Analysis in a murine model points to IgG responses against the 34k2 salivary proteins from < i > Aedes albopictus < /i > and < i > Aedes aegypti < /i > as novel promising candidate markers of host exposure to < i > Aedes < /i > mosquitoes
Conclusions/significanceOur study shows that exposure to bites ofAe.albopictus orAe.aegypti evokes in mice species-specific IgG responses to al34k2 or ae34k2, respectively. Deeper understanding of duration of antibody response and validation in natural conditions of human exposure toAedes mosquitoes are certainly needed. However, our findings point to the al34k2 salivary protein as a promising potential candidate for the development of immunoassays to evaluate human exposure toAe.albopictus. This would be a step forward in the establishment of a serological toolbox for the simultaneous assessment of human exposure toAedes ...
Source: PLoS Neglected Tropical Diseases - October 16, 2019 Category: Tropical Medicine Authors: Sara Buezo Montero Source Type: research

Population genetics of Aedes albopictus (Diptera: Culicidae) in its native range in Lao People ’s Democratic Republic
The Asian tiger mosquito, Aedes (Stegomyia) albopictus (Skuse) is an important worldwide invasive species and can be a locally important vector of chikungunya, dengue and, potentially, Zika. This species is nativ... (Source: Parasites and Vectors)
Source: Parasites and Vectors - October 14, 2019 Category: Microbiology Authors: Maysa Tiemi Motoki, Dina Madera Fonseca, Elliott Frederic Miot, Bruna Demari-Silva, Phoutmany Thammavong, Somsanith Chonephetsarath, Nothasine Phommavanh, Jeffrey Conrad Hertz, Pattamaporn Kittayapong, Paul Trevor Brey and Sebastien Marcombe Tags: Research Source Type: research

Differentiation of Long Non-Coding RNA and mRNA Expression Profiles in Male and Female Aedes albopictus
This study provides valuable data on sex-specific expression of protein-coding genes and lncRNAs in adult Ae. albopictus, which will guide further studies aimed at understanding sex development and determination mechanisms in this species. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - October 14, 2019 Category: Genetics & Stem Cells Source Type: research

Management of insecticide resistance in the major Aedes vectors of arboviruses: Advances and challenges
Conclusions and significanceAlthough IRM should be a fixture of all vector control programs, it is currently often absent from the strategic plans to control mosquito-borne diseases, especially arboviruses. Experiences from other public health disease vectors and agricultural pests underscore the need for urgent action in implementing IRM for invasiveAedes mosquitoes. Based on a plan developed for malaria vectors, here we propose some key activities to establish a global plan for IRM inAedes spp. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - October 10, 2019 Category: Tropical Medicine Authors: Isabelle Dusfour Source Type: research

Consensus and uncertainty in the geographic range of < i > Aedes aegypti < /i > and < i > Aedes albopictus < /i > in the contiguous United States: Multi-model assessment and synthesis
by Andrew J. Monaghan, Rebecca J. Eisen, Lars Eisen, Janet McAllister, Harry M. Savage, John-Paul Mutebi, Michael A. JohanssonAedes (Stegomyia) aegypti (L.) andAe.(Stegomyia) albopictus (Skuse) mosquitoes can transmit dengue, chikungunya, yellow fever, and Zika viruses. Limited surveillance has led to uncertainty regarding the geographic ranges of these vectors globally, and particularly in regions at the present-day margins of habitat suitability such as the contiguous United States. Empirical habitat suitability models based on environmental conditions can augment surveillance gaps to describe the estimated potential spe...
Source: PLoS Computational Biology - October 10, 2019 Category: Biology Authors: Andrew J. Monaghan Source Type: research

Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses
The magnitude and duration of vertebrate viremia is a critical determinant of arbovirus transmission, geographic spread, and disease severity. We find that multiple alphaviruses, including chikungunya (CHIKV), Ross River (RRV), and o'nyong 'nyong (ONNV) viruses, are cleared from the circulation of mice by liver Kupffer cells, impeding viral dissemination. Clearance from the circulation was independent of natural antibodies or complement factor C3, and instead relied on scavenger receptor SR-A6 (MARCO). Remarkably, lysine to arginine substitutions at distinct residues within the E2 glycoproteins of CHIKV and ONNV (E2 K200R)...
Source: eLife - October 9, 2019 Category: Biomedical Science Tags: Microbiology and Infectious Disease Source Type: research

