Clinical, Epidemiological, and Laboratory Features of Mayaro Virus Infection: a Systematic Review
AbstractPurpose of ReviewMayaro virus is an arbovirus that circulates in a wild cycle transmitted byHaemagogus janthinomys; however, case reports in urban areas suggest that other arthropods could be acting as vectors. It shares several similarities with Chikungunya virus, being highly probable that many cases are being misdiagnosed. The disease caused by this pathogen is known as Mayaro fever, which is restricted to regions of Central and South America, mainly the Amazon rainforest. Cases of Mayaro fever have continuously been increasing, suggesting that Mayaro virus would become another major epidemic arbovirus in Americ...
Source: Current Tropical Medicine Reports - November 27, 2023 Category: Tropical Medicine Source Type: research
Mitochondrial protein BNIP3 regulates Chikungunya virus replication in the early stages of infection
by Liliana Echavarria-Consuegra, Nilima Dinesh Kumar, Marleen van der Laan, Mario Mauthe, Denise Van de Pol, Fulvio Reggiori, Jolanda M. Smit
Chikungunya virus (CHIKV) is a human pathogen causing outbreaks of febrile illness for which vaccines and specific treatments remain unavailable. Autophagy-related (ATG) proteins and autophagy receptors are a set of host factors that participate in autophagy, but have also shown to function in other unrelated cellular pathways. Although autophagy is reported to both inhibit and enhance CHIKV replication, the specific role of individual ATG proteins remains largely unknown. Here, a s...
Source: PLoS Neglected Tropical Diseases - November 27, 2023 Category: Tropical Medicine Authors: Liliana Echavarria-Consuegra Source Type: research
Synergistic In Vitro Antiviral Effect of Combinations of Ivermectin, Essential Oils, and 18-(Phthalimid-2-yl)ferruginol against Arboviruses and Herpesvirus
Pharmaceuticals (Basel). 2023 Nov 13;16(11):1602. doi: 10.3390/ph16111602.ABSTRACTCombining antiviral drugs with different mechanisms of action can help prevent the development of resistance by attacking the infectious agent through multiple pathways. Additionally, by using faster and more economical screening methods, effective synergistic drug candidates can be rapidly identified, facilitating faster paths to clinical testing. In this work, a rapid method was standardized to identify possible synergisms from drug combinations. We analyzed the possible reduction in the antiviral effective concentration of drugs already ap...
Source: Herpes - November 25, 2023 Category: Infectious Diseases Authors: Liliana Betancur-Galvis Orlando Jos é Jimenez-Jarava Fatima Rivas William E Mendoza-Hern ández Miguel A Gonz ález-Cardenete Source Type: research
Synergistic In Vitro Antiviral Effect of Combinations of Ivermectin, Essential Oils, and 18-(Phthalimid-2-yl)ferruginol against Arboviruses and Herpesvirus
Pharmaceuticals (Basel). 2023 Nov 13;16(11):1602. doi: 10.3390/ph16111602.ABSTRACTCombining antiviral drugs with different mechanisms of action can help prevent the development of resistance by attacking the infectious agent through multiple pathways. Additionally, by using faster and more economical screening methods, effective synergistic drug candidates can be rapidly identified, facilitating faster paths to clinical testing. In this work, a rapid method was standardized to identify possible synergisms from drug combinations. We analyzed the possible reduction in the antiviral effective concentration of drugs already ap...
Source: Herpes - November 25, 2023 Category: Infectious Diseases Authors: Liliana Betancur-Galvis Orlando Jos é Jimenez-Jarava Fatima Rivas William E Mendoza-Hern ández Miguel A Gonz ález-Cardenete Source Type: research
Viruses, Vol. 15, Pages 2298: Viral RNA in Mosquitoes (Diptera: Culicidae) Collected between 2019 and 2021 in Germany
Helge Kampen
Due to globalisation and climate change, mosquito-borne pathogens are emerging in new areas on all continents, including Europe, which has recently faced outbreaks of dengue, chikungunya and West Nile fever. The present study complements previous investigations to evaluate the circulation of mosquito-borne viruses in Germany, with the aim of identifying potential vector species and risk areas. Mosquitoes collected from 2019 to 2021 and identified to species or species group level were screened for viruses of the families Flaviviridae, Peribunyaviridae and the genus Alphavirus of the family Togaviridae. In ...
