Transmission dynamics of dengue and chikungunya in a changing climate: do we understand the eco-evolutionary response?
Authors: Tozan Y, Sjödin H, Muñoz ÁG, Rocklöv J Abstract INTRODUCTION: We are witnessing an alarming increase in the burden and range of mosquito-borne arboviral diseases. The transmission dynamics of arboviral diseases is highly sensitive to climate and weather and is further affected by non-climatic factors such as human mobility, urbanization, and disease control. As evidence also suggests, climate-driven changes in species interactions may trigger evolutionary responses in both vectors and pathogens with important consequences for disease transmission patterns. AREAS COVERED: Focusin...
Source: Expert Review of Anti-Infective Therapy - August 4, 2020 Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research

Viruses, Vol. 12, Pages 853: Chikungunya virus Detection in Aedes aegypti and Culex quinquefasciatus during an Outbreak in the Amazon Region
icardo José de Paula Souza e Guimarães Carine Fortes Aragão Lívia Carício Martins Chikungunya virus (CHIKV) was first reported in Brazil in 2014 and, after it spread countrywide, an outbreak of febrile illness with reports of arthralgia happened in the municipality of Xinguara, Pará, Brazil in 2017, indicating the virus’ circulation. Here, we aimed to investigate CHIKV in mosquito vectors collected during an active surveillance of virus isolation in cell culture by using molecular detection and viral genome sequencing. A total of 492 Aedes, Culex and M...
Source: Viruses - August 4, 2020 Category: Virology Authors: Ana Cec ília Ribeiro Cruz Joaquim Pinto Nunes Neto Sandro Patroca da Silva Eliana Vieira Pinto da Silva Glennda Juscely Galv ão Pereira Maissa Maia Santos Hamilton Ant ônio de Oliveira Monteiro Flavia Barreto dos Santos Ricardo Jos é de Paula Souza e Tags: Article Source Type: research

Update on the treatment of musculoskeletal manifestations in chikungunya fever: a guideline
Abstract Since the emergence of the chikungunya virus in Brazil in 2014, more than 700,000 cases have been reported throughout the country, corresponding to one-third of all cases reported in the Americas. In addition to its high attack rates, resulting in hundreds of thousands of cases, the disease has high chronicity rates with persistent joint manifestations for more than 3 months, which can spread to more than half of the patients affected in the acute phase. Pain associated with musculoskeletal manifestations, often disabling, has an effect on patients ’ quality of life at different stages of the disease. Curren...
Source: Revista da Sociedade Brasileira de Medicina Tropical - July 31, 2020 Category: Tropical Medicine Source Type: research

[Methodological quality assessment of guidelines for surveillance and clinical management of dengue and chikungunya].
YHM Abstract The study aimed to assess the methodological quality of guidelines by the Brazilian Ministry of Health, Pan American Health Organization (PAHO), and World Health Organization (WHO) on surveillance and clinical management of dengue and chikungunya. This was a descriptive study in which the tool Appraisal of Guidelines for Research & Evaluation Reporting Checklist II (AGREE II) was applied by four evaluators in independent and masked fashion for six guidelines. Each evaluator assigned a score from 1 (disagree completely) to 7 (agree completely) to the 23 items in the AGREE II domains: scope and purp...
Source: Cadernos de Saude Publica - July 31, 2020 Category: International Medicine & Public Health Authors: Feitosa MC, Leite PHADC, Costa JH, Hökerberg YHM Tags: Cad Saude Publica Source Type: research

Molecules, Vol. 25, Pages 3484: Plant Natural Products for the Control of Aedes aegypti: The Main Vector of Important Arboviruses
pes Vieira The mosquito species Aedes aegypti is one of the main vectors of arboviruses, including dengue, Zika and chikungunya. Considering the deficiency or absence of vaccines to prevent these diseases, vector control remains an important strategy. The use of plant natural product-based insecticides constitutes an alternative to chemical insecticides as they are degraded more easily and are less harmful to the environment, not to mention their lower toxicity to non-target insects. This review details plant species and their secondary metabolites that have demonstrated insecticidal properties (ovicidal, larvicidal...
Source: Molecules - July 31, 2020 Category: Chemistry Authors: Silv ério Espindola Lopes Vieira Tags: Review Source Type: research

