Ongoing mpox outbreak in Kamituga, South Kivu province, associated with monkeypox virus of a novel Clade I sub-lineage, Democratic Republic of the Congo, 2024
We report near-to-complete MPXV genome sequences derived from six cases from the South Kivu province. Phylogenetic analyses reveal that the MPXV affecting the cases belongs to a novel Clade I sub-lineage. The outbreak strain genome lacks the target sequence of the probe and primers of a commonly used Clade I-specific real-time PCR.PMID:38487886 | PMC:PMC10941309 | DOI:10.2807/1560-7917.ES.2024.29.11.2400106 (Source: Euro Surveill)
Source: Euro Surveill - March 15, 2024 Category: Infectious Diseases Authors: Leandre Murhula Masirika Jean Claude Udahemuka Leonard Schuele Pacifique Ndishimye Saria Otani Justin Bengehya Mbiribindi Jean M Marekani L éandre Mutimbwa Mambo Nadine Malyamungu Bubala Marjan Boter David F Nieuwenhuijse Trudie Lang Ernest Balyahamwabo Source Type: research
Examining geospatial and temporal distribution of invasive non-typhoidal Salmonella disease occurrence in sub-Saharan Africa: a systematic review and modelling study
Conclusion
The iNTS disease occurrence varied greatly across sub-Saharan Africa, with certain regions being disproportionately affected. Exploring regions at high risk for iNTS disease, despite the limitations in our data, may inform focused resource allocation. This targeted approach may enhance efforts to combat iNTS disease in more affected areas. (Source: BMJ Open)
Source: BMJ Open - March 14, 2024 Category: General Medicine Authors: Kim, J.-H., Tack, B., Fiorino, F., Pettini, E., Marchello, C., Jacobs, J., Crump, J., Marks, F., Vacc-iNTS Consortium Tags: Open access, Epidemiology Source Type: research
Ongoing mpox outbreak in Kamituga, South Kivu province, associated with monkeypox virus of a novel Clade I sub-lineage, Democratic Republic of the Congo, 2024
We report near-to-complete MPXV genome sequences derived from six cases from the South Kivu province. Phylogenetic analyses reveal that the MPXV affecting the cases belongs to a novel Clade I sub-lineage. The outbreak strain genome lacks the target sequence of the probe and primers of a commonly used Clade I-specific real-time PCR. (Source: Eurosurveillance)
Source: Eurosurveillance - March 14, 2024 Category: Infectious Diseases Authors: Leandre Murhula Masirika, Jean Claude Udahemuka, Leonard Schuele, Pacifique Ndishimye, Saria Otani, Justin Bengehya Mbiribindi, Jean M. Marekani, L éandre Mutimbwa Mambo, Nadine Malyamungu Bubala, Marjan Boter, David F. Nieuwenhuijse, Trudie Lang, Ernest Source Type: research
An Investigation into the Prospective Applications of Bio-Catalyst Metal Frameworks: A Novel Catalyst for Improved Removal of Congo Red from Aqueous Solutions
This study explores the potential of Orange Peel (OP) as a... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - March 13, 2024 Category: Chemistry Authors: Harez Ahmed Source Type: research
Approaching the complexity of Crimean-Congo hemorrhagic fever virus serology: a study in swine
J Virol Methods. 2024 Mar 11:114915. doi: 10.1016/j.jviromet.2024.114915. Online ahead of print.ABSTRACTCrimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne zoonotic orthonairovirus of public health concern and widespread geographic distribution. Several animal species are known to seroconvert after infection with CCHFV without showing clinical symptoms. The commercial availability of a multi-species ELISA has led to an increase in recent serosurveillance studies as well as in the range of species reported to be exposed to CCHFV in the field, including wild boar (Sus scrofa). However, development and validation of...