Arboviral diseases in pediatrics †.
CONCLUSIONS: Children are especially vulnerable to this group of diseases due to characteristics that facilitate the development of the most severe forms. More detailed knowledge of this group of diseases allows the pediatrician to diagnose them earlier, implement the correct treatment, monitor warning signs for the most severe forms, and establish effective preventive measures. PMID: 31605670 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - October 9, 2019 Category: Pediatrics Authors: Martins MM, Prata-Barbosa A, Cunha AJLAD Tags: J Pediatr (Rio J) Source Type: research

Clinical evaluation of Acute Febrile Thrombocytopenia in Western Rajasthan - A hospital-based study.
CONCLUSION: The study showed that acute febrile thrombocytopenia is an important seasonal syndrome. The common causes are dengue fever and malaria. Early identification of these diseases and prompt treatment decreases complications and reduces mortality. PMID: 31593535 [PubMed - as supplied by publisher] (Source: Infectious Disorders Drug Targets)
Source: Infectious Disorders Drug Targets - October 8, 2019 Category: Infectious Diseases Authors: Choudhary S, Kumar D, Bohra GK, Gupta A, Meena DS, Yadav RS, Bhambu SK Tags: Infect Disord Drug Targets Source Type: research

A peridomestic < i > Aedes malayensis < /i > population in Singapore can transmit yellow fever virus
by Elliott F. Miot, Fabien Aubry, St éphanie Dabo, Ian H. Mendenhall, Sébastien Marcombe, Cheong H. Tan, Lee C. Ng, Anna-Bella Failloux, Julien Pompon, Paul T. Brey, Louis Lambrechts The case-fatality rate of yellow fever virus (YFV) is one of the highest among arthropod-borne viruses (arboviruses). Although historically, the Asia-Pacific region has remained free of YFV, the risk of introduction has never been higher due to the increasing influx of people from endemic regions and the recent outbreaks in Africa and South America. Singapore is a global hub for trade and tourism and therefore at high risk for Y...
Source: PLoS Neglected Tropical Diseases - October 7, 2019 Category: Tropical Medicine Authors: Elliott F. Miot Source Type: research

[S íntomas subagudos y crónicos de la fiebre de chikungunya en un grupo de personas adultas en Ibagué, Colombia].
Conclusiones. Los síntomas de la fase subaguda y crónica de la fiebre de chikungunya coincidieron con los descritos en la literatura médica, su duración se extendió hasta por un año o más en algunos de los casos y su intensidad disminuyó con el tiempo. Los síntomas referidos fueron más comunes en las mujeres que en los hombre. PMID: 31584771 [PubMed - in process] (Source: Biomedica : Revista del Instituto Nacional de Salud)
Source: Biomedica : Revista del Instituto Nacional de Salud - October 6, 2019 Category: International Medicine & Public Health Tags: Biomedica Source Type: research

Clinical profile and factors associated with hospitalization during a Chikungunya epidemic in Ceará, Brazil
CONCLUSIONS The pre-existing comorbidities have shown the potential to destabilize the patients' clinical status. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - October 4, 2019 Category: Tropical Medicine Source Type: research

A major chikungunya epidemic with high mortality in northeastern Brazil
CONCLUSIONS: Rapid transmission and high mortality rate are serious problems, especially in regions with co-circulating arboviruses. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - October 4, 2019 Category: Tropical Medicine Source Type: research

