EPH15 Transmission Dynamics and Vaccination Strategies for Chikungunya Virus (CHIKV): An Outbreak Simulation Study in Rome, Italy
This study assessed the transmission dynamics and effectiveness of vaccination as an intervention strategy in the event of an CHIKV outbreak. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: G. Tiozzo, B. Sloof, H. Hofstra, G.T. Vondeling, A. de Roo Source Type: research
EPH122 Global Burden of Disease Study on Chikungunya: Estimating Dalys and Cost Burden
This study aimed to assess the global burden of chikungunya in terms of disability-adjusted life years (DALYs) and economic costs. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: A. de Roo, G.T. Vondeling Source Type: research
EPH125 A Systematic Literature Review and Meta-Analysis on the Disease Burden of Chikungunya
The objective of the meta-analyses was to consolidate data on symptom rates and hospitalization. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: G. Tiozzo, T. Louwsma, K. Rama, H. Hofstra, A. de Roo, G.T. Vondeling Source Type: research
Introduction of invasive mosquito species into Europe and prospects for arbovirus transmission and vector control in an era of globalization
ConclusionsClimate change and globalization resulting in the increased establishment of invasive mosquitoes in particular of the Asian tiger mosquitoAe. albopictus in Europe within the last 30 years and increasing outbreaks of infections by mosquito-borne viruses warrants intensification of research and monitoring. Further, effective future mosquito control programs require increase in intense community and private participation, applying physical, chemical, biological, and genetical co ntrol activities. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - November 30, 2023 Category: Infectious Diseases Source Type: research
FDA Approves First Chikungunya Vaccine
The US Food and Drug Administration (FDA) recently greenlit the first vaccine to prevent chikungunya, a disease spread by mosquitos carrying the chikungunya virus. The agency called the virus an “emerging global health threat” due to its growing prevalence and geographic range. The vaccine, marketed as Ixchiq by Valneva Austria GmbH, is approved for adults 18 years or older who are at high risk of exposure to chikungunya virus. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - November 29, 2023 Category: General Medicine Source Type: research
Clinical, Epidemiological, and Laboratory Features of Mayaro Virus Infection: a Systematic Review
AbstractPurpose of ReviewMayaro virus is an arbovirus that circulates in a wild cycle transmitted byHaemagogus janthinomys; however, case reports in urban areas suggest that other arthropods could be acting as vectors. It shares several similarities with Chikungunya virus, being highly probable that many cases are being misdiagnosed. The disease caused by this pathogen is known as Mayaro fever, which is restricted to regions of Central and South America, mainly the Amazon rainforest. Cases of Mayaro fever have continuously been increasing, suggesting that Mayaro virus would become another major epidemic arbovirus in Americ...
Source: Current Tropical Medicine Reports - November 27, 2023 Category: Tropical Medicine Source Type: research
Mitochondrial protein BNIP3 regulates Chikungunya virus replication in the early stages of infection
by Liliana Echavarria-Consuegra, Nilima Dinesh Kumar, Marleen van der Laan, Mario Mauthe, Denise Van de Pol, Fulvio Reggiori, Jolanda M. Smit
Chikungunya virus (CHIKV) is a human pathogen causing outbreaks of febrile illness for which vaccines and specific treatments remain unavailable. Autophagy-related (ATG) proteins and autophagy receptors are a set of host factors that participate in autophagy, but have also shown to function in other unrelated cellular pathways. Although autophagy is reported to both inhibit and enhance CHIKV replication, the specific role of individual ATG proteins remains largely unknown. Here, a s...
Source: PLoS Neglected Tropical Diseases - November 27, 2023 Category: Tropical Medicine Authors: Liliana Echavarria-Consuegra Source Type: research
Synergistic In Vitro Antiviral Effect of Combinations of Ivermectin, Essential Oils, and 18-(Phthalimid-2-yl)ferruginol against Arboviruses and Herpesvirus
Pharmaceuticals (Basel). 2023 Nov 13;16(11):1602. doi: 10.3390/ph16111602.ABSTRACTCombining antiviral drugs with different mechanisms of action can help prevent the development of resistance by attacking the infectious agent through multiple pathways. Additionally, by using faster and more economical screening methods, effective synergistic drug candidates can be rapidly identified, facilitating faster paths to clinical testing. In this work, a rapid method was standardized to identify possible synergisms from drug combinations. We analyzed the possible reduction in the antiviral effective concentration of drugs already ap...
Source: Herpes - November 25, 2023 Category: Infectious Diseases Authors: Liliana Betancur-Galvis Orlando Jos é Jimenez-Jarava Fatima Rivas William E Mendoza-Hern ández Miguel A Gonz ález-Cardenete Source Type: research
Synergistic In Vitro Antiviral Effect of Combinations of Ivermectin, Essential Oils, and 18-(Phthalimid-2-yl)ferruginol against Arboviruses and Herpesvirus
Pharmaceuticals (Basel). 2023 Nov 13;16(11):1602. doi: 10.3390/ph16111602.ABSTRACTCombining antiviral drugs with different mechanisms of action can help prevent the development of resistance by attacking the infectious agent through multiple pathways. Additionally, by using faster and more economical screening methods, effective synergistic drug candidates can be rapidly identified, facilitating faster paths to clinical testing. In this work, a rapid method was standardized to identify possible synergisms from drug combinations. We analyzed the possible reduction in the antiviral effective concentration of drugs already ap...
