Localized Sustained Release of Copper Enhances Antitumor Effects of Disulfiram in Head and Neck Cancer
Biomacromolecules. 2024 Apr 30. doi: 10.1021/acs.biomac.3c01420. Online ahead of print.ABSTRACTDrug repurposing uses approved drugs as candidate anticancer therapeutics, harnesses previous research and development efforts, and benefits from available clinically suitable formulations and evidence of patient tolerability. In this work, the drug used clinically to treat chronic alcoholism, disulfiram (DSF), was studied for its antitumor efficacy in a copper-dependent manner. The combination of DSF and copper could achieve a tumor cell growth inhibition effect comparable to those of 5-fluorouracil and taxol on head and neck ca...
Source: Biomacromolecules - April 30, 2024 Category: Biochemistry Authors: Juan Wang Boxuan Li Remy C Cooper Da Huang Hu Yang Source Type: research
Green synthesis of chitosan-encapsulated CuO nanocomposites for efficient degradation of cephalosporin antibiotics in contaminated water
Environ Sci Pollut Res Int. 2024 Apr 30. doi: 10.1007/s11356-024-33476-7. Online ahead of print.ABSTRACTThe synthesis and characterization of chitosan encapsulated copper oxide nanocomposites (CuNPs) using plant extracts for the photocatalytic degradation of second-generation antibiotics, cefixime and cefuroxime, were investigated. The study revealed that the presence of diverse chemical components in the plant extract significantly influenced the size of the CuNPs, with transmission electron microscopy (TEM) showing spherical shapes and sizes ranging from 11-35 nm. The encapsulation process was confirmed by an increase in...
Source: Environmental Science and Pollution Research International - April 30, 2024 Category: Environmental Health Authors: Nishat Bhatia Asha Kumari Ragini Raj Singh Gulshan Kumar Abhishek Kandwal Rahul Sharma Source Type: research
Deciphering Cuproptosis-related Signatures in Pediatric Allergic Asthma using Integrated scRNA-seq and Bulk RNA-seq Analysis
Conclusion This work provided a machine learning model containing five important variables, which may have good diagnostic efficiency for pediatric AA.PMID:38687912 | DOI:10.1080/02770903.2024.2349596 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Jingping Liu Yujia Sun Chunxin Tian Dong Qin Lanying Gao Source Type: research
Graphene Growth by Chemical Vapour Deposition on Cross-Rolled Surface Textured Nickel-Copper Foils
CrystEngComm, 2024, Accepted Manuscript DOI: 10.1039/D4CE00090K, PaperPalash Chandra Maity, Narasimha Vinod Pulagara, Mamleshwar Kumar, K.N. Chaithanya Kumar, Taraknath Das, K.S. Suresh, Indranil Lahiri The current work correlates the microstructure of multi-step cross-rolled (MSCR) and annealed polycrystalline nickel/copper (Ni/Cu) alloy with the graphene synthesis by using chemical vapor deposition (CVD). Due to the effects... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - April 29, 2024 Category: Chemistry Authors: Palash Chandra Maity Source Type: research
Relationship Between Dietary Intakes and Elevated Diastolic Blood Pressure Among Children: A Cross-Sectional Study Using Wearable Devices
CONCLUSION: This study indicates that dietary intakes of high saturated fat, copper, and vitamin B12, but not parental blood pressure statuses, determine high diastolic blood pressure among children regardless of daily sodium intake. Early dietary consumption behavioral adaptation should be considered to prevent further hypertension in adulthood.PMID:38682517 | DOI:10.3233/SHTI240024 (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 29, 2024 Category: Information Technology Authors: Kukiat Tudpor Panthicha Chinnakhot Montira Boonsorn Wiriyaporn Lomthaisong Worrameth Kareechum Charnyuth Sriphuwong Le Ke Nghiep Niruwan Turnbull Source Type: research
Solution processed metal chalcogenide semiconductors for inorganic thin film photovoltaics
Chem Commun (Camb). 2024 Apr 29. doi: 10.1039/d4cc01057d. Online ahead of print.ABSTRACTThin film photovoltaics are a key part of both current and future solar energy technologies and have been heavily reliant on metal chalcogenide semiconductors as the absorber layer. Developing solution processing methods to deposit metal chalcogenide semiconductors offers the promise of low-cost and high-throughput fabrication of thin film photovoltaics. In this review article we lay out the key chemistry and engineering that has propelled research on solution processing of metal chalcogenide semiconductors, focusing on Cu(In,Ga)(S,Se)2...