Viruses, Vol. 12, Pages 830: Effects of Mosquito Biology on Modeled Chikungunya Virus Invasion Potential in Florida
W. Alto Arboviruses transmitted by Aedes aegypti and Aedes albopictus have been introduced to Florida on many occasions. Infrequently, these introductions lead to sporadic local transmission and, more rarely, sustained local transmission. Both mosquito species are present in Florida, with spatio-temporal variation in population composition. We developed a two-vector compartmental, deterministic model to investigate factors influencing Chikungunya virus (CHIKV) establishment. The model includes a nonlinear, temperature-dependent mosquito mortality function based on minimum mortality in a central temperature region. Lati...
Source: Viruses - July 30, 2020 Category: Virology Authors: Cynthia C. Lord L. Philip Lounibos Joseph J. Pohedra Barry W. Alto Tags: Article Source Type: research

The great potential of entomopathogenic bacteria Xenorhabdus and Photorhabdus for mosquito control: a review
The control of insects of medical importance, such as Aedes aegypti and Aedes albopictus are still the only effective way to prevent the transmission of diseases, such as dengue, chikungunya and Zika. Their contr... (Source: Parasites and Vectors)
Source: Parasites and Vectors - July 29, 2020 Category: Microbiology Authors: Wellington Junior da Silva, Harry Luiz Pilz-J únior, Ralf Heermann and Onilda Santos da Silva Tags: Review Source Type: research

IgG Antibody Responses to the Aedes albopictus 34k2 Salivary Protein as Novel Candidate Marker of Human Exposure to the Tiger Mosquito
In this study we measured IgG responses to al34k2 and to Ae. albopictus salivary gland protein extracts (SGE) in individuals naturally exposed to the tiger mosquito. Sera were collected in two areas of Northeast Italy (Padova and Belluno) during two different time periods: at the end of the low- and shortly after the high-density mosquito seasons. Anti-SGE and anti-al34k2 IgG levels increased after the summer period of exposure to mosquito bites and were higher in Padova as compared to Belluno. An age-dependent decrease of anti-saliva IgG responses was found especially in Padova, an area with at least 25 years history of A...
Source: Frontiers in cellular and infection microbiology - July 29, 2020 Category: Microbiology Source Type: research

Viruses, Vol. 12, Pages 823: Profiling Transcripts of Vector Competence between Two Different Aedes aegypti Populations in Florida
martt A Chikungunya virus (CHIKV) outbreak in Italy in 2007 spread to include the islands of the Caribbean and most of the Americas and still circulates in Europe and Africa. Florida being close in distance to the Caribbean islands experienced a CHIKV outbreak in 2014 and continues to have a few travel-related cases each year. It is known that different environmental conditions in different regions can result in genetic variation that favor changes in competence to arbovirus. We evaluated the vector competence of Florida Aedes aegypti for CHIKV and determined if there is a geographic component that influences genes inv...
Source: Viruses - July 29, 2020 Category: Virology Authors: Dongyoung Shin Seokyoung Kang Chelsea T. Smartt Tags: Article Source Type: research

Figure Error
In the Original Investigation titled “Effect of a Chikungunya Virus–Like Particle Vaccine on Safety and Tolerability Outcomes: A Randomized Clinical Trial,” published in the April 14, 2020, issue of JAMA, a decimal was missing in the lowest number on the y-axis of Figure 3. The number “75” should have been “7.5.” This art icle was corrected online. (Source: JAMA)
Source: JAMA - July 28, 2020 Category: General Medicine Source Type: research

Reduced Duration of Postchikungunya Musculoskeletal Pain in Rheumatological Patients Treated with Biologicals.
This study was performed to evaluate the clinical course of the infection in 168 patients with autoimmune inflammatory disease using biological disease-modifying antirheumatic drugs (bDMARDs), comparing this group with 56 household controls. Anti-CHIKV IgG serology was positive in 42 (25%) of the patients in the bDMARD group and in 15 (27%) of the controls (p=0.79). Of those with positive serology, 32 (76%) and 14 (93%) were symptomatic among subjects in the bDMARD and control groups, respectively (p=0.87). Persistence of musculoskeletal symptoms for more than three months occurred in 64% of the patients in the control gro...
Source: Journal of Tropical Medicine - July 24, 2020 Category: Tropical Medicine Tags: J Trop Med Source Type: research

Association of Dengue Virus and Leptospira Co-Infections with Malaria Severity.
Abstract Plasmodium infections are co-endemic with infections caused by other agents of acute febrile illnesses, such as dengue virus (DENV), chikungunya virus, Leptospira spp., and Orientia tsutsugamushi. However, co-infections may influence disease severity, treatment outcomes, and development of drug resistance. When we analyzed cases of acute febrile illness at the All India Institute of Medical Sciences, New Delhi, India, from July 2017 through September 2018, we found that most patients with malaria harbored co-infections (Plasmodium mixed species and other pathogens). DENV was the most common malaria co-inf...
Source: Emerging Infectious Diseases - July 22, 2020 Category: Infectious Diseases Authors: Mandage R, Kaur C, Pramanik A, Kumar V, Kodan P, Singh A, Saha S, Pandey S, Wig N, Pandey RM, Soneja M, Acharya P Tags: Emerg Infect Dis Source Type: research

