Over 90% of Childhood BCG Vaccine-Induced Keloids in Japan Occur in Women
ConclusionTo our knowledge, this is the largest report in the literature on childhood-onset keloids. There was overall female predominance in childhood-onset keloids, and even more significant female predominance in BCG-induced keloids. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 23, 2023 Category: Dermatology Source Type: research
Analysis: Flawed Datasets of Monkeypox Skin Images
AbstractThe self-proclaimed first publicly available dataset of Monkeypox skin images consists of medically irrelevant images extracted from Google and photography repositories through a process denominated web-scrapping. Yet, this did not stop other researchers from employing it to build Machine Learning (ML) solutions aimed at computer-aided diagnosis of Monkeypox and other viral infections presenting skin lesions. Neither did it stop the reviewers or editors from publishing these subsequent works in peer-reviewed journals. Several of these works claimed extraordinary performance in the classification of Monkeypox, Chick...
Source: Journal of Medical Systems - March 18, 2023 Category: Information Technology Source Type: research
Varicella Zoster Virus infects mucosal associated Invariant T cells
DiscussionThese data identify MAIT cells as being permissive to VZV infection and identify impacts of such infection on co- expressed functional markers. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 17, 2023 Category: Allergy & Immunology Source Type: research
Delayed acyclovir therapy for disseminated varicella zoster in an adult kidney transplant recipient: a case report and literature review
CONCLUSION: We experienced a successful ACV treatment for delayed and severe VZV infection with a literature review of VZV pneumonitis among kidney transplant recipients. To the best of our knowledge, this is the first case that presented a disseminated skin form with pneumonitis of VZV from Syria. This case supports the initiation of antiviral therapy for transplant patients even after 72 hours the onset of the rash despite the lack of evidence in these circumstances.PMID:36923769 | PMC:PMC10010797 | DOI:10.1097/MS9.0000000000000231 (Source: Annals of Medicine)
Source: Annals of Medicine - March 16, 2023 Category: Internal Medicine Authors: Mohammad Alsultan Marwa Kliea Qussai Hassan Kassem Basha Source Type: research
Poxes Great and Small: The Stories Behind Their Names
The word “pox” indicated, during the late 15th Century, a disease characterized by eruptive sores. When an outbreak of syphilis began in Europe during that time, it was called by many names including the French term “La Grosse Verole” (“the great pox”) to distinguish it from smallpox which was te rmed “La Petite Verole” (“the small pox”). Chickenpox was initially confused with smallpox until 1767, when the English physician William Heberden (1710-1801) provided a detailed description of chickenpox, differentiating it from smallpox. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - March 9, 2023 Category: Dermatology Authors: Amber B. Czinn, Leonard J. Hoenig Tags: Reflections on Dermatology: Past, Present, and Future Source Type: research
Incidence and clinical and microbiological features of invasive and probable invasive streptococcal group A infections in children and adults in the Brussels-Capital Region, 2005 –2020
AbstractAssess the incidence, risk factors, clinical and microbiological features, and outcome of both probable invasive and invasive group AStreptococcus (GAS) infections in children and adults in the BrusselsCapital Region between 2005 and 2020. A retrospective, multicentric study was performed in three university hospitals in Brussels. Patients were identified through the centralized laboratory information system. Epidemiological and clinical data were collected from patients ’ hospital records. A total of 467 cases were identified. Incidence has increased from 2.1 to 10.9/100,000 inhabitants between 2009 and 2019 in ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 7, 2023 Category: Microbiology Source Type: research
The impact of patient skin colour on diagnostic ability and confidence of medical students
This study aimed to examine whether patient skin colour can affect the diagnostic ability and confidence of medical students, and their cognitive reasoning processes. We presented students with 12 different clinical presentations on both white skin (WS) and non-white skin (NWS). A think aloud (TA) study was conducted to explore students ’ cognitive reasoning processes (n = 8). An online quiz was also conducted where students submitted a diagnosis and confidence level for each clinical presentation (n = 185). In the TA interviews, students used similar levels of information gathering and analytical reasoning for e...
