trans-Cinnamaldehyde Reverses Depressive-Like Behaviors in Chronic Unpredictable Mild Stress Rats by Inhibiting NF- κB/NLRP3 Inflammasome Pathway.
trans-Cinnamaldehyde Reverses Depressive-Like Behaviors in Chronic Unpredictable Mild Stress Rats by Inhibiting NF-κB/NLRP3 Inflammasome Pathway.
Evid Based Complement Alternat Med. 2020;2020:4572185
Authors: Wang M, Yan S, Zhou Y, Xie P
Abstract
trans-Cinnamaldehyde (TCA) is the main active component extracted from Cinnamomum cassia (C. cassia), which has many pharmacological effects, such as anti-inflammation, lowering blood glucose, and improving nerve function. However, there is no report of TCA in the treatment of depression. The purpose of this study was to investigate the ...
Source: Evidence-based Complementary and Alternative Medicine - April 26, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Cinnamaldehyde protects against oxidative stress and inhibits the TNF ‑α‑induced inflammatory response in human umbilical vein endothelial cells.
Cinnamaldehyde protects against oxidative stress and inhibits the TNF‑α‑induced inflammatory response in human umbilical vein endothelial cells.
Int J Mol Med. 2020 Apr 16;:
Authors: Kim NY, Trinh NT, Ahn SG, Kim SA
Abstract
Oxidative stress and inflammation play critical roles in the development of cardiovascular diseases. Cinnamaldehyde (CA) is a natural compound from Cinnamomum cassia, and its anticancer, antimicrobial and anti‑inflammatory activities have been widely investigated. In the present study, the cytoprotective and anti‑inflammatory effects of CA on H2O2‑ ...
Source: International Journal of Molecular Medicine - April 15, 2020 Category: Molecular Biology Authors: Kim NY, Trinh NT, Ahn SG, Kim SA Tags: Int J Mol Med Source Type: research
Protective effects of Cinnamomum verum, Cinnamomum cassia and cinnamaldehyde against 6-OHDA-induced apoptosis in PC12 cells.
Abstract
Cinnamon (Cinnamomum verum and C. cassia) is a medicinal plant, widely-used as a culinary spice. It possesses various therapeutic effects and can slow down the progression of neurological disorders impressively. In this article, the effects of hydro-alcohol extract and essential oil of C. verum and C. cassia and its main bioactive component cinnamaldehyde, has been examined on 6-OHDA-exposed PC12 cells as an in vitro model of Parkinson's disease. The cytotoxicity and cell apoptosis has been induced by 6-OHDA in PC12 cells. The protective effect was determined by measuring cell viability, the amoun...
Source: Molecular Biology Reports - March 11, 2020 Category: Molecular Biology Authors: Ramazani E, YazdFazeli M, Emami SA, Mohtashami L, Javadi B, Asili J, Tayarani-Najaran Z Tags: Mol Biol Rep Source Type: research
A Systems Pharmacology Approach for Identifying the Multiple Mechanisms of Action for the Rougui-Fuzi Herb Pair in the Treatment of Cardiocerebral Vascular Diseases.
This study was designed to apply a system pharmacology approach to reveal the molecular mechanisms of the rougui-fuzi anti-CCVDs. The 163 candidate compounds were retrieved from Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP). And 84 potential active compounds and the corresponding 42 targets were obtained from systematic model. The underlying mechanisms of the therapeutic effect for rougui-fuzi were investigated with gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Then, component-target-disease (C-T-D) and target...
Source: Evidence-based Complementary and Alternative Medicine - February 7, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Baihu Jia Guizhi Decoction Improves Rheumatoid Arthritis Inflammation by Regulating Succinate/SUCNR1 Metabolic Signaling Pathway.
In this study, we tested the role of damp and heat environments in exacerbating RA inflammation and the anti-inflammatory effect of BHGZ, based on succinate/SUCNR1/IL-1β pathway in the adjuvant arthritis (AA) model with damp and heat environment (AA + DHE). Results showed that paw swelling and synovial pathology were significantly increased in AA rats, and these results were aggravated by stimulation in damp and heat environment. BHGZ improved AA + DHE rats' paw swelling, synovial hyperplasia, and inflammatory cell infiltration and reduced IL-1β. In addition, AA rats significantly increased the expression of SUCN...
