Current knowledge of ferroptosis in the pathogenesis and prognosis of oral squamous cell carcinoma
In this study, we performed a first attempt to collect the current evidence on the proposed roles of ferroptosis in OSCC through a comprehensive review. Based on clinical data from the relevant studies within this topic, we found that ferroptosis-associated tumor microenvironment, ferroptosis-related genes (FRGs), and ferroptosis-related lncRNAs exhibited a potent prognostic value for OSCC patients. Mechanistically, experimental data revealed that the proliferation and tumorigenesis of OSCC might be associated with the inhibition of cellular ferroptosis through the activation of glutathione peroxidase 4 (GPX4) and adipocyt...
Source: Cellular Signalling - April 18, 2024 Category: Cytology Authors: Liyuan Zhou Youjun Wu Yukang Ying Yan Ding Source Type: research
Ortho-ester-substituted diaryliodonium salts enabled regioselective arylocyclization of naphthols toward 3,4-benzocoumarins
Abstract
Cyclic annulation involving diaryliodonium salts is an efficient tool for the construction of two or more chemical bonds in a one-pot process. Ortho-functionalized diaryliodonium salts have showcased distinct reactivity in the exploration of benzocyclization or arylocyclization. With this strategy of ortho-ester-substituted diaryliodonium salts, herein, we utilized a copper catalyst to activate the C–I bond of diaryliodonium salts in the generation of aryl radicals, thus resulting in an annulation reaction with naphthols and substituted phenols. This approach yielded a diverse array of 3,4-benzocoumarin deri...
Source: Beilstein Journal of Organic Chemistry - April 18, 2024 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: annulation arylocyclization 3,4-benzocoumarin diaryliodonium salts naphthol Letter Source Type: research
Molecules, Vol. 29, Pages 1850: Effect of Particle Heterogeneity in Catalytic Copper-Containing Single-Chain Polymeric Nanoparticles Revealed by Single-Particle Kinetics
In this study, we introduce the use of single-molecule fluorescence microscopy to study the kinetics of Cu(I)-containing SCPNs towards depropargylation reactions. We developed Cu(I)-containing SCPNs that exhibit fast kinetics towards depropargylation and Cu-catalyzed azide-alkyne click reactions, making them suitable for single-particle kinetic studies. SCPNs were then immobilized on the surface of glass coverslips and the catalytic reactions were monitored at a single-particle level using total internal reflection fluorescence (TIRF) microscopy. Our studies revealed the interparticle turnover dispersity for Cu(I)-catalyze...
Source: Molecules - April 18, 2024 Category: Chemistry Authors: Sathyan Archontakis Spiering Albertazzi Palmans Tags: Article Source Type: research
X-ray absorption and emission spectroscopy of N2S2 Cu(II)/(III) complexes
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Blaise L. Geoghegan, Jessica K. Bilyj, Paul V. Bernhardt, Serena DeBeer, George E. Cutsail The competing influences of both oxidation state and ligand protonation state in Cu(II) and Cu(III) Schiff base complexes are explored through copper K-edge X-ray absorption and valence-to-core emission spectroscopies along with DFT calculations. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - April 17, 2024 Category: Chemistry Authors: Blaise L. Geoghegan Source Type: research
Modelling on a Biomimetic [Cu-O-Cu]2+-mediated Methane-to-Methanol Conversion Unveils the Site for Methane Activation
Chem Asian J. 2024 Apr 16:e202400282. doi: 10.1002/asia.202400282. Online ahead of print.ABSTRACTThe Cu-O-Cu core exhibits methane-to-methanol conversion, mirroring the reactivity of the copper-containing enzyme pMMO. Herein, we computationally examined the reactivity of a biomimetic Cu-O-Cu core towards methane-to-methanol conversion. The oxygen atom of the Cu-O-Cu core abstracts hydrogen present in the C-H bond of methane. The spin density at the bridging oxygen helps to abstract hydrogen from the C-H bond. We modulated the spin density of the bridging oxygen by substituting only a single copper atom of the Cu-O-Cu core ...
