Mechanistic of Vesicular Ethosomes and Elastic Liposomes on Permeation Profiles of Acyclovir across Artificial Membrane, Human Cultured EpiDerm, and Rat Skin: In Vitro-Ex Vivo Study
Pharmaceutics. 2023 Aug 24;15(9):2189. doi: 10.3390/pharmaceutics15092189.ABSTRACTAcyclovir (ACV) controls cutaneous herpes, genital herpes, herpes keratitis, varicella zoster, and chickenpox. From previously reported ACV formulations, we continued to explore the permeation behavior of the optimized ACV loaded optimized ethosome (ETHO2R) and elastic liposome (ELP3R) and their respective carbopol gels across artificial membrane, cultured human EpiDerm, and rat skin. Transepidermal water loss (TEWL), scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM), and atomic force microscopy (AFM) were used to ...
Source: Herpes - September 28, 2023 Category: Infectious Diseases Authors: Afzal Hussain Mohammad A Altamimi Obaid Afzal Abdulmalik S A Altamimi Mohhammad Ramzan Tahir Khuroo Source Type: research
Postexposure prophylaxis for varicella/shingles: a review of the UKHSA guidelines
Background Varicella zoster virus (VZV) is a human herpes virus that causes chickenpox (or varicella) and shingles. Chickenpox, which occurs with primary VZV infection, is highly contagious and is typically a mild illness in childhood. Shingles, which occurs with reactivation of latent VZV, is less common in childhood than adulthood but can still affect both immunocompromised and immunocompetent children following previous chickenpox infection or varicella vaccination. Information about the current guideline The UK Health Security Agency (UKHSA) ‘guidelines on postexposure prophylaxis (PEP) for varicella/shingles&rsq...
Source: Archives of Disease in Childhood - Education and Practice - September 20, 2023 Category: Pediatrics Authors: Jeyaraj, R., Alexander, E., Cutino-Moguel, T., Li, S., Kainth, R. Tags: Guideline review Source Type: research
Clinical profile, risk factors and complications of paediatric herpes zoster ophthalmicus & #8212;A case series
Josephine S Christy, Sushad Prasad, Aaishwariya A GulaniIndian Journal of Dermatology 2023 68(4):455-458
To study the clinical profile, risk factors and complications of paediatric Herpes zoster ophthalmicus (HZO). Case records of clinically diagnosed paediatric HZO over the past five years period were collected. An analysis was done with the existing data to determine the patient's clinical presentation, risk factors and treatment outcomes. Among seven children (three males and four females), two were less than ten years. Risk factors like previous history of chickenpox were present in one patient and immunosu...
Source: Indian Journal of Dermatology - August 31, 2023 Category: Dermatology Authors: Josephine S Christy Sushad Prasad Aaishwariya A Gulani Source Type: research
A case of varicella zoster infection in kidney transplant recipient using immunosuppressant
Admission pictures of the patient. Key Clinical MessageKidney transplant recipients must take lifelong immunosuppression to prevent acute or chronic allograft injury. However, they are also at risk for opportunistic infections due to compromised immune cell functionality. Disseminated HZ in kidney transplant recipients can result in a very high overall mortality rate of up to 30%. Here we described a 23-year-old male patient who presented to the emergency room with a complaint of high-grade fever, chills, and non-dermatomal lesion of varicella zoster skin infection that affected the face and trunk. After investigation the ...
