Chemical profiling and identification of anti-osteoporosis chemical-markers of < em > Cinnamomum cassia (L.) < /em > presl extracts using GC-MS and spectrum-activity analyses
Nat Prod Res. 2022 Sep 13:1-5. doi: 10.1080/14786419.2022.2123480. Online ahead of print.ABSTRACTCinnamomum cassia (L.) Presl (cinnamon), an important folk medicine is widely used to prevent osteoporosis for long time in China. Our study aimed to investigate the anti-osteoporosis activity and mechanisms of cinnamon extracts obtained by supercritical CO2 extraction (SFE) and identify activity associated chemical components by gas chromatography-mass spectrometry. The cinnamon SFE exhibited superior anti-osteoporosis efficacy in an ovariectomised mice model to common alcohol extracts. It could induce calcified nodules and AL...
Source: Natural Product Research - September 13, 2022 Category: Biochemistry Authors: Shan Zhao Yali Wu Yafang Qian Yifan Qian Shuai Xue Junyan Chen Qinghe Zeng Mancang Gu Source Type: research

Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9
The prevalence of asthma is gradually increasing, and endangers human health. Many therapeutic agents have been developed to address this concern. Cinnamomum cassia (L.) J.Presl is a traditional herbal remedy in China, Japan, and Korea and used mainly to control common cold, cough, pneumonitis and fever in Donguibogam, a medical encyclopedia of Korea. Therefore, we investigated whether C. cassia (L.) J.Presl extract (CCE) confers protective effects on asthma model induced by ovalbumin (OVA). The animals were received intraperitoneal administration of OVA on day 1 and 14, and then subjected to OVA inhalation from day 21–2...
Source: Frontiers in Pharmacology - August 11, 2022 Category: Drugs & Pharmacology Source Type: research

Natural Herbal Medicine as a Treatment Strategy for Myocardial Infarction through the Regulation of Angiogenesis
CONCLUSIONS: Some herbs have the effect of promoting angiogenesis. In the future, natural proangiogenic drugs may become candidates for the treatment of cardiovascular diseases.PMID:35600953 | PMC:PMC9119779 | DOI:10.1155/2022/8831750 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - May 23, 2022 Category: Complementary Medicine Authors: Mu-Xin Zhang Yu Song Wan-Li Xu Ling-Xiao Zhang Chao Li Yun-Lun Li Source Type: research

Preparation, characterization, and biological activity of Cinnamomum cassia essential oil nano-emulsion
In this study, Cinnamomum cassia Essential oil nano-emulsion (CCEO-NE) was successfully synthesized by the oil-in-water method and characterized by standard analytical methods, including dynamic light scattering (DLS), Scanning electron microscopy (SEM), and Transmission electron microscopy (TEM). The results show that the synthesized CCEO is spherical, smooth in surface, and uniform in shape, with an average particle size of 221.8 ± 1.95 nm, which is amorphous. In this experiment, by simulating the digestion of CCEO-NE in the gastrointestinal tract, it was found that CCEO-NE was undigested in the oral cavity, mainly in t...
Source: Ultrasonics Sonochemistry - April 26, 2022 Category: Chemistry Authors: Dongyi Liang Baijian Feng Na Li Linhan Su Zhong Wang Fansheng Kong Yongguang Bi Source Type: research

Preparation, characterization, and biological activity of Cinnamomum cassia essential oil nano-emulsion
In this study, Cinnamomum cassia Essential oil nano-emulsion (CCEO-NE) was successfully synthesized by the oil-in-water method and characterized by standard analytical methods, including dynamic light scattering (DLS), Scanning electron microscopy (SEM), and Transmission electron microscopy (TEM). The results show that the synthesized CCEO is spherical, smooth in surface, and uniform in shape, with an average particle size of 221.8 ± 1.95 nm, which is amorphous. In this experiment, by simulating the digestion of CCEO-NE in the gastrointestinal tract, it was found that CCEO-NE was undigested in the oral cavity, mainly in t...
Source: Ultrasonics Sonochemistry - April 26, 2022 Category: Chemistry Authors: Dongyi Liang Baijian Feng Na Li Linhan Su Zhong Wang Fansheng Kong Yongguang Bi Source Type: research

Trans-cinnamaldehyde protects against phenylephrine-induced cardiomyocyte hypertrophy through the CaMKII/ERK pathway
This study was carrie... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - April 25, 2022 Category: Complementary Medicine Authors: Dongdong Qian, Jing Tian, Sining Wang, Xiaoli Shan, Pei Zhao, Huihua Chen, Ming Xu, Wei Guo, Chen Zhang and Rong Lu Tags: Research Source Type: research