Source: Advances in Health Sciences Education - March 1, 2023 Category: Universities & Medical Training Source Type: research
Herpes Simplex Virus and Varicella Zoster Virus Infections in Cancer Patients
Viruses. 2023 Feb 5;15(2):439. doi: 10.3390/v15020439.ABSTRACTHerpes simplex virus (HSV) and varicella zoster virus (VZV) are alpha herpesviruses that establish life-long latent infection in neuronal ganglia after primary infection. Periodic reactivation of these viruses results in recurrent infections that can have significant impact on patients' quality of life. HSV commonly causes oral and genital mucocutaneous infections whereas VZV is responsible for varicella/chickenpox and herpes zoster/shingles, but cancer patients are at particularly higher risk of complications including disseminated and visceral infections due t...
Source: Herpes - February 28, 2023 Category: Infectious Diseases Authors: Ralph Tayyar Dora Ho Source Type: research
Herpes Simplex Virus and Varicella Zoster Virus Infections in Cancer Patients
Viruses. 2023 Feb 5;15(2):439. doi: 10.3390/v15020439.ABSTRACTHerpes simplex virus (HSV) and varicella zoster virus (VZV) are alpha herpesviruses that establish life-long latent infection in neuronal ganglia after primary infection. Periodic reactivation of these viruses results in recurrent infections that can have significant impact on patients' quality of life. HSV commonly causes oral and genital mucocutaneous infections whereas VZV is responsible for varicella/chickenpox and herpes zoster/shingles, but cancer patients are at particularly higher risk of complications including disseminated and visceral infections due t...
Source: Herpes - February 28, 2023 Category: Infectious Diseases Authors: Ralph Tayyar Dora Ho Source Type: research
Designing of thiazolidinones against chicken pox, monkey pox, and hepatitis viruses: A computational approach
Comput Biol Chem. 2023 Feb 12;103:107827. doi: 10.1016/j.compbiolchem.2023.107827. Online ahead of print.ABSTRACTComputational designing of four different series (D-G) of thiazolidinone was done starting from different amines which was further condensed with various aldehydes. These underwent in silico molecular investigations for density functional theory (DFT), molecular docking, and absorption, distribution metabolism, excretion, and toxicity (ADMET) studies. The different electrochemical parameters of the compounds are predicted using quantum mechanical modeling approach with Gaussian. The docking software was used to ...
Source: Computational Biology and Chemistry - February 22, 2023 Category: Bioinformatics Authors: Muhammad Asam Raza Umme Farwa Fatima Ishaque Abdullah G Al-Sehemi Source Type: research
Designing of thiazolidinones against chicken pox, monkey pox, and hepatitis viruses: A computational approach
Comput Biol Chem. 2023 Feb 12;103:107827. doi: 10.1016/j.compbiolchem.2023.107827. Online ahead of print.ABSTRACTComputational designing of four different series (D-G) of thiazolidinone was done starting from different amines which was further condensed with various aldehydes. These underwent in silico molecular investigations for density functional theory (DFT), molecular docking, and absorption, distribution metabolism, excretion, and toxicity (ADMET) studies. The different electrochemical parameters of the compounds are predicted using quantum mechanical modeling approach with Gaussian. The docking software was used to ...
Source: Computational Biology and Chemistry - February 22, 2023 Category: Bioinformatics Authors: Muhammad Asam Raza Umme Farwa Fatima Ishaque Abdullah G Al-Sehemi Source Type: research
Monkeypox Infection Causing Conjunctival Vesicles and Anterior Uveitis
Ocul Immunol Inflamm. 2023 Feb 17:1-2. doi: 10.1080/09273948.2023.2174884. Online ahead of print.ABSTRACTHuman monkeypox is a zoonosis caused by an orthopoxvirus and the clinical presentation resembles that of smallpox and chickenpox. The disease may start with a prodrome that includes lymphadenopathy, headache, fatigue, and fever, followed by a vesiculo-pustular rash. Ocular manifestations such as conjunctivitis and edema are present in approximately 20% of affected people, with a greater incidence among unvaccinated patients. Corneal involvement has also been reported and can result in corneal scarring and severe forms o...
Source: Ocular Immunology and Inflammation - February 17, 2023 Category: Allergy & Immunology Authors: Erika Moreira Carvalho Manuela Medeiros Valdilea Gon çalves Veloso Ana Luiza Biancardi Andr é Luiz Land Curi Source Type: research
