Surgical Decision-Making in Familial Adenomatous Polyposis
Clin Colon Rectal Surg. 2023 Aug 10;37(3):191-197. doi: 10.1055/s-0043-1770732. eCollection 2024 May.ABSTRACTFamilial adenomatous polyposis (FAP) is an autosomal dominant disorder affecting patients with germline mutations of the adenomatous polyposis coli (APC) tumor suppressor gene. The surgical treatment of colorectal disease in FAP, which has the goal of colorectal cancer prevention, varies based on both patient and disease factors but can include the following: total colectomy with ileorectal anastomosis, proctocolectomy with stapled or hand-sewn ileal pouch-anal anastomosis, or total proctocolectomy with end ileostom...
Source: Hand Surgery - April 15, 2024 Category: Surgery Authors: Allie E Steinberger Maggie L Westfal Paul E Wise Source Type: research
Microenvironment-induced restoration of cohesive growth associated with focal activation of P-cadherin expression in lobular breast carcinoma metastatic to the colon
J Pathol Clin Res. 2024 Mar;10(2):e12361. doi: 10.1002/2056-4538.12361.ABSTRACTInvasive lobular carcinoma (ILC) is a special breast cancer type characterized by noncohesive growth and E-cadherin loss. Focal activation of P-cadherin expression in tumor cells that are deficient for E-cadherin occurs in a subset of ILCs. Switching from an E-cadherin deficient to P-cadherin proficient status (EPS) partially restores cell-cell adhesion leading to the formation of cohesive tubular elements. It is unknown what conditions control EPS. Here, we report on EPS in ILC metastases in the large bowel. We reviewed endoscopic colon biopsie...
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Malte Gronewold Isabel Grote Stephan Bartels Henriette Christgen Leonie D Kandt Maria Jose Brito G àbor Cserni Maximilian E Daemmrich Franz Fogt Burkhard M Helmke Natalie Ter Hoeve Corinna Lang-Schwarz Michael Vieth Axel Wellmann Elna Kuehnle Ulf Kulik G Source Type: research
Microenvironment-induced restoration of cohesive growth associated with focal activation of P-cadherin expression in lobular breast carcinoma metastatic to the colon
J Pathol Clin Res. 2024 Mar;10(2):e12361. doi: 10.1002/2056-4538.12361.ABSTRACTInvasive lobular carcinoma (ILC) is a special breast cancer type characterized by noncohesive growth and E-cadherin loss. Focal activation of P-cadherin expression in tumor cells that are deficient for E-cadherin occurs in a subset of ILCs. Switching from an E-cadherin deficient to P-cadherin proficient status (EPS) partially restores cell-cell adhesion leading to the formation of cohesive tubular elements. It is unknown what conditions control EPS. Here, we report on EPS in ILC metastases in the large bowel. We reviewed endoscopic colon biopsie...
Source: Clinical Breast Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Malte Gronewold Isabel Grote Stephan Bartels Henriette Christgen Leonie D Kandt Maria Jose Brito G àbor Cserni Maximilian E Daemmrich Franz Fogt Burkhard M Helmke Natalie Ter Hoeve Corinna Lang-Schwarz Michael Vieth Axel Wellmann Elna Kuehnle Ulf Kulik G Source Type: research
Surgical Decision-Making in Familial Adenomatous Polyposis
Clin Colon Rectal Surg. 2023 Aug 10;37(3):191-197. doi: 10.1055/s-0043-1770732. eCollection 2024 May.ABSTRACTFamilial adenomatous polyposis (FAP) is an autosomal dominant disorder affecting patients with germline mutations of the adenomatous polyposis coli (APC) tumor suppressor gene. The surgical treatment of colorectal disease in FAP, which has the goal of colorectal cancer prevention, varies based on both patient and disease factors but can include the following: total colectomy with ileorectal anastomosis, proctocolectomy with stapled or hand-sewn ileal pouch-anal anastomosis, or total proctocolectomy with end ileostom...