A clinical scoring system to predict long-term arthralgia in Chikungunya disease: A  cohort study
by Laise de Moraes, Thiago Cerqueira-Silva, Victor Nobrega, Kevan Akrami, Luciane Amorim Santos, Cibele Orge, Paula Casais, Lais Cambui, Rita de C ássia Pontello Rampazzo, Karen Soares Trinta, Camila Amato Montalbano, Maria Jania Teixeira, Luciano Pamplona Cavalcante, Bruno B. Andrade, Rivaldo Venâncio da Cunha, Marco Aurélio Krieger, Manoel Barral-Netto, Aldina Barral, Ricardo Khouri, Viviane Sampaio Boaventura BackgroundChikungunya virus (CHIKV) has caused worldwide epidemics that impose a major burden on health systems. Approximately half of infected individuals develop chronic debilitating arthralgi...
Source: PLoS Neglected Tropical Diseases - July 21, 2020 Category: Tropical Medicine Authors: Laise de Moraes Source Type: research

Quantifying sociodemographic heterogeneities in the distribution of < i > Aedes aegypti < /i > among California households
by Marisa A. P. Donnelly, Susanne Kluh, Robert E. Snyder, Christopher M. Barker The spread ofAedes aegypti in California and other regions of the U.S. has increased the need to understand the potential for local chains ofAe.aegypti-borne virus transmission, particularly in arid regions of the state where the ecology of these mosquitoes is less understood. For public health and vector control programs, it is helpful to know whether variation in risk of local transmission can be attributed to socio-demographic factors that could help to target surveillance and control programs. Socio-demographic factors have been shown to i...
Source: PLoS Neglected Tropical Diseases - July 21, 2020 Category: Tropical Medicine Authors: Marisa A. P. Donnelly Source Type: research

Serological evidence of exposure to Rift Valley, Dengue and Chikungunya Viruses  among agropastoral communities in Manyara and Morogoro regions in Tanzania: A community survey
We report a considerable exposure to RVFV and CHIKV among Wami-Dakawa residents during the dry season and an absence of exposure of the viruses among hum ans in Magugu site. In both sites, no DENV exposure nor infection was detected. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - July 20, 2020 Category: Tropical Medicine Authors: Rule M. Budodo Source Type: research

Interepidemic Detection of Chikungunya Virus Infection and Transmission in Northeastern Thailand.
This study clearly demonstrated the presence and local transmission of the ECSA genotype of CHIKV in the northeastern region of Thailand. PMID: 32700661 [PubMed - as supplied by publisher] (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - July 20, 2020 Category: Tropical Medicine Authors: Le BCT, Ekalaksananan T, Thaewnongiew K, Phanthanawiboon S, Aromseree S, Phanitchat T, Chuerduangphui J, Suwannatrai AT, Alexander N, Overgaard HJ, Bangs MJ, Pientong C Tags: Am J Trop Med Hyg Source Type: research

[Hemicerebellitis due to chikungunya associated with refractory status epilepticus in the paediatric age].
co-Tovar GA PMID: 32672351 [PubMed - in process] (Source: Revista de Neurologia)
Source: Revista de Neurologia - July 18, 2020 Category: Neurology Authors: Ramírez-Zamora M, Veliz-Martínez V, Barahona GE, Mena ID, Ortez CI, Nolasco-Tovar GA Tags: Rev Neurol Source Type: research

Cell fusing agent virus ( Flavivirus ) infection in Aedes aegypti in Texas: seasonality, comparison by trap type, and individual viral loads
AbstractSouth Texas has experienced local transmission of Zika virus and of other mosquito-borne viruses such as chikungunya virus and dengue virus in the last decades. Using a mosquito surveillance program in the Lower Rio Grande Valley (LRGV) and San Antonio, TX, from 2016 to 2018, we detected the presence of an insect-specific virus, cell fusing agent virus (CFAV), in theAedes aegypti mosquito population. We tested 6,326 females and 1,249 males from the LRGV and 659 females from San Antonio for CFAV by RT-PCR using specific primers. Infection rates varied from 0 to 261 per 1,000 mosquitoes in the LRGV and 115 to 208 per...
Source: Archives of Virology - July 10, 2020 Category: Virology Source Type: research

Is Chikungunya Virus Infection an Independent Risk Factor for 2-Year Mortality in Older Afro-Caribbean Subjects?
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - July 9, 2020 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

