Cinnamomum zeylanicum (Ceylon cinnamon) as a potential pharmaceutical agent for type-2 diabetes mellitus: study protocol for a randomized controlled trial
Previous studies have explored the anti-diabetic effects of Cinnamomum cassia extract in vivo and in vitro. However, there are no studies at present exploring the effects of the indigenous species of Sri Lankan c... (Source: Trials)
Source: Trials - September 29, 2017 Category: General Medicine Authors: Priyanga Ranasinghe, Priyadarshani Galappaththy, Godwin Roger Constantine, Ranil Jayawardena, Hasitha Dhananjaya Weeratunga, Sirimal Premakumara and Prasad Katulanda Tags: Study protocol Source Type: research
Protective effect of cinnamaldehyde against glutamate-induced oxidative stress and apoptosis in PC12 cells.
Abstract
Cinnamaldehyde is a main ingredient of cinnamon oils from the stem bark of Cinnamomum cassia, which has been widely used in food and traditional herbal medicine in Asia. In the present study, the neuroprotective effects and the potential mechanisms of cinnamaldehyde against glutamate-induced oxidative stress in PC12 cells were investigated. Exposure to 4mM glutamate altered the GSH, MDA levels and SOD activity, caused the generation of reactive oxygen species, resulted in the induction of oxidative stress in PC12 cell, ultimately induced cell death. However, pretreatment with cinnamaldehyde at 5, ...
Source: European Journal of Pharmacology - September 9, 2017 Category: Drugs & Pharmacology Authors: Lv C, Yuan X, Zeng HW, Liu RH, Zhang WD Tags: Eur J Pharmacol Source Type: research
Synergistic Uric Acid-Lowering Effects of the Combination of Chrysanthemum indicum Linne Flower and Cinnamomum cassia (L.) J. Persl Bark Extracts.
Authors: Lee YS, Son E, Kim SH, Lee YM, Kim OS, Kim DS
Abstract
Chrysanthemum indicum Linne flower (CF) and Cinnamomum cassia (L.) J. Persl bark (CB) extracts have served as the main ingredients in several prescriptions designed to treat hyperuricemia and gout in traditional Chinese and Korean medicine. However, little is known about the combination effects of a CF and CB (CC) mixture on hyperuricemia. In our study, we investigated the antihyperuricemic effects of CC mixture and the mechanisms underlying these effects in normal and potassium oxonate- (PO-) induced hyperuricemic rats. The CC mixture signifi...
Source: Evidence-based Complementary and Alternative Medicine - August 6, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Caffeic Acid Phenethyl Ester from the Twigs of Cinnamomum
cassia Inhibits Malignant Cell Transformation
by Inducing c-Fos Degradation
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.7b00433 (Source: Journal of Natural Products)
Source: Journal of Natural Products - July 6, 2017 Category: Biochemistry Authors: Seung Ho Shin, Seoung Rak Lee, Eunjung Lee, Ki Hyun Kim and Sanguine Byun Source Type: research
Cinnamomum cassia Prevents High-Fat Diet-Induced Obesity in Mice Through the Increase of Muscle Energy.
Abstract
The cortex of Cinnamomum cassia Presl (Cinnamomi Cortex: CC) has commonly been used for weight control in traditional medicines, but without a scientific basis. Therefore, this study was undertaken to investigate the anti-obesity effect of CC extract in a high-fat diet (HFD)-induced obese mouse model and in C2C12 mouse skeletal muscle cells. Male C57BL/6 mice were fed a normal diet or a HFD for 16 consecutive weeks, and orally administered CC extract (100 or 300[Formula: see text]mg/kg) or metformin (250[Formula: see text]mg/kg; positive control) daily for 16 weeks. CC extract administration signi...
Source: The American Journal of Chinese Medicine - June 28, 2017 Category: Complementary Medicine Authors: Song MY, Kang SY, Kang A, Hwang JH, Park YK, Jung HW Tags: Am J Chin Med Source Type: research
Molecules, Vol. 22, Pages 1071: In Vitro Anti-Leishmanial Activity of Essential Oils Extracted from Vietnamese Plants
Leishmania mexicana is one of the pathogens causing cutaneous leishmaniasis which is associated with patient morbidity. In our researches for new safe and effective treatments, thirty-seven essential oils (EOs) extracted from Vietnamese plants were screened in vitro for the first time on Leishmania mexicana mexicana (Lmm) promastigotes at the maximum concentration of 50 nL/mL. Active EOs were also analyzed for cytotoxicity on mammalian cell lines (WI38, J774) and their selectivity indices (SI) were calculated. Their composition was determined by GC-MS and GC-FID. Our results indicated that EOs extracted from Cinnamomum cas...
Source: Molecules - June 27, 2017 Category: Chemistry Authors: Thanh Binh Le Claire Beaufay Duc Trong Nghiem Marie-Paule Mingeot-Leclercq Jo ëlle Quetin-Leclercq Tags: Article Source Type: research
Assessment of Titanium Dioxide Nanoparticles (TiO2-NPs) Induced Hepatotoxicity and Ameliorative Effects of Cinnamomum cassia in Sprague-Dawley Rats.
