Design, synthesis, and lead optimization of piperazinyl-pyrimidine analogues as potent small molecules targeting the viral capping machinery of Chikungunya virus

This study identified 31b and 34 as potent, safe, and stable lead compounds for further development as selective CHIKV inhibitors. Finally, the collected insight led to a successful scaffold hop (64b) for future antiviral research studies.PMID:38104375 | DOI:10.1016/j.ejmech.2023.116010

Source: European Journal of Medicinal Chemistry - December 17, 2023 Category: Chemistry Authors: Verena Battisti Julia Moesslacher Rana Abdelnabi Pieter Leyssen Ana Lucia Rosales Rosas Lana Langendries Mohammed Aufy Christian Studenik Jadel M Kratz Judith M Rollinger Gerhard Puerstinger Johan Neyts Leen Delang Ernst Urban Thierry Langer Source Type: research