Sodium glucose cotransporter 2 inhibitors with cardiac arrhythmias in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized placebo-controlled trials
ConclusionSGLT2 inhibitors were associated with a reduced risk of atrial arrhythmias in patients with T2DM. Our results support the use of SGLT2 inhibitors in T2DM with high cardiovascular risk populations. We also recommend the long-term use of SGLT2 inhibitors to achieve further benefits.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 14, 2024 Category: Cardiology Source Type: research
Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling
Cell Mol Life Sci. 2024 Feb 13;81(1):88. doi: 10.1007/s00018-024-05125-2.ABSTRACTAtrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia, and recent epidemiological studies suggested type 2 diabetes mellitus (T2DM) is an independent risk factor for the development of AF. Zinc finger and BTB (broad-complex, tram-track and bric-a-brac) domain containing 16 (Zbtb16) serve as transcriptional factors to regulate many biological processes. However, the potential effects of Zbtb16 in AF under T2DM condition remain unclear. Here, we reported that db/db mice displayed higher AF vulnerability and Zbtb16 was ident...
Source: Cellular and Molecular Life Sciences : CMLS - February 13, 2024 Category: Cytology Authors: Zhi-Xing Wei Xing-Xing Cai Yu-Dong Fei Qian Wang Xiao-Liang Hu Cheng Li Jian-Wen Hou Yu-Li Yang Tai-Zhong Chen Xiao-Lei Xu Yue-Peng Wang Yi-Gang Li Source Type: research
Paroxysmal atrial fibrillation and hemochromatosis: a narrative review
Ann Med Surg (Lond). 2023 Dec 4;86(2):909-919. doi: 10.1097/MS9.0000000000001605. eCollection 2024 Feb.ABSTRACTParoxysmal atrial fibrillation (PAF) and hemochromatosis have a complex relationship. This review explores its mechanisms, prevalence, correlations, and clinical manifestations. Hereditary hemochromatosis (HH) involves iron overload due to HFE protein mutations, while atrial fibrillation (AF) is characterized by irregular heart rhythms. Iron overload in hemochromatosis can promote cardiac arrhythmias. AF is prevalent in developed countries and may be linked to cryptogenic strokes. Genetic variations and demographi...
Source: Annals of Medicine - February 9, 2024 Category: Internal Medicine Authors: Gulzar Ahmed Sushma Rathi Harmandeep K Sidhu Momil Muzaffar Muhammad H Wajid Komal Kumari Hajar Fakhor Nada M Attia Koushik Majumder Vikash Kumar Usha Tejwaney Nanik Ram Source Type: research
Hypercalcaemia: intensive care or general ward
Aktuelle Urol. 2024 Feb;55(1):54-59. doi: 10.1055/a-2201-6428. Epub 2024 Feb 8.ABSTRACTHypercalcaemia is a life-threatening electrolyte imbalance, which not only occurs in the context of an endocrinological disease but is also frequently associated with a tumour. Its severity is determined by the level of deviation from normal, acuity of occurrence, and severity of the symptoms. These are unspecific, can affect any organ system and ultimately result in a life-threatening hypercalcaemic crisis characterised by cardiac arrhythmia, metabolic acidosis, exsiccosis, fever, psychotic states and, ultimately, coma. Endocrinological...
Source: Aktuelle Urologie - February 8, 2024 Category: Urology & Nephrology Authors: Jenny Mauch Katerina Cascetta Source Type: research
Hypercalcaemia: intensive care or general ward
Aktuelle Urol. 2024 Feb;55(1):54-59. doi: 10.1055/a-2201-6428. Epub 2024 Feb 8.ABSTRACTHypercalcaemia is a life-threatening electrolyte imbalance, which not only occurs in the context of an endocrinological disease but is also frequently associated with a tumour. Its severity is determined by the level of deviation from normal, acuity of occurrence, and severity of the symptoms. These are unspecific, can affect any organ system and ultimately result in a life-threatening hypercalcaemic crisis characterised by cardiac arrhythmia, metabolic acidosis, exsiccosis, fever, psychotic states and, ultimately, coma. Endocrinological...
