The Chikungunya virus: A reemerging cause of acute febrile illness in the high jungle of northern Peru
ConclusionThe study reports a considerable frequency of CHIKV infections among patients with AFI from the high jungle of northern Peru. These findings highlight the importance of recognizing CHIKV as an ongoing pathogen with continuous transmission in various areas of Peru. It is crucial to enhance epidemiological surveillance by implementing reliable diagnostic techniques, as the clinical symptoms of CHIKV infection can be nonspecific. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - December 11, 2023 Category: Tropical Medicine Authors: Miguel Angel Aguilar-Luis Source Type: research
“It’s very saddening, you keep on wondering when the symptoms will be over”: A qualitative study exploring the long-term chikungunya disease impact on daily life and well-being, 6 years after disease onset
Conclusions/SignificanceThis study, the first of its kind, indicated that the adverse impact of long-term chikungunya disease is currently underreported. The persistent rheumatic symptoms had a negative effect on functional ability, which in turn impacted broad aspects of daily life and well-being, beyond what is captured by generic instruments. In the view of the findings, physical exercise programs including manual therapy, aerobics, resistance and stretching exercises, and orthopaedic footwear interventions in a multidisciplinary patient-centred approach may improve physical function and subsequently overall well-being....
Source: PLoS Neglected Tropical Diseases - December 6, 2023 Category: Tropical Medicine Authors: Churnalisa Doran Source Type: research
Biological evaluation of 1,3-benzodioxole acids points to 3,4-(methylenedioxy) cinnamic acid as a potential larvicide against Aedes aegypti (Diptera: Culicidae)
Exp Parasitol. 2023 Dec 1:108657. doi: 10.1016/j.exppara.2023.108657. Online ahead of print.ABSTRACTAedes aegypti serves as the primary vector for viruses like dengue, Chikungunya, Zika, and yellow fever, posing a significant public health challenge in Brazil. Given the absence of approved vaccines for these diseases, effective mosquito control becomes paramount in preventing outbreaks. However, currently available chemical insecticides face issues related to toxicity and the emergence of resistance, necessitating the exploration of new active compounds. Drawing inspiration from natural products, we identified the 1,3-benz...
Source: Experimental Parasitology - December 3, 2023 Category: Parasitology Authors: Mariza Severina de Lima Silva Marcilene Souza da Silva R ômulo Carlos Dantas da Cruz Bruno de Oliveira Veras Ivone Antonia de Souza Rafael Matos Ximenes Thiago Mendon ça de Aquino Alexandre Jos é da Silva Góes Source Type: research
A multiparametric and orthogonal approach indicates low toxicity for zein nanoparticles in a repellent formulation
This study evaluates the cytotoxicity of a repellent formulation containing zein nanoparticles (NP) loading geraniol (Ger) and icaridin (Ica) in three cell lines: NIH/3 T3, HaCaT, and SIRC. To address formulation hazards, IC50 values were determined by MTT and Calcein-AM assays. In both NIH/3 T3 and HaCaT, the IC50 values for NP + Ger + Ica formulation were around 0.2%. For risk assessment, cell viability was also determined after a single exposure and repeated exposure to the formulation. No evidence of cytotoxicity was observed for NP + Ger + Ica formulation-treated cells. The risk assessment for eye damage revealed cyto...
Source: Toxicology in Vitro - December 3, 2023 Category: Toxicology Authors: Tuanny Leite Almeida Aline Francisca Moreira Jhones Luiz de Oliveira Carolina Barbara Rogerio Samara Flamini Kiihl Leonardo Fernandes Fraceto Marcelo Bispo de Jesus Source Type: research
Transcriptome analysis of Huh7 cells upon Chikungunya virus infection and capsid transfection reveals regulation of distinct cellular and metabolic pathways
Virology. 2023 Nov 28;589:109953. doi: 10.1016/j.virol.2023.109953. Online ahead of print.ABSTRACTChikungunya virus (CHIKV) causes persistent arthritis and neurological problems imposing a huge burden globally. The present study aims to understand the interaction mechanism of Chikungunya virus and CHIKV-capsid in Huh7 cells. The RNA-sequencing and qRT-PCR method was used for the transcript and gene profiles of CHIKV virus and CHIKV capsid alone. Transcriptional analysis showed capsid induced 1114 and 956 differentially expressed genes (DEGs) to be upregulated and downregulated respectively, while in virus, 933 genes were u...