Source: Chemical Communications - April 29, 2024 Category: Chemistry Authors: Jonathan W Turnley Rakesh Agrawal Source Type: research
Assessment of Protective Effects of DTPA, NAC, and Taurine on Possible Cytotoxicity Induced by Individual and Combined Zinc Oxide and Copper Oxide Nanoparticles in SH-SY5Y Cells
Biol Trace Elem Res. 2024 Apr 29. doi: 10.1007/s12011-024-04161-0. Online ahead of print.ABSTRACTThe present study investigated the cytotoxic effects of ZnO, CuO, and mixed combinations of them on SH-SY5Y cells. For this purpose, the cells were exposed to various concentrations of these NPs alone for 24-96 h and as a mixture for 24 h. Variations in cell viability were noted. MTT results showed that ZnO and/or CuO NPs decreased cell survival by about 59% at 200 (ZnO, at 24 h) and 800 µg/ml (ZnO and/or CuO, at 72 and 96 h). When the NR assay was used, slight decreases were noted with ZnO NPs at 72 and 96 h. With CuO NPs alo...
Source: Biological Trace Element Research - April 29, 2024 Category: Biology Authors: Duygu Pasl ı Aylin G ürbay Source Type: research
Binding and Stabilization of a Semiquinone Radical by an artificial Metalloenzyme containing a Binuclear copper (II) cofactor
Chembiochem. 2024 Apr 29:e202400139. doi: 10.1002/cbic.202400139. Online ahead of print.ABSTRACTA binuclear Cu(II) cofactor was covalently bound to a lauric acid anchor. The resulting conjugate was characterized then combined with beta-lactoglobulin (βLG) to generate a new biohybrid following the so-called "Trojan horse" strategy. This biohybrid was examined for its effectiveness in the oxidation of a catechol derivative to the corresponding quinone. The resulting biohybrid did not exhibit the sought after catecholase activity, likely due to its ability to bind and stabilize the semiquinone radical intermediate DTB-SQ. Th...
Source: Chembiochem - April 29, 2024 Category: Biochemistry Authors: R émy Gay Yannick Masson Wadih Ghattas Guillermo A Oliveira Udry Christian Herrero Agathe Urvoas Jean-Pierre Mahy R émy Ricoux Source Type: research
Sulfide-Induced Dimerization Versus Demetallation of Tricopper(I) Clusters Protected by Tris-Thiolato Metalloligands
Chem Asian J. 2024 Apr 28:e202400266. doi: 10.1002/asia.202400266. Online ahead of print.ABSTRACTHere, we report the reactivity of copper(I) clusters toward sulfide ions; these sulfide copper(I) clusters have attracted much attention due to their relevance to biologically active centers and their fascinating structural and photophysical properties. Treatment of the CuI3RhIII2 pentanuclear complex, [Cu3{Rh(aet)3}2]3+ (aet = 2-aminoethanethiolate), in which a {CuI3}3+ cluster moiety is bound by two fac-[Rh(aet)3] metalloligands, with NaSH in water produced the CuI6RhIII4 decanuclear complex, [Cu6S{Rh(aet)3}4]4+, accompanied ...
Source: Chemistry, an Asian Journal - April 29, 2024 Category: Chemistry Authors: Zi Lang Goo Nobuto Yoshinari Yuhei Yasukawa Katsue Minami Takumi Konno Source Type: research
Polyoxomolybdate-Based Metal-Organic Framework-Derived Cu-Embedded Molybdenum Dioxide Hybrid Nanoparticles as Highly Efficient Electrocatalysts for Al-S Batteries
ChemSusChem. 2024 Apr 29:e202400424. doi: 10.1002/cssc.202400424. Online ahead of print.ABSTRACTHigh-performance rechargeable aluminum-sulfur batteries (RASB) have great potential for various applications owing to their high theoretical capacity, abundant sulfur resources, and good safety. Nevertheless, the practical application of RASB still faces several challenges, including the polysulfide shuttle phenomenon and low sulfur utilization efficiency. Here, we first developed a synergistic copper heterogeneous metal oxide MoO2 derived from polymolybdate-based metal-organic framework as an efficient catalyst for mitigating p...
Source: ChemSusChem - April 29, 2024 Category: Chemistry Authors: Qiuping Zhou Xinyuan Jiang Xuecheng Zhang Dawei Wang Guang Yang He Zhou Yuchao Wu Fang Guo Ming Chen Guowang Diao Lubin Ni Source Type: research
Metal Cross-Linked Supramolecular Gel Noodles: Structural Insights and Antibacterial Assessment
Biomacromolecules. 2024 Apr 29. doi: 10.1021/acs.biomac.4c00300. Online ahead of print.ABSTRACTAchieving precise control over gelator alignment and morphology is crucial for crafting tailored materials and supramolecular structures with distinct properties. We successfully aligned the self-assembled micelles formed by a functionalized dipeptide 2NapFF into long 1-D "gel noodles" by cross-linking with divalent metal chlorides. We identify the most effective cross-linker for alignment, enhancing mechanical stability, and imparting functional properties. Our study shows that Group 2 metal ions are particularly suited for crea...