Source: Clinical Colorectal Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Allie E Steinberger Maggie L Westfal Paul E Wise Source Type: research
Microenvironment-induced restoration of cohesive growth associated with focal activation of P-cadherin expression in lobular breast carcinoma metastatic to the colon
J Pathol Clin Res. 2024 Mar;10(2):e12361. doi: 10.1002/2056-4538.12361.ABSTRACTInvasive lobular carcinoma (ILC) is a special breast cancer type characterized by noncohesive growth and E-cadherin loss. Focal activation of P-cadherin expression in tumor cells that are deficient for E-cadherin occurs in a subset of ILCs. Switching from an E-cadherin deficient to P-cadherin proficient status (EPS) partially restores cell-cell adhesion leading to the formation of cohesive tubular elements. It is unknown what conditions control EPS. Here, we report on EPS in ILC metastases in the large bowel. We reviewed endoscopic colon biopsie...
Source: Clinical Genitourinary Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Malte Gronewold Isabel Grote Stephan Bartels Henriette Christgen Leonie D Kandt Maria Jose Brito G àbor Cserni Maximilian E Daemmrich Franz Fogt Burkhard M Helmke Natalie Ter Hoeve Corinna Lang-Schwarz Michael Vieth Axel Wellmann Elna Kuehnle Ulf Kulik G Source Type: research
Surgical Decision-Making in Familial Adenomatous Polyposis
Clin Colon Rectal Surg. 2023 Aug 10;37(3):191-197. doi: 10.1055/s-0043-1770732. eCollection 2024 May.ABSTRACTFamilial adenomatous polyposis (FAP) is an autosomal dominant disorder affecting patients with germline mutations of the adenomatous polyposis coli (APC) tumor suppressor gene. The surgical treatment of colorectal disease in FAP, which has the goal of colorectal cancer prevention, varies based on both patient and disease factors but can include the following: total colectomy with ileorectal anastomosis, proctocolectomy with stapled or hand-sewn ileal pouch-anal anastomosis, or total proctocolectomy with end ileostom...
Source: Hand Surgery - April 15, 2024 Category: Surgery Authors: Allie E Steinberger Maggie L Westfal Paul E Wise Source Type: research
What is true ambulatory colectomy?
(Source: Techniques in Coloproctology)
Source: Techniques in Coloproctology - April 13, 2024 Category: Surgery Source Type: research
Chemoprevention in Inherited Colorectal Cancer Syndromes
Clin Colon Rectal Surg. 2023 Jul 19;37(3):172-179. doi: 10.1055/s-0043-1770384. eCollection 2024 May.ABSTRACTCancer prevention in hereditary gastrointestinal predisposition syndromes relies primarily on intensive screening (e.g., colonoscopy) or prophylactic surgery (e.g., colectomy). The use of chemopreventive agents as an adjunct to these measures has long been studied both in the general population and in hereditary cancer patients, in whom the risk of malignancy, and therefore the potential risk reduction, is considerably greater. However, to date only few compounds have been found to be effective, safe, and tolerable ...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Ophir Gilad Charles Muller Sonia S Kupfer Source Type: research
Chemoprevention in Inherited Colorectal Cancer Syndromes
Clin Colon Rectal Surg. 2023 Jul 19;37(3):172-179. doi: 10.1055/s-0043-1770384. eCollection 2024 May.ABSTRACTCancer prevention in hereditary gastrointestinal predisposition syndromes relies primarily on intensive screening (e.g., colonoscopy) or prophylactic surgery (e.g., colectomy). The use of chemopreventive agents as an adjunct to these measures has long been studied both in the general population and in hereditary cancer patients, in whom the risk of malignancy, and therefore the potential risk reduction, is considerably greater. However, to date only few compounds have been found to be effective, safe, and tolerable ...
Source: Clinical Colorectal Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Ophir Gilad Charles Muller Sonia S Kupfer Source Type: research
Neoadjuvant immunotherapy in a locally advanced colon cancer patient with MSI-H and suspected Lynch syndrome: A case report
We present the case of a 46-year-old male who sought medical attention at our institution due to a history of hematochezia for two weeks, right-sided abdominal pain for one week, and loose stools. Imaging indicated duodenal involvement, and a biopsy confirmed ascending colon adenocarcinoma with MSI-H status. Given that the patient's family exhibited a history of more than three confirmed cases of colorectal cancer spanning two generations, Lynch syndrome was considered. After four cycles of PD-1 antagonist immunotherapy with carrilizumab, the patient's symptoms resolved, and physical examination revealed no abdominal tende...
