Visible-light-driven photocatalytic degradation of ibuprofen by Cu-doped tubular C < sub > 3 < /sub > N < sub > 4 < /sub > : Mechanisms, Degradation pathway and DFT calculation
This study will lay an important scientific foundation and a possible new approach for the treatment of emerging aromatic organic pollutants in visible-light-driven heterogeneous catalytic oxidation environment.PMID:38670512 | DOI:10.1016/j.chemosphere.2024.142106 (Source: Chemosphere)
Source: Chemosphere - April 26, 2024 Category: Chemistry Authors: Zhi-Bang Lv Jiao Feng Ru-Jin Zhao Jun-Jian Shen Wen-Wen Yang Source Type: research
1,2,3-Triazole-totarol conjugates as potent PIP5K1 α lipid kinase inhibitors
Bioorg Med Chem. 2024 Apr 23;105:117727. doi: 10.1016/j.bmc.2024.117727. Online ahead of print.ABSTRACTThe human phosphatidylinositol 4-phosphate 5-kinase type I α (hPIP5K1α) plays a key role in the development of prostate cancer. In this work, seventeen derivatives of the natural diterpene totarol were prepared by copper(I)-catalysed Huisgen 1,3-dipolar cycloaddition reaction of the correspondingO-propargylated totarol with aryl or alkyl azides and screened for their inhibitory activities toward hPIP5K1α. Five compounds, 3a, 3e, 3f, 3i, and 3r, strongly inhibited the enzyme activity with IC50 values of 1.44, 0.46, 1.02...
Source: Bioorganic and Medicinal Chemistry - April 26, 2024 Category: Chemistry Authors: Samer Haidar Ángel Amesty Sandra Oramas-Royo Claudia G ötz Ehab El-Awaad Jana Kaiser Sarah B ödecker Amelie Arnold Dagmar Aichele Juan M Amaro-Luis Ana Est évez-Braun Joachim Jose Source Type: research
Visible-light-driven photocatalytic degradation of ibuprofen by Cu-doped tubular C < sub > 3 < /sub > N < sub > 4 < /sub > : Mechanisms, Degradation pathway and DFT calculation
This study will lay an important scientific foundation and a possible new approach for the treatment of emerging aromatic organic pollutants in visible-light-driven heterogeneous catalytic oxidation environment.PMID:38670512 | DOI:10.1016/j.chemosphere.2024.142106 (Source: Chemosphere)
Source: Chemosphere - April 26, 2024 Category: Chemistry Authors: Zhi-Bang Lv Jiao Feng Ru-Jin Zhao Jun-Jian Shen Wen-Wen Yang Source Type: research
Peptide-Based electrochemical potential Scanning: A novel approach for disulfide manipulation in pediatric Respiratory syncytial virus detection
This study introduces an innovative approach using peptides and electrochemical potential scanning for RSV detection. By replacing enzymatic catalysis with electrochemical scanning, the method simplifies the process and reduces costs. Unbound peptides undergo potential-induced disulfide bridge opening, while target-bound peptides remain protected. After removing the target protein, copper ions and a reduced short peptide promote disulfide bridge formation, leading to crosslinking and passivation of the electrode surface. The degree of polymerization and passivation correlates with the target protein levels, generating a si...
Source: Bioelectrochemistry - April 26, 2024 Category: Biochemistry Authors: Jin Yu Yan Li Hui Zou Wenmin Hou Xia Li Lei Zhou Source Type: research
Ultra-sensitive electrochemical detection of levofloxacin using a binder-free copper and graphene composite
Talanta. 2024 Apr 25;275:126132. doi: 10.1016/j.talanta.2024.126132. Online ahead of print.ABSTRACTGiven the levels of pollution in the aquatic environment and the development of antimicrobial resistance, it is essential to develop sensors, with sensitivity, selectivity, stability, and cost-effectiveness, for the determination of antibiotics. The present article highlights the fabrication of an ultra-sensitive graphene and copper sensor, Gr/Cu, supported on glassy carbon (GCE/Gr/Cu) for the electroanalysis of levofloxacin through a cost-effective electrodeposition method. The sequential electrodeposition of graphene and Cu...