Source: Clinical Case Reports - August 24, 2023 Category: General Medicine Authors: Abdirahim Ali Nur Adam,
Abdulrashid Hashi Mohamed,
Mohamed Osman Omar Jeele Tags: CASE REPORT Source Type: research
Causal Relations between Prodromal Infection and Neuromyelitis Optica Spectrum Disorder: A Mendelian Randomization Study
CONCLUSION: These findings suggested the positive associations between cold sores, shingles and AQP4-ab-positive NMOSD, indicating there may be causal relations between herpes simplex virus, varicella-zoster virus infection and AQP4-ab-positive NMOSD.PMID:37540821 | DOI:10.1111/ene.16014 (Source: Herpes)
Source: Herpes - August 4, 2023 Category: Infectious Diseases Authors: Liang Wang Lei Zhou Jingzi ZhangBao Wenjuan Huang Hongmei Tan Yuxin Fan Chuanzhen Lu Jian Yu Min Wang Jiahong Lu Chongbo Zhao Tiansong Zhang Chao Quan Source Type: research
Causal Relations between Prodromal Infection and Neuromyelitis Optica Spectrum Disorder: A Mendelian Randomization Study
CONCLUSION: These findings suggested the positive associations between cold sores, shingles and AQP4-ab-positive NMOSD, indicating there may be causal relations between herpes simplex virus, varicella-zoster virus infection and AQP4-ab-positive NMOSD.PMID:37540821 | DOI:10.1111/ene.16014 (Source: Herpes)
Source: Herpes - August 4, 2023 Category: Infectious Diseases Authors: Liang Wang Lei Zhou Jingzi ZhangBao Wenjuan Huang Hongmei Tan Yuxin Fan Chuanzhen Lu Jian Yu Min Wang Jiahong Lu Chongbo Zhao Tiansong Zhang Chao Quan Source Type: research
Rapid detection of varicella-zoster virus based on an immunochromatographic strip
In this study, VZV gE protein, expressed in CHO cells, was used to immunize BALB/c mice for the generation of monoclonal antibodies (mAbs). For the first time, we developed a colloidal gold-based immunochromatographic strip for rapid detection of VZV using a pair of mAbs against gE protein. The limit of detection (LOD) of the strip was 30 ng mL-1 of purified VZV gE antigen, and it could specifically test VZV without cross-reactivity with Enterovirus 71 (EV-71), Herpes simplex virus 1 (HSV-1) and Herpes simplex virus 2 (HSV-2). The coincidence rate between the strip and commercial real-time PCR diagnostic kit was 100% using...
Source: Virology - July 23, 2023 Category: Virology Authors: Aiping Wang Yan Niu Jianguo Zhao Hongliang Liu Peiyang Ding Yumei Chen Jingming Zhou Xifang Zhu Ying Zhang Chao Liang Gaiping Zhang Source Type: research
Rapid detection of varicella-zoster virus based on an immunochromatographic strip
In this study, VZV gE protein, expressed in CHO cells, was used to immunize BALB/c mice for the generation of monoclonal antibodies (mAbs). For the first time, we developed a colloidal gold-based immunochromatographic strip for rapid detection of VZV using a pair of mAbs against gE protein. The limit of detection (LOD) of the strip was 30 ng mL-1 of purified VZV gE antigen, and it could specifically test VZV without cross-reactivity with Enterovirus 71 (EV-71), Herpes simplex virus 1 (HSV-1) and Herpes simplex virus 2 (HSV-2). The coincidence rate between the strip and commercial real-time PCR diagnostic kit was 100% using...
Source: Herpes - July 23, 2023 Category: Infectious Diseases Authors: Aiping Wang Yan Niu Jianguo Zhao Hongliang Liu Peiyang Ding Yumei Chen Jingming Zhou Xifang Zhu Ying Zhang Chao Liang Gaiping Zhang Source Type: research
Rapid detection of varicella-zoster virus based on an immunochromatographic strip
In this study, VZV gE protein, expressed in CHO cells, was used to immunize BALB/c mice for the generation of monoclonal antibodies (mAbs). For the first time, we developed a colloidal gold-based immunochromatographic strip for rapid detection of VZV using a pair of mAbs against gE protein. The limit of detection (LOD) of the strip was 30 ng mL-1 of purified VZV gE antigen, and it could specifically test VZV without cross-reactivity with Enterovirus 71 (EV-71), Herpes simplex virus 1 (HSV-1) and Herpes simplex virus 2 (HSV-2). The coincidence rate between the strip and commercial real-time PCR diagnostic kit was 100% using...