Molecules, Vol. 27, Pages 1428: Saprophytic Bacillus Accelerates the Release of Effective Components in Agarwood by Degrading Cellulose
In conclusion, our experiment revealed that the saprophytic Bacillus release the effective components of Agarwood by degrading cellulose, and we provide a promising way to accelerate this process by using this bacterial agent. (Source: Molecules)
Source: Molecules - February 20, 2022 Category: Chemistry Authors: Huizhen Yang Runying He Yao Cui Ying Li Xizhen Ge Tags: Article Source Type: research

Screening of Antimicrobial Activity of Essential Oils against Bovine Respiratory Pathogens – Focusing on Pasteurella multocida
In conclusion, cinnamon cassia and lemongrass as well as coriander, winter savory, and thyme oil are promising candidates for treatment of P. multocida-associated bovine respiratory infections. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Planta Medica)
Source: Planta Medica - February 18, 2022 Category: Drugs & Pharmacology Authors: Bismarck, Doris Becker, Jens M üller, Elisabeth Becher, Vera Nau, Lisa Mayer, Philipp Tags: Original Papers Source Type: research

Development of a strategy for a quick process for separation of volatile compounds in counter-current chromatography: purification of cinnamaldehyde from Cinnamomum cassia by high performance counter-current chromatography
(Source: Preparative Biochemistry)
Source: Preparative Biochemistry - January 16, 2022 Category: Biochemistry Authors: Fan, Qingfei Huang, Fengmei Zhou, Lan He, Wenqian Jiang, Xian Na, Zhi Gongpan, Pianchou Hu, Huabin Song, Qishi Source Type: research

Ethnopharmacological Survey of Traditional Chinese Medicine Pharmacy Prescriptions for Dysmenorrhea
This study provides a record of valuable knowledge on TCM pharmacy prescriptions for dysmenorrhea. The rich medicinal knowledge of TCM pharmacies in Taiwan is worthy of further exploration, and the results of this study can serve as a basis for future pharmacological research and the development of naturally derived medications for dysmenorrhea. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 21, 2021 Category: Drugs & Pharmacology Source Type: research

A Traditional Chinese Medicine Plant Extract Prevents Alcohol-Induced Osteopenia
In this study, Balb/c male mice were orally administrated alcohol (3.2 g/kg/day) with/without TCM herbal extracts (0.125 g/kg, 0.25 g/kg, or 0.5 g/kg) by gavage. Our results showed that after 50 days of oral administration, TCM herbal extracts prevented alcohol-induced osteopenia demonstrated by μ-CT bone morphological analysis in young adults and middle-aged/old Balb/c male mice. Biochemical analysis demonstrated that chronic alcohol consumption inhibits bone formation and has a neutral impact on bone resorption, suggesting that TCM herbal extracts (Jing extracts) mitigate the alcohol-induced abnormal bone metabolis...
Source: Frontiers in Pharmacology - December 15, 2021 Category: Drugs & Pharmacology Source Type: research

Trans-cinnamaldehyde suppresses microtubule detyrosination and alleviates cardiac hypertrophy
CONCLUSION: Our study indicated that the therapeutic effects of TCA against cardiac hypertrophy may be associated with its ability to reduce tubulin detyrosination.PMID:34883072 | DOI:10.1016/j.ejphar.2021.174687 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - December 9, 2021 Category: Drugs & Pharmacology Authors: Jing Tian Xiao-Li Shan Si-Ning Wang Hui-Hua Chen Pei Zhao Dong-Dong Qian Ming Xu Wei Guo Chen Zhang Rong Lu Source Type: research

Trans-cinnamaldehyde suppresses microtubule detyrosination and alleviates cardiac hypertrophy
CONCLUSION: Our study indicated that the therapeutic effects of TCA against cardiac hypertrophy may be associated with its ability to reduce tubulin detyrosination.PMID:34883072 | DOI:10.1016/j.ejphar.2021.174687 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - December 9, 2021 Category: Drugs & Pharmacology Authors: Jing Tian Xiao-Li Shan Si-Ning Wang Hui-Hua Chen Pei Zhao Dong-Dong Qian Ming Xu Wei Guo Chen Zhang Rong Lu Source Type: research

A new megastimane sesquiterpenoid from the leaves of Cinnamomum cassia
. (Source: Journal of Asian Natural Products Research)
Source: Journal of Asian Natural Products Research - October 14, 2021 Category: Complementary Medicine Authors: Lei Zhou Gui-Juan Zheng Peng-Fei Jin Zheng-Xi Hu Guang-Min Yao Yong-Hui Zhang Source Type: research