Source: Talanta - April 26, 2024 Category: Chemistry Authors: Tian Yu Palanisamy Rupa Kasturi Carmel B Breslin Source Type: research
Contribution of technological aids to the extraction of orbital foreign bodies
CONCLUSION: Vegetal orbital foreign bodies must be systematically removed. Removal of non-vegetal orbital foreign bodies should be considered on a case-by-case basis based on their size, best assessed using a "low artifact" scanner, their location, and their intrinsic ferromagnetism. Intraoperative navigation does not appear useful, while intraoperative scope imaging does. A dedicated orbital magnet might be helpful in removing ferromagnetic orbital foreign bodies. However, an orbital magnet may be ineffective in removing intraorbital bullets, since they are made primarily of an alloy of copper and lead.PMID:38669863 | DOI...
Source: Journal Francais d Ophtalmologie - April 26, 2024 Category: Opthalmology Authors: G Bula S Baillif P Labalette P Martel M De Massary C Ghetemme L Mondot A Martel Source Type: research
Neurological Deterioration in Wilson's Disease-Types, Etiology, Course, and Management
Discov Med. 2024 Apr;36(183):646-654. doi: 10.24976/Discov.Med.202436183.61.ABSTRACTWilson's disease (WD) is an inherited disorder of copper metabolism in which pathological copper accumulation, mainly in the liver and the brain, leads to hepatic and/or neuropsychiatric signs and symptoms. Chelators and zinc salts can successfully induce negative copper balance in many patients; however, neurological deterioration may still be observed. This phenomenon can be divided into: (1) early 'paradoxical' neurological deterioration, which usually develops in the first 6 months of anti-copper treatment and may be commonly related to...
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Tomasz Litwin Agnieszka Antos Jan Bembenek Anna Cz Onkowska Source Type: research
Prevalence of high-risk HPV and cervical dysplasia in IUD users and controls: a cross sectional study
CONCLUSIONS: Reported use of levonorgestrel intrauterine system and hormonal contraception, but not use of copper IUD, was associated with a higher prevalence of HPV infections and histological HSIL + compared to no reported use of contraception.PMID:38666336 | DOI:10.1080/13625187.2024.2340521 (Source: The European Journal of Contraception and Reproductive Health Care)
Source: The European Journal of Contraception and Reproductive Health Care - April 26, 2024 Category: Reproduction Medicine Authors: Lina Jans Jan Brynhildsen Evin Cherif Linnea Tenerz Lovisa Bergengren Source Type: research
Are the elements zinc, copper, magnesium, and rubidium related to nutrition and iodine deficiency in pregnant Bulgarian women from iodine deficient region?
CONCLUSION: The high Cu levels were associated with subclinical hypothyroidism (SCH) and less pulse consumption during pregnancy in an iodine deficiency endemic area. SCH was found in 24% of the pregnant women in such an area while in 13% of them SCH had progressed to overt hypothyroidism.PMID:38669155 | DOI:10.21101/cejph.a7796 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Mariana Georgieva Bacelova Penka Dimitrova Gatseva Tanya Ivanova Deneva Delyana Miteva Davcheva Anelia Veselinova Bivolarska Source Type: research
Peptide-Based electrochemical potential Scanning: A novel approach for disulfide manipulation in pediatric Respiratory syncytial virus detection
This study introduces an innovative approach using peptides and electrochemical potential scanning for RSV detection. By replacing enzymatic catalysis with electrochemical scanning, the method simplifies the process and reduces costs. Unbound peptides undergo potential-induced disulfide bridge opening, while target-bound peptides remain protected. After removing the target protein, copper ions and a reduced short peptide promote disulfide bridge formation, leading to crosslinking and passivation of the electrode surface. The degree of polymerization and passivation correlates with the target protein levels, generating a si...
