The Evil DExH/D: Chikungunya virus runs but cannot hide from DDX39A
In this issue, Tapescu et al.11 identify DDX39A as a novel antiviral protein that acts on conserved features of alphavirus RNA to limit infection in an IFN-independent manner. (Source: Molecular Cell)
Source: Molecular Cell - November 16, 2023 Category: Cytology Authors: Matthew G. Thompson, Stacy M. Horner Tags: Preview Source Type: research
Viral infections and pathogenesis of glaucoma: a comprehensive review
Clin Microbiol Rev. 2023 Nov 15:e0005723. doi: 10.1128/cmr.00057-23. Online ahead of print.ABSTRACTSUMMARYGlaucoma is a leading cause of irreversible blindness worldwide, caused by the gradual degeneration of retinal ganglion cells and their axons. While glaucoma is primarily considered a genetic and age-related disease, some inflammatory conditions, such as uveitis and viral-induced anterior segment inflammation, cause secondary or uveitic glaucoma. Viruses are predominant ocular pathogens and can impose both acute and chronic pathological insults to the human eye. Many viruses, including herpes simplex virus, varicella-z...
Source: Clinical Microbiology Reviews - November 15, 2023 Category: Microbiology Authors: Faraz Ahmad Nikhil Deshmukh Aaron Webel Sandra Johnson Ayman Suleiman Rajiv R Mohan Frederick Fraunfelder Pawan Kumar Singh Source Type: research
Viral infections and pathogenesis of glaucoma: a comprehensive review
Clin Microbiol Rev. 2023 Nov 15:e0005723. doi: 10.1128/cmr.00057-23. Online ahead of print.ABSTRACTSUMMARYGlaucoma is a leading cause of irreversible blindness worldwide, caused by the gradual degeneration of retinal ganglion cells and their axons. While glaucoma is primarily considered a genetic and age-related disease, some inflammatory conditions, such as uveitis and viral-induced anterior segment inflammation, cause secondary or uveitic glaucoma. Viruses are predominant ocular pathogens and can impose both acute and chronic pathological insults to the human eye. Many viruses, including herpes simplex virus, varicella-z...
Source: Herpes - November 15, 2023 Category: Infectious Diseases Authors: Faraz Ahmad Nikhil Deshmukh Aaron Webel Sandra Johnson Ayman Suleiman Rajiv R Mohan Frederick Fraunfelder Pawan Kumar Singh Source Type: research
Viral infections and pathogenesis of glaucoma: a comprehensive review
Clin Microbiol Rev. 2023 Nov 15:e0005723. doi: 10.1128/cmr.00057-23. Online ahead of print.ABSTRACTSUMMARYGlaucoma is a leading cause of irreversible blindness worldwide, caused by the gradual degeneration of retinal ganglion cells and their axons. While glaucoma is primarily considered a genetic and age-related disease, some inflammatory conditions, such as uveitis and viral-induced anterior segment inflammation, cause secondary or uveitic glaucoma. Viruses are predominant ocular pathogens and can impose both acute and chronic pathological insults to the human eye. Many viruses, including herpes simplex virus, varicella-z...
Source: Clinical Microbiology Reviews - November 15, 2023 Category: Microbiology Authors: Faraz Ahmad Nikhil Deshmukh Aaron Webel Sandra Johnson Ayman Suleiman Rajiv R Mohan Frederick Fraunfelder Pawan Kumar Singh Source Type: research
Viral infections and pathogenesis of glaucoma: a comprehensive review
Clin Microbiol Rev. 2023 Nov 15:e0005723. doi: 10.1128/cmr.00057-23. Online ahead of print.ABSTRACTSUMMARYGlaucoma is a leading cause of irreversible blindness worldwide, caused by the gradual degeneration of retinal ganglion cells and their axons. While glaucoma is primarily considered a genetic and age-related disease, some inflammatory conditions, such as uveitis and viral-induced anterior segment inflammation, cause secondary or uveitic glaucoma. Viruses are predominant ocular pathogens and can impose both acute and chronic pathological insults to the human eye. Many viruses, including herpes simplex virus, varicella-z...
