A Compound Essential Oil Alters Stratum Corneum Structure, Potentially Promoting the Transdermal Permeation of Hydrophobic and Hydrophilic Ingredients
CONCLUSION: It is concluded that the prepared CEO can promote the transdermal permeation of hydrophobic and hydrophilic ingredients. This study will provide a reference for the application of the prepared CEO in the development of cosmeceuticals with natural efficacy.PMID:36683374 | DOI:10.2174/1567201820666230120122206 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 23, 2023 Category: Drugs & Pharmacology Authors: Na Yang Xinyi Ai Kang Cheng Yihan Wu Zhi Lu Zhenda Liu Teng Guo Nianping Feng Source Type: research
A Compound Essential Oil Alters Stratum Corneum Structure, Potentially Promoting the Transdermal Permeation of Hydrophobic and Hydrophilic Ingredients
CONCLUSION: It is concluded that the prepared CEO can promote the transdermal permeation of hydrophobic and hydrophilic ingredients. This study will provide a reference for the application of the prepared CEO in the development of cosmeceuticals with natural efficacy.PMID:36683374 | DOI:10.2174/1567201820666230120122206 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 23, 2023 Category: Drugs & Pharmacology Authors: Na Yang Xinyi Ai Kang Cheng Yihan Wu Zhi Lu Zhenda Liu Teng Guo Nianping Feng Source Type: research
Cinnamaldehyde ameliorates dextran sulfate sodium-induced colitis in mice by modulating TLR4/NF- κB signaling pathway and NLRP3 inflammasome activation
In this study, network pharmacology and molecular docking analyses were introduced to predict the potential targets and mechanism of CIN against UC. The therapeutic effect and the predicted targets of CIN on UC were further validated by in vivo and in vitro experiments. Seven intersection targets shared by CIN and UC were obtained, and four hub targets, i.e., toll-like receptor 4 (TLR4), transcription factor p65 (NF-κB), NF-kappa-B inhibitor alpha (IκBα), prostaglandin G/H synthase 2 (COX2) were acquired, which were mainly involved in NF-κB, tumour necrosis factor (TNF), Toll-like receptor and NOD-like receptor signali...
Source: Chemistry and Biodiversity - January 18, 2023 Category: Biochemistry Authors: Xiaofen Tan Yifan Wen Zhijun Han Xuyang Su Jing Peng Feng Chen Yadong Wang Tianming Wang Changzhong Wang Kelong Ma Source Type: research
Microwave-assisted extraction of polysaccharide from Cinnamomum cassia with anti-hyperpigmentation properties: Optimization and characterization studies
Int J Biol Macromol. 2022 Dec 8:S0141-8130(22)02917-8. doi: 10.1016/j.ijbiomac.2022.12.023. Online ahead of print.NO ABSTRACTPMID:36502951 | DOI:10.1016/j.ijbiomac.2022.12.023 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - December 12, 2022 Category: Biochemistry Authors: Al-Hareth AbdulRaheem Salem Al-Ajalein Muhammad Hakimin Shafie Pei-Gee Yap Mohd Asyraf Kassim Idanawati Naharudin Tin-Wui Wong Chee-Yuen Gan Source Type: research
Microwave-assisted extraction of polysaccharide from Cinnamomum cassia with anti-hyperpigmentation properties: Optimization and characterization studies
Int J Biol Macromol. 2022 Dec 8:S0141-8130(22)02917-8. doi: 10.1016/j.ijbiomac.2022.12.023. Online ahead of print.NO ABSTRACTPMID:36502951 | DOI:10.1016/j.ijbiomac.2022.12.023 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - December 12, 2022 Category: Biochemistry Authors: Al-Hareth AbdulRaheem Salem Al-Ajalein Muhammad Hakimin Shafie Pei-Gee Yap Mohd Asyraf Kassim Idanawati Naharudin Tin-Wui Wong Chee-Yuen Gan Source Type: research