Source: Herpes - November 25, 2023 Category: Infectious Diseases Authors: Liliana Betancur-Galvis Orlando Jos é Jimenez-Jarava Fatima Rivas William E Mendoza-Hern ández Miguel A Gonz ález-Cardenete Source Type: research
Viruses, Vol. 15, Pages 2298: Viral RNA in Mosquitoes (Diptera: Culicidae) Collected between 2019 and 2021 in Germany
Helge Kampen
Due to globalisation and climate change, mosquito-borne pathogens are emerging in new areas on all continents, including Europe, which has recently faced outbreaks of dengue, chikungunya and West Nile fever. The present study complements previous investigations to evaluate the circulation of mosquito-borne viruses in Germany, with the aim of identifying potential vector species and risk areas. Mosquitoes collected from 2019 to 2021 and identified to species or species group level were screened for viruses of the families Flaviviridae, Peribunyaviridae and the genus Alphavirus of the family Togaviridae. In ...
Source: Viruses - November 23, 2023 Category: Virology Authors: Janine Rau Katharina K öchling Mandy Sch äfer Birke A. Tews Claudia Wylezich G ünter A. Schaub Doreen Werner Helge Kampen Tags: Article Source Type: research
Development and pre-clinical evaluation of a Zika virus diagnostic for low resource settings
DiscussionContrary to conventional RT-qPCR, our Iso-ZIKV-Dx does not require expensive machinery, specialised laboratory settings or extensively trained personnel. Pre-clinical evaluation demonstrates that our test exhibits robust, in-field capabilities without compromising sensitivity or specificity. When compared to the gold-standard RT-qPCR, our Iso-ZIKV-Dx test offers an array of applications that extend beyond diagnostics alone, including potential for surveillance and monitoring of ZIKV vector competency. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - November 20, 2023 Category: Microbiology Source Type: research
Mayaro virus pathogenesis and immunity in rhesus macaques
by Whitney C. Weber, Caralyn S. Labriola, Craig N. Kreklywich, Karina Ray, Nicole N. Haese, Takeshi F. Andoh, Michael Denton, Samuel Medica, Magdalene M. Streblow, Patricia P. Smith, Nobuyo Mizuno, Nina Frias, Miranda B. Fisher, Aaron M. Barber-Axthelm, Kimberly Chun, Samantha Uttke, Danika Whitcomb, Victor DeFilippis, Shauna Rakshe, Suzanne S. Fei, Michael K. Axthelm, Jeremy V. Smedley, Daniel N. Streblow
Mayaro virus (MAYV) is a mosquito-transmitted alphavirus that causes debilitating and persistent arthritogenic disease. While MAYV was previously reported to infect non-human primates (NHP), characterization of MAYV pat...
Source: PLoS Neglected Tropical Diseases - November 20, 2023 Category: Tropical Medicine Authors: Whitney C. Weber Source Type: research
The Evil DExH/D: Chikungunya virus runs but cannot hide from DDX39A
In this issue, Tapescu et al.11 identify DDX39A as a novel antiviral protein that acts on conserved features of alphavirus RNA to limit infection in an IFN-independent manner. (Source: Molecular Cell)
Source: Molecular Cell - November 16, 2023 Category: Cytology Authors: Matthew G. Thompson, Stacy M. Horner Tags: Preview Source Type: research
Viral infections and pathogenesis of glaucoma: a comprehensive review
Clin Microbiol Rev. 2023 Nov 15:e0005723. doi: 10.1128/cmr.00057-23. Online ahead of print.ABSTRACTSUMMARYGlaucoma is a leading cause of irreversible blindness worldwide, caused by the gradual degeneration of retinal ganglion cells and their axons. While glaucoma is primarily considered a genetic and age-related disease, some inflammatory conditions, such as uveitis and viral-induced anterior segment inflammation, cause secondary or uveitic glaucoma. Viruses are predominant ocular pathogens and can impose both acute and chronic pathological insults to the human eye. Many viruses, including herpes simplex virus, varicella-z...
Source: Clinical Microbiology Reviews - November 15, 2023 Category: Microbiology Authors: Faraz Ahmad Nikhil Deshmukh Aaron Webel Sandra Johnson Ayman Suleiman Rajiv R Mohan Frederick Fraunfelder Pawan Kumar Singh Source Type: research
Viral infections and pathogenesis of glaucoma: a comprehensive review
Clin Microbiol Rev. 2023 Nov 15:e0005723. doi: 10.1128/cmr.00057-23. Online ahead of print.ABSTRACTSUMMARYGlaucoma is a leading cause of irreversible blindness worldwide, caused by the gradual degeneration of retinal ganglion cells and their axons. While glaucoma is primarily considered a genetic and age-related disease, some inflammatory conditions, such as uveitis and viral-induced anterior segment inflammation, cause secondary or uveitic glaucoma. Viruses are predominant ocular pathogens and can impose both acute and chronic pathological insults to the human eye. Many viruses, including herpes simplex virus, varicella-z...
Source: Herpes - November 15, 2023 Category: Infectious Diseases Authors: Faraz Ahmad Nikhil Deshmukh Aaron Webel Sandra Johnson Ayman Suleiman Rajiv R Mohan Frederick Fraunfelder Pawan Kumar Singh Source Type: research