Source: Clinical Microbiology Reviews - November 15, 2023 Category: Microbiology Authors: Faraz Ahmad Nikhil Deshmukh Aaron Webel Sandra Johnson Ayman Suleiman Rajiv R Mohan Frederick Fraunfelder Pawan Kumar Singh Source Type: research
Viruses, Vol. 15, Pages 2258: High Seroprevalence of IgG Antibodies to Multiple Arboviruses in People Living with HIV (PLWHIV) in Madagascar
nçois Xavier Babin
Tahinamandranto Rasamoelina
Eric Delaporte
Luc Hervé Samison
Martine Peeters
Eric Nerrienet
Ahidjo Ayouba
To estimate the prevalence of IgG antibodies against six arboviruses in people living with HIV-1 (PLWHIV) in Madagascar, we tested samples collected between January 2018 and June 2021. We used a Luminex-based serological assay to detect IgG antibodies against antigens from Dengue virus serotypes 1–4 (DENV1–4), Zika virus (ZIKV), West Nile virus (WNV), Usutu virus (USUV), Chikungunya virus (CHIKV), and O’nyong nyong virus (ONNV). Of the 1036 ...
Source: Viruses - November 15, 2023 Category: Virology Authors: Fetra Angelot Rakotomalala Julie Bouillin Santatriniaina Dauphin Randriarimanana Guillaume Thaurignac Luca Maharavo Mihaja Raberahona Lucien Razafindrakoto Jasmina Rasoanarivo Mala Rakoto-Andrianarivelo Danielle Aurore Doll Rakoto Fran çois Xavier Babin Tags: Article Source Type: research
"What will the doctor give me, the same painkiller?": a qualitative study exploring health-care seeking and symptoms self-management among patients for the treatment of long-term chikungunya disease, in Cura çao
CONCLUSIONS: To promote the benefits of long-term health-care seeking and subsequently reduce the possible harmful use of analgesics, a collaborative physician-patient therapeutic relationship need to be encouraged. To facilitate this, important shifts may be needed in chikungunya sequalae education of both patients and health-care professionals, and policy makers need to revise health systems for the long-term provision of multidisciplinary care to achieve beneficial health outcomes in long-term chikungunya disease.PMID:37957621 | DOI:10.1186/s12913-023-10254-8 (Source: Pain Physician)
Source: Pain Physician - November 14, 2023 Category: Anesthesiology Authors: Churnalisa Doran Ashley Duits Izzy Gerstenbluth Adriana Tami Ajay Bailey Source Type: research
"What will the doctor give me, the same painkiller?": a qualitative study exploring health-care seeking and symptoms self-management among patients for the treatment of long-term chikungunya disease, in Cura çao
CONCLUSIONS: To promote the benefits of long-term health-care seeking and subsequently reduce the possible harmful use of analgesics, a collaborative physician-patient therapeutic relationship need to be encouraged. To facilitate this, important shifts may be needed in chikungunya sequalae education of both patients and health-care professionals, and policy makers need to revise health systems for the long-term provision of multidisciplinary care to achieve beneficial health outcomes in long-term chikungunya disease.PMID:37957621 | PMC:PMC10641972 | DOI:10.1186/s12913-023-10254-8 (Source: Pain Physician)
Source: Pain Physician - November 14, 2023 Category: Anesthesiology Authors: Churnalisa Doran Ashley Duits Izzy Gerstenbluth Adriana Tami Ajay Bailey Source Type: research
“What will the doctor give me, the same painkiller?”: a qualitative study exploring health-care seeking and symptoms self-management among patients for the treatment of long-term chikungunya disease, in Curaçao
Long-term chikungunya disease, characterized by persistent disabling rheumatic symptoms, including poly-arthralgia/arthritis of severe pain intensity, can persist for years after infection with the re-emerging... (Source: BMC Health Services Research)
Source: BMC Health Services Research - November 13, 2023 Category: General Medicine Authors: Churnalisa Doran, Ashley Duits, Izzy Gerstenbluth, Adriana Tami and Ajay Bailey Tags: Research Source Type: research
Novel strains of Culex flavivirus and Hubei chryso-like virus 1 from the Anopheles mosquito in western Kenya
In this study we used advanced molecular tools, such as DNA barcoding in combination with novel sequencing technologies to discover new and already known viruses in genetically identified mosquito species. Mosquitoes were captured using BG sentinel traps in Western Kenya during May and July 2019, and homogenized individually before pooled into groups of ten mosquitoes. The pools and individual samples were then used for molecular analysis and to infect cell cultures. Of a total of fifty-four (54) 10-pools, thirteen (13) showed cytopathic effect (CPE) on VeroB4 cells, eighteen (18) showed CPE on C6/36 cells. Eight (8) 10-po...
