Administration of USP7 inhibitor p22077 alleviates Angiotensin II (Ang II)-induced atrial fibrillation in Mice
Hypertens Res. 2024 Feb 19. doi: 10.1038/s41440-024-01581-2. Online ahead of print.ABSTRACTAtrial fibrillation (AF), the most common cardiac arrhythmia, is an important contributor to mortality and morbidity. Ubquitin-specific protease 7 (USP7), one of the most abundant ubiquitin-specific proteases (USP), participated in many cellular events, such as cell proliferation, apoptosis, and tumourigenesis. However, its role in AF remains unknown. Here, the mice were treated with Ang II infusion to induce the AF model. Echocardiography was used to measure the atrial diameter. Electrical stimulation was programmed to measure the i...
Source: Cell Research - February 19, 2024 Category: Cytology Authors: Yu Wang Yu-Hui Gu Kai-Wen Ren Xin Xie Shi-Hao Wang Xiao-Xue Zhu Lei Wang Xiao-Lei Yang Hai-Lian Bi Source Type: research
Protocol for a multicentre and prospective follow-up cohort study of early detection of atrial fibrillation, silent stroke and cognitive impairment in high-risk primary care patients: the PREFA-TE study
This study protocol has been reviewed and approved by the Independent Ethics Committee of the Foundation University Institute for Primary Health Care Research-IDIAP Jordi Gol (expedient file 22/090-P). The authors plan to disseminate the study results to the general public through various scientific events. Publication in open-access journals and presentations at scientific congresses, seminars and meetings is also foreseen.
Trial registration number
NCT05772806. (Source: BMJ Open)
Source: BMJ Open - February 19, 2024 Category: General Medicine Authors: Hernandez-Pinilla, A., Clua-Espuny, J.-L., Satue-Gracia, E. M., Palleja-Millan, M., Martin-Lujan, F. M., PREFA-TE Study-Group, Panisello-Tafalla, Clua-Queralt, Grau-Roche, Forcadell-Arenas, Yanez-Cabrera, Muria-Subirats, Lloren-Insa, Forcadell-Peris, Batl Tags: Open access, Cardiovascular medicine Source Type: research
Obstructive sleep apnoea and nocturnal atrial fibrillation in patients with ischaemic heart disease
CONCLUSION: In patients with IHD, there was a significant association between severe OSA and nocturnal AF/flutter. This underscores the need to evaluate for OSA in patients with IHD, as it may have important implications on clinical outcomes.PMID:38363738 | DOI:10.4103/singaporemedj.SMJ-2021-293 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - February 16, 2024 Category: General Medicine Authors: Silin Kuang Yiong Huak Chan Serene Wong See Meng Khoo Source Type: research
Obstructive sleep apnoea and nocturnal atrial fibrillation in patients with ischaemic heart disease
CONCLUSION: In patients with IHD, there was a significant association between severe OSA and nocturnal AF/flutter. This underscores the need to evaluate for OSA in patients with IHD, as it may have important implications on clinical outcomes.PMID:38363738 | DOI:10.4103/singaporemedj.SMJ-2021-293 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - February 16, 2024 Category: General Medicine Authors: Silin Kuang Yiong Huak Chan Serene Wong See Meng Khoo Source Type: research
Obstructive sleep apnoea and nocturnal atrial fibrillation in patients with ischaemic heart disease
CONCLUSION: In patients with IHD, there was a significant association between severe OSA and nocturnal AF/flutter. This underscores the need to evaluate for OSA in patients with IHD, as it may have important implications on clinical outcomes.PMID:38363738 | DOI:10.4103/singaporemedj.SMJ-2021-293 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - February 16, 2024 Category: General Medicine Authors: Silin Kuang Yiong Huak Chan Serene Wong See Meng Khoo Source Type: research
Obstructive sleep apnoea and nocturnal atrial fibrillation in patients with ischaemic heart disease
CONCLUSION: In patients with IHD, there was a significant association between severe OSA and nocturnal AF/flutter. This underscores the need to evaluate for OSA in patients with IHD, as it may have important implications on clinical outcomes.PMID:38363738 | DOI:10.4103/singaporemedj.SMJ-2021-293 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - February 16, 2024 Category: General Medicine Authors: Silin Kuang Yiong Huak Chan Serene Wong See Meng Khoo Source Type: research
Obstructive sleep apnoea and nocturnal atrial fibrillation in patients with ischaemic heart disease
CONCLUSION: In patients with IHD, there was a significant association between severe OSA and nocturnal AF/flutter. This underscores the need to evaluate for OSA in patients with IHD, as it may have important implications on clinical outcomes.PMID:38363738 | DOI:10.4103/singaporemedj.SMJ-2021-293 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - February 16, 2024 Category: General Medicine Authors: Silin Kuang Yiong Huak Chan Serene Wong See Meng Khoo Source Type: research
Obstructive sleep apnoea and nocturnal atrial fibrillation in patients with ischaemic heart disease
CONCLUSION: In patients with IHD, there was a significant association between severe OSA and nocturnal AF/flutter. This underscores the need to evaluate for OSA in patients with IHD, as it may have important implications on clinical outcomes.PMID:38363738 | DOI:10.4103/singaporemedj.SMJ-2021-293 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - February 16, 2024 Category: General Medicine Authors: Silin Kuang Yiong Huak Chan Serene Wong See Meng Khoo Source Type: research
Obstructive sleep apnoea and nocturnal atrial fibrillation in patients with ischaemic heart disease
CONCLUSION: In patients with IHD, there was a significant association between severe OSA and nocturnal AF/flutter. This underscores the need to evaluate for OSA in patients with IHD, as it may have important implications on clinical outcomes.PMID:38363738 | DOI:10.4103/singaporemedj.SMJ-2021-293 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - February 16, 2024 Category: General Medicine Authors: Silin Kuang Yiong Huak Chan Serene Wong See Meng Khoo Source Type: research
Obstructive sleep apnoea and nocturnal atrial fibrillation in patients with ischaemic heart disease
CONCLUSION: In patients with IHD, there was a significant association between severe OSA and nocturnal AF/flutter. This underscores the need to evaluate for OSA in patients with IHD, as it may have important implications on clinical outcomes.PMID:38363738 | DOI:10.4103/singaporemedj.SMJ-2021-293 (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - February 16, 2024 Category: General Medicine Authors: Silin Kuang Yiong Huak Chan Serene Wong See Meng Khoo Source Type: research
Clonal Hematopoiesis of Indeterminate Potential With Loss of < em > Tet2 < /em > Enhances Risk for Atrial Fibrillation Through < em > Nlrp3 < /em > Inflammasome Activation
CONCLUSIONS: We identified a modest association between CHIP, particularly TET2 CHIP, and incident AF in the UK Biobank population. In a mouse model of AF resulting from hematopoietic-specific inactivation of Tet2, we propose altered calcium handling as an arrhythmogenic mechanism, dependent on Nlrp3 inflammasome activation. Our data are in keeping with previous studies of CHIP in cardiovascular disease, and further studies into the therapeutic potential of NLRP3 inhibition for individuals with TET2 CHIP may be warranted.PMID:38357791 | DOI:10.1161/CIRCULATIONAHA.123.065597 (Source: Circulation)
Source: Circulation - February 15, 2024 Category: Cardiology Authors: Amy Erica Lin Aneesh C Bapat Ling Xiao Abhishek Niroula Jianchuan Ye Waihay J Wong Mridul Agrawal Christopher J Farady Andreas Boettcher Christopher B Hergott Marie McConkey Patