Safety and tolerability of β-blockers: importance of cardioselectivity
Curr Med Res Opin. 2024;40(sup1):55-62. doi: 10.1080/03007995.2024.2317433. Epub 2024 Apr 10.ABSTRACTCardioselective β-blockade is generally well tolerated in practice and contraindications to this therapy are uncommon. β-blockers are a diverse therapeutic class, and their individual tolerability profiles are influenced strongly by their pharmacodynamic effects across different adrenergic receptors. Bisoprolol, probably the β-blocker with the highest selectivity for blockade of β1- vs. β2-adrenoceptors, does not block β2-adrenoceptors to an appreciable extent at doses in therapeutic use. Side-effects often attributed...
Source: Current Medical Research and Opinion - April 10, 2024 Category: Research Authors: Hans-Peter Marti Abel Alberto Pav ía López Pedro Schwartzmann Source Type: research
The current position of β-blockers in hypertension: guidelines and clinical practice
Curr Med Res Opin. 2024;40(sup1):25-32. doi: 10.1080/03007995.2024.2318003. Epub 2024 Apr 10.ABSTRACTThe benefits of improved clinical outcomes through blood pressure (BP) reduction have been proven in multiple clinical trials and meta-analyses. The new (2023) guideline from the European Society of Hypertension (ESH) includes β-blockers within five main classes of antihypertensive agents suitable for initiation of antihypertensive pharmacotherapy and for combination with other antihypertensive agents. This is in contrast to the 2018 edition of ESH guidelines that recommended β-blockers for use primarily in patients with ...
Source: Current Medical Research and Opinion - April 10, 2024 Category: Research Authors: Felix Mahfoud Jiguang Wang Saumitra Ray Source Type: research
Safety and tolerability of β-blockers: importance of cardioselectivity
Curr Med Res Opin. 2024;40(sup1):55-62. doi: 10.1080/03007995.2024.2317433. Epub 2024 Apr 10.ABSTRACTCardioselective β-blockade is generally well tolerated in practice and contraindications to this therapy are uncommon. β-blockers are a diverse therapeutic class, and their individual tolerability profiles are influenced strongly by their pharmacodynamic effects across different adrenergic receptors. Bisoprolol, probably the β-blocker with the highest selectivity for blockade of β1- vs. β2-adrenoceptors, does not block β2-adrenoceptors to an appreciable extent at doses in therapeutic use. Side-effects often attributed...
Source: Current Medical Research and Opinion - April 10, 2024 Category: Research Authors: Hans-Peter Marti Abel Alberto Pav ía López Pedro Schwartzmann Source Type: research
Associations Between HbA1c and Glucose Time in Range Using Continuous Glucose Monitoring in Type 1 Diabetes: Cross-Sectional Population-Based Study
ConclusionsThis descriptive study demonstrates that the degree of association between HbA1c and new and readily available CGM-derived metrics, i.e., time in range (TIR), time above range (TAR), and CGM mean glucose, is robust in assessing the management of individuals with type 1 diabetes in clinical settings. Metrics from CGM that pertain to variability and hypoglycemia exhibit only weak correlations with HbA1c. (Source: Diabetes Therapy)
Source: Diabetes Therapy - April 10, 2024 Category: Endocrinology Source Type: research
Differential age-specific associations of LDL cholesterol and body mass index with coronary heart disease
Low ‐density lipoprotein cholesterol (LDLc) and body mass index (BMI) are not always correlated and their relationship is probably dependent on age, indicating differential age-specific associations of these factors with health outcomes. We aim to discriminate the roles of LDLc and BMI in coronary hea rt disease (CHD) across different age groups. (Source: Atherosclerosis)
Source: Atherosclerosis - April 10, 2024 Category: Cardiology Authors: Jun Xiao, Hongye Wei, Ziting Gao, Liangwan Chen, Weimin Ye, Wuqing Huang Source Type: research
Associations Between HbA1c and Glucose Time in Range Using Continuous Glucose Monitoring in Type 1 Diabetes: Cross-Sectional Population-Based Study
ConclusionsThis descriptive study demonstrates that the degree of association between HbA1c and new and readily available CGM-derived metrics, i.e., time in range (TIR), time above range (TAR), and CGM mean glucose, is robust in assessing the management of individuals with type 1 diabetes in clinical settings. Metrics from CGM that pertain to variability and hypoglycemia exhibit only weak correlations with HbA1c. (Source: Diabetes Therapy)
Source: Diabetes Therapy - April 10, 2024 Category: Endocrinology Source Type: research
Characteristics of Postoperative Heart Failure in Older Hip Fractures Patients Combined with Coronary Heart Disease and Construction of a Prediction Model of Nomogram, a Retrospective Cohort Study
(Source: Clinical Interventions in Aging)
Source: Clinical Interventions in Aging - April 8, 2024 Category: Geriatrics Tags: Clinical Interventions in Aging Source Type: research
Functional capacity in smoking patients after coronary artery bypass grafting surgery: a quasi-experimental study
J Med Life. 2023 Dec;16(12):1760-1768. doi: 10.25122/jml-2023-0282.ABSTRACTCoronary artery bypass grafting surgery (CABG) is an important approach to treating coronary heart disease. However, patients undergoing open heart surgery are at risk of postoperative complications. Cigarette smoking is one of the preoperative risk factors that may increase postoperative complications. Studies show that early mobilization intervention may reduce these complications and improve functional capacity, but the impact of smoking on early outcomes after CABG has been controversial for the past two decades. This quasi-experimental study ex...
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Mohammed Essa Alsubaiei Wadha Althukair Hind Almutairi Source Type: research
