Immigrant Mothers' Perspectives on Pediatric Primary Care: Challenges and Solutions to Improve Medical Home Use
J Health Care Poor Underserved. 2024;35(1):299-315.ABSTRACTChildren in immigrant families (CIF) constitute 25% of all children in the United States. Known barriers to accessing and navigating the health care system for immigrants (i.e., poverty, fear, limited English proficiency, lack of insurance) lead to decreased medical home establishment among CIF, although the ways in which these obstacles affect medical home access are less studied. With a focus on Congolese, Afghan, Syrian/Iraqi, and Central American immigrants, key informant interviews and focus groups were conducted to identify mothers' perceptions of and experie...
Source: Journal of Health Care for the Poor and Underserved - April 25, 2024 Category: International Medicine & Public Health Authors: Tricia Francisco Wagner Allison Olmsted Kimberly Kay Lopez Karla Fredricks Source Type: research
Immigrant Mothers' Perspectives on Pediatric Primary Care: Challenges and Solutions to Improve Medical Home Use
J Health Care Poor Underserved. 2024;35(1):299-315.ABSTRACTChildren in immigrant families (CIF) constitute 25% of all children in the United States. Known barriers to accessing and navigating the health care system for immigrants (i.e., poverty, fear, limited English proficiency, lack of insurance) lead to decreased medical home establishment among CIF, although the ways in which these obstacles affect medical home access are less studied. With a focus on Congolese, Afghan, Syrian/Iraqi, and Central American immigrants, key informant interviews and focus groups were conducted to identify mothers' perceptions of and experie...
Source: Journal of Health Care for the Poor and Underserved - April 25, 2024 Category: International Medicine & Public Health Authors: Tricia Francisco Wagner Allison Olmsted Kimberly Kay Lopez Karla Fredricks Source Type: research
Men ’s education and intimate partner violence—Beyond the victim-oriented perspective: Evidence from demographic and health surveys in Central Africa
ConclusionThese findings have policy and programmatic implications because they might impede progress towards SDG goals on the elimination of all forms of violence against girls and women in Central Africa, which recorded the worst development indicators in sub-Saharan Africa. On a methodological note, studies are increasingly using pooled data to increase statistical power. Those studies can be very limited to devise effective IPV —interventions since they mask geographical variations within and across countries. More effective IPV—interventions should be culturally rooted and accounting for geographical variations be...
Source: PLoS One - April 25, 2024 Category: Biomedical Science Authors: Zacharie Tsala Dimbuene Source Type: research
Genetic background of adaptation of Crimean-Congo haemorrhagic fever virus to the different tick hosts
by Seyma S. Celina, Ji ří Černý
Crimean-Congo haemorrhagic fever orthonairovirus (CCHFV) is a negative-sense, single-stranded RNA virus with a segmented genome and the causative agent of a severe Crimean-Congo haemorrhagic fever (CCHF) disease. The virus is transmitted mainly by tick species inHyalomma genus but other ticks such as representatives of generaDermacentor andRhipicephalus may also be involved in virus life cycle. To improve our understanding of CCHFV adaptation to its tick species, we compared nucleotide composition and codon usage patterns among the all CCHFV strains i) which sequences and other metadata...
Source: PLoS One - April 25, 2024 Category: Biomedical Science Authors: Seyma S. Celina Source Type: research
Discovery of baloxavir sodium as a novel anti-CCHFV inhibitor: biological evaluation of in vitro and in vivo
This study identified baloxavir sodium as a novel scaffold structure and mechanism of anti-CCHF compound, providing a promising new strategy for clinical treatment of CCHF after further optimization.PMID:38657838 | DOI:10.1016/j.antiviral.2024.105890 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Kai Liu Liushuai Li Yajie Liu Xi Wang Jia Liu Jiang Li Fei Deng Runze Zhang Yiwu Zhou Zhihong Hu Wu Zhong Manli Wang Chun Guo Source Type: research
Discovery of baloxavir sodium as a novel anti-CCHFV inhibitor: biological evaluation of in vitro and in vivo
This study identified baloxavir sodium as a novel scaffold structure and mechanism of anti-CCHF compound, providing a promising new strategy for clinical treatment of CCHF after further optimization.PMID:38657838 | DOI:10.1016/j.antiviral.2024.105890 (Source: Antiviral Research)
Source: Antiviral Research - April 24, 2024 Category: Virology Authors: Kai Liu Liushuai Li Yajie Liu Xi Wang Jia Liu Jiang Li Fei Deng Runze Zhang Yiwu Zhou Zhihong Hu Wu Zhong Manli Wang Chun Guo Source Type: research
Molecules, Vol. 29, Pages 1944: A Rapid Self-Assembling Peptide Hydrogel for Delivery of TFF3 to Promote Gastric Mucosal Injury Repair
Zhao
Luo
Self-assembled peptide-based nanobiomaterials exhibit promising prospects for drug delivery applications owing to their commendable biocompatibility and biodegradability, facile tissue uptake and utilization, and minimal or negligible unexpected toxicity. TFF3 is an active peptide autonomously secreted by gastric mucosal cells, possessing multiple biological functions. It acts on the surface of the gastric mucosa, facilitating the repair process of gastric mucosal damage. However, when used as a drug, TFF3 faces significant challenges, including short retention time in the gastric mucosal cavity and deacti...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Chen Luo Su Lu Zhao Luo Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1944: A Rapid Self & minus;Assembling Peptide Hydrogel for Delivery of TFF3 to Promote Gastric Mucosal Injury Repair