Association between vitiligo lesions and acute chikungunya infection: is there a causal relationship?
Abstract Reports of simultaneous infections and neoplasms in patients with acquired immune deficiency syndrome (AIDS) are occasionally seen in the literature. However, coexistent lymphoma with tuberculosis, and Kaposi sarcoma (KS) with tuberculosis occurring in the same lymph node is rare. Coexistent lesions pose diagnostic difficulties. In this article, we report two HIV-positive patients from Zimbabwe who displayed KS and tuberculosis; KS and diffuse large B-cell lymphoma in the same lymph node. We found only one similar case presentation in the literature, which was reported in India. (Source: Revista da Sociedade Brasi...
Source: Revista da Sociedade Brasileira de Medicina Tropical - October 4, 2019 Category: Tropical Medicine Source Type: research

Chikungunya vaccine candidate is shelf-stable
The multi-functional synthetic vaccine candidate doesn't require refrigeration (Source: Chemical and Engineering News)
Source: Chemical and Engineering News - October 2, 2019 Category: Chemistry Authors: Giuliana Viglione Source Type: research

Sylvatic cycles of arboviruses in non-human primates
Arboviruses infecting people primarily exist in urban transmission cycles involving urban mosquitoes in densely populated tropical regions. For dengue, chikungunya, Zika and yellow fever viruses, sylvatic (for... (Source: Parasites and Vectors)
Source: Parasites and Vectors - October 2, 2019 Category: Microbiology Authors: Matthew John Valentine, Courtney Cuin Murdock and Patrick John Kelly Tags: Review Source Type: research

Mayaro Virus Replication Restriction and Induction of Muscular Inflammation in Mice Are Dependent on Age, Type-I Interferon Response, and Adaptive Immunity
Mayaro virus (MAYV) is an emergent arbovirus first described in forest regions of the American continent, with recent and increasing notification of urban area circulation. Similar to Chikungunya (CHIKV) and other arthritogenic Alphavirus, MAYV-induced disease shows a high prevalence of persistent arthralgia, and myalgia. Despite this, knowledge regarding pathogenesis and characteristics of host immune response of MAYV infections are still limited. Here, using different ages of wild-type (WT), adult Type I Interferon receptor deficient (IFNAR–/–), and adult recombination activation gene-1 deficient (RAG–/...
Source: Frontiers in Microbiology - October 1, 2019 Category: Microbiology Source Type: research

Neuro-Chikungunya: Acute Transverse Myelopathy Associated with Chikungunya Virus Infection.
Authors: Kumar R, Rajvanshi P, Khosla H, Arora S Abstract Chikungunya is an arboviral infection caused by Chikungunya virus, an RNA virus from Togaviridae family.1 The disease manifests as fever, rash and characteristically, with arthralgia.1 Chikungunya is strongly believed to have neurotropism but has not been well studied like other neurotropic arboviruses.2 Encephalitis appears to represent the most common clinical manifestation6 and occurs either simultaneously or within few days of onset of systemic symptoms, during the period of viremia. A delay of more than two weeks has been reported with other complicatio...
Source: Journal of the Association of Physicians of India - September 30, 2019 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Seroprevalence of Zika virus among blood donors before the epidemic in Barranquilla, Colombia, 2015-2016.
The objective of the study was estimate the seroprevalence of ZIKV infection during the pre-epidemic phase in Barranquilla, Colombia, and demonstrate the presence of virus before the Colombian Ministry of Health confirmed the first case. We conducted a descriptive study of the seroprevalence of Zika virus in 390 samples obtained from a blood bank located in Barranquilla, Colombia - a city endemic for dengue, and with a recent history of a Chikungunya disease epidemic. The serum pools were tested using Euroimmun ZIKV ELISA kit. Seroprevalence of Zika virus IgG were: May 2015: 0%, June and July 2015: 2.62% (95% CI = 0.28-12....
Source: An Acad Bras Cienc - September 27, 2019 Category: Science Authors: Bayona-Pacheco B, Acosta-Reyes J, Navarro E, San-Juan H, Bula J, Baquero H Tags: An Acad Bras Cienc Source Type: research