Source: Virology - July 23, 2023 Category: Virology Authors: Aiping Wang Yan Niu Jianguo Zhao Hongliang Liu Peiyang Ding Yumei Chen Jingming Zhou Xifang Zhu Ying Zhang Chao Liang Gaiping Zhang Source Type: research
Causal association between inflammatory bowel disease and herpes virus infections: a two-sample bidirectional Mendelian randomization study
CONCLUSION: This study showed a suggestive causality for both CD-chickenpox and UC-mononucleosis, despite no associations reaching a statistical significance value after corrections for multiple testing. There was no evidence of a causal association between IBD and its two subtypes on herpes zoster.PMID:37465669 | PMC:PMC10351388 | DOI:10.3389/fimmu.2023.1203707 (Source: Herpes)
Source: Herpes - July 19, 2023 Category: Infectious Diseases Authors: Menglong Zou Wei Zhang Lele Shen Yin Xu Ying Zhu Source Type: research
Causal association between inflammatory bowel disease and herpes virus infections: a two-sample bidirectional Mendelian randomization study
CONCLUSION: This study showed a suggestive causality for both CD-chickenpox and UC-mononucleosis, despite no associations reaching a statistical significance value after corrections for multiple testing. There was no evidence of a causal association between IBD and its two subtypes on herpes zoster.PMID:37465669 | PMC:PMC10351388 | DOI:10.3389/fimmu.2023.1203707 (Source: Herpes)
Source: Herpes - July 19, 2023 Category: Infectious Diseases Authors: Menglong Zou Wei Zhang Lele Shen Yin Xu Ying Zhu Source Type: research
A study on knowledge, attitude, and vaccination behavior of herpes zoster vaccine among urban residents in selected areas of China
Conclusion: Low knowledge of herpes zoster and its vaccine, positive attitudes towards the preventive effects of herpes zoster and its vaccine, and extremely low vaccination rates among the urban population in China call for multiple measures to strengthen health education and vaccination recommendations for residents, especially for the elderly, low-education and low-income populations.PMID:37380410 | DOI:10.3760/cma.j.cn112338-20221125-00998 (Source: Herpes)
Source: Herpes - June 28, 2023 Category: Infectious Diseases Authors: M Wang C Long M Z Hu Y S Wang Y Q Xia B B Yuan D W Zhu P He Source Type: research
Stroke risk after varicella-zoster virus infection: a systematic review and meta-analysis
In conclusion, the risk of stroke increases after VZV infection, decreasing over time. Post-infection vascular inflammatory changes often occur in the middle cerebral artery and its branches, with a better prognosis in most patients and less frequent persistent progression.PMID:37219811 | DOI:10.1007/s13365-023-01144-0 (Source: Herpes)
Source: Herpes - May 23, 2023 Category: Infectious Diseases Authors: Ping Lu Lingyun Cui Xinghu Zhang Source Type: research
Stroke risk after varicella-zoster virus infection: a systematic review and meta-analysis
In conclusion, the risk of stroke increases after VZV infection, decreasing over time. Post-infection vascular inflammatory changes often occur in the middle cerebral artery and its branches, with a better prognosis in most patients and less frequent persistent progression.PMID:37219811 | DOI:10.1007/s13365-023-01144-0 (Source: Herpes)
Source: Herpes - May 23, 2023 Category: Infectious Diseases Authors: Ping Lu Lingyun Cui Xinghu Zhang Source Type: research
Stroke risk after varicella-zoster virus infection: a systematic review and meta-analysis
In conclusion, the risk of stroke increases after VZV infection, decreasing over time. Po st-infection vascular inflammatory changes often occur in the middle cerebral artery and its branches, with a better prognosis in most patients and less frequent persistent progression. (Source: Journal of NeuroVirology)
Source: Journal of NeuroVirology - May 23, 2023 Category: Neurology Source Type: research
