Are the elements zinc, copper, magnesium, and rubidium related to nutrition and iodine deficiency in pregnant Bulgarian women from iodine deficient region?
CONCLUSION: The high Cu levels were associated with subclinical hypothyroidism (SCH) and less pulse consumption during pregnancy in an iodine deficiency endemic area. SCH was found in 24% of the pregnant women in such an area while in 13% of them SCH had progressed to overt hypothyroidism.PMID:38669155 | DOI:10.21101/cejph.a7796 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Mariana Georgieva Bacelova Penka Dimitrova Gatseva Tanya Ivanova Deneva Delyana Miteva Davcheva Anelia Veselinova Bivolarska Source Type: research
Neurological Deterioration in Wilson's Disease-Types, Etiology, Course, and Management
Discov Med. 2024 Apr;36(183):646-654. doi: 10.24976/Discov.Med.202436183.61.ABSTRACTWilson's disease (WD) is an inherited disorder of copper metabolism in which pathological copper accumulation, mainly in the liver and the brain, leads to hepatic and/or neuropsychiatric signs and symptoms. Chelators and zinc salts can successfully induce negative copper balance in many patients; however, neurological deterioration may still be observed. This phenomenon can be divided into: (1) early 'paradoxical' neurological deterioration, which usually develops in the first 6 months of anti-copper treatment and may be commonly related to...
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Tomasz Litwin Agnieszka Antos Jan Bembenek Anna Cz Onkowska Source Type: research
Contribution of technological aids to the extraction of orbital foreign bodies
CONCLUSION: Vegetal orbital foreign bodies must be systematically removed. Removal of non-vegetal orbital foreign bodies should be considered on a case-by-case basis based on their size, best assessed using a "low artifact" scanner, their location, and their intrinsic ferromagnetism. Intraoperative navigation does not appear useful, while intraoperative scope imaging does. A dedicated orbital magnet might be helpful in removing ferromagnetic orbital foreign bodies. However, an orbital magnet may be ineffective in removing intraorbital bullets, since they are made primarily of an alloy of copper and lead.PMID:38669863 | DOI...
Source: Journal Francais d Ophtalmologie - April 26, 2024 Category: Opthalmology Authors: G Bula S Baillif P Labalette P Martel M De Massary C Ghetemme L Mondot A Martel Source Type: research
Neurological Deterioration in Wilson's Disease-Types, Etiology, Course, and Management
Discov Med. 2024 Apr;36(183):646-654. doi: 10.24976/Discov.Med.202436183.61.ABSTRACTWilson's disease (WD) is an inherited disorder of copper metabolism in which pathological copper accumulation, mainly in the liver and the brain, leads to hepatic and/or neuropsychiatric signs and symptoms. Chelators and zinc salts can successfully induce negative copper balance in many patients; however, neurological deterioration may still be observed. This phenomenon can be divided into: (1) early 'paradoxical' neurological deterioration, which usually develops in the first 6 months of anti-copper treatment and may be commonly related to...
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Tomasz Litwin Agnieszka Antos Jan Bembenek Anna Cz Onkowska Source Type: research
Are the elements zinc, copper, magnesium, and rubidium related to nutrition and iodine deficiency in pregnant Bulgarian women from iodine deficient region?