Microwave-assisted extraction of polysaccharide from Cinnamomum cassia with anti-hyperpigmentation properties: Optimization and characterization studies
Int J Biol Macromol. 2022 Dec 8:S0141-8130(22)02917-8. doi: 10.1016/j.ijbiomac.2022.12.023. Online ahead of print.NO ABSTRACTPMID:36502951 | DOI:10.1016/j.ijbiomac.2022.12.023 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - December 12, 2022 Category: Biochemistry Authors: Al-Hareth AbdulRaheem Salem Al-Ajalein Muhammad Hakimin Shafie Pei-Gee Yap Mohd Asyraf Kassim Idanawati Naharudin Tin-Wui Wong Chee-Yuen Gan Source Type: research
Molecules, Vol. 27, Pages 8138: Syringaresinol Alleviates Oxaliplatin-Induced Neuropathic Pain Symptoms by Inhibiting the Inflammatory Responses of Spinal Microglia
This study aimed to investigate the causal relationship between spinal microglial activation and OIPN and explore the analgesic effects of syringaresinol, a phytochemical from the bark of Cinnamomum cassia, on OIPN symptoms. The causality between microglial activation and OIPN was investigated by assessing cold and mechanical allodynia in mice after intrathecal injection of the serum supernatant from a BV-2 microglial cell line treated with oxaliplatin. The microglial inflammatory response was measured based on inducible nitric oxide synthase (iNOS), phosphorylated extracellular signal-regulated kinase (p-ERK), and phospho...
Source: Molecules - November 23, 2022 Category: Chemistry Authors: Ji Hwan Lee Jong Hee Choi Jaihwan Kim Tai Wan Kim Ji-Young Kim Geehoon Chung Ik-Hyun Cho Dae Sik Jang Sun Kwang Kim Tags: Article Source Type: research
Cinnamon cassia oil chitosan nanoparticles: Physicochemical properties and anti-breast cancer activity
Int J Biol Macromol. 2022 Nov 7:S0141-8130(22)02433-3. doi: 10.1016/j.ijbiomac.2022.10.191. Online ahead of print.ABSTRACTThe aim of this study was to prepare Cinnamomum cassia essential oil (CEO) impregnated chitosan nanoparticles (CS-CEO) and assess its pharmacological activity against breast cancer. Cinnamon oil-loaded chitosan nanoparticles were investigated for their physicochemical properties, stability, and anti-cancer activities both in vitro and in vivo. The prepared CS-CEO nanoparticles have a particle size, zeta-potential, entrapment efficiency and drug loading of (215.40 ± 3.90) nm, (51.70 ± 1.90) mV, (83.37 ...
Source: International Journal of Biological Macromolecules - November 11, 2022 Category: Biochemistry Authors: Xiqiang Xu Qiuxiang Li Wei Dong Guowei Zhao Yongfeng Lu Xiaoying Huang Xinli Liang Source Type: research
Cinnamon cassia oil chitosan nanoparticles: Physicochemical properties and anti-breast cancer activity
Int J Biol Macromol. 2022 Nov 7:S0141-8130(22)02433-3. doi: 10.1016/j.ijbiomac.2022.10.191. Online ahead of print.ABSTRACTThe aim of this study was to prepare Cinnamomum cassia essential oil (CEO) impregnated chitosan nanoparticles (CS-CEO) and assess its pharmacological activity against breast cancer. Cinnamon oil-loaded chitosan nanoparticles were investigated for their physicochemical properties, stability, and anti-cancer activities both in vitro and in vivo. The prepared CS-CEO nanoparticles have a particle size, zeta-potential, entrapment efficiency and drug loading of (215.40 ± 3.90) nm, (51.70 ± 1.90) mV, (83.37 ...