Source: Viruses - November 23, 2023 Category: Virology Authors: Janine Rau Katharina K öchling Mandy Sch äfer Birke A. Tews Claudia Wylezich G ünter A. Schaub Doreen Werner Helge Kampen Tags: Article Source Type: research
Development and pre-clinical evaluation of a Zika virus diagnostic for low resource settings
DiscussionContrary to conventional RT-qPCR, our Iso-ZIKV-Dx does not require expensive machinery, specialised laboratory settings or extensively trained personnel. Pre-clinical evaluation demonstrates that our test exhibits robust, in-field capabilities without compromising sensitivity or specificity. When compared to the gold-standard RT-qPCR, our Iso-ZIKV-Dx test offers an array of applications that extend beyond diagnostics alone, including potential for surveillance and monitoring of ZIKV vector competency. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - November 20, 2023 Category: Microbiology Source Type: research
Mayaro virus pathogenesis and immunity in rhesus macaques
by Whitney C. Weber, Caralyn S. Labriola, Craig N. Kreklywich, Karina Ray, Nicole N. Haese, Takeshi F. Andoh, Michael Denton, Samuel Medica, Magdalene M. Streblow, Patricia P. Smith, Nobuyo Mizuno, Nina Frias, Miranda B. Fisher, Aaron M. Barber-Axthelm, Kimberly Chun, Samantha Uttke, Danika Whitcomb, Victor DeFilippis, Shauna Rakshe, Suzanne S. Fei, Michael K. Axthelm, Jeremy V. Smedley, Daniel N. Streblow
Mayaro virus (MAYV) is a mosquito-transmitted alphavirus that causes debilitating and persistent arthritogenic disease. While MAYV was previously reported to infect non-human primates (NHP), characterization of MAYV pat...
Source: PLoS Neglected Tropical Diseases - November 20, 2023 Category: Tropical Medicine Authors: Whitney C. Weber Source Type: research
The Evil DExH/D: Chikungunya virus runs but cannot hide from DDX39A
In this issue, Tapescu et al.11 identify DDX39A as a novel antiviral protein that acts on conserved features of alphavirus RNA to limit infection in an IFN-independent manner. (Source: Molecular Cell)
Source: Molecular Cell - November 16, 2023 Category: Cytology Authors: Matthew G. Thompson, Stacy M. Horner Tags: Preview Source Type: research
Viral infections and pathogenesis of glaucoma: a comprehensive review
Clin Microbiol Rev. 2023 Nov 15:e0005723. doi: 10.1128/cmr.00057-23. Online ahead of print.ABSTRACTSUMMARYGlaucoma is a leading cause of irreversible blindness worldwide, caused by the gradual degeneration of retinal ganglion cells and their axons. While glaucoma is primarily considered a genetic and age-related disease, some inflammatory conditions, such as uveitis and viral-induced anterior segment inflammation, cause secondary or uveitic glaucoma. Viruses are predominant ocular pathogens and can impose both acute and chronic pathological insults to the human eye. Many viruses, including herpes simplex virus, varicella-z...
Source: Clinical Microbiology Reviews - November 15, 2023 Category: Microbiology Authors: Faraz Ahmad Nikhil Deshmukh Aaron Webel Sandra Johnson Ayman Suleiman Rajiv R Mohan Frederick Fraunfelder Pawan Kumar Singh Source Type: research
Viral infections and pathogenesis of glaucoma: a comprehensive review
Clin Microbiol Rev. 2023 Nov 15:e0005723. doi: 10.1128/cmr.00057-23. Online ahead of print.ABSTRACTSUMMARYGlaucoma is a leading cause of irreversible blindness worldwide, caused by the gradual degeneration of retinal ganglion cells and their axons. While glaucoma is primarily considered a genetic and age-related disease, some inflammatory conditions, such as uveitis and viral-induced anterior segment inflammation, cause secondary or uveitic glaucoma. Viruses are predominant ocular pathogens and can impose both acute and chronic pathological insults to the human eye. Many viruses, including herpes simplex virus, varicella-z...
Source: Herpes - November 15, 2023 Category: Infectious Diseases Authors: Faraz Ahmad Nikhil Deshmukh Aaron Webel Sandra Johnson Ayman Suleiman Rajiv R Mohan Frederick Fraunfelder Pawan Kumar Singh Source Type: research
Viral infections and pathogenesis of glaucoma: a comprehensive review
Clin Microbiol Rev. 2023 Nov 15:e0005723. doi: 10.1128/cmr.00057-23. Online ahead of print.ABSTRACTSUMMARYGlaucoma is a leading cause of irreversible blindness worldwide, caused by the gradual degeneration of retinal ganglion cells and their axons. While glaucoma is primarily considered a genetic and age-related disease, some inflammatory conditions, such as uveitis and viral-induced anterior segment inflammation, cause secondary or uveitic glaucoma. Viruses are predominant ocular pathogens and can impose both acute and chronic pathological insults to the human eye. Many viruses, including herpes simplex virus, varicella-z...