First report of Chikungunya fever in Rawalpindi, Pakistan.
Conclusions: The clinical features observed and investigated confirmed our reporting of the first case of chikungunya in Rawalpindi, Pakistan. PMID: 32621511 [PubMed - in process] (Source: Eastern Mediterranean Health Journal)
Source: Eastern Mediterranean Health Journal - July 7, 2020 Category: Middle East Health Tags: East Mediterr Health J Source Type: research

Artificial Selection Finds New Hypotheses for the Mechanism of Wolbachia-Mediated Dengue Blocking in Mosquitoes
In this study, we investigate the genetic variation associated with blocking and use these analyses to generate testable hypotheses surrounding the mechanism of Wolbachia-mediated dengue blocking. From our results, we hypothesize that Wolbachia may block virus replication by increasing the regeneration rate of mosquito cells via the Notch signaling pathway. We also propose that Wolbachia modulates the host’s transcriptional pausing pathway either to prime the host’s anti-viral response or to directly inhibit viral replication. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - July 7, 2020 Category: Microbiology Source Type: research

The role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases.
Abstract Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of the heterocyclic aromatic compound quinoline. These economical compounds were used as antimalarial agents for many years. Currently, they are used as monotherapy or in conjunction with other therapies for the treatment of autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren's syndrome (SS) and antiphospholipid antibody syndrome (APS). Based on its effects on the modulation of the autophagy process, various clinical studies suggest that CQ and HCQ could be used in combination with other chemo...
Source: Current Pharmaceutical Design - July 7, 2020 Category: Drugs & Pharmacology Authors: Martinez GP, Zabaleta ME, Di Giulio C, Charris JE, Mijares MR Tags: Curr Pharm Des Source Type: research

Phylogenetic analysis of the ATP-binding cassette proteins suggests a new ABC protein subfamily J in Aedes aegypti (Diptera: Culicidae)
We performed an in-depth analysis of the ABC gene family in Aedes aegypti (Diptera: Culicidae), which is an important vector species of arthropod-borne viral infections such as chikungunya, dengue, and Zika. Desp... (Source: BMC Genomics)
Source: BMC Genomics - July 6, 2020 Category: Genetics & Stem Cells Authors: Janaina Figueira-Mansur, Carlos G. Schrago, Tiago S. Salles, Evelyn S. L. Alvarenga, Brenda M. Vasconcellos, Ana Claudia A. Melo and Monica F. Moreira Tags: Research article Source Type: research

High proportion of Guillain-Barre syndrome associated with chikungunya in Northeast Brazil
From 2013 to 2015, sanitary authorities reported an increased incidence of Guillain-Barré syndrome (GBS) associated with Zika virus (ZIKV) in French Polynesia, Caribbean, and Brazil.1–3 After the end of ZIKV epidemics, GBS cases where still above the usual limits in countries where the arrival of chikungunya virus (CHIKV) was also a concern.3 (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - July 6, 2020 Category: Neurology Authors: Matos, A. d. M. B., Maia Carvalho, F. M., Malta, D. L., Rodrigues, C. L., Felix, A. C., Pannuti, C. S., Lima, A. D. d. R., Esposito, D. L. A., dos Santos, L. M. B., von Glehn, F., Colares, J. K. B., da Fonseca, B. A. L., de Oliveira, A. C. P., Romano, C. Tags: Autoimmune diseases, All Infections, Viral infections, Post-infectious, Guillain-Barre syndrome Clinical/Scientific Notes Source Type: research

Chikungunya virus infection induces differential inflammatory and antiviral responses in human monocytes and monocyte-derived macrophages.
In conclusion, our data provides evidence that CHIKV infection activates the TLR pathways in primary monocytes and MDMs, which play a crucial role in CHIKV pathogenesis and/or host defense, differentially. However, additional studies are required to determine the functional role of TLRs in monocytes and MDMs. PMID: 32634389 [PubMed - as supplied by publisher] (Source: Acta Tropica)
Source: Acta Tropica - July 4, 2020 Category: Infectious Diseases Authors: Felipe VLJ, Paula A V, Silvio UI Tags: Acta Trop Source Type: research

Viruses, Vol. 12, Pages 722: Cathepsin B Protease Facilitates Chikungunya Virus Envelope Protein-Mediated Infection via Endocytosis or Macropinocytosis
ao Kubo Chikungunya virus (CHIKV) is an enveloped virus that enters host cells and transits within the endosomes before starting its replication cycle, the precise mechanism of which is yet to be elucidated. Endocytosis and endosome acidification inhibitors inhibit infection by CHIKV, murine leukemia virus (MLV), or SARS-coronavirus, indicating that these viral entries into host cells occur through endosomes and require endosome acidification. Although endosomal cathepsin B protease is necessary for MLV, Ebola virus, and SARS-CoV infections, its role in CHIKV infection is unknown. Our results revealed that endocytosis ...
Source: Viruses - July 3, 2020 Category: Virology Authors: Mai Izumida Hideki Hayashi Atsushi Tanaka Yoshinao Kubo Tags: Article Source Type: research

