When a neglected tropical disease goes global: early estimates from the Monkeypox outbreak, the first 1,054 cases
Acta Biomed. 2022 Dec 16;93(6):e2022330. doi: 10.23750/abm.v93i6.13306.ABSTRACTMonkeypox virus (MPXV), genus Orthopoxvirus, is a large double-stranded DNA virus (200-250 nm), that is evolutionarily related to human variola virus (VARV) (1), and causes a clinical syndrome quite similar to smallpox, with a generally less severe outcome (1,2). MPXV has a wide range of hosts and reservoirs in wild animals, and since 1970 has been commonly acknowledged as a human pathogen, endemic to Central and Western African countries through two distinctive clades (2,3). Central African clade (CAC) is responsible of the majority of 20,000 i...
Source: Acta Bio-Medica : Atenei Parmensis - December 19, 2022 Category: General Medicine Authors: Matteo Ricc ò Source Type: research
When a neglected tropical disease goes global: early estimates from the Monkeypox outbreak, the first 1,054 cases
Acta Biomed. 2022 Dec 16;93(6):e2022330. doi: 10.23750/abm.v93i6.13306.ABSTRACTMonkeypox virus (MPXV), genus Orthopoxvirus, is a large double-stranded DNA virus (200-250 nm), that is evolutionarily related to human variola virus (VARV) (1), and causes a clinical syndrome quite similar to smallpox, with a generally less severe outcome (1,2). MPXV has a wide range of hosts and reservoirs in wild animals, and since 1970 has been commonly acknowledged as a human pathogen, endemic to Central and Western African countries through two distinctive clades (2,3). Central African clade (CAC) is responsible of the majority of 20,000 i...
Source: Acta Bio-Medica : Atenei Parmensis - December 19, 2022 Category: General Medicine Authors: Matteo Ricc ò Source Type: research
When a neglected tropical disease goes global: early estimates from the Monkeypox outbreak, the first 1,054 cases
Acta Biomed. 2022 Dec 16;93(6):e2022330. doi: 10.23750/abm.v93i6.13306.ABSTRACTMonkeypox virus (MPXV), genus Orthopoxvirus, is a large double-stranded DNA virus (200-250 nm), that is evolutionarily related to human variola virus (VARV) (1), and causes a clinical syndrome quite similar to smallpox, with a generally less severe outcome (1,2). MPXV has a wide range of hosts and reservoirs in wild animals, and since 1970 has been commonly acknowledged as a human pathogen, endemic to Central and Western African countries through two distinctive clades (2,3). Central African clade (CAC) is responsible of the majority of 20,000 i...
Source: Acta Bio-Medica : Atenei Parmensis - December 19, 2022 Category: General Medicine Authors: Matteo Ricc ò Source Type: research
When a neglected tropical disease goes global: early estimates from the Monkeypox outbreak, the first 1,054 cases
Acta Biomed. 2022 Dec 16;93(6):e2022330. doi: 10.23750/abm.v93i6.13306.ABSTRACTMonkeypox virus (MPXV), genus Orthopoxvirus, is a large double-stranded DNA virus (200-250 nm), that is evolutionarily related to human variola virus (VARV) (1), and causes a clinical syndrome quite similar to smallpox, with a generally less severe outcome (1,2). MPXV has a wide range of hosts and reservoirs in wild animals, and since 1970 has been commonly acknowledged as a human pathogen, endemic to Central and Western African countries through two distinctive clades (2,3). Central African clade (CAC) is responsible of the majority of 20,000 i...
Source: Acta Bio-Medica : Atenei Parmensis - December 19, 2022 Category: General Medicine Authors: Matteo Ricc ò Source Type: research
When a neglected tropical disease goes global: early estimates from the Monkeypox outbreak, the first 1,054 cases
Acta Biomed. 2022 Dec 16;93(6):e2022330. doi: 10.23750/abm.v93i6.13306.ABSTRACTMonkeypox virus (MPXV), genus Orthopoxvirus, is a large double-stranded DNA virus (200-250 nm), that is evolutionarily related to human variola virus (VARV) (1), and causes a clinical syndrome quite similar to smallpox, with a generally less severe outcome (1,2). MPXV has a wide range of hosts and reservoirs in wild animals, and since 1970 has been commonly acknowledged as a human pathogen, endemic to Central and Western African countries through two distinctive clades (2,3). Central African clade (CAC) is responsible of the majority of 20,000 i...
