Aedes albopictus distribution in Ibagu é, Colombia: Potential risk of arboviral outbreaks
CONCLUSIONS: Aedes albopictus is distributed throughout all the communes of Ibague. Its dispersion has probably been favored by this region’s environmental and social conditions. We recommend annual monitoring of these vectors populations and molecular characterization of the found arboviruses. Ascertaining this mosquito’s distribution throughout the city will enable focusing entomological control strategies and preventing future arbovirus outbreaks.PMID:38109139 | PMC:PMC10826468 | DOI:10.7705/biomedica.7010 (Source: Biomedica : Revista del Instituto Nacional de Salud)
Source: Biomedica : Revista del Instituto Nacional de Salud - December 18, 2023 Category: International Medicine & Public Health Authors: Cristian Camilo Canizales Julio Cesar Carranza Gustavo Adolfo Vallejo Daniel Alfonso Urrea Source Type: research
Integrated control strategies for dengue, Zika, and Chikungunya virus infections
In conclusion, combatting the global threat of arbovirus diseases needs a comprehensive approach integrating antiviral research, vaccination, and vector control. The continued efforts of research communities, alongside collaborative partnerships with public health authorities, are imperative to effectively address and mitigate the impact of these arboviral infections on public health worldwide. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - December 18, 2023 Category: Allergy & Immunology Source Type: research
Population genetics of Aedes albopictus in the port cities of Hainan Island and Leizhou Peninsula, China
CONCLUSION: Ae. albopictus in port areas are not significantly different from urban and rural populations due to strong gene flow, which prevents differentiation and increases the genetic diversity of the populations. High genetic diversity facilitates mosquito adaptation to complex environmental changes, which is a challenge for vector-borne disease control in port areas.PMID:38104852 | DOI:10.1016/j.meegid.2023.105539 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - December 17, 2023 Category: Genetics & Stem Cells Authors: Minghui Zhao Xin Ran Dan Xing Wei Liu Zu Ma Yun Liao Qiang Zhang Yu Bai Lan Liu Kan Chen Mingyu Wu Jian Gao Hengduan Zhang Tongyan Zhao Source Type: research
Rational design of a multivalent vaccine targeting arthropod-borne viruses using reverse vaccinology strategies
In this study, we employed immunoinformatics methodologies, incorporating reverse vaccinology, to design a multivalent vaccine targeting the predominant arboviruses. Epitopes of B and T cells were recognized within the non-structural proteins of Dengue, Zika, and Chikungunya viruses. The predicted epitopes were enhanced with adjuvants β-defensin and RS-09 to boost the vaccine's immunogenicity. Sixteen distinct vaccine candidates were constructed, each incorporating epitopes from all three viruses. FUVAC-11 emerged as the most promising vaccine candidate through molecular docking and molecular dynamics simulations, demonst...
Source: International Journal of Biological Macromolecules - December 17, 2023 Category: Biochemistry Authors: T Dhanushkumar Prasanna Kumar Selvam Santhosh M E Karthick Vasudevan George Priya Doss C Hatem Zayed Balu Kamaraj Source Type: research
Design, synthesis, and lead optimization of piperazinyl-pyrimidine analogues as potent small molecules targeting the viral capping machinery of Chikungunya virus
This study identified 31b and 34 as potent, safe, and stable lead compounds for further development as selective CHIKV inhibitors. Finally, the collected insight led to a successful scaffold hop (64b) for future antiviral research studies.PMID:38104375 | DOI:10.1016/j.ejmech.2023.116010 (Source: European Journal of Medicinal Chemistry)
Source: European Journal of Medicinal Chemistry - December 17, 2023 Category: Chemistry Authors: Verena Battisti Julia Moesslacher Rana Abdelnabi Pieter Leyssen Ana Lucia Rosales Rosas Lana Langendries Mohammed Aufy Christian Studenik Jadel M Kratz Judith M Rollinger Gerhard Puerstinger Johan Neyts Leen Delang Ernst Urban Thierry Langer Source Type: research
Population genetics of Aedes albopictus in the port cities of Hainan Island and Leizhou Peninsula, China
CONCLUSION: Ae. albopictus in port areas are not significantly different from urban and rural populations due to strong gene flow, which prevents differentiation and increases the genetic diversity of the populations. High genetic diversity facilitates mosquito adaptation to complex environmental changes, which is a challenge for vector-borne disease control in port areas.PMID:38104852 | DOI:10.1016/j.meegid.2023.105539 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - December 17, 2023 Category: Genetics & Stem Cells Authors: Minghui Zhao Xin Ran Dan Xing Wei Liu Zu Ma Yun Liao Qiang Zhang Yu Bai Lan Liu Kan Chen Mingyu Wu Jian Gao Hengduan Zhang Tongyan Zhao Source Type: research
Rational design of a multivalent vaccine targeting arthropod-borne viruses using reverse vaccinology strategies
In this study, we employed immunoinformatics methodologies, incorporating reverse vaccinology, to design a multivalent vaccine targeting the predominant arboviruses. Epitopes of B and T cells were recognized within the non-structural proteins of Dengue, Zika, and Chikungunya viruses. The predicted epitopes were enhanced with adjuvants β-defensin and RS-09 to boost the vaccine's immunogenicity. Sixteen distinct vaccine candidates were constructed, each incorporating epitopes from all three viruses. FUVAC-11 emerged as the most promising vaccine candidate through molecular docking and molecular dynamics simulations, demonst...
Source: International Journal of Biological Macromolecules - December 17, 2023 Category: Biochemistry Authors: T Dhanushkumar Prasanna Kumar Selvam Santhosh M E Karthick Vasudevan George Priya Doss C Hatem Zayed Balu Kamaraj Source Type: research
Design, synthesis, and lead optimization of piperazinyl-pyrimidine analogues as potent small molecules targeting the viral capping machinery of Chikungunya virus
This study identified 31b and 34 as potent, safe, and stable lead compounds for further development as selective CHIKV inhibitors. Finally, the collected insight led to a successful scaffold hop (64b) for future antiviral research studies.PMID:38104375 | DOI:10.1016/j.ejmech.2023.116010 (Source: European Journal of Medicinal Chemistry)
Source: European Journal of Medicinal Chemistry - December 17, 2023 Category: Chemistry Authors: Verena Battisti Julia Moesslacher Rana Abdelnabi Pieter Leyssen Ana Lucia Rosales Rosas Lana Langendries Mohammed Aufy Christian Studenik Jadel M Kratz Judith M Rollinger Gerhard Puerstinger Johan Neyts Leen Delang Ernst Urban Thierry Langer Source Type: research
Design, synthesis, and lead optimization of piperazinyl-pyrimidine analogues as potent small molecules targeting the viral capping machinery of Chikungunya virus
This study identified 31b and 34 as potent, safe, and stable lead compounds for further development as selective CHIKV inhibitors. Finally, the collected insight led to a successful scaffold hop (64b) for future antiviral research studies.PMID:38104375 | DOI:10.1016/j.ejmech.2023.116010 (Source: European Journal of Medicinal Chemistry)
Source: European Journal of Medicinal Chemistry - December 17, 2023 Category: Chemistry Authors: Verena Battisti Julia Moesslacher Rana Abdelnabi Pieter Leyssen Ana Lucia Rosales Rosas Lana Langendries Mohammed Aufy Christian Studenik Jadel M Kratz Judith M Rollinger Gerhard Puerstinger Johan Neyts Leen Delang Ernst Urban Thierry Langer Source Type: research