Source: Biomacromolecules - April 29, 2024 Category: Biochemistry Authors: Dipankar Ghosh Sophie M Coulter Garry Laverty Chris Holland James J Doutch Massimo Vassalli Dave J Adams Source Type: research
Synthesis, Characterization and Evaluation of the Antimicrobial and Herbicidal Activities of Some Transition Metal Ions Complexes with the Tranexamic Acid
Chem Biodivers. 2024 Apr 29:e202301970. doi: 10.1002/cbdv.202301970. Online ahead of print.ABSTRACTNew tranexamic acid (TXA) complexes of ferric(III), cobalt(II), nickel(II), copper(II) and zirconium(IV) were synthesized and characterized by elemental analysis (CHN), conductimetric (Λ), magnetic susceptibility investigations (μeff), Fourier transform infrared (FT-IR), proton nuclear magnetic resonance (1H NMR), ultraviolet visible (UV-vis.), optical band gap energy (Eg) and thermal studies (TG/DTG and DTA). TXA complexes were established in 1:2 (metal: ligand) stoichiometric ratio according to CHN data. Based on FT-IR an...
Source: Chemistry and Biodiversity - April 29, 2024 Category: Biochemistry Authors: Amira Mohamed Sadeek A Sadeek Nihad Rashid Hazem Elshafie Ippolito Camele Source Type: research
Relationship Between Dietary Intakes and Elevated Diastolic Blood Pressure Among Children: A Cross-Sectional Study Using Wearable Devices
CONCLUSION: This study indicates that dietary intakes of high saturated fat, copper, and vitamin B12, but not parental blood pressure statuses, determine high diastolic blood pressure among children regardless of daily sodium intake. Early dietary consumption behavioral adaptation should be considered to prevent further hypertension in adulthood.PMID:38682517 | DOI:10.3233/SHTI240024 (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 29, 2024 Category: Information Technology Authors: Kukiat Tudpor Panthicha Chinnakhot Montira Boonsorn Wiriyaporn Lomthaisong Worrameth Kareechum Charnyuth Sriphuwong Le Ke Nghiep Niruwan Turnbull Source Type: research
Polyoxomolybdate-Based Metal-Organic Framework-Derived Cu-Embedded Molybdenum Dioxide Hybrid Nanoparticles as Highly Efficient Electrocatalysts for Al-S Batteries
ChemSusChem. 2024 Apr 29:e202400424. doi: 10.1002/cssc.202400424. Online ahead of print.ABSTRACTHigh-performance rechargeable aluminum-sulfur batteries (RASB) have great potential for various applications owing to their high theoretical capacity, abundant sulfur resources, and good safety. Nevertheless, the practical application of RASB still faces several challenges, including the polysulfide shuttle phenomenon and low sulfur utilization efficiency. Here, we first developed a synergistic copper heterogeneous metal oxide MoO2 derived from polymolybdate-based metal-organic framework as an efficient catalyst for mitigating p...
Source: ChemSusChem - April 29, 2024 Category: Chemistry Authors: Qiuping Zhou Xinyuan Jiang Xuecheng Zhang Dawei Wang Guang Yang He Zhou Yuchao Wu Fang Guo Ming Chen Guowang Diao Lubin Ni Source Type: research
Sulfide-Induced Dimerization Versus Demetallation of Tricopper(I) Clusters Protected by Tris-Thiolato Metalloligands
Chem Asian J. 2024 Apr 28:e202400266. doi: 10.1002/asia.202400266. Online ahead of print.ABSTRACTHere, we report the reactivity of copper(I) clusters toward sulfide ions; these sulfide copper(I) clusters have attracted much attention due to their relevance to biologically active centers and their fascinating structural and photophysical properties. Treatment of the CuI3RhIII2 pentanuclear complex, [Cu3{Rh(aet)3}2]3+ (aet = 2-aminoethanethiolate), in which a {CuI3}3+ cluster moiety is bound by two fac-[Rh(aet)3] metalloligands, with NaSH in water produced the CuI6RhIII4 decanuclear complex, [Cu6S{Rh(aet)3}4]4+, accompanied ...
Source: Chemistry, an Asian Journal - April 29, 2024 Category: Chemistry Authors: Zi Lang Goo Nobuto Yoshinari Yuhei Yasukawa Katsue Minami Takumi Konno Source Type: research