Source: Virology - December 3, 2023 Category: Virology Authors: Nitika Gaurav Shivani Kumar Siva Raghavendhar Praveen Kumar Tripathi Shipra Gupta Ravi Arya Ashok Kumar Patel Source Type: research
Biological evaluation of 1,3-benzodioxole acids points to 3,4-(methylenedioxy) cinnamic acid as a potential larvicide against Aedes aegypti (Diptera: Culicidae)
Exp Parasitol. 2023 Dec 1:108657. doi: 10.1016/j.exppara.2023.108657. Online ahead of print.ABSTRACTAedes aegypti serves as the primary vector for viruses like dengue, Chikungunya, Zika, and yellow fever, posing a significant public health challenge in Brazil. Given the absence of approved vaccines for these diseases, effective mosquito control becomes paramount in preventing outbreaks. However, currently available chemical insecticides face issues related to toxicity and the emergence of resistance, necessitating the exploration of new active compounds. Drawing inspiration from natural products, we identified the 1,3-benz...
Source: Experimental Parasitology - December 3, 2023 Category: Parasitology Authors: Mariza Severina de Lima Silva Marcilene Souza da Silva R ômulo Carlos Dantas da Cruz Bruno de Oliveira Veras Ivone Antonia de Souza Rafael Matos Ximenes Thiago Mendon ça de Aquino Alexandre Jos é da Silva Góes Source Type: research
A multiparametric and orthogonal approach indicates low toxicity for zein nanoparticles in a repellent formulation
This study evaluates the cytotoxicity of a repellent formulation containing zein nanoparticles (NP) loading geraniol (Ger) and icaridin (Ica) in three cell lines: NIH/3 T3, HaCaT, and SIRC. To address formulation hazards, IC50 values were determined by MTT and Calcein-AM assays. In both NIH/3 T3 and HaCaT, the IC50 values for NP + Ger + Ica formulation were around 0.2%. For risk assessment, cell viability was also determined after a single exposure and repeated exposure to the formulation. No evidence of cytotoxicity was observed for NP + Ger + Ica formulation-treated cells. The risk assessment for eye damage revealed cyto...
Source: Toxicology in Vitro - December 3, 2023 Category: Toxicology Authors: Tuanny Leite Almeida Aline Francisca Moreira Jhones Luiz de Oliveira Carolina Barbara Rogerio Samara Flamini Kiihl Leonardo Fernandes Fraceto Marcelo Bispo de Jesus Source Type: research
Biological evaluation of 1,3-benzodioxole acids points to 3,4-(methylenedioxy) cinnamic acid as a potential larvicide against Aedes aegypti (Diptera: Culicidae)
Exp Parasitol. 2023 Dec 1:108657. doi: 10.1016/j.exppara.2023.108657. Online ahead of print.ABSTRACTAedes aegypti serves as the primary vector for viruses like dengue, Chikungunya, Zika, and yellow fever, posing a significant public health challenge in Brazil. Given the absence of approved vaccines for these diseases, effective mosquito control becomes paramount in preventing outbreaks. However, currently available chemical insecticides face issues related to toxicity and the emergence of resistance, necessitating the exploration of new active compounds. Drawing inspiration from natural products, we identified the 1,3-benz...
Source: Experimental Parasitology - December 3, 2023 Category: Parasitology Authors: Mariza Severina de Lima Silva Marcilene Souza da Silva R ômulo Carlos Dantas da Cruz Bruno de Oliveira Veras Ivone Antonia de Souza Rafael Matos Ximenes Thiago Mendon ça de Aquino Alexandre Jos é da Silva Góes Source Type: research