This study assessed the protective effects of Cinnamomum cassia (cinnamon) bark extract in rats exposed to titanium dioxide nanoparticles or titanium dioxide bulk salt. For in vivo evaluation of the ameliorative role of the cinnamon extract, the experimental groups were orally administered with the cinnamon extract at different dose levels (50 or 100 or 150 mg/kg bodyweight) along with the subcutaneous injections of 150 mg/kg bodyweight titanium dioxide nanoparticles or titanium dioxide bulk salt. The extract showed significant ameliorative role on the antioxidant system in response to elevated levels of titanium dioxide...
Source: Biological Trace Element Research - June 19, 2017 Category: Biology Authors: Shakeel M, Jabeen F, Iqbal R, Chaudhry AS, Zafar S, Ali M, Khan MS, Khalid A, Shabbir S, Asghar MS Tags: Biol Trace Elem Res Source Type: research
A herbal formula attenuates collagen-induced arthritis via inhibition of JAK2-STAT3 signaling and regulation of Th17 cells in mice.
This study explored the effect and mechanism of WJHL on collagen-induced arthritis mice. WJHL could significantly improve clinical arthritic conditions; inhibit bone erosion and osteophyte formation in joints; decrease expression of proinflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-17); reduce protein expression levels of JAK2, p-JAK2, STAT3, p-STAT3 and gene expression levels of JAK2, STAT3, IL-17A, RORγt mRNA; elevate osteoprotegerin and Foxp3 mRNA levels and lower Th17 cell proportions in splenocytes. Results suggest that WJHL, specifically regulating the JAK2/STAT3 pathway and Th17 cells, may be a promising herb...
Source: Oncotarget - June 2, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
The essential oil from the twigs of Cinnamomum cassia Presl inhibits oxytocin-induced uterine contraction in vitro and in vivo
Conclusion Both in vivo and in vitro results suggest that the EOCC possesses significant spasmolytic effect on uterine contraction. Thus, the EOCC yields a possible therapeutic choice for the prevention and treatment of primary dysmenorrhea. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 25, 2017 Category: Drugs & Pharmacology Source Type: research
Cinnamomols A and B, Immunostimulative Diterpenoids
with a New Carbon Skeleton from the Leaves of Cinnamomum
cassia
Organic LettersDOI: 10.1021/acs.orglett.7b01323 (Source: Organic Letters)
Source: Organic Letters - May 23, 2017 Category: Chemistry Authors: Lei Zhou, Yali Tuo, Yi Hao, Xiaoman Guo, Wei Tang, Yongbo Xue, Junfen Zeng, Yu Zhou, Ming Xiang, Jianping Zuo, Guangmin Yao and Yonghui Zhang Source Type: research
Protective effects of Cinnamomum cassia (Lamaceae) against gout and septic responses via attenuation of inflammasome activation in experimental models
Conclusions CA treatment significantly attenuated danger signals-induced inflammatory responses via regulation of inflammasome activation, substantiating the traditional claims of its use in the treatment of inflammation-related disorders. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 13, 2017 Category: Drugs & Pharmacology Source Type: research
Antimicrobial efficacy of cinnamon oil against Salmonella in almond based matrices
In conclusion, C. cassia oil is effective against S. Enteritidis PT30 and S. Tennessee K4643, but its antimicrobial efficacy against the tested Salmonella was compromised by low moisture environment and food matrix. (Source: Food Control)
Source: Food Control - May 12, 2017 Category: Food Science Source Type: research
A New Lactone from the Twigs of Cinnamomum cassia
A new lactone, 5R-methyl-3-heptatriacontyl-2(5H)-furanone (1), was isolated from the twigs ofCinnamomum cassia. The structure of the new compound was established on the basis of high-resolution MS, 1D and 2D NMR data. The absolute configuration was determined by electronic circular dichroism (ECD) analysis. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - April 19, 2017 Category: Chemistry Source Type: research
Use of various essential oils as bio preservatives and their effect on the quality of vacuum packaged fresh chicken sausages under frozen conditions
Publication date: August 2017 Source:LWT - Food Science and Technology, Volume 81 Author(s): Heena Sharma, S.K. Mendiratta, Ravi Kant Agrawal, Kandeepan Gurunathan, Sudheer Kumar, Tarun Pal Singh The present study was undertaken to evaluate antimicrobial and antioxidant effect of essential oils on the quality of fresh chicken sausages. Total 15 essential oils (EOs) were screened for their antimicrobial activity; however only 9 EOs showed desired results in disc diffusion assay. It was found that four essential oils namely, clove oil (0.25%), holy basil oil (0.125%), cassia oil (0.25%) and thyme oil (0.125%) could p...
Source: LWT Food Science and Technology - April 4, 2017 Category: Food Science Source Type: research
Luhong formula inhibits myocardial fibrosis in a paracrine manner by activating the gp130/JAK2/STAT3 pathway in cardiomyocytes
Conclusion LHF treatment attenuates myocardial fibrosis in vivo. LHF inhibits cardiac fibroblasts proliferation and collagen synthesis in a paracrine manner by activating the gp130/JAK2/STAT3 pathway in cardiomyocytes, thereby inhibiting the secretion of downstream profibrogenic cytokines. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - March 10, 2017 Category: Drugs & Pharmacology Source Type: research