Source: Clinical Microbiology Reviews - November 15, 2023 Category: Microbiology Authors: Faraz Ahmad Nikhil Deshmukh Aaron Webel Sandra Johnson Ayman Suleiman Rajiv R Mohan Frederick Fraunfelder Pawan Kumar Singh Source Type: research
Viral infections and pathogenesis of glaucoma: a comprehensive review
Clin Microbiol Rev. 2023 Nov 15:e0005723. doi: 10.1128/cmr.00057-23. Online ahead of print.ABSTRACTSUMMARYGlaucoma is a leading cause of irreversible blindness worldwide, caused by the gradual degeneration of retinal ganglion cells and their axons. While glaucoma is primarily considered a genetic and age-related disease, some inflammatory conditions, such as uveitis and viral-induced anterior segment inflammation, cause secondary or uveitic glaucoma. Viruses are predominant ocular pathogens and can impose both acute and chronic pathological insults to the human eye. Many viruses, including herpes simplex virus, varicella-z...
Source: Clinical Microbiology Reviews - November 15, 2023 Category: Microbiology Authors: Faraz Ahmad Nikhil Deshmukh Aaron Webel Sandra Johnson Ayman Suleiman Rajiv R Mohan Frederick Fraunfelder Pawan Kumar Singh Source Type: research
Viruses, Vol. 15, Pages 2258: High Seroprevalence of IgG Antibodies to Multiple Arboviruses in People Living with HIV (PLWHIV) in Madagascar
nçois Xavier Babin
Tahinamandranto Rasamoelina
Eric Delaporte
Luc Hervé Samison
Martine Peeters
Eric Nerrienet
Ahidjo Ayouba
To estimate the prevalence of IgG antibodies against six arboviruses in people living with HIV-1 (PLWHIV) in Madagascar, we tested samples collected between January 2018 and June 2021. We used a Luminex-based serological assay to detect IgG antibodies against antigens from Dengue virus serotypes 1–4 (DENV1–4), Zika virus (ZIKV), West Nile virus (WNV), Usutu virus (USUV), Chikungunya virus (CHIKV), and O’nyong nyong virus (ONNV). Of the 1036 ...
Source: Viruses - November 15, 2023 Category: Virology Authors: Fetra Angelot Rakotomalala Julie Bouillin Santatriniaina Dauphin Randriarimanana Guillaume Thaurignac Luca Maharavo Mihaja Raberahona Lucien Razafindrakoto Jasmina Rasoanarivo Mala Rakoto-Andrianarivelo Danielle Aurore Doll Rakoto Fran çois Xavier Babin Tags: Article Source Type: research
"What will the doctor give me, the same painkiller?": a qualitative study exploring health-care seeking and symptoms self-management among patients for the treatment of long-term chikungunya disease, in Cura çao
CONCLUSIONS: To promote the benefits of long-term health-care seeking and subsequently reduce the possible harmful use of analgesics, a collaborative physician-patient therapeutic relationship need to be encouraged. To facilitate this, important shifts may be needed in chikungunya sequalae education of both patients and health-care professionals, and policy makers need to revise health systems for the long-term provision of multidisciplinary care to achieve beneficial health outcomes in long-term chikungunya disease.PMID:37957621 | DOI:10.1186/s12913-023-10254-8 (Source: Pain Physician)
Source: Pain Physician - November 14, 2023 Category: Anesthesiology Authors: Churnalisa Doran Ashley Duits Izzy Gerstenbluth Adriana Tami Ajay Bailey Source Type: research
"What will the doctor give me, the same painkiller?": a qualitative study exploring health-care seeking and symptoms self-management among patients for the treatment of long-term chikungunya disease, in Cura çao
CONCLUSIONS: To promote the benefits of long-term health-care seeking and subsequently reduce the possible harmful use of analgesics, a collaborative physician-patient therapeutic relationship need to be encouraged. To facilitate this, important shifts may be needed in chikungunya sequalae education of both patients and health-care professionals, and policy makers need to revise health systems for the long-term provision of multidisciplinary care to achieve beneficial health outcomes in long-term chikungunya disease.PMID:37957621 | PMC:PMC10641972 | DOI:10.1186/s12913-023-10254-8 (Source: Pain Physician)
Source: Pain Physician - November 14, 2023 Category: Anesthesiology Authors: Churnalisa Doran Ashley Duits Izzy Gerstenbluth Adriana Tami Ajay Bailey Source Type: research