Promising application of monoclonal antibody against chikungunya virus E1-antigen across genotypes in immunochromatographic rapid diagnostic tests
Three different genotypes of chikungunya virus (CHIKV) have been classified: East/Central/South African (ECSA), West African (WA), and Asian. Previously, a rapid immunochromatographic (IC) test detecting CHIKV... (Source: Virology Journal)
Source: Virology Journal - July 2, 2020 Category: Virology Authors: Keita Suzuki, Ralph Huits, Juthamas Phadungsombat, Aekkachai Tuekprakhon, Emi E. Nakayama, Riemsdijk van den Berg, Barbara Barb é, Lieselotte Cnops, Rummana Rahim, Abu Hasan, Hisahiko Iwamoto, Pornsawan Leaungwutiwong, Marjan van Esbroeck, Mizanur Rahman Tags: Research Source Type: research

Chik sign in chikungunya fever
(Source: Infection)
Source: Infection - July 1, 2020 Category: Infectious Diseases Source Type: research

Possible Mechanisms Explaining the Association between Zika Virus and Guillain-barre Syndrome: An Immunological Approach
After the outbreak in French Polynesia, Zika virus (ZIKV) explosive pandemic occurred in 2015, reports that ZIKV was linked to other diseases, especially neurological complications such as Guillain-Barré Syndrome (GBS), also burst in almost every continent, thereby turning into an international concern. In South America, the highest incidence occurred in Venezuela with approximately 680 cases of GBS after ZIKV infection. Currently, the main roots of this association remain unknown. In this regard, it is thought that the immune system plays a central role in such association through the host protection or even improv...
Source: Current Immunology Reviews - June 30, 2020 Category: Allergy & Immunology Source Type: research

Detection of arboviruses in mosquitoes: Evidence of circulation of chikungunya virus in Iran
In this study, we used a recently developed high-throughput chip based on the BioMark Dynamic arrays system capable of detecting more than 50 arboviruses in a single experiment. A total of 1,212 mosquitoes collected in Mazandaran, North-Khorasan, and Fars provinces of Iran were analyze d. Eighteen species were identified, belonging to five genera; the most prevalent species wereAnopheles maculipennis s.l. (42.41%),Culex pipiens (19.39%),An.superpictus (11.72%), andCx.tritaeniorhynchus (10.64%). We detected chikungunya virus (CHIKV) of the Asian genotype in six mosquito pools collected in North Khorasan and Mazandaran provi...
Source: PLoS Neglected Tropical Diseases - June 30, 2020 Category: Tropical Medicine Authors: Hasan Bakhshi Source Type: research

Bioassay and molecular monitoring of insecticide resistance status in Aedes albopictus populations from Greece, to support evidence-based vector control
Aedes albopictus has a well-established presence in southern European countries, associated with recent disease outbreaks (e.g. chikungunya). Development of insecticide resistance in the vector is a major concern... (Source: Parasites and Vectors)
Source: Parasites and Vectors - June 29, 2020 Category: Microbiology Authors: Sofia Balaska, Emmanouil A. Fotakis, Ilias Kioulos, Linda Grigoraki, Spyridoula Mpellou, Alexandra Chaskopoulou and John Vontas Tags: Research Source Type: research

A new knockdown resistance (kdr) mutation, F1534L, in the voltage-gated sodium channel of Aedes aegypti, co-occurring with F1534C, S989P and V1016G
Aedes aegypti is a primary vector of dengue, chikungunya and Zika infections in India. In the absence of specific drugs or safe and effective vaccines for these infections, their control relies mainly on vector c... (Source: Parasites and Vectors)
Source: Parasites and Vectors - June 29, 2020 Category: Microbiology Authors: Raja Babu S. Kushwah, Taranjeet Kaur, Cherry L. Dykes, H. Ravi Kumar, Neera Kapoor and Om P. Singh Tags: Research Source Type: research