Source: Chemistry, an Asian Journal - April 17, 2024 Category: Chemistry Authors: Sumangla Arora Puneet Gupta Source Type: research
A Dicopper(II)-Based Carbonic Anhydrase Model - Quantum-Chemical Evaluation of the Mechanistic Pathway
Angew Chem Int Ed Engl. 2024 Apr 17:e202319530. doi: 10.1002/anie.202319530. Online ahead of print.ABSTRACTThe cyanobacterium Prochloron didemni, an obligate symbiont of different species of colonial ascidians, occurring in the Pacific and Indian Oceans, produces a variety of cyclic peptides. These patellamide-type macrocycles lead to relatively stable dicopper(II) complexes that are extremely efficient carbonic anhydrase mimics, the most active model systems known so far. Importantly, it recently was shown that copper(II) is coordinated to patellamide derivatives in Prochloron cells. An interesting question therefore is, ...
Source: Angewandte Chemie - April 17, 2024 Category: Chemistry Authors: Peter Comba Gunasekaran Velmurugan Philipp Baur Source Type: research
Comparison of trace elements in peripheral blood and bone marrow of newly diagnosed multiple myeloma patients
In this study, we aimed to evaluate alterations in trace elements in the blood and bone marrow serum of patients with newly diagnosed multiple myeloma (NMM). The levels of zinc (Zn), copper (Cu), iron (Fe), manganese (Mn), magnesium (Mg), selenium (Se), arsenic (As), boron (B), nickel (Ni), silicon (Si) and chromium (Cr) were analyzed in the venous blood samples of the patient group comprising 70 patients with NMM (41 males and 29 females) and compared to those in the control group comprising 30 individuals (18 males and 12 females). In addition, trace element levels were analyzed in bone marrow samples from the patient gr...
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Ayse Nilgun Kul Bahar Ozturk Kurt Source Type: research
High-energy X-ray diffraction experiment employing a compact synchrotron X-ray source based on inverse Compton scattering
This study demonstrates high-energy XRD at an ICS with strongly absorbing mineralogical samples embedded in soft tissue. A quantitative comparison of the measured XRD patterns with calculations of their expected shapes validates the performance of ICSs for XRD. This analysis was performed for two types of kidney stones of different materials. Since these stones are not isolated in a human body, the influence of the surrounding soft tissue on the XRD pattern is investigated and a correction for this soft tissue contribution is introduced.PMID:38631968 | DOI:10.1016/j.zemedi.2024.03.003 (Source: Zeitschrift fur Medizinische Physik)
Source: Zeitschrift fur Medizinische Physik - April 17, 2024 Category: Radiology Authors: Johannes Melcher Martin Dierolf Benedikt G ünther Klaus Achterhold Daniela Pfeiffer Franz Pfeiffer Source Type: research
A Dicopper(II)-Based Carbonic Anhydrase Model - Quantum-Chemical Evaluation of the Mechanistic Pathway
Angew Chem Int Ed Engl. 2024 Apr 17:e202319530. doi: 10.1002/anie.202319530. Online ahead of print.ABSTRACTThe cyanobacterium Prochloron didemni, an obligate symbiont of different species of colonial ascidians, occurring in the Pacific and Indian Oceans, produces a variety of cyclic peptides. These patellamide-type macrocycles lead to relatively stable dicopper(II) complexes that are extremely efficient carbonic anhydrase mimics, the most active model systems known so far. Importantly, it recently was shown that copper(II) is coordinated to patellamide derivatives in Prochloron cells. An interesting question therefore is, ...
Source: Angewandte Chemie - April 17, 2024 Category: Chemistry Authors: Peter Comba Gunasekaran Velmurugan Philipp Baur Source Type: research
Blue Long Afterglow and Ultra Broadband Vis-NIR Emission from All-Inorganic Copper-Doped Silver Halide Single Crystals
Angew Chem Int Ed Engl. 2024 Apr 17:e202403927. doi: 10.1002/anie.202403927. Online ahead of print.ABSTRACTAll-inorganic metal halides with afterglow emission have attracted increasing attention due to their significantly longer afterglow duration and higher stability compared to their organic-inorganic hybrid counterparts. However, their afterglow colors have not yet reached the blue spectral region. Here, we report all-inorganic copper-doped Rb2AgBr3 single crystals with ultralong blue afterglow (>300 s) by modulating defect states through doping engineering. The introduction of copper(I) ions into Rb2AgBr3 facilitate...