Source: Evidence-based Complementary and Alternative Medicine - January 18, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Evaluation of relaxant responses properties of cinnamon essential oil and its major component, cinnamaldehyde on human and rat corpus cavernosum
ABSTRACT Cinnamomum cassia (Cinnamon) is a well-known traditional medicine with therapeutic benefits for centuries. We evaluated the effects of cinnamon essential oil (CEO) and its main component cinnamaldehyde (CA) on human corpus cavernosum (HCC) and rat CC. The essential oil of cinnamon was analyzed for the confirmation of the oil profile. HCC specimens from patients undergoing penile prosthesis surgery (age 48-69 years) were utilized for functional studies. In addition, erectile responses in anesthetized control and diabetic rats were evaluated in vivo after intracavernosal injection of CEO and CA, and rat CC strips we...
Source: International Braz J Urol - November 7, 2019 Category: Urology & Nephrology Source Type: research
Efficacy and safety of HT080 for lower urinary tract symptoms associated with benign prostatic hyperplasia: A study protocol for a randomized, double-blind, placebo-controlled trial
Discussion:
This is a first-in human trial designed to investigate the efficacy and safety of HT080 among middle-aged and elderly men with LUTS/BPH. This prospective study with a double-blind randomized design will provide high-quality evidence supporting the use of HT080 for LUTS/BPH.
Trial registration:
Korean Clinical Research Information Service (KCT0004286) Registered September 6, 2019. (Source: Medicine)
Source: Medicine - November 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
Fungicidal Activity of Essential Oils from Cinnamomum cassia against the Pathogenic Fungi of Panax notoginseng Diseases.
Abstract
The frequent disease of Panax notoginseng caused by the pathogenic fungi in field cultivation has become the major threaten to the sustainable development of it. The present study was conducted to find natural agent with potential inhibition against pathogen. Therefore, the inhibitory effects of Cinnamomum cassia (L.) J.Presl essential oils (EOs) against P. notoginseng associated pathogenic fungi were conducted both in vitro and in vivo experiments. The results of the Oxford cup test revealed that C. cassia dry bark EO (50 mg/mL) had significant inhibitory activity on the growth of all teste...
Source: Chemistry and Biodiversity - October 20, 2019 Category: Biochemistry Authors: Ma YN, Chen CJ, Li Q, Wang W, Xu FR, Cheng YX, Dong X Tags: Chem Biodivers Source Type: research
Four spices prevent mice from contracting Salmonella enterica serovar Typhimurium.
Authors: Chang CH, Fu JH, Su CH, Yin MC, Hsu YM
Abstract
Ligustrum lucidum Ait (LL), Lysimachia christinae Hance (LC), Mentha piperita Linn (MP), and Cinnamomum cassia Presl (CC) are common spices used in Asia. The present study investigated the anti-Salmonella effects of the four spices using aqueous extracts. The amount of phenolic acids and flavonoids in each spice aqueous extract was determined as indicators of purity. Mice were pretreated with LL, LC, MP or CC aqueous extract for 7 days. Following infection with Salmonella enterica serovar Typhimurium strain ST21 (ST21), the aqueous extract of each sp...
Source: Experimental and Therapeutic Medicine - October 2, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research
Molecules, Vol. 24, Pages 3473: Cinnamomum cassia Presl: A Review of Its Traditional Uses, Phytochemistry, Pharmacology and Toxicology
n
Lingying Yu
Cinnamomum cassia Presl is a tropical aromatic evergreen tree of the Lauraceae family, commonly used in traditional Chinese medicine. It is also a traditional spice, widely used around the world. This paper summarizes the achievements of modern research on C. cassia, including the traditional uses, phytochemistry, pharmacology and toxicology. In addition, this review also discusses some significant issues and the potential direction of future C. cassia research. More than 160 chemicals have been separated and identified from C. cassia. The main constituents of C. cassia are terpenoids, phenylpropanoids,...