Source: Journal of Virological Methods - March 13, 2024 Category: Virology Authors: Caroline Bost Sabrina Castro-Scholten Balal Sadeghi David Cano-Terriza Mario Fr ías Sa úl Jiménez-Ruiz Martin H Groschup Ignacio Garc ía-Bocanegra Kerstin Fischer Source Type: research
Approaching the complexity of Crimean-Congo hemorrhagic fever virus serology: a study in swine
J Virol Methods. 2024 Mar 11:114915. doi: 10.1016/j.jviromet.2024.114915. Online ahead of print.ABSTRACTCrimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne zoonotic orthonairovirus of public health concern and widespread geographic distribution. Several animal species are known to seroconvert after infection with CCHFV without showing clinical symptoms. The commercial availability of a multi-species ELISA has led to an increase in recent serosurveillance studies as well as in the range of species reported to be exposed to CCHFV in the field, including wild boar (Sus scrofa). However, development and validation of...
Source: Journal of Virological Methods - March 13, 2024 Category: Virology Authors: Caroline Bost Sabrina Castro-Scholten Balal Sadeghi David Cano-Terriza Mario Fr ías Sa úl Jiménez-Ruiz Martin H Groschup Ignacio Garc ía-Bocanegra Kerstin Fischer Source Type: research
Approaching the complexity of Crimean-Congo hemorrhagic fever virus serology: A study in swine
J Virol Methods. 2024 Mar 12;326:114915. doi: 10.1016/j.jviromet.2024.114915. Online ahead of print.ABSTRACTCrimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne zoonotic orthonairovirus of public health concern and widespread geographic distribution. Several animal species are known to seroconvert after infection with CCHFV without showing clinical symptoms. The commercial availability of a multi-species ELISA has led to an increase in recent serosurveillance studies as well as in the range of species reported to be exposed to CCHFV in the field, including wild boar (Sus scrofa). However, development and validatio...
Source: Journal of Virological Methods - March 13, 2024 Category: Virology Authors: Caroline Bost Sabrina Castro-Scholten Balal Sadeghi David Cano-Terriza Mario Fr ías Sa úl Jiménez-Ruiz Martin H Groschup Ignacio Garc ía-Bocanegra Kerstin Fischer Source Type: research
Approaching the complexity of Crimean-Congo hemorrhagic fever virus serology: A study in swine
J Virol Methods. 2024 Mar 12;326:114915. doi: 10.1016/j.jviromet.2024.114915. Online ahead of print.ABSTRACTCrimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne zoonotic orthonairovirus of public health concern and widespread geographic distribution. Several animal species are known to seroconvert after infection with CCHFV without showing clinical symptoms. The commercial availability of a multi-species ELISA has led to an increase in recent serosurveillance studies as well as in the range of species reported to be exposed to CCHFV in the field, including wild boar (Sus scrofa). However, development and validatio...
Source: Journal of Virological Methods - March 13, 2024 Category: Virology Authors: Caroline Bost Sabrina Castro-Scholten Balal Sadeghi David Cano-Terriza Mario Fr ías Sa úl Jiménez-Ruiz Martin H Groschup Ignacio Garc ía-Bocanegra Kerstin Fischer Source Type: research
Approaching the complexity of Crimean-Congo hemorrhagic fever virus serology: A study in swine
J Virol Methods. 2024 Mar 12;326:114915. doi: 10.1016/j.jviromet.2024.114915. Online ahead of print.ABSTRACTCrimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne zoonotic orthonairovirus of public health concern and widespread geographic distribution. Several animal species are known to seroconvert after infection with CCHFV without showing clinical symptoms. The commercial availability of a multi-species ELISA has led to an increase in recent serosurveillance studies as well as in the range of species reported to be exposed to CCHFV in the field, including wild boar (Sus scrofa). However, development and validatio...