Viruses, Vol. 12, Pages 698: Distinct New York City Aedes albopictus Mosquito Populations Display Differences in Salivary Gland Protein D7 Diversity and Chikungunya Virus Replication
Stapleford In an increasingly interconnected world, the exposure and subsequent spread of emergent viruses has become inevitable. This is particularly true for Aedes (Ae.) mosquito-vectored viruses, whose range has increased over the past decade from tropical to temperate regions. However, it is unclear if all populations of Ae. mosquitoes in temperate New York City are able to successfully replicate and transmit arboviruses. To answer this question, we reared Ae. albopictus mosquitoes living in a temperate climate from three locations in New York City. We first sequenced the salivary antiviral protein D7 from indi...
Source: Viruses - June 28, 2020 Category: Virology Authors: Kaczmarek Herzog Noval Zuzworsky Shah Bajwa Stapleford Tags: Article Source Type: research

Viruses, Vol. 12, Pages 695: Ross River Virus Provokes Differentially Expressed MicroRNA and RNA Interference Responses in Aedes aegypti Mosquitoes
gari Alphaviruses are globally distributed and predominately transmitted by mosquitoes. Aedes species are common vectors for the clinically important alphaviruses&amp;mdash;Chikungunya, Sindbis, and Ross River (RRV) viruses&amp;mdash;with Aedes aegypti also being a vector for the flaviviruses dengue, Yellow Fever, and Zika viruses. Ae. aegypti was putatively implicated in the large 1979&amp;ndash;1980 South Pacific Islands outbreak of RRV&amp;mdash;the leading cause of arboviral disease in Australia today. The RNA interference (RNAi) defense response in mosquitoes involves a number of small RNAs, with t...
Source: Viruses - June 27, 2020 Category: Virology Authors: Sinclair Asgari Tags: Article Source Type: research

Emerging arboviruses (dengue, chikungunya, and Zika) in Southeastern Mexico: influence of socio-environmental determinants on knowledge and practices.
This study consists of the application of a community prevention project. Different surveys and methodological approaches were used. Associations between socio-environmental determinants and knowledge and practices for arboviruses transmission control were estimated by odds ratio. Logistic regression and qualitative techniques were used. Although around 75% of households had an adequate knowledge about arboviruses' origin and transmission, only 30% of them adopted adequate practices. Domestic risk practices were associated with serious deficiencies in water and sanitation services. Furthermore, a perception of greater risk...
Source: Cadernos de Saude Publica - June 26, 2020 Category: International Medicine & Public Health Authors: Causa R, Ochoa-Díaz-López H, Dor A, Rodríguez-León F, Solís-Hernández R, Pacheco-Soriano AL Tags: Cad Saude Publica Source Type: research

Concurrent amplification of Zika, chikungunya, and yellow fever virus in a sylvatic focus of arboviruses in Southeastern Senegal, 2015
Chikungunya (CHIKV), yellow fever (YFV) and Zika (ZIKV) viruses circulate in sylvatic transmission cycles in southeastern Senegal, where they share common hosts and vectors. All three viruses undergo periodic amp... (Source: BMC Microbiology)
Source: BMC Microbiology - June 26, 2020 Category: Microbiology Authors: Diawo Diallo, Gamou Fall, Cheikh Tidiane Diagne, Alioune Gaye, Yamar Ba, Ibrahima Dia, Ousmane Faye and Mawlouth Diallo Tags: Research article Source Type: research

Chikungunya Virus: An Emergent Arbovirus to the South American Continent and a Continuous Threat to the World
Chikungunya virus (CHIKV) is an arthropod-borne virus (arbovirus) of epidemic concern, transmitted by Aedes ssp. mosquitoes, and is the etiologic agent of a febrile and incapacitating arthritogenic illness responsible for millions of human cases worldwide. After major outbreaks starting in 2004, CHIKV spread to subtropical areas and western hemisphere coming from sub-Saharan Africa, South East Asia, and the Indian subcontinent. Even though CHIKV disease is self-limiting and non-lethal, more than 30% of the infected individuals will develop chronic disease with persistent severe joint pain, tenosynovitis, and incapacitating...
Source: Frontiers in Microbiology - June 26, 2020 Category: Microbiology Source Type: research

Chikungunya encephalitis: report of a fatal case in Northeastern Brazil.
We report a 57-year-old male patient with comorbidities, admitted with high fever, arthralgia, asthenia, vomiting, psychomotor agitation, behavioral changes and seizures. Cerebrospinal fluid (CSF) values revealed pleocytosis (98 cells/mm3 with 68% lymphocytes and 12% monocytes) and high levels of protein (161 mg%). Brain MRI showed hyperintense lesions in the temporal and frontal lobes and bilaterally in the posterior thalamus. CSF serology was positive for IgM antibodies to Chikungunya virus. Encephalitis due to an acute viral infection by Chikungunya was diagnosed. The patient's clinical condition worsened and he died on...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - June 25, 2020 Category: Tropical Medicine Authors: Lima ECB, Januário AMS, Fortuna EG, Real MEC, Lacerda HR Tags: Rev Inst Med Trop Sao Paulo Source Type: research

