Self-assembly of amphiphilic helical-coiled peptide nanofibers and inhibition of fibril formation with curcumin
Bioorg Med Chem Lett. 2024 Mar 1:129682. doi: 10.1016/j.bmcl.2024.129682. Online ahead of print.ABSTRACTAmphiphilic peptide sequences are conducive to secondary structures that self-assemble into higher-ordered peptide nanostructures. A select set of amphiphilic polycationic peptides displayed stable helical-coiled structures that self-assembled into peptide nanofibers. The progression of peptide fibril formation revealed short protofibrils that extended into thin filaments and into an entangled network of nanofibers over an extended (5 days) incubation period. Ligand binding with 8-anilinonaphthalene-1-sulfonic acid (ANS)...
Source: Bioorganic and Medicinal Chemistry Letters - March 3, 2024 Category: Chemistry Authors: Grace Daniel George Hilan Lisa Ploeg David Sabatino Source Type: research
Self-assembly of amphiphilic helical-coiled peptide nanofibers and inhibition of fibril formation with curcumin
Bioorg Med Chem Lett. 2024 Mar 1:129682. doi: 10.1016/j.bmcl.2024.129682. Online ahead of print.ABSTRACTAmphiphilic peptide sequences are conducive to secondary structures that self-assemble into higher-ordered peptide nanostructures. A select set of amphiphilic polycationic peptides displayed stable helical-coiled structures that self-assembled into peptide nanofibers. The progression of peptide fibril formation revealed short protofibrils that extended into thin filaments and into an entangled network of nanofibers over an extended (5 days) incubation period. Ligand binding with 8-anilinonaphthalene-1-sulfonic acid (ANS)...
Source: Bioorganic and Medicinal Chemistry Letters - March 3, 2024 Category: Chemistry Authors: Grace Daniel George Hilan Lisa Ploeg David Sabatino Source Type: research
Double network self-healing hydrogels based on carboxyethyl chitosan/oxidized sodium alginate/Ca < sup > 2+ < /sup > : Preparation, characterization and application in dye absorption
Int J Biol Macromol. 2024 Feb 29:130564. doi: 10.1016/j.ijbiomac.2024.130564. Online ahead of print.ABSTRACTThis paper presents the formation of a self-healing hydrogel prepared by carboxyethyl modification of chitosan and crosslinking with oxidized sodium alginate. Concurrently, the incorporation of Ca2+ facilitated the formation of "calcium bridges" through intricate coordination with carboxyl moieties, bolstering the attributes of the hydrogel. Various characterization methods, including scanning electron microscopy, texture analysis, and rheological measurements, demonstrated that the introduction of carboxyethyl group...
Source: International Journal of Biological Macromolecules - March 2, 2024 Category: Biochemistry Authors: Linyu Zhang Qianqi Li Xinru Bai Xiaoqin Li Guoguang Zhang Jinmei Zou Peng Fei Wenqiang Lai Source Type: research
Contribution of Anopheles gambiae sensu lato mosquitoes to malaria transmission during the dry season in Djoumouna and Ntoula villages in the Republic of the Congo
This study assessed the relative importance of members of An. gambiae s.l. in malaria tran... (Source: Parasites and Vectors)
Source: Parasites and Vectors - March 2, 2024 Category: Microbiology Authors: Jacques Dollon Mbama Ntabi, Espoir Divin Malda Bali, Abel Lissom, Romaric Akoton, Jean Claude Djontu, Georges Missontsa, Freisnel Hermeland Mouzinga, Marcel Tapsou Baina, Luc Djogbenou, Cyrille Ndo, Charles Wondji, Ayola Akim Adegnika, Ars ène Lenga, Ste Tags: Brief report Source Type: research
Knowledge and practices of sickle cell disease among healthcare providers in Kinshasa, Democratic Republic of the Congo
CONCLUSION: The practices of healthcare providers on SCD were far from optimal. These practices were significantly associated with knowledge and experience of healthcare providers.Contribution: This study highlighted the need for continuing professional education to enhance the management of SCD in the setting.PMID:38426772 | DOI:10.4102/phcfm.v16i1.3631 (Source: Primary Care)
Source: Primary Care - March 1, 2024 Category: Primary Care Authors: Ange-Christian M Ngonde Jean-Pierre L Fina Edu Burgueno Phillippe N Lukanu Source Type: research
