Inflammatory bowel disease-associated colorectal cancer negatively affects surgery outcomes and health care costs
Inflammatory bowel disease may affect the pathogenesis and clinicopathologic course of colorectal cancer. We sought to characterize the impact of inflammatory bowel disease on outcomes after colectomy and/or proctectomy for a malignant indication. (Source: Surgery)
Source: Surgery - April 6, 2024 Category: Surgery Authors: Erryk S. Katayama, Selamawit Woldesenbet, Diamantis Tsilimigras, Muhammad Musaab Munir, Yutaka Endo, Emily Huang, Lisa Cunningham, Alan Harzman, Alessandra Gasior, Syed Husain, Mark Arnold, Matthew Kalady, Timothy M. Pawlik Source Type: research
Propensity-score matched outcomes of resection of stage IV primary colon cancer with and without simultaneous resection of liver metastases
This study aimed to compare short-term and survival outcomes of simultaneous resection of CLM and primary colon cancer compared to resection of only colon cancer. This retrospective matched cohort study included patients from the National Cancer Database (2015 –2019) with stage IV colon adenocarcinoma and synchronous liver metastases who underwent colectomy. Patients were divided into two groups: colectomy-only (resection of primary colon cancer only) and colectomy-plus (simultaneous resection of primary colon cancer and liver metastases). The groups we re matched using the propensity score method. The primary outcome wa...
Source: Updates in Surgery - April 3, 2024 Category: Surgery Source Type: research
Impact of cytomegalovirus on outcomes in acute severe ulcerative colitis: a retrospective observational study
CONCLUSION: CMV positivity was associated with worse outcomes of need for rescue therapy, hospital stay and readmissions. Antiviral therapy was not found to reduce the risk of colectomy but did extend the time to colectomy. Further prospective studies will be required to more clearly determine its benefit in patients with concomitant CMV and ASUC.PMID:38560721 | PMC:PMC10981253 | DOI:10.1177/20406223241233203 (Source: Adv Data)
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Dazhong Huang Michael Rennie Alicia Krasovec Shyam Nagubandi Sichang Liu Edward Ge Barinder Khehra Michael Au Shobini Sivagnanam Vu Kwan Claudia Rogge Nikola Mitrev Viraj Kariyawasam Source Type: research
Correction: Implementation of 3D printed superior mesenteric vascular models for surgical planning and/or navigation in right colectomy with extended D3 mesenterectomy: comparison of virtual and physical models to the anatomy found at surgery
(Source: Surgical Endoscopy)
Source: Surgical Endoscopy - March 29, 2024 Category: Surgery Source Type: research
Nonconventional Dysplasia is Frequently Associated With Goblet Cell Deficient and Serrated Variants of Colonic Adenocarcinoma in Inflammatory Bowel Disease
In conclusion, goblet cell deficient dysplasia and dysplasias featuring a serrated component could potentially serve as high-risk markers for GCDACs and SACs, respectively.PMID:38546105 | DOI:10.1097/PAS.0000000000002217 (Source: Cancer Control)
Source: Cancer Control - March 28, 2024 Category: Cancer & Oncology Authors: Andrew Xiao Masato Yozu Bence P K ővári Lindsay Yassan Xiaoyan Liao Marcela Salomao Maria Westerhoff Anita Sejben Gregory Y Lauwers Won-Tak Choi Source Type: research
CACNA2D1 regulates the progression and influences the microenvironment of colon cancer
ConclusionsCACNA2D1 plays an important role in the progression and the microenvironment of CC by regulating fibroblasts and may act as a biomarker for disease progression and a therapeutic target for CC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 27, 2024 Category: Gastroenterology Source Type: research
Effect of Tofacitinib on One-Year Colectomy Risk in Anti-TNF Refractory Ulcerative Colitis: A Prospective Multicenter Italian Study
ConclusionsIn a real-life setting of patients with anti-TNF refractory UC, tofacitinib has proved to be effective in preventing colectomy and inducing clinical and endoscopic remission at 52 weeks with a good safety profile. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 26, 2024 Category: Gastroenterology Source Type: research
A SICE (Societ à Italiana di Chirurgia Endoscopica e Nuove Tecnologie) observational prospective multicenter study on anatomical variants of the superior mesenteric artery: intraoperative analysis during laparoscopic right hemicolectomy—CoDIG 2 database (ColonDx Italian Group)
AbstractColorectal cancer, the third most common cancer worldwide, affects 40 –45% of patients on the right side. Surgery, especially minimally invasive methods such as laparoscopic and robotic procedures, is the preferred treatment. However, these techniques present technical complications. The anatomical complexity and variations in vessel branching patterns pose challeng es, particularly for less experienced surgeons. The CoDIG 2 is a nationwide observational study involving 76 specialized Italian general surgery departments focused on colorectal surgery. The centres were directed to maintain their standard surgical a...