Endophytic Fungi In The Fight Against Neglected Tropical Diseases.
Abstract Neglected tropical diseases are a serious global public health problem and they are one of the main causes of mortality and morbidity, especially in underdeveloped countries. These diseases have several implications for health and they are considered a priority in global eradication programs for disease control. The aim of this mini-review is to report recent studies on the fight against neglected diseases, namely dengue fever, chikungunya, zika, malaria protozoa, Chagas disease, leishmaniasis, schistosomiasis helminths, filariasis, and tuberculosis bacteria using extracts and isolated substances of endop...
Source: Mini Reviews in Medicinal Chemistry - June 24, 2020 Category: Chemistry Authors: Costa MBS, de Oliveira CM Tags: Mini Rev Med Chem Source Type: research

Chemical composition and larvicidal activity of Citrus limonia Osbeck bark essential oil
In this study, the main constituent, the predominant class of essential oil extracted from the husks of Citrus limonia Osbeck was identified and evaluated to know if it has biological act... (Source: Journal of Medicinal Plants Research)
Source: Journal of Medicinal Plants Research - June 23, 2020 Category: Complementary Medicine Source Type: research

Transmission of Chikungunya Virus in an Urban Slum, Brazil.
Abstract After a chikungunya outbreak in Salvador, Brazil, we performed a cross-sectional, community-based study of 1,776 inhabitants to determine chikungunya virus (CHIKV) seroprevalence, identify factors associated with exposure, and estimate the symptomatic infection rate. From November 2016 through February 2017, we collected sociodemographic and clinical data by interview and tested serum samples for CHIKV IgG. CHIKV seroprevalence was 11.8% (95% CI 9.8%-13.7%), and 15.3% of seropositive persons reported an episode of fever and arthralgia. Infections were independently and positively associated with residence...
Source: Emerging Infectious Diseases - June 23, 2020 Category: Infectious Diseases Authors: Anjos RO, Mugabe VA, Moreira PSS, Carvalho CX, Portilho MM, Khouri R, Sacramento GA, Nery NRR, Reis MG, Kitron UD, Ko AI, Costa F, Ribeiro GS Tags: Emerg Infect Dis Source Type: research

Genomic surveillance of the Chikungunya Virus (CHIKV) in Northeast Brazil after the first outbreak in 2014
CONCLUSIONS: The genomic surveillance of CHIKV showed that only ECSA lineage circulated in Bahia since the 2014 outbreak. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - June 23, 2020 Category: Tropical Medicine Source Type: research

Construction and Immunogenicity of Recombinant Vaccinia Virus Vaccine Against Japanese Encephalitis and Chikungunya Viruses Infection in Mice
Vector-Borne and Zoonotic Diseases, Ahead of Print. (Source: Vector-Borne and Zoonotic Diseases)
Source: Vector-Borne and Zoonotic Diseases - June 23, 2020 Category: Infectious Diseases Authors: Ying Zhang Ji-cheng Han Jie Jing Hao Liu He Zhang Zhao-hui Li Ning-yi Jin Hui-jun Lu Source Type: research

Viruses, Vol. 12, Pages 671: Flavivirus Infection Associated with Cerebrovascular Events
aurício L. Nogueira Arthropod-borne viruses (arboviruses) of the genus Flavivirus are distributed globally and cause significant human disease and mortality annually. Flavivirus infections present a spectrum of clinical manifestations, ranging from asymptomatic to severe manifestations, including hemorrhage, encephalitis and death. Herein, we describe 3 case reports of cerebrovascular involvement in patients infected by dengue and Zika viruses in Sao Jose do Rio Preto, S&amp;atilde;o Paulo State, Brazil, a hyperendemic area for arbovirus circulation, including dengue, yellow fever, chikungunya and Saint Loui...
Source: Viruses - June 22, 2020 Category: Virology Authors: C ássia F. Estofolete Bruno H. G. A. Milhim Nathalia Zini Samuel N. Scamardi Joana D ’Arc Selvante Nikos Vasilakis Maur ício L. Nogueira Tags: Article Source Type: research

Tracing temporal and geographic distribution of resistance to pyrethroids in the arboviral vector < i > Aedes albopictus < /i >
ConclusionsHere we provide the most-up-to-date survey on the geographic and temporal distribution of pyrethroid-predictive mutations inAe.albopictus by combiningkdr genotyping on current and historical samples with published data. While we confirm low levels of pyrethroid resistance in most analyzed samples, we find increasing frequencies of F1534C/S and V1016G in China and Greece or Italy, respectively. The observed patterns ofkdr allele distribution support the hypothesis that on site emergence of resistance has contributed more than spread of resistance through mosquito migration/invasions to the current widespread ofkd...
Source: PLoS Neglected Tropical Diseases - June 22, 2020 Category: Tropical Medicine Authors: Alessandra Tancredi Source Type: research