CONCLUSION: The high Cu levels were associated with subclinical hypothyroidism (SCH) and less pulse consumption during pregnancy in an iodine deficiency endemic area. SCH was found in 24% of the pregnant women in such an area while in 13% of them SCH had progressed to overt hypothyroidism.PMID:38669155 | DOI:10.21101/cejph.a7796 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Mariana Georgieva Bacelova Penka Dimitrova Gatseva Tanya Ivanova Deneva Delyana Miteva Davcheva Anelia Veselinova Bivolarska Source Type: research
Copper (II) nanodots stabilized on Cassia fistula galactomannan: preparation and catalytic application towards fast solvent-free Biginelli reaction
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00441H, PaperBAL DEV SINGH, Jyoti Pandey, Huda Khanam, Bhoopendra Tiwari, Tazeen Azaz, Ayushi Mishra, Preeti Kanchan New Cu (II) nanodots have been developed by the use of biopolymeric polysaccharide galactomannan. The nanocatalyst Cu(II)NDs@CFG has been developed by one-step clean and sustainable reaction of Cassia fistula galactomannan... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 26, 2024 Category: Molecular Biology Authors: BAL DEV SINGH Source Type: research
Xanthene-Based Dyes for Photoacoustic Imaging and Their Use as Analyte-Responsive Probes
Chemistry. 2024 Apr 25:e202400598. doi: 10.1002/chem.202400598. Online ahead of print.ABSTRACTDeveloping imaging tools that can report on the presence of disease-relevant analytes in multicellular organisms can provide insight into fundamental disease mechanisms as well as provide diagnostic tools for the clinic. Photoacoustic imaging (PAI) is a light-in, sound-out imaging technique that allows for high resolution, deep-tissue imaging with applications in pre-clinical and point-of-care settings. The continued development of near-infrared (NIR) absorbing small-molecule dyes promises to improve the capabilities of this emerg...
Source: Chemistry - April 25, 2024 Category: Chemistry Authors: Frederik Br øndsted Cliff Stains Source Type: research
In-vitro and in silco analysis and antitumor studies of novel Cu(II) and V(V) complexes of N-p-Tolylbenzohydroxamic acid
Int J Biol Macromol. 2024 Apr 23:131768. doi: 10.1016/j.ijbiomac.2024.131768. Online ahead of print.ABSTRACTCopper(L2Cu) and vanadium(L2VOCl) complexes of N-p-tolylbenzohydroxamic acid (LH) ligand have been investigated for DNA binding efficacy by multiple analytical, spectral, and computational techniques. The results revealed that complexes as groove binders as evidenced by UV absorption. Fluorescence studies including displacement assay using classical intercalator ethidium bromide as fluorescent probe also confirmed as groove binders. The viscometric analysis too supports the inferences as strong groove binders for bot...
Source: International Journal of Biological Macromolecules - April 25, 2024 Category: Biochemistry Authors: M Tripathi Y Thakur R Syed A K Asatkar M S Al Qahtani D Das R Agrawal B Verma R Pande Source Type: research
Biocompatible arabinogalactan-chitosan scaffolds for photothermal pharmacology in wound healing and tissue regeneration
In this study, we report a biomacromolecule-based scaffold (ArCh) by uniquely combining arabinogalactan (Ar) and chitosan (Ch) using a Schiff-based reaction. Further, the optimized ArCh scaffolds were loaded with Glycyrrhizin (GA: anti-inflammatory molecule) conjugated NIR light-absorbing Copper sulfide (CuS) nanoparticles. The resultant GACuS ArCh scaffolds were characterized for different wound healing parameters in in-vitro and in-vivo models. Our results indicated that GACuS ArCh scaffolds showed excellent swelling, biodegradation, and biocompatibility in vitro. Further results obtained indicated that GACuS ArCh scaffo...
Source: International Journal of Biological Macromolecules - April 25, 2024 Category: Biochemistry Authors: Nidhi Poddar Donker Chonzom Santimoy Sen None Malsawmtluangi Nidhi Parihar Prathamesh Mahadev Patil Jagdish Balani U Suryanarayana Murty Deepak B Pemmaraju Source Type: research
Attuning doped ZnO-based composites for an effective light-driven mineralization of pharmaceuticals via PMS activation
In this study, we investigated the effect of doping ZnO nanoparticles with either copper, gallium or indium on the structure, morphology, photophysical properties and photocatalytic mineralization of pharmaceuticals. Their architecture was further improved through the fabrication of composites, pairing the best performing doped ZnO with either BaFe12O19 or nickel nanoparticles. Their suitability was tested on a complex 60-ppm multi-pollutant solution (tetracycline, levofloxacin and lansoprazole). The activation strategy combined photocatalysis with peroxymonosulfate (PMS) as an environmentally friendly source of highly oxi...