Source: Acta Bio-Medica : Atenei Parmensis - December 19, 2022 Category: General Medicine Authors: Matteo Ricc ò Source Type: research
When a neglected tropical disease goes global: early estimates from the Monkeypox outbreak, the first 1,054 cases
Acta Biomed. 2022 Dec 16;93(6):e2022330. doi: 10.23750/abm.v93i6.13306.ABSTRACTMonkeypox virus (MPXV), genus Orthopoxvirus, is a large double-stranded DNA virus (200-250 nm), that is evolutionarily related to human variola virus (VARV) (1), and causes a clinical syndrome quite similar to smallpox, with a generally less severe outcome (1,2). MPXV has a wide range of hosts and reservoirs in wild animals, and since 1970 has been commonly acknowledged as a human pathogen, endemic to Central and Western African countries through two distinctive clades (2,3). Central African clade (CAC) is responsible of the majority of 20,000 i...
Source: Acta Bio-Medica : Atenei Parmensis - December 19, 2022 Category: General Medicine Authors: Matteo Ricc ò Source Type: research
When a neglected tropical disease goes global: early estimates from the Monkeypox outbreak, the first 1,054 cases
Acta Biomed. 2022 Dec 16;93(6):e2022330. doi: 10.23750/abm.v93i6.13306.ABSTRACTMonkeypox virus (MPXV), genus Orthopoxvirus, is a large double-stranded DNA virus (200-250 nm), that is evolutionarily related to human variola virus (VARV) (1), and causes a clinical syndrome quite similar to smallpox, with a generally less severe outcome (1,2). MPXV has a wide range of hosts and reservoirs in wild animals, and since 1970 has been commonly acknowledged as a human pathogen, endemic to Central and Western African countries through two distinctive clades (2,3). Central African clade (CAC) is responsible of the majority of 20,000 i...
Source: Acta Bio-Medica : Atenei Parmensis - December 19, 2022 Category: General Medicine Authors: Matteo Ricc ò Source Type: research
When a neglected tropical disease goes global: early estimates from the Monkeypox outbreak, the first 1,054 cases
Acta Biomed. 2022 Dec 16;93(6):e2022330. doi: 10.23750/abm.v93i6.13306.ABSTRACTMonkeypox virus (MPXV), genus Orthopoxvirus, is a large double-stranded DNA virus (200-250 nm), that is evolutionarily related to human variola virus (VARV) (1), and causes a clinical syndrome quite similar to smallpox, with a generally less severe outcome (1,2). MPXV has a wide range of hosts and reservoirs in wild animals, and since 1970 has been commonly acknowledged as a human pathogen, endemic to Central and Western African countries through two distinctive clades (2,3). Central African clade (CAC) is responsible of the majority of 20,000 i...
Source: Acta Bio-Medica : Atenei Parmensis - December 19, 2022 Category: General Medicine Authors: Matteo Ricc ò Source Type: research
When a neglected tropical disease goes global: early estimates from the Monkeypox outbreak, the first 1,054 cases
Acta Biomed. 2022 Dec 16;93(6):e2022330. doi: 10.23750/abm.v93i6.13306.ABSTRACTMonkeypox virus (MPXV), genus Orthopoxvirus, is a large double-stranded DNA virus (200-250 nm), that is evolutionarily related to human variola virus (VARV) (1), and causes a clinical syndrome quite similar to smallpox, with a generally less severe outcome (1,2). MPXV has a wide range of hosts and reservoirs in wild animals, and since 1970 has been commonly acknowledged as a human pathogen, endemic to Central and Western African countries through two distinctive clades (2,3). Central African clade (CAC) is responsible of the majority of 20,000 i...
Source: Acta Bio-Medica : Atenei Parmensis - December 19, 2022 Category: General Medicine Authors: Matteo Ricc ò Source Type: research
Viruses, Vol. 14, Pages 2800: Reassessment of Evidence about Coinfection of Chickenpox and Monkeypox (Mpox) in African Children
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In west and central Africa, monkeypox occurs mainly in older children, adolescents and young adults. In two large epidemiology studies of monkeypox outbreaks, the investigators observed a sizable number of coinfections of chickenpox (varicella) and monkeypox. Based on a review of the literature, we propose that chickenpox (human herpesvirus-3 infection) is a risk factor for acquisition of monkeypox infection. Our hypothesis states that the chickenpox skin lesion provides an entry site for the monkeypox virus, which is harbored on a fomite in the environment of the patient. The fact that monkeypox can enter via a sc...