Source: Molecules - September 24, 2019 Category: Chemistry Authors: Chunling Zhang Linhong Fan Shunming Fan Jiaqi Wang Ting Luo Yu Tang Zhimin Chen Lingying Yu Tags: Review Source Type: research
Endophytic actinomycetes associated with Cinnamomum cassia Presl in Hoa Binh province, Vietnam: Distribution, antimicrobial activity and, genetic features.
Authors: Vu THN, Nguyen QH, Dinh TML, Quach NT, Khieu TN, Hoang H, Son CK, Vu TT, Chu HH, Lee J, Kang H, Li WJ, Phi QT
Abstract
Endophytic microbes associated with medicinal plants are considered to be potential producers of various bioactive secondary metabolites. The present study investigated the distribution, antimicrobial activity and genetic features of endophytic actinomycetes isolated from the medicinal plant Cinnamomum cassia Presl collected in Hoa Binh province of northern Vietnam. Based on phenotypic characteristics, 111 actinomycetes were isolated from roots, stems and leaves of the host plants...
Source: Journal of General and Applied Microbiology - August 7, 2019 Category: Microbiology Tags: J Gen Appl Microbiol Source Type: research
Trans-cinnamaldehyde Improves Neuroinflammation-mediated NMDA Receptor Dysfunction and Memory Deficits through Blocking NF-κB Pathway in Presenilin1/2 Conditional Double Knockout Mice
Publication date: Available online 31 July 2019Source: Brain, Behavior, and ImmunityAuthor(s): Yang Zhao, Haiyan Deng, Kun Li, Lijun Wang, Yongkang Wu, Xianwen Dong, Xingyu Wang, Yongjun Chen, Ying XuAbstractA chronic neuroinflammatory response has been considered as a critical pathogenesis promoting neurodegenerative progression in Alzheimer’s disease (AD). During neuroinflammatory process, microglia are excessively activated and simultaneously release numerous pro-inflammatory mediators that cause synaptic dysfunction in the forebrain prior to neuronal degeneration and memory deficits in AD. Thus, prevention of neuroin...
Source: Brain, Behavior, and Immunity - August 1, 2019 Category: Neurology Source Type: research
The Pungent and Hot Chinese Herbs Cause Heat Syndrome in Rats by Affecting the Regulatory T Cells.
Authors: Wu DH, Xu L, Xie GQ, Fan YS, Zhou J
Abstract
Heat syndrome is a folk saying in China, which is used to describe people with symptoms such as aphtha, oral ulcer, glossitis, swelling and aching of gingiva, and dry eye. Aconitum carmichaelii Debx. (A), Zingiber officinale Rosc. (Z), and Cinnamomum cassia Presl (C) are the representatives of pungent and hot Chinese herbs which may cause heat syndrome. In order to explore the mechanism of pungent herbs-induced heat syndrome, rats were treated with AZC extracts at different concentrations and at different time periods. A series of cytokines were determi...
Source: Evidence-based Complementary and Alternative Medicine - July 31, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Trans-cinnamaldehyde Improves Neuroinflammation-mediated NMDA Receptor Dysfunction and Memory Deficits through Blocking NF- κB Pathway in Presenilin1/2 Conditional Double Knockout Mice.
Trans-cinnamaldehyde Improves Neuroinflammation-mediated NMDA Receptor Dysfunction and Memory Deficits through Blocking NF-κB Pathway in Presenilin1/2 Conditional Double Knockout Mice.
Brain Behav Immun. 2019 Jul 31;:
Authors: Zhao Y, Deng H, Li K, Wang L, Wu Y, Dong X, Wang X, Chen Y, Xu Y
Abstract
A chronic neuroinflammatory response has been considered as a critical pathogenesis promoting neurodegenerative progression in Alzheimer's disease (AD). During neuroinflammatory process, microglia are excessively activated and simultaneously release numerous pro-inflammatory mediators...
Source: Brain, Behavior, and Immunity - July 30, 2019 Category: Neurology Authors: Zhao Y, Deng H, Li K, Wang L, Wu Y, Dong X, Wang X, Chen Y, Xu Y Tags: Brain Behav Immun Source Type: research