Source: Virus Research - November 9, 2023 Category: Virology Authors: Olivia Wesula Lwande Jonas N äslund Andreas Sj ödin Rebecca Lantto Verah Nafula Luande G öran Bucht Clas Ahlm Bernard Agwanda Vincent Obanda Magnus Evander Source Type: research
Novel strains of Culex flavivirus and Hubei chryso-like virus 1 from the Anopheles mosquito in western Kenya
In this study we used advanced molecular tools, such as DNA barcoding in combination with novel sequencing technologies to discover new and already known viruses in genetically identified mosquito species. Mosquitoes were captured using BG sentinel traps in Western Kenya during May and July 2019, and homogenized individually before pooled into groups of ten mosquitoes. The pools and individual samples were then used for molecular analysis and to infect cell cultures. Of a total of fifty-four (54) 10-pools, thirteen (13) showed cytopathic effect (CPE) on VeroB4 cells, eighteen (18) showed CPE on C6/36 cells. Eight (8) 10-po...
Source: Cell Research - November 9, 2023 Category: Cytology Authors: Olivia Wesula Lwande Jonas N äslund Andreas Sj ödin Rebecca Lantto Verah Nafula Luande G öran Bucht Clas Ahlm Bernard Agwanda Vincent Obanda Magnus Evander Source Type: research
One receptor, two worlds: MXRA8's alphavirus tango
Cell Host Microbe. 2023 Nov 8;31(11):1763-1764. doi: 10.1016/j.chom.2023.10.008.ABSTRACTMammalian MXRA8 functions as a receptor for chikungunya and other related alphaviruses. A recent study in Cell molecularly characterizes host-specific receptor usage, specifically showing avian MXRA8 acts as a receptor for several alphaviruses with avian reservoirs in an inverted manner relative to alphaviruses that use mammalian MXRA8 as a receptor.PMID:37944485 | DOI:10.1016/j.chom.2023.10.008 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - November 9, 2023 Category: Microbiology Authors: James Weger-Lucarelli Source Type: research
Novel strains of Culex flavivirus and Hubei chryso-like virus 1 from the Anopheles mosquito in western Kenya
In this study we used advanced molecular tools, such as DNA barcoding in combination with novel sequencing technologies to discover new and already known viruses in genetically identified mosquito species. Mosquitoes were captured using BG sentinel traps in Western Kenya during May and July 2019, and homogenized individually before pooled into groups of ten mosquitoes. The pools and individual samples were then used for molecular analysis and to infect cell cultures. Of a total of fifty-four (54) 10-pools, thirteen (13) showed cytopathic effect (CPE) on VeroB4 cells, eighteen (18) showed CPE on C6/36 cells. Eight (8) 10-po...
Source: Virus Research - November 9, 2023 Category: Virology Authors: Olivia Wesula Lwande Jonas N äslund Andreas Sj ödin Rebecca Lantto Verah Nafula Luande G öran Bucht Clas Ahlm Bernard Agwanda Vincent Obanda Magnus Evander Source Type: research
Novel strains of Culex flavivirus and Hubei chryso-like virus 1 from the Anopheles mosquito in western Kenya
In this study we used advanced molecular tools, such as DNA barcoding in combination with novel sequencing technologies to discover new and already known viruses in genetically identified mosquito species. Mosquitoes were captured using BG sentinel traps in Western Kenya during May and July 2019, and homogenized individually before pooled into groups of ten mosquitoes. The pools and individual samples were then used for molecular analysis and to infect cell cultures. Of a total of fifty-four (54) 10-pools, thirteen (13) showed cytopathic effect (CPE) on VeroB4 cells, eighteen (18) showed CPE on C6/36 cells. Eight (8) 10-po...
Source: Cell Research - November 9, 2023 Category: Cytology Authors: Olivia Wesula Lwande Jonas N äslund Andreas Sj ödin Rebecca Lantto Verah Nafula Luande G öran Bucht Clas Ahlm Bernard Agwanda Vincent Obanda Magnus Evander Source Type: research
One receptor, two worlds: MXRA8's alphavirus tango
Cell Host Microbe. 2023 Nov 8;31(11):1763-1764. doi: 10.1016/j.chom.2023.10.008.ABSTRACTMammalian MXRA8 functions as a receptor for chikungunya and other related alphaviruses. A recent study in Cell molecularly characterizes host-specific receptor usage, specifically showing avian MXRA8 acts as a receptor for several alphaviruses with avian reservoirs in an inverted manner relative to alphaviruses that use mammalian MXRA8 as a receptor.PMID:37944485 | DOI:10.1016/j.chom.2023.10.008 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - November 9, 2023 Category: Microbiology Authors: James Weger-Lucarelli Source Type: research