Source: Viruses - December 15, 2022 Category: Virology Authors: Ola Khallafallah Charles Grose Tags: Review Source Type: research
EE396 Public Health Impact and Cost-Effectiveness of Herpes Zoster Vaccination for Older Adults in the Netherlands
Varicella-zoster virus (VZV) causes chickenpox in children, and subsequently establishes a latent infection in dorsal root ganglia in the spinal cord. Decades later, it may reactivate, causing herpes zoster (HZ), a painful dermatomal skin rash ( “shingles”), in adults and especially in older individuals. Reactivation of latent VZV is mostly due to immunosenescence, i.e., an age-related functional decline of the immune system. A potential complication linked to HZ is postherpetic neuralgia (PHN), characterised by neuropathic pain which c an last for months or years. (Source: Value in Health)
Source: Value in Health - December 1, 2022 Category: International Medicine & Public Health Authors: S Van der Pol, N Giannelos, S Joost, JC Wilschut, MJ Postma, C Boersma Source Type: research
Viruses, Vol. 14, Pages 2667: Prevention of Herpes Zoster: A Focus on the Effectiveness and Safety of Herpes Zoster Vaccines
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Infection with varicella zoster virus typically occurs in children and it can cause primary varicella infection or “chickenpox”, or it can reactivate later in life and cause herpes zoster or “shingles”. Herpes zoster mainly occurs in older adults, causing a reduction in activities of daily living, impacting quality of life, and may lead to serious complications, including chronic pain. Two vaccines are marketed to prevent herpes zoster: the live zoster vaccine and the non-live, recombinant zoster vaccine. The pre-licensure clinical trials show the efficacy of ...
Source: Viruses - November 29, 2022 Category: Virology Authors: Yasmin Marra Fawziah Lalji Tags: Review Source Type: research
A simple transwell-based infection system for obtaining pure populations of VZV-infected cells
J Virol Methods. 2022 Nov 25:114661. doi: 10.1016/j.jviromet.2022.114661. Online ahead of print.ABSTRACTVaricella-Zoster virus (VZV) is a human herpesvirus and causes chickenpox and shingles. Research into its molecular virology has been hampered by a lack of methods for generation of high-titre, cell-free infectious virus preparations. VZV propagation and infection in vitro is therefore commonly achieved by co-culture of uninfected 'target' cells with infected 'inoculum' cells. A major drawback of this approach is that it results in mixed cell populations after infection. To overcome this limitation we developed a transwe...
Source: Journal of Virological Methods - November 28, 2022 Category: Virology Authors: Jonny Hertzog Jan Rehwinkel Source Type: research
A simple transwell-based infection system for obtaining pure populations of VZV-infected cells
J Virol Methods. 2022 Nov 25:114661. doi: 10.1016/j.jviromet.2022.114661. Online ahead of print.ABSTRACTVaricella-Zoster virus (VZV) is a human herpesvirus and causes chickenpox and shingles. Research into its molecular virology has been hampered by a lack of methods for generation of high-titre, cell-free infectious virus preparations. VZV propagation and infection in vitro is therefore commonly achieved by co-culture of uninfected 'target' cells with infected 'inoculum' cells. A major drawback of this approach is that it results in mixed cell populations after infection. To overcome this limitation we developed a transwe...
Source: Journal of Virological Methods - November 28, 2022 Category: Virology Authors: Jonny Hertzog Jan Rehwinkel Source Type: research
Herpes zoster: A primary care approach to diagnosis and treatment
This article describes recent changes in diagnostic testing, treatment, prevention, and practice guidelines as well as the approach clinicians should take when evaluating patients with herpes zoster and assessing risk for complications. (Source: Journal of the American Academy of Physician Assistants)
Source: Journal of the American Academy of Physician Assistants - November 24, 2022 Category: Primary Care Tags: CME: Primary Care Source Type: research