Source: Zeitschrift fur Gastroenterologie - April 11, 2024 Category: Gastroenterology Authors: Xiaoyun Li Yining Xiang Yunhuan Zhen Yong Yu Source Type: research
Neoadjuvant immunotherapy in a locally advanced colon cancer patient with MSI-H and suspected Lynch syndrome: A case report
We present the case of a 46-year-old male who sought medical attention at our institution due to a history of hematochezia for two weeks, right-sided abdominal pain for one week, and loose stools. Imaging indicated duodenal involvement, and a biopsy confirmed ascending colon adenocarcinoma with MSI-H status. Given that the patient's family exhibited a history of more than three confirmed cases of colorectal cancer spanning two generations, Lynch syndrome was considered. After four cycles of PD-1 antagonist immunotherapy with carrilizumab, the patient's symptoms resolved, and physical examination revealed no abdominal tende...
Source: Zeitschrift fur Gastroenterologie - April 11, 2024 Category: Gastroenterology Authors: Xiaoyun Li Yining Xiang Yunhuan Zhen Yong Yu Source Type: research
Neoadjuvant immunotherapy in a locally advanced colon cancer patient with MSI-H and suspected Lynch syndrome: A case report
We present the case of a 46-year-old male who sought medical attention at our institution due to a history of hematochezia for two weeks, right-sided abdominal pain for one week, and loose stools. Imaging indicated duodenal involvement, and a biopsy confirmed ascending colon adenocarcinoma with MSI-H status. Given that the patient's family exhibited a history of more than three confirmed cases of colorectal cancer spanning two generations, Lynch syndrome was considered. After four cycles of PD-1 antagonist immunotherapy with carrilizumab, the patient's symptoms resolved, and physical examination revealed no abdominal tende...
Source: Zeitschrift fur Gastroenterologie - April 11, 2024 Category: Gastroenterology Authors: Xiaoyun Li Yining Xiang Yunhuan Zhen Yong Yu Source Type: research
Extent of Resection and Long-Term Outcomes for Appendiceal Adenocarcinoma: a SEER Database Analysis of Mucinous and non-Mucinous Histologies
CONCLUSIONS: Colectomy was associated with improved DSS for patients with NMAA but not MAA. Colectomy for MAA may not be required.PMID:38594579 | DOI:10.1245/s10434-024-15233-9 (Source: Ann Oncol)
Source: Ann Oncol - April 9, 2024 Category: Cancer & Oncology Authors: Vasileios Tsagkalidis Jennie K Choe Toni Beninato Mariam F Eskander Miral S Grandhi Haejin In Timothy J Kennedy Russell C Langan Jason C Maggi Henry A Pitt H Richard Alexander Brett L Ecker Source Type: research
Laparoscopic right colectomy: correct technique based on key anatomical principles
Minim Invasive Ther Allied Technol. 2024 Apr 8:1-13. doi: 10.1080/13645706.2024.2332880. Online ahead of print.ABSTRACTSince the early1990s, laparoscopic right colon resections have been the most performed advanced laparoscopic procedures just after laparoscopic left colectomies and sigmoid resections. Indications for laparoscopic right colectomies are either benign or malignant diseases. Despite its many indications, a laparoscopic right or extended right colectomy is mostly performed for cancer of the caecum, the ascending colon, the hepatic flexure or the proximal transverse colon. Worldwide, colorectal cancer is the th...
Source: Minimally Invasive Therapy and Allied Technologies - April 8, 2024 Category: Surgery Authors: Marco Maria Lirici Giovanni Dapri Cristiano G S Huescher John Marks Source Type: research
Inflammatory bowel disease-associated colorectal cancer negatively affects surgery outcomes and health care costs
Inflammatory bowel disease may affect the pathogenesis and clinicopathologic course of colorectal cancer. We sought to characterize the impact of inflammatory bowel disease on outcomes after colectomy and/or proctectomy for a malignant indication. (Source: Surgery)
Source: Surgery - April 6, 2024 Category: Surgery Authors: Erryk S. Katayama, Selamawit Woldesenbet, Diamantis Tsilimigras, Muhammad Musaab Munir, Yutaka Endo, Emily Huang, Lisa Cunningham, Alan Harzman, Alessandra Gasior, Syed Husain, Mark Arnold, Matthew Kalady, Timothy M. Pawlik Source Type: research