Liaisons dangereuses: cross-border gene flow and dispersal of insecticide resistance-associated genes in the mosquito Aedes aegypti from Brazil and French Guiana.
CONCLUSIONS: The present study highlights the need for regional-local vector surveillance and transnational collaboration between neighboring countries to assess the impact of implemented vector control strategies, promote timely actions and develop preparedness plans. PMID: 31553370 [PubMed - in process] (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - September 26, 2019 Category: Infectious Diseases Authors: Salgueiro P, Restrepo-Zabaleta J, Costa M, Galardo AKR, Pinto J, Gaborit P, Guidez A, Martins AJ, Dusfour I Tags: Mem Inst Oswaldo Cruz Source Type: research

Secondary Autochthonous Outbreak of Chikungunya, Southern Italy, 2017
F. Riccardo et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - September 26, 2019 Category: Infectious Diseases Source Type: research

FHL1 is a major host factor for chikungunya virus infection
Nature, Published online: 25 September 2019; doi:10.1038/s41586-019-1578-4FHL1 is a key factor expressed by humans and mice that is required for chikungunya virus infection and is therefore a promising target for the development of therapies against chikungunya virus. (Source: Nature AOP)
Source: Nature AOP - September 25, 2019 Category: Research Authors: Laurent Meertens Mohamed Lamine Hafirassou Th érèse Couderc Lucie Bonnet-Madin Vasiliya Kril Beate M. K ümmerer Athena Labeau Alexis Brugier Etienne Simon-Loriere Julien Burlaud-Gaillard C écile Doyen Laura Pezzi Thibaud Goupil Sophia Rafasse Pierre-O Source Type: research

Reducing the cost and assessing the performance of a novel adult mass-rearing cage for the dengue, chikungunya, yellow fever and Zika vector, < i > Aedes aegypti < /i > (Linnaeus)
ConclusionThe low-cost mass-rearing prototype cage can be recommended to produceAe.aegypti in the context of rear and release techniques. The proposed adult-index can be used as a quick proxy of mosquito survival rates in mass-rearing settings. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - September 25, 2019 Category: Tropical Medicine Authors: Hamidou Ma ïga Source Type: research

GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 3: Epidemiological distribution of Mayaro virus
Publication date: Available online 20 September 2019Source: Antiviral ResearchAuthor(s): L. Pezzi, A.J. Rodriguez-Morales, C.B. Reusken, G.S. Ribeiro, A.D. LaBeaud, R. Lourenço-de-Oliveira, P. Brasil, M. Lecuit, A.B. Failloux, P. Gallian, T. Jaenisch, F. Simon, A.M. Siqueira, M.G. Rosa-Freitas, A. Vega Rua, S.C. Weaver, J.F. Drexler, N. Vasilakis, de Lamballerie X, S. Boyer (Source: Antiviral Therapy)
Source: Antiviral Therapy - September 21, 2019 Category: Virology Source Type: research

GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 2: Epidemiological distribution of o'nyong-nyong virus
Publication date: Available online 20 September 2019Source: Antiviral ResearchAuthor(s): L. Pezzi, A.D. LaBeaud, C.B. Reusken, J.F. Drexler, N. Vasilakis, M. Diallo, F. Simon, T. Jaenisch, P. Gallian, A. Sall, A.B. Failloux, S.C. Weaver, X. de Lamballerie, S. Boyer, P. Brasil, M. Busch, M.S. Diamond, M.A. Drebot, A. Kohl, M. Lecuit (Source: Antiviral Therapy)
Source: Antiviral Therapy - September 21, 2019 Category: Virology Source Type: research

GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 2: Epidemiological distribution of o'nyong-nyong virus.
PMID: 31545982 [PubMed - as supplied by publisher] (Source: Antiviral Research)
Source: Antiviral Research - September 20, 2019 Category: Virology Authors: Pezzi L, LaBeaud AD, Reusken CB, Drexler JF, Vasilakis N, Diallo M, Simon F, Jaenisch T, Gallian P, Sall A, Failloux AB, Weaver SC, de Lamballerie X, GloPID-R chikungunya, o'nyong-nyong and Mayaro virus Working Group Tags: Antiviral Res Source Type: research

GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 3: Epidemiological distribution of Mayaro virus.
X, GloPID-R chikungunya, o'nyong-nyong and Mayaro virus Working Group PMID: 31545981 [PubMed - as supplied by publisher] (Source: Antiviral Research)
Source: Antiviral Research - September 20, 2019 Category: Virology Authors: Pezzi L, Rodriguez-Morales AJ, Reusken CB, Ribeiro GS, LaBeaud AD, Lourenço-de-Oliveira R, Brasil P, Lecuit M, Failloux AB, Gallian P, Jaenisch T, Simon F, Siqueira AM, Rosa-Freitas MG, Vega Rua A, Weaver SC, Drexler JF, Vasilakis N, de Lamballerie X, Gl Tags: Antiviral Res Source Type: research

Selected arboviral diseases imported to Poland - current state of knowledge and perspectives for research.
CONCLUSIONS: Further epidemiologic studies in Polish travellers are necessary in order to prevent importation or introduction of the above-mentioned viruses, and to act against potential problems related to blood transfusion or organ transplantation from infected donors. PMID: 31559790 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)
Source: Annals of Agricultural and Environmental Medicine : AAEM - September 19, 2019 Category: Environmental Health Authors: Kuna A, Gajewski M, Biernat B Tags: Ann Agric Environ Med Source Type: research

Viruses, Vol. 11, Pages 867: Vector Competence: What Has Zika Virus Taught Us?
ver The unprecedented outbreak of Zika virus (ZIKV) infection in the Americas from 2015 to 2017 prompted the publication of a large body of vector competence data in a relatively short period of time. Although differences in vector competence as a result of disparities in mosquito populations and viral strains are to be expected, the limited competence of many populations of the urban mosquito vector, Aedes aegypti, from the Americas (when its susceptibility is viewed relative to other circulating/reemerging mosquito-borne viruses such as dengue (DENV), yellow fever (YFV), and chikungunya viruses (CHIKV)) has proven a ...
Source: Viruses - September 17, 2019 Category: Virology Authors: Sasha R. Azar Scott C. Weaver Tags: Review Source Type: research

Authors' response to the letter to the editor entitled: Co-circulation of dengue, chikungunya, and Zika viruses and cross-protection.
Authors: Rico-Mendoza A, Porras-Ramírez A, Chang A, Encinales L, Lynch R Abstract PMID: 31507639 [PubMed] (Source: Pan American Journal of Public Health)
Source: Pan American Journal of Public Health - September 13, 2019 Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research

Co-circulation of dengue, chikungunya, and Zika viruses and cross-protection.
Authors: Joob B, Wiwanitkit V Abstract PMID: 31507637 [PubMed] (Source: Pan American Journal of Public Health)
Source: Pan American Journal of Public Health - September 13, 2019 Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research

Chikungunya-attributable deaths: A neglected outcome of a neglected disease
by Antonio S. Lima Neto, Geziel S. Sousa, Osmar J. Nascimento, Marcia C. Castro (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - September 12, 2019 Category: Tropical Medicine Authors: Antonio S. Lima Neto Source Type: research

Viral encephalitis: a practical review on diagnostic approach and treatment.
CONCLUSION: Clinical data, laboratory results, and neuroimaging findings support the diagnosis of encephalitis and the specific viral etiology. To increase the likelihood of etiologic confirmation, it is important to know the best approach to collecting samples and to choose the best identification technique for each virus. The differential diagnosis of viral encephalitis includes other infections and immune-mediated inflammatory central nervous system disorders. PMID: 31513761 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - September 9, 2019 Category: Pediatrics Authors: Costa BKD, Sato DK Tags: J Pediatr (Rio J) Source Type: research

Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila
Publication date: 3 September 2019Source: Cell Reports, Volume 28, Issue 10Author(s): Rong Zhang, James T. Earnest, Arthur S. Kim, Emma S. Winkler, Pritesh Desai, Lucas J. Adams, Gaowei Hu, Christopher Bullock, Beth Gold, Sara Cherry, Michael S. DiamondSummaryMxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O’nyong nyong (ONNV) viruses. To determine its role in pathogenesis, we generated mice with mutant Mxra8 alleles: an 8-nucleotide deletion that produces a truncated, soluble form (Mxra8Δ8/Δ8) and a 97-nucleotide deleti...
Source: Cell Reports - September 5, 2019 Category: Cytology Source Type: research