Source: Aktuelle Urologie - February 8, 2024 Category: Urology & Nephrology Authors: Jenny Mauch Katerina Cascetta Source Type: research
Hypercalcaemia: intensive care or general ward
Aktuelle Urol. 2024 Feb;55(1):54-59. doi: 10.1055/a-2201-6428. Epub 2024 Feb 8.ABSTRACTHypercalcaemia is a life-threatening electrolyte imbalance, which not only occurs in the context of an endocrinological disease but is also frequently associated with a tumour. Its severity is determined by the level of deviation from normal, acuity of occurrence, and severity of the symptoms. These are unspecific, can affect any organ system and ultimately result in a life-threatening hypercalcaemic crisis characterised by cardiac arrhythmia, metabolic acidosis, exsiccosis, fever, psychotic states and, ultimately, coma. Endocrinological...
Source: Aktuelle Urologie - February 8, 2024 Category: Urology & Nephrology Authors: Jenny Mauch Katerina Cascetta Source Type: research
Hypercalcaemia: intensive care or general ward
Aktuelle Urol. 2024 Feb;55(1):54-59. doi: 10.1055/a-2201-6428. Epub 2024 Feb 8.ABSTRACTHypercalcaemia is a life-threatening electrolyte imbalance, which not only occurs in the context of an endocrinological disease but is also frequently associated with a tumour. Its severity is determined by the level of deviation from normal, acuity of occurrence, and severity of the symptoms. These are unspecific, can affect any organ system and ultimately result in a life-threatening hypercalcaemic crisis characterised by cardiac arrhythmia, metabolic acidosis, exsiccosis, fever, psychotic states and, ultimately, coma. Endocrinological...
Source: Aktuelle Urologie - February 8, 2024 Category: Urology & Nephrology Authors: Jenny Mauch Katerina Cascetta Source Type: research
Hypercalcaemia: intensive care or general ward
Aktuelle Urol. 2024 Feb;55(1):54-59. doi: 10.1055/a-2201-6428. Epub 2024 Feb 8.ABSTRACTHypercalcaemia is a life-threatening electrolyte imbalance, which not only occurs in the context of an endocrinological disease but is also frequently associated with a tumour. Its severity is determined by the level of deviation from normal, acuity of occurrence, and severity of the symptoms. These are unspecific, can affect any organ system and ultimately result in a life-threatening hypercalcaemic crisis characterised by cardiac arrhythmia, metabolic acidosis, exsiccosis, fever, psychotic states and, ultimately, coma. Endocrinological...
Source: Aktuelle Urologie - February 8, 2024 Category: Urology & Nephrology Authors: Jenny Mauch Katerina Cascetta Source Type: research
Hypercalcaemia: intensive care or general ward
Aktuelle Urol. 2024 Feb;55(1):54-59. doi: 10.1055/a-2201-6428. Epub 2024 Feb 8.ABSTRACTHypercalcaemia is a life-threatening electrolyte imbalance, which not only occurs in the context of an endocrinological disease but is also frequently associated with a tumour. Its severity is determined by the level of deviation from normal, acuity of occurrence, and severity of the symptoms. These are unspecific, can affect any organ system and ultimately result in a life-threatening hypercalcaemic crisis characterised by cardiac arrhythmia, metabolic acidosis, exsiccosis, fever, psychotic states and, ultimately, coma. Endocrinological...
Source: Aktuelle Urologie - February 8, 2024 Category: Urology & Nephrology Authors: Jenny Mauch Katerina Cascetta Source Type: research
Hypercalcaemia: intensive care or general ward
Aktuelle Urol. 2024 Feb;55(1):54-59. doi: 10.1055/a-2201-6428. Epub 2024 Feb 8.ABSTRACTHypercalcaemia is a life-threatening electrolyte imbalance, which not only occurs in the context of an endocrinological disease but is also frequently associated with a tumour. Its severity is determined by the level of deviation from normal, acuity of occurrence, and severity of the symptoms. These are unspecific, can affect any organ system and ultimately result in a life-threatening hypercalcaemic crisis characterised by cardiac arrhythmia, metabolic acidosis, exsiccosis, fever, psychotic states and, ultimately, coma. Endocrinological...