Source: Chemosphere - April 25, 2024 Category: Chemistry Authors: Roger Bujald ón Majdi Benamara Ramzi Dhahri Elvira G ómez Albert Serr à Source Type: research
Copper enhances aggregational toxicity of mutant huntingtin in a Drosophila model of Huntington's Disease
Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166928. doi: 10.1016/j.bbadis.2023.166928. Epub 2023 Oct 28.ABSTRACTHuntington's disease (HD) is a progressive neurodegenerative disorder with clinical presentations of moderate to severe cognitive, motor, and psychiatric disturbances. HD is caused by the trinucleotide repeat expansion of CAG of the huntingtin (HTT) gene. The mutant HTT protein containing pathological polyglutamine (polyQ) extension is prone to misfolding and aggregation in the brain. It has previously been observed that copper and iron concentrations are increased in the striata of post-mortem human HD ...
Source: Biochimica et Biophysica Acta - April 25, 2024 Category: Biochemistry Authors: Amanda G Lobato Natalie Ortiz-Vega Yi Zhu Deepa Neupane Katlyn K Meier R Grace Zhai Source Type: research
Water and Air Stable Copper(I) Complexes of Tetracationic Catenane Ligands for Oxidative C-C Cross-Coupling
Angew Chem Int Ed Engl. 2024 Apr 25:e202405971. doi: 10.1002/anie.202405971. Online ahead of print.ABSTRACTAqueous soluble and stable Cu(I) molecular catalysts featuring a catenane ligand composed of two dicationic, mutually repelling but mechanically interlocked macrocycles are reported. The ligand interlocking not only fine-tunes the coordination sphere and kinetically stabilizes the Cu(I) against air oxidation and disproportionation, but also buries the hydrophobic portions of the ligands and prevents their dissociation which are necessary for their good water solubility and a sustained activity. These catenane Cu(I) co...
Source: Angewandte Chemie - April 25, 2024 Category: Chemistry Authors: Man Pang Tang Lihui Zhu Yulin Deng Yixiang Shi Samuel Kin-Man Lai Xiaoyong Mo Xin-Yu Pang Chunyu Liu Wei Jiang Edmund Chun Ming Tse Ho Yu Au-Yeung Source Type: research
Copper enhances aggregational toxicity of mutant huntingtin in a Drosophila model of Huntington's Disease
Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166928. doi: 10.1016/j.bbadis.2023.166928. Epub 2023 Oct 28.ABSTRACTHuntington's disease (HD) is a progressive neurodegenerative disorder with clinical presentations of moderate to severe cognitive, motor, and psychiatric disturbances. HD is caused by the trinucleotide repeat expansion of CAG of the huntingtin (HTT) gene. The mutant HTT protein containing pathological polyglutamine (polyQ) extension is prone to misfolding and aggregation in the brain. It has previously been observed that copper and iron concentrations are increased in the striata of post-mortem human HD ...
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Amanda G Lobato Natalie Ortiz-Vega Yi Zhu Deepa Neupane Katlyn K Meier R Grace Zhai Source Type: research
Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review
J Cancer Res Clin Oncol. 2024 Apr 25;150(4):213. doi: 10.1007/s00432-024-05641-5.ABSTRACTCopper is a necessary micronutrient for maintaining the well-being of the human body. The biological activity of organic ligands, especially their anticancer activity, is often enhanced when they coordinate with copper(I) and (II) ions. Copper and its compounds are capable of inducing tumor cell death through various mechanisms of action, including activation of apoptosis signaling pathways by reactive oxygen species (ROS), inhibition of angiogenesis, induction of cuproptosis, and paraptosis. Some of the copper complexes are currently ...
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Sara Abdolmaleki Alireza Aliabadi Samad Khaksar Source Type: research