Dengue and chikungunya among outpatients with acute undifferentiated fever in Kinshasa, Democratic Republic of Congo: A cross-sectional study
DiscussionChikungunya outbreaks have been reported in the study area in the past, so the high seroprevalence is not surprising. However, scarce evidence exists on dengue transmission in Kinshasa and based on our data, circulation is more important than previously reported. Furthermore, our study shows that the prescription of antibiotics, both antibacterial and antimalarial drugs, is rampant. Studies like this one, elucidating the causes of acute fever, may lead to a more considerate and rigorous use of antibiotics. This will not only stem the ever-increasing problem of antimicrobial resistance, but will –ultimately ...
Source: PLoS Neglected Tropical Diseases - September 5, 2019 Category: Tropical Medicine Authors: Sam Proesmans Source Type: research

Aedes spp. and Their Microbiota: A Review
Aedes spp. are a major public health concern due to their ability to be efficient vectors of dengue, Chikungunya, Zika and other arboviruses. With limited vaccines available and no effective therapeutic treatments against arboviruses, the control of Aedes spp. populations is currently the only strategy to prevent disease transmission. Host-associated microbes (i.e. microbiota) recently emerged as a promising field to be explored for novel environmentally-friendly vector control strategies. In particular, gut microbiota is revealing its impact on multiple aspects of Aedes spp. biology, including vector competence, thus bein...
Source: Frontiers in Microbiology - September 4, 2019 Category: Microbiology Source Type: research

Chikungunya virus requires cellular chloride channels for efficient genome replication
In this study, we investigated the role of host-cell chloride (Cl-) channels on CHIKV replication.We demonstrate that specific pharmacological Cl- channel inhibitors significantly inhibit CHIKV replication in a dose-dependent manner, suggesting that Cl-channels are pro-viral factors in human cells. Further analysis of the effect of the inhibitors on CHIKV attachment, entry, viral protein expression and replicon replication demonstrated that Cl- channels are specifically required for efficient CHIKV genome replication. This was conserved in mosquito cells, where CHIKV replication and genome copy number was significantly red...
Source: PLoS Neglected Tropical Diseases - September 4, 2019 Category: Tropical Medicine Authors: Marietta M üller Source Type: research

Clinical, laboratorial diagnosis and prophylaxis of measles in Brazil
ABSTRACT Measles is an acute febrile exanthematic disease of viral etiology, highly contagious, being the cause of morbidity and mortality of children in developing countries, whereas it has become rarer in developed countries due to vaccination. Its differential diagnosis should be made with other childhood viral respiratory diseases such as influenza, rhinovirus and adenovirus, and exanthematic febrile diseases such as rubella, roseola and varicella. In tropical regions, it should be performed with dengue, zika and chikungunya. Its clinical picture presents the following phases: incubation, usually asymptomatic; a prodro...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - September 3, 2019 Category: Pathology Source Type: research

Rheumatic manifestations of chikungunya: emerging concepts and interventions
Nature Reviews Rheumatology, Published online: 03 September 2019; doi:10.1038/s41584-019-0276-9Chikungunya can be a mild and self-limiting disease, but can also involve a complex spectrum of atypical, severe and/or chronic rheumatic manifestations that place a considerable burden on individuals. New strategies are under development to help treat and prevent this disease. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - September 3, 2019 Category: Rheumatology Authors: Andreas Suhrbier Source Type: research

Isolation of phenanthrenes and identification of phorbol ester derivatives as potential anti-CHIKV agents using FBMN and NAP from Sagotia racemosa
Publication date: November 2019Source: Phytochemistry, Volume 167Author(s): Simon Remy, Deyvis Solis, Pierre Silland, Johan Neyts, Fanny Roussi, David Touboul, Marc LitaudonAbstractIn an effort to identify inhibitors of Chikungunya virus (CHIKV) replication, a systematic study of 594 extracts of plant species originating from the French Guiana plateau region was performed in a virus-cell-based assay for CHIKV assay. The extract obtained from the stem bark of Sagotia racemosa was selected for its potent antiviral activity. Using a classical bioassay-guided procedure, three undescribed degraded diterpenoids, i.e. trigohowilo...
Source: Phytochemistry - August 31, 2019 Category: Chemistry Source Type: research