Source: International Journal of Biological Macromolecules - November 11, 2022 Category: Biochemistry Authors: Xiqiang Xu Qiuxiang Li Wei Dong Guowei Zhao Yongfeng Lu Xiaoying Huang Xinli Liang Source Type: research
Cardioprotective effect of cinnamaldehyde pretreatment on ischemia/ reperfusion injury via inhibiting NLRP3 inflammasome activation and gasdermin D mediated cardiomyocyte pyroptosis
Chem Biol Interact. 2022 Oct 29;368:110245. doi: 10.1016/j.cbi.2022.110245. Online ahead of print.ABSTRACTCinnamaldehyde (CD) is one of the most important active compounds derived from Cinnamomum cassia and showed multiple biological activities. Accumulating evidence has shown that the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome significantly contributes to sterile inflammatory response and gasdermin D (GSDMD)-mediated pyroptosis in myocardial ischemia/reperfusion injury (MI/RI). Whether CD has any influence on NLRP3 inflammasome activation and pyroptosis du...
Source: Chemico-Biological Interactions - November 7, 2022 Category: Molecular Biology Authors: Fei Luan Ziqin Lei Xi Peng Li Chen Lixia Peng Yao Liu Zhili Rao Ruocong Yang Nan Zeng Source Type: research
Cardioprotective effect of cinnamaldehyde pretreatment on ischemia/ reperfusion injury via inhibiting NLRP3 inflammasome activation and gasdermin D mediated cardiomyocyte pyroptosis
Chem Biol Interact. 2022 Oct 29;368:110245. doi: 10.1016/j.cbi.2022.110245. Online ahead of print.ABSTRACTCinnamaldehyde (CD) is one of the most important active compounds derived from Cinnamomum cassia and showed multiple biological activities. Accumulating evidence has shown that the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome significantly contributes to sterile inflammatory response and gasdermin D (GSDMD)-mediated pyroptosis in myocardial ischemia/reperfusion injury (MI/RI). Whether CD has any influence on NLRP3 inflammasome activation and pyroptosis du...
Source: Chemico-Biological Interactions - November 7, 2022 Category: Molecular Biology Authors: Fei Luan Ziqin Lei Xi Peng Li Chen Lixia Peng Yao Liu Zhili Rao Ruocong Yang Nan Zeng Source Type: research
A Phase II, Randomized, Double-Blind, Double-Dummy, Active-Controlled Clinical Trial to Investigate the Efficacy and Safety of NW Low-Glu ® in Patients Newly Diagnosed with Type 2 Diabetes Mellitus
CONCLUSIONS: After 3 months of treatment, NW Low-Glu® was noninferior to metformin in reducing HbA1c and 2 hr PPG, while leading to significantly higher weight reduction in newly diagnosed T2DM patients. It was also safe and well tolerated.PMID:36204125 | PMC:PMC9532066 | DOI:10.1155/2022/9176026 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 7, 2022 Category: Complementary Medicine Authors: Samir Assaad-Khalil Nabil Elkafrawy Mohsen Khaled Omneya Mogeib Hytham Badr Ahmed Rashwan Mahmoud Youssef Khaled Eltamawy Shahnaz Mohamed Source Type: research
Chemical profiling and identification of anti-osteoporosis chemical-markers of < em > Cinnamomum cassia (L.) < /em > presl extracts using GC-MS and spectrum-activity analyses
Nat Prod Res. 2022 Sep 13:1-5. doi: 10.1080/14786419.2022.2123480. Online ahead of print.ABSTRACTCinnamomum cassia (L.) Presl (cinnamon), an important folk medicine is widely used to prevent osteoporosis for long time in China. Our study aimed to investigate the anti-osteoporosis activity and mechanisms of cinnamon extracts obtained by supercritical CO2 extraction (SFE) and identify activity associated chemical components by gas chromatography-mass spectrometry. The cinnamon SFE exhibited superior anti-osteoporosis efficacy in an ovariectomised mice model to common alcohol extracts. It could induce calcified nodules and AL...
Source: Natural Product Research - September 13, 2022 Category: Biochemistry Authors: Shan Zhao Yali Wu Yafang Qian Yifan Qian Shuai Xue Junyan Chen Qinghe Zeng Mancang Gu Source Type: research