Source: Aktuelle Urologie - February 8, 2024 Category: Urology & Nephrology Authors: Jenny Mauch Katerina Cascetta Source Type: research
Hypercalcaemia: intensive care or general ward
Aktuelle Urol. 2024 Feb;55(1):54-59. doi: 10.1055/a-2201-6428. Epub 2024 Feb 8.ABSTRACTHypercalcaemia is a life-threatening electrolyte imbalance, which not only occurs in the context of an endocrinological disease but is also frequently associated with a tumour. Its severity is determined by the level of deviation from normal, acuity of occurrence, and severity of the symptoms. These are unspecific, can affect any organ system and ultimately result in a life-threatening hypercalcaemic crisis characterised by cardiac arrhythmia, metabolic acidosis, exsiccosis, fever, psychotic states and, ultimately, coma. Endocrinological...
Source: Aktuelle Urologie - February 8, 2024 Category: Urology & Nephrology Authors: Jenny Mauch Katerina Cascetta Source Type: research
Hypercalcaemia: intensive care or general ward
Aktuelle Urol. 2024 Feb;55(1):54-59. doi: 10.1055/a-2201-6428. Epub 2024 Feb 8.ABSTRACTHypercalcaemia is a life-threatening electrolyte imbalance, which not only occurs in the context of an endocrinological disease but is also frequently associated with a tumour. Its severity is determined by the level of deviation from normal, acuity of occurrence, and severity of the symptoms. These are unspecific, can affect any organ system and ultimately result in a life-threatening hypercalcaemic crisis characterised by cardiac arrhythmia, metabolic acidosis, exsiccosis, fever, psychotic states and, ultimately, coma. Endocrinological...
Source: Aktuelle Urologie - February 8, 2024 Category: Urology & Nephrology Authors: Jenny Mauch Katerina Cascetta Source Type: research
Hypercalcaemia: intensive care or general ward
Aktuelle Urol. 2024 Feb;55(1):54-59. doi: 10.1055/a-2201-6428. Epub 2024 Feb 8.ABSTRACTHypercalcaemia is a life-threatening electrolyte imbalance, which not only occurs in the context of an endocrinological disease but is also frequently associated with a tumour. Its severity is determined by the level of deviation from normal, acuity of occurrence, and severity of the symptoms. These are unspecific, can affect any organ system and ultimately result in a life-threatening hypercalcaemic crisis characterised by cardiac arrhythmia, metabolic acidosis, exsiccosis, fever, psychotic states and, ultimately, coma. Endocrinological...
Source: Aktuelle Urologie - February 8, 2024 Category: Urology & Nephrology Authors: Jenny Mauch Katerina Cascetta Source Type: research
Hypercalcaemia: intensive care or general ward
Aktuelle Urol. 2024 Feb;55(1):54-59. doi: 10.1055/a-2201-6428. Epub 2024 Feb 8.ABSTRACTHypercalcaemia is a life-threatening electrolyte imbalance, which not only occurs in the context of an endocrinological disease but is also frequently associated with a tumour. Its severity is determined by the level of deviation from normal, acuity of occurrence, and severity of the symptoms. These are unspecific, can affect any organ system and ultimately result in a life-threatening hypercalcaemic crisis characterised by cardiac arrhythmia, metabolic acidosis, exsiccosis, fever, psychotic states and, ultimately, coma. Endocrinological...
Source: Aktuelle Urologie - February 8, 2024 Category: Urology & Nephrology Authors: Jenny Mauch Katerina Cascetta Source Type: research
Hypercalcaemia: intensive care or general ward
Aktuelle Urol. 2024 Feb;55(1):54-59. doi: 10.1055/a-2201-6428. Epub 2024 Feb 8.ABSTRACTHypercalcaemia is a life-threatening electrolyte imbalance, which not only occurs in the context of an endocrinological disease but is also frequently associated with a tumour. Its severity is determined by the level of deviation from normal, acuity of occurrence, and severity of the symptoms. These are unspecific, can affect any organ system and ultimately result in a life-threatening hypercalcaemic crisis characterised by cardiac arrhythmia, metabolic acidosis, exsiccosis, fever, psychotic states and, ultimately, coma. Endocrinological...
Source: Aktuelle Urologie - February 8, 2024 Category: Urology & Nephrology Authors: Jenny Mauch Katerina Cascetta Source Type: research