Chikungunya fever and mental illness: a poorly understood relationship needing additional study
Discussion There is in adequate awareness of anxiety and depressive disorders among non-psychiatric clinicians in general hospitals in China. This awareness/understanding increased with increasing hospital level. (Source: Revista de Psiquiatria Clinica)
Source: Revista de Psiquiatria Clinica - August 30, 2019 Category: Psychiatry Source Type: research

IJERPH, Vol. 16, Pages 3165: Climatic Conditions: Conventional and Nanotechnology-Based Methods for the Control of Mosquito Vectors Causing Human Health Issues
Scholz Climate variability is highly impacting on mosquito-borne diseases causing malaria and dengue fever across the globe. Seasonal variability change in temperature and rainfall patterns are impacting on human health. Mosquitoes cause diseases like dengue fever, yellow fever, malaria, Chikungunya, West Nile and Japanese encephalitis. According to estimations by health organizations, annually one million human deaths are caused by vector-borne diseases, and dengue fever has increased about 30-fold over the past 50 years. Similarly, over 200 million cases of malaria are being reported annually. Mosquito-borne disease...
Source: International Journal of Environmental Research and Public Health - August 30, 2019 Category: Environmental Health Authors: Toqeer Ahmed Muhammad Zeeshan Hyder Irfan Liaqat Miklas Scholz Tags: Review Source Type: research

Evaluation of larvicidal activity of esters of 4-mercapto-2-butenoic acid against Aedes albopictus (Diptera: Culicidae)
Publication date: September 2019Source: Saudi Journal of Biological Sciences, Volume 26, Issue 6Author(s): Marco Pezzi, Francesco Zamberlan, Milvia Chicca, Marilena LeisAbstractAedes albopictus (Skuse) (Diptera: Culicidae), an aggressive and annoying vector of several arbovirus including Chikungunya and Zika, is a serious health problem worldwide. Control of this mosquito is difficult because of high adaptability, egg resistance to dehydration and ability to exploit many man-made microhabitats. The most effective strategy appears the control of larval population. Based on previous data showing a larvicidal effect of plant ...
Source: Saudi Journal of Biological Sciences - August 29, 2019 Category: Biology Source Type: research

Toxic effect of essential oil and its compounds isolated from Sphaeranthus amaranthoides Burm. f. against dengue mosquito vector Aedes aegypti Linn.
Publication date: Available online 28 August 2019Source: Pesticide Biochemistry and PhysiologyAuthor(s): Annamalai Thanigaivel, Kanagaraj Muthu-Pandian Chanthini, Sengodan Karthi, Prabhakaran Vasantha-Srinivasan, Athirstam Ponsankar, Haridoss Sivanesh, Vethamonickam Stanley-Raja, Narayanan Shyam-Sundar, Kilapavoor Raman Narayanan, Sengottayan Senthil-NathanAbstractAedes aegypti is a major mosquito vector that can transfer many deadly diseases such as dengue, chikungunya, Zika, and yellow fever viruses. Due to the developing resistance among the vector populations by the application of chemical insecticides, alternative eco...
Source: Pesticide Biochemistry and Physiology - August 29, 2019 Category: Biochemistry Source Type: research

Viruses, Vol. 11, Pages 798: Updated Phylogeny of Chikungunya Virus Suggests Lineage-Specific RNA Architecture
. Wolfinger Chikungunya virus (CHIKV), a mosquito-borne alphavirus of the family Togaviridae, has recently emerged in the Americas from lineages from two continents: Asia and Africa. Historically, CHIKV circulated as at least four lineages worldwide with both enzootic and epidemic transmission cycles. To understand the recent patterns of emergence and the current status of the CHIKV spread, updated analyses of the viral genetic data and metadata are needed. Here, we performed phylogenetic and comparative genomics screens of CHIKV genomes, taking advantage of the public availability of many recently sequenced isolates. ...
Source: Viruses - August 29, 2019 Category: Virology Authors: Adriano de Bernardi Schneider Roman Ochsenreiter Reilly Hostager Ivo L. Hofacker Daniel Janies Michael T. Wolfinger Tags: Article Source Type: research