Source: Updates in Surgery - March 25, 2024 Category: Surgery Source Type: research
Early Discharge after Enhanced Recovery Colectomy Does Not Increase Emergency Department Visits and Readmissions: A Single Institution Analysis
CONCLUSION: Early discharge after left and right colectomy is not associated with increased rates of ED visits and readmissions. Same-day discharge may be feasible in selected enhanced recovery patients. Standardized post-discharge resources that safely allow same-day discharge require further investigation.PMID:38520237 | DOI:10.1177/00031348241241653 (Source: The American Surgeon)
Source: The American Surgeon - March 23, 2024 Category: Surgery Authors: Katherine Baur Evan M Sood Marianne Huebner Carole Ramm Nivya Kolli Robert K Cleary Source Type: research
Early Discharge after Enhanced Recovery Colectomy Does Not Increase Emergency Department Visits and Readmissions: A Single Institution Analysis
CONCLUSION: Early discharge after left and right colectomy is not associated with increased rates of ED visits and readmissions. Same-day discharge may be feasible in selected enhanced recovery patients. Standardized post-discharge resources that safely allow same-day discharge require further investigation.PMID:38520237 | DOI:10.1177/00031348241241653 (Source: The American Surgeon)
Source: The American Surgeon - March 23, 2024 Category: Surgery Authors: Katherine Baur Evan M Sood Marianne Huebner Carole Ramm Nivya Kolli Robert K Cleary Source Type: research
Management of a Complex Fistula Involving Abdominal Wall, Small Bowel, Colon, and Bladder
We present a challenging case involving a Jackson-Pratt (JP) drain from prior surgery causing a complex intra-abdominal fistula. The JP drain traversed multiple small bowel loops and the sigmoid colon before terminating in the bladder. Management required multi-disciplinary coordination involving colorectal surgery and urology. The patient's definitive surgery included anterior resection, colostomy takedown, right colectomy, three small bowel resections, and bladder repair. The use of JP drains after abdominal surgery is not without risk. Clinicians should have standardized indications for placement of JP drains and consis...
Source: The American Surgeon - March 22, 2024 Category: Surgery Authors: Mishal Gillani Seth A Rosen Source Type: research
Management of a Complex Fistula Involving Abdominal Wall, Small Bowel, Colon, and Bladder
We present a challenging case involving a Jackson-Pratt (JP) drain from prior surgery causing a complex intra-abdominal fistula. The JP drain traversed multiple small bowel loops and the sigmoid colon before terminating in the bladder. Management required multi-disciplinary coordination involving colorectal surgery and urology. The patient's definitive surgery included anterior resection, colostomy takedown, right colectomy, three small bowel resections, and bladder repair. The use of JP drains after abdominal surgery is not without risk. Clinicians should have standardized indications for placement of JP drains and consis...
Source: The American Surgeon - March 22, 2024 Category: Surgery Authors: Mishal Gillani Seth A Rosen Source Type: research
Management of an undetectable Diverticular Bleed: A Case Report and Literature review
Key Clinical MessageDiverticular bleeding is the most common cause of lower gastrointestinal bleeding and accounts for 20.8% –41.6% of cases in the Western world. Management involves initial resuscitation followed by diagnostic assessment. Colonoscopy is the investigation of choice as it localizes the bleed and has the potential to effectively deliver therapeutic interventions. Other diagnostic modalities include flexib le sigmoidoscopy, a tagged red blood cell scan, or angiography. In cases where the bleeding source cannot be identified, intraoperative enteroscopy has emerged as a valuable tool for investigating obscure...
Source: Clinical Case Reports - March 22, 2024 Category: General Medicine Authors: Zubir S. Rentiya,
Lokeshwar Raaju Addi Palle,
Sanni Emmanuel,
Heeya Shah,
Abiodun Adegbite,
Carlo Kristian Chu Carredo,
Ronald Mauricio Blanco Montecino,
Ummul Z. Asfeen,
Akbar Hussain,
Ogbonnaya Akuma,
Aadil Mahmood Khan,
Anasonye Emmanuel Tags: CASE REPORT Source Type: research