Source: Angewandte Chemie - April 17, 2024 Category: Chemistry Authors: Sijia Wang Runze Liu Juntao Li Caixia Meng Jianyong Liu Junsheng Chen Pengfei Cheng Kaifeng Wu Source Type: research
Tragacanth gum-based copper oxide nanoparticles: Comprehensive characterization, antibiofilm, antimicrobial and photocatalytic potentials
In conclusion, the findings underline the promising multifunctional properties of TG-based CuO NPs for different practical applications.PMID:38631575 | DOI:10.1016/j.ijbiomac.2024.131600 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 17, 2024 Category: Biochemistry Authors: Sumayyah Ihsan Hira Munir Zihui Meng Muhammad Tayyab Nadia Zeeshan Ajwa Rehman Sawaira Nadeem Muhammad Irfan Source Type: research
Modelling on a Biomimetic [Cu-O-Cu]2+-mediated Methane-to-Methanol Conversion Unveils the Site for Methane Activation
Chem Asian J. 2024 Apr 16:e202400282. doi: 10.1002/asia.202400282. Online ahead of print.ABSTRACTThe Cu-O-Cu core exhibits methane-to-methanol conversion, mirroring the reactivity of the copper-containing enzyme pMMO. Herein, we computationally examined the reactivity of a biomimetic Cu-O-Cu core towards methane-to-methanol conversion. The oxygen atom of the Cu-O-Cu core abstracts hydrogen present in the C-H bond of methane. The spin density at the bridging oxygen helps to abstract hydrogen from the C-H bond. We modulated the spin density of the bridging oxygen by substituting only a single copper atom of the Cu-O-Cu core ...
Source: Chemistry, an Asian Journal - April 17, 2024 Category: Chemistry Authors: Sumangla Arora Puneet Gupta Source Type: research
Understanding the Remarkable Stability of Well-defined Dinuclear Copper(I) Carbene Complexes
Chemistry. 2024 Apr 17:e202400283. doi: 10.1002/chem.202400283. Online ahead of print.ABSTRACTThe synthesis of a well-defined dicopper carbene complex supported by the PNNP (2,7-bis(di-tert-butylphosphaneyl)methyl-1,8-naphthyridine) expanded pincer ligand is reported. This carbene complex is remarkably stable, even in the presence of air and water. The reactivity of this complex was explored towards typical carbene transfer substrates and its electronic structure was investigated. Using a combination of experiments and DFT calculations, the principles that underly the stability of dinuclear carbene complexes are probed.PMI...
Source: Chemistry - April 17, 2024 Category: Chemistry Authors: Roel Bienenmann Marianne de Vries Martin Lutz Daniel Broere Source Type: research
A Triply Linked Copper(III) Dicarbacorrole Dimer
Chemistry. 2024 Apr 17:e202401240. doi: 10.1002/chem.202401240. Online ahead of print.ABSTRACTA triply linked dicarbacorrole dimer (7) was synthesized from a new meso-meso singly linked dicarbacorrole dimer precursor (6) via an oxidative fusion reaction by 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) in the presence of trifluoromethanesulfonic acid (TfOH). Single crystal X-ray structure of 7 adopts a flat conformation with a length as ca. 15.946 Å and a width as 6.903 Å, which can be regarded as a short carbaporphyrinoid tape. Two coordinated Cu ions keeps the +3 oxidation state in 7, as confirmed by NMR spectroscopy, s...
Source: Chemistry - April 17, 2024 Category: Chemistry Authors: Ruijuan Jiao Ningchao Liu Zhaohui Zong Xian-Sheng Ke Source Type: research
Influence of the use of remediated soil and agricultural drainage water on the safety of tomato fruits
In conclusion, the employed bioremediation techniques successfully reduced the PTE content and microbial load in both soil and drainage water ecosystems and in harvested tomato fruits. Henceforth, no health risks are expected from the consumption of this product.PMID:38632200 | DOI:10.1007/s11356-024-33187-z (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - April 17, 2024 Category: Environmental Health Authors: Salah H Salem Mohamed Saber Samir Gadow Hoda Kabary Alaa Zaghloul Source Type: research
