely turned around by banish...
Source: Wheat Belly Blog - May 9, 2018 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle autoimmune bowel flora diabetes gluten-free grain-free grains Inflammation joint pain undoctored Source Type: blogs
Death by donut
I don’t mean that you will be struck down by simply stepping into a Dunkin’ Donuts. I mean that donuts and others things wheat and grains will substantially abbreviate y0ur life, or at least make your time on earth a lot more miserable.
I’ve been accused of exaggeration to get the no-wheat, no-grain message through. But if you see what I see every day, I think that you would agree: The consumption of wheat and grains is entirely inappropriate for humans; we exchange near-term calories for deterioration of long-term health that takes numerous forms. And when you see lives completely turned around by banish...
Source: Wheat Belly Blog - May 9, 2018 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle autoimmune bowel flora diabetes gluten-free grain-free grains Inflammation joint pain undoctored Source Type: blogs
Chest Pain, " Negative " Stress Tests, POCUS, & ECG Equations -- A Case from Salim Rezaie (R.E.B.E.L. EM)
This case is posted by Salim Rezaie (@srrezaie)Chest Pain, “Negative” Stress Tests, POCUS,& ECG EquationsIt has some peer review by me at the end, so we ' reco-posting!!Chest Pain, " Negative " Stress Tests, POCUS,& ECG Equationsby Salim RezaieI was working a busy shift in the ED, like many of us do, and the next patient I was going to see was a 57 year old male with no real medical problems complaining of chest pain. I remember thinking as I walked into the room this guy looks ashen and diaphoretic ….he doesn’t look well. He is a paramedic telling me how he has been having off and on chest pain...
Source: Dr. Smith's ECG Blog - April 30, 2018 Category: Cardiology Authors: Steve Smith Source Type: blogs
Towards a Better Epigenetic Clock
Researchers here report on an improved version of the epigenetic clock. A few carefully defined patterns of DNA methylation, including the original epigenetic clock, correlate quite closely with age. The current commercial implementation of the epigenetic clock, MyDNAge, has a margin of error of two years or so. While the consensus is that the clock reflects biological age, it is still the case that we might ask what exactly is being measured. The answer to that question remains to be established. It is plausible that DNA methylation changes with age are a reaction to all of the forms of cell and tissue damage that drive a...
Source: Fight Aging! - April 24, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 9th 2018
This studycounters that notion, and the findings may suggest that many senior citizens remain more cognitively and emotionally intact than commonly believed.
"We found that older people have similar ability to make thousands of hippocampal new neurons from progenitor cells as younger people do. We also found equivalent volumes of the hippocampus (a brain structure used for emotion and cognition) across ages. Nevertheless, older individuals had less vascularization and maybe less ability of new neurons to make connections. It is possible that ongoing hippocampal neurogenesis sustains human-specific cognitive function...
Source: Fight Aging! - April 8, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Finding a Causal Relationship Between Exercise and Longevity in Human Data is More Challenging than One Might Imagine
It is straightforward enough to prove that exercise extends healthy (but not average or overall) life span in studies of mice. It is far less straightforward to demonstrate that same proof in human epidemiological data. We can't put humans into carefully controlled groups stratified by life-long differences in exercise and follow them from birth to death, as is the case for mice. As a consequence, near all studies of physical activity and longevity produce only correlations, as there is no practical way to derive causation given the data to hand. It is felt that these correlations likely reflect causation because of the ex...
Source: Fight Aging! - April 2, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