Source: Journal of Virological Methods - March 13, 2024 Category: Virology Authors: Caroline Bost Sabrina Castro-Scholten Balal Sadeghi David Cano-Terriza Mario Fr ías Sa úl Jiménez-Ruiz Martin H Groschup Ignacio Garc ía-Bocanegra Kerstin Fischer Source Type: research
Anticoagulation control among patients on vitamin K antagonists in nine countries in Sub-Saharan Africa
This study assessed the quality of anticoagulation and associated factors among VKA-treated patients in nine SSA countries. We conducted a retrospective cohort study of randomly selected patients on anticoagulation from 20 clinics in Botswana, the Democratic Republic of Congo, Ethiopia, Gambia, Ghana, Mozambique, Nigeria, Tanzania, and South Africa. Eligible participants were those on VKAs for at least three months and with at least four international normalised ratios (INR) results in 2019 –2021. We report the proportion of INR values in the therapeutic range, time-in-therapeutic range (TTR) using the Rosendaal method, ...
Source: Journal of Thrombosis and Thrombolysis - March 13, 2024 Category: Hematology Source Type: research
Compulsory Vaccination Coverage in 12 Sub-Saharan African Countries Two Years Following the COVID-19 Pandemic
This study aimed to assess compulsory vaccination coverage in 12 Sub-Saharan African countries two years following the COVID-19 pandemic using the Health Belief Model. A cross-sectional survey was conducted from November 1 to December 15, 2022. Multivariate logistic re gression was conducted to identify the determinants of vaccination coverage. Among the 5032 respondents, 73.1% reported that their children received compulsory vaccination. The lowest coverage was observed in Ghana (36.5%), while the highest was in Burkina Faso and Congo (92.0%). Factors associated with non-vaccination included older mothers (adjusted odds r...
Source: Journal of Community Health - March 11, 2024 Category: International Medicine & Public Health Source Type: research
GSE236799 Expresion data from yeast (wild type strain and pat1 mutant) exposed to Congo Red (CR)
Series Type : Expression profiling by arrayOrganism : Saccharomyces cerevisiae ; Schizosaccharomyces pombeWe did transcription profiling on the effect of PAT1 (moonlight protein whose most studied function is to degrade mRNA.) deletion in genes involved in Congo Red response (2 hours of treatment). (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 11, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Saccharomyces cerevisiae Schizosaccharomyces pombe Source Type: research
Seroprevalence of Crimean-Congo hemorrhagic fever virus in the population of Turkestan region
CONCLUSION: IgG ELISA was performed to screen CCH-FV in 4259 village inhabitants of Turkestan Region and revealed the presence of antibodies in 2.39% of its population. Weak linear correlation relationship was established between CCHFV seroprevalence rate and CCH-FV morbidity rate in the particular districts of Turkestan Region. As people grow older, CCHFV IgG detection rate increases. Living on CHHF endemic territories is a serious risk factor to become CHHF positive which is characterized by manifestation of the subclinical forms of this disease.PMID:38456018 | PMC:PMC10917566 | DOI:10.53854/liim-3201-11 (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - March 8, 2024 Category: Infectious Diseases Authors: Gulzhan Narkenovna Abuova Farida Abdullayevna Berdaliyeva Tatyana Vasiliyevna Polukchi Daulet Sabyrovich Aliyev Gulamzhan Sattarkulovich Raymkulov Maksim Vladimirovich Kulemin Ratbek Saylaubekuly Source Type: research
Characterization of preclinical Alzheimer's disease model: spontaneous type 2 diabetic cynomolgus monkeys with systemic pro-inflammation, positive biomarkers and developing AD-like pathology
CONCLUSIONS: Overall, T2DM monkeys showed elevated levels of peripheral and intracerebral inflammation, positive AD biomarkers in body fluids, and developing AD-like pathology in the brain, including Aβ and tau pathology, glial cell activation, and partial synaptic damage, but no neuronal degeneration or death as compared to the healthy normal group. Hereby, we consider the T2DM monkeys with elevation of the peripheral pro-inflammatory factors and positive AD biomarkers can be potentially regarded as a preclinical AD model.PMID:38459540 | DOI:10.1186/s13195-024-01416-9 (Source: Cell Research)
Source: Cell Research - March 8, 2024 Category: Cytology Authors: Xinxin Huang Shanshan Huang Fangyan Fu Junzhen Song Yuling Zhang Feng Yue Source Type: research