Source: Bioelectrochemistry - April 26, 2024 Category: Biochemistry Authors: Jin Yu Yan Li Hui Zou Wenmin Hou Xia Li Lei Zhou Source Type: research
Neurological Deterioration in Wilson's Disease-Types, Etiology, Course, and Management
Discov Med. 2024 Apr;36(183):646-654. doi: 10.24976/Discov.Med.202436183.61.ABSTRACTWilson's disease (WD) is an inherited disorder of copper metabolism in which pathological copper accumulation, mainly in the liver and the brain, leads to hepatic and/or neuropsychiatric signs and symptoms. Chelators and zinc salts can successfully induce negative copper balance in many patients; however, neurological deterioration may still be observed. This phenomenon can be divided into: (1) early 'paradoxical' neurological deterioration, which usually develops in the first 6 months of anti-copper treatment and may be commonly related to...
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Tomasz Litwin Agnieszka Antos Jan Bembenek Anna Cz Onkowska Source Type: research
Contribution of technological aids to the extraction of orbital foreign bodies
CONCLUSION: Vegetal orbital foreign bodies must be systematically removed. Removal of non-vegetal orbital foreign bodies should be considered on a case-by-case basis based on their size, best assessed using a "low artifact" scanner, their location, and their intrinsic ferromagnetism. Intraoperative navigation does not appear useful, while intraoperative scope imaging does. A dedicated orbital magnet might be helpful in removing ferromagnetic orbital foreign bodies. However, an orbital magnet may be ineffective in removing intraorbital bullets, since they are made primarily of an alloy of copper and lead.PMID:38669863 | DOI...
Source: Journal Francais d Ophtalmologie - April 26, 2024 Category: Opthalmology Authors: G Bula S Baillif P Labalette P Martel M De Massary C Ghetemme L Mondot A Martel Source Type: research
Are the elements zinc, copper, magnesium, and rubidium related to nutrition and iodine deficiency in pregnant Bulgarian women from iodine deficient region?
CONCLUSION: The high Cu levels were associated with subclinical hypothyroidism (SCH) and less pulse consumption during pregnancy in an iodine deficiency endemic area. SCH was found in 24% of the pregnant women in such an area while in 13% of them SCH had progressed to overt hypothyroidism.PMID:38669155 | DOI:10.21101/cejph.a7796 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Mariana Georgieva Bacelova Penka Dimitrova Gatseva Tanya Ivanova Deneva Delyana Miteva Davcheva Anelia Veselinova Bivolarska Source Type: research
Prevalence of high-risk HPV and cervical dysplasia in IUD users and controls: a cross sectional study
CONCLUSIONS: Reported use of levonorgestrel intrauterine system and hormonal contraception, but not use of copper IUD, was associated with a higher prevalence of HPV infections and histological HSIL + compared to no reported use of contraception.PMID:38666336 | DOI:10.1080/13625187.2024.2340521 (Source: The European Journal of Contraception and Reproductive Health Care)
Source: The European Journal of Contraception and Reproductive Health Care - April 26, 2024 Category: Reproduction Medicine Authors: Lina Jans Jan Brynhildsen Evin Cherif Linnea Tenerz Lovisa Bergengren Source Type: research
Peptide-Based electrochemical potential Scanning: A novel approach for disulfide manipulation in pediatric Respiratory syncytial virus detection
This study introduces an innovative approach using peptides and electrochemical potential scanning for RSV detection. By replacing enzymatic catalysis with electrochemical scanning, the method simplifies the process and reduces costs. Unbound peptides undergo potential-induced disulfide bridge opening, while target-bound peptides remain protected. After removing the target protein, copper ions and a reduced short peptide promote disulfide bridge formation, leading to crosslinking and passivation of the electrode surface. The degree of polymerization and passivation correlates with the target protein levels, generating a si...
Source: Bioelectrochemistry - April 26, 2024 Category: Biochemistry Authors: Jin Yu Yan Li Hui Zou Wenmin Hou Xia Li Lei Zhou Source Type: research