Coordination among neighbors improves the efficacy of Zika control despite economic costs
by Natalie J. Lemanski, Samantha R. Schwab, Dina M. Fonseca, Nina H. Fefferman Emerging mosquito-borne viruses like Zika, dengue, and chikungunya pose a major threat to public health, especially in low-income regions of Central and South America, southeast Asia, and the Caribbean. Outbreaks of these diseases are likely to have long-term social and economic consequences due t o Zika-induced congenital microcephaly and other complications. Larval control of the container-inhabiting mosquitoes that transmit these infections is an important tool for mitigating outbreaks. However, metapopulation theory suggests that spatiotemp...
Source: PLoS Neglected Tropical Diseases - June 22, 2020 Category: Tropical Medicine Authors: Natalie J. Lemanski Source Type: research

Investigation of the ability of the oviposition-stimulant lectin from Moringa oleifera seeds (WSMoL) to bind with membrane proteins present in the legs of Aedes aegypti.
This study aimed to investigate whether WSMoL could bind to membrane proteins from A. aegypti legs. Initially, proteins from the legs were extracted using sodium deoxycholate, digitonin, dodecyl sodium sulfate (SDS) or Triton X-100. The protein concentration was found to be higher in the extract obtained using Triton X-100, which was applied to a WSMoL-Sepharose column. The adsorbed proteins were evaluated using gel filtration chromatography and polyacrylamide gel electrophoresis (PAGE) in presence of SDS. The similarity in the sequences of adsorbed proteins with those available in databases was determined. The proteins ad...
Source: International Journal of Biological Macromolecules - June 22, 2020 Category: Biochemistry Authors: de Santana Silva LL, de Lima Santos ND, Silva SCC, de Albuquerque Lima T, Coelho LCBB, Zingali RB, do Amaral Ferraz Navarro DM, Napoleão TH, Paiva PMG Tags: Int J Biol Macromol Source Type: research

Seroprevalence of Dengue, Zika, and Chikungunya Viruses in Wild Monkeys in Thailand.
This study aims to determine the exposure history of different macaque species from national parks in Thailand to mosquito-borne flaviviruses and alphavirus by testing the serum samples collected from 25 northern pigtailed macaques, 33 stump-tailed macaques, and 4 long-tailed macaques for the presence of antibodies against dengue, Zika, and chikungunya viruses by plaque reduction neutralization assay. Specific neutralizing antibodies against Dengue virus (DENV1-4) and Zika virus (ZIKV) were mainly found in stump-tailed macaques, whereas neutralizing antibody titers were not detected in long-tailed macaques and pigtailed ma...
Source: The American Journal of Tropical Medicine and Hygiene - June 22, 2020 Category: Tropical Medicine Authors: Tongthainan D, Mongkol N, Jiamsomboon K, Suthisawat S, Sanyathitiseree P, Sukmak M, Wajjwalku W, Poovorawan Y, Ieamsaard G, Sangkharak B, Taruyanon K, Fungfuang W, Tulayakul P, Boonnak K Tags: Am J Trop Med Hyg Source Type: research

Lab-on-paper for all-in-one molecular diagnostics (LAMDA) of zika, dengue, and chikungunya virus from human serum
Publication date: Available online 20 June 2020Source: Biosensors and BioelectronicsAuthor(s): Youngung Seok, Bhagwan S. Batule, Min-Gon Kim (Source: Biosensors and Bioelectronics)
Source: Biosensors and Bioelectronics - June 21, 2020 Category: Biotechnology Source Type: research

Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya
by Claire J. Heath, Elysse N. Grossi-Soyster, Bryson A. Ndenga, Francis M. Mutuku, Malaya K. Sahoo, Harun N. Ngugi, Joel O. Nbakaya, Peter Siema, Uriel Kitron, Nayer Zahiri, Jimmy Hortion, Jesse J. Waggoner, Charles H. King, Benjamin A. Pinsky, A. Desiree LaBeaud Arboviruses are among the most important emerging pathogens due to their increasing public health impact. In Kenya, continued population growth and associated urbanization are conducive to vector spread in both urban and rural environments, yet mechanisms of viral amplification in vector populatio ns is often overlooked when assessing risks for outbreaks. Thus, t...
Source: PLoS Neglected Tropical Diseases - June 19, 2020 Category: Tropical Medicine Authors: Claire J. Heath Source Type: research