Macropinocytosis Dependent Entry of Chikungunya Virus into Human Muscle Cells
This study shows for the first time, that the infectious entry of CHIKV into human muscle cells is mediated by macropinocytosis. Together, the da ta from this study may pave the way for the development of specific inhibitors that target the entry process of CHIKV into cells. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - August 26, 2019 Category: Tropical Medicine Authors: Ching Hua, Regina Lee Source Type: research

Is the brazilian diverse environment is a crib for the emergence and maintenance of exotic arboviruses?
Abstract We review the potential of Amazon forest as a source for circulation and maintenance of native arboviruses as well its capacity to host exotic arboviruses introduced in Brazil during their process of adapting to the Amazon environment. After a brief introduction about arboviruses isolated in Amazon region and description of the main arboviruses pathogenic to humans, we highlight the history of the last two exotic viruses introduced in Brazil - Chikungunya virus (CHIKV) and Zika virus (ZIKV) - and their consequences to the public health. Finally, we discuss and hypothesize what will happen with them after ...
Source: An Acad Bras Cienc - August 26, 2019 Category: Science Authors: Medeiros DBA, Vasconcelos PFC Tags: An Acad Bras Cienc Source Type: research

Viruses, Vol. 11, Pages 779: Chikungunya Virus and (Re-) Emerging Alphaviruses
ang Alphaviruses belong to a family of positive sense, single-stranded RNA viruses that are transmitted mainly by mosquitoes through a blood meal and cause arthritis and/or encephalitis in humans and animals [...] (Source: Viruses)
Source: Viruses - August 24, 2019 Category: Virology Authors: Penghua Wang Rong Zhang Tags: Editorial Source Type: research

Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 protein.
Abstract Alphavirus nsP3 proteins contain long, intrinsically disordered, hypervariable domains, HVD, which serve as hubs for interaction with many cellular proteins. Here, we have deciphered the mechanism and function of HVD interaction with host factors in alphavirus replication. Using NMR spectroscopy, we show that CHIKV HVD contains two SH3 domain-binding sites. Using an innovative chemical shift perturbation signature approach, we demonstrate that CD2AP interaction with HVD is mediated by its SH3-A and SH3-C domains, and this leaves the SH3-B domain available for interaction with other cellular factor(s). Thi...
Source: Virology - August 22, 2019 Category: Virology Authors: Agback P, Dominguez F, Pustovalova Y, Lukash T, Shiliaev N, Orekhov VY, Frolov I, Agback T, Frolova EI Tags: Virology Source Type: research

The use of green fluorescent protein-tagged virus-like particles as a tracer in the early phase of chikungunya infection.
Abstract To visually examine the early phase of chikungunya virus (CHIKV) infection in target cells, we constructed a virus-like particle (VLP) in which the envelope protein E1 is fused with green fluorescent protein (GFP). This chikungunya VLP-GFP (CHIK-VLP-EGFP), purified by density gradient fractionation, was observed as 60-70 nm-dia. particles and was detected as tiny puncta of fluorescence in the cells. CHIK-VLP-EGFP showed binding properties similar to those of the wild-type viruses. Most of the fluorescence signals that had bound on Vero cells disappeared within 30 min at 37 °C, but...
Source: Virus Research - August 21, 2019 Category: Virology Authors: Tumkosit U, Maeda Y, Kishishita N, Siripanyaphinyo U, Omori H, Chetanachan P, Sittisaman P, Jityam C, Priengprom T, Mizushima H, Wongjaroen P, Mekada E, Tatsumi M, Takeda N, Tanaka A Tags: Virus Res Source Type: research