Molecules, Vol. 29, Pages 1944: A Rapid Self−Assembling Peptide Hydrogel for Delivery of TFF3 to Promote Gastric Mucosal Injury Repair
Molecules doi: 10.3390/molecules29091944
Authors:
Jialei Chen
Jing Luo
Di Su
Na Lu
Jiawei Zhao
Zhongli Luo
Self-assembled peptide-based nanobiomaterials exhibit promising prospects for drug delivery applications owing to their commendable biocompatibility and biodegradability, facile tissue uptake and utilization, and minimal or negligible unexpected toxicity. TFF3 is an active peptide autonomously secreted by gastric mucosal cells, possessing multiple biological...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Jialei Chen Jing Luo Di Su Na Lu Jiawei Zhao Zhongli Luo Tags: Article Source Type: research
Monkeypox virus: dangerous strain gains ability to spread through sex, new data suggest
Nature, Published online: 23 April 2024; doi:10.1038/d41586-024-01167-5A cluster of mpox cases in the Democratic Republic of the Congo sparks worries of a wider outbreak. (Source: Nature AOP)
Source: Nature AOP - April 23, 2024 Category: Research Authors: Max Kozlov Source Type: research
Development of a non-infectious control for viral hemorrhagic fever PCR assays
by Matthew A. Knox, Collette Bromhead, David TS Hayman
Assay validation is an essential component of disease surveillance testing, but can be problematic in settings where access to positive control material is limited and a safety risk for handlers. Here we describe a single non-infectious synthetic control that can help develop and validate the PCR based detection of the viral causes of Crimean-Congo hemorrhagic fever, Ebola virus disease, Lassa fever, Marburg virus disease and Rift Valley fever. We designed non-infectious synthetic DNA oligonucleotide sequences incorporating primer binding sites suitable for five assay...
Source: PLoS Neglected Tropical Diseases - April 22, 2024 Category: Tropical Medicine Authors: Matthew A. Knox Source Type: research
Unveilling genetic profiles and correlations of biofilm-associated genes, quorum sensing, and antibiotic resistance in Staphylococcus aureus isolated from a Malaysian Teaching Hospital
ConclusionsThe high prevalence of biofilm and slime production among MSSA and MRSA isolates correlates well with the detection of a high prevalence of biofilm-associated genes andagr quorum sensing system. A significant association ofagrI gene was found with cefoxitin, oxacillin, and fluoroquinolone resistance. A more focused approach targeting biofilm-associated and quorum sensing genes is important in developing new surveillance and treatment strategies againstS. aureus biofilm infection. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 22, 2024 Category: Research Source Type: research
Insights into the interaction and inhibitory action of palmatine on lysozyme fibrillogenesis: Spectroscopic and computational studies
Int J Biol Macromol. 2024 Apr 19:131703. doi: 10.1016/j.ijbiomac.2024.131703. Online ahead of print.ABSTRACTInteraction under amyloidogenic condition between naturally occurring protoberberine alkaloid palmatine and hen egg white lysozyme was executed by adopting spectrofluorometric and theoretical molecular docking and dynamic simulation analysis. In spetrofluorometric method, different types of experiments were performed to explore the overall mode and mechanism of interaction. Intrinsic fluorescence quenching of lysozyme (Trp residues) by palmatine showed effective binding interaction and also yielded different binding ...
Source: International Journal of Biological Macromolecules - April 21, 2024 Category: Biochemistry Authors: Arindam Das Gouranga Jana Shukdeb Sing Anirban Basu Source Type: research
Green biocatalyst for decolorization of azo dyes from industrial wastewater: Coriolopsis trogii 2SMKN laccase immobilized on recycled brewer's spent grain
This study presents an innovative approach for the reuse and recycling of waste material, brewer's spent grain (BSG) for creating a novel green biocatalyst. The same BSG was utilized in several consecutive steps: initially, it served as a substrate for the cultivation and production of laccase by a novel isolated fungal strain, Coriolopsis trogii 2SMKN, then, it was reused as a carrier for laccase immobilization, aiding in the process of azo dye decolorization and finally, reused as recycled BSG for the second successful laccase immobilization for six guaiacol oxidation, contributing to a zero-waste strategy. The novel fun...
Source: Environmental Science and Pollution Research International - April 21, 2024 Category: Environmental Health Authors: Nevena Ili ć Sla đana Davidović Marija Mili ć Jelena La đarević Antonije Onjia Suzana Dimitrijevi ć-Branković Katarina Mihajlovski Source Type: research
Structural properties and adsorption performance relationship towards three categories of lignin and their derived biochar
This study focused on three types of lignin and their corresponding biochar derivatives. Among them, ZnCl2-activated acidic/alkali densified lignin preparation of lignin-derived active carbon exhibited superior adsorption performance, achieving 526.32 mg/g for methylene blue and 2156.77 mg/g for congo red. Its exceptional adsorption capacity was attributed to its unique structural properties, including low alkyl and O-alkyl group content and high aromatic carbon levels. Furthermore, the adsorption mechanisms adhered to pseudo-second-order kinetics and the Langmuir model, signifying a spontaneous process. Intriguingly, lign...
Source: Bioresource Technology - April 19, 2024 Category: Biotechnology Authors: Mingyang Hu Jiangwei Chen Yun Liu Source Type: research
Crimean-Congo Hemorrhagic Fever Virus for Clinicians —Epidemiology, Clinical Manifestations, and Prevention
M. G. Frank et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - April 19, 2024 Category: Infectious Diseases Source Type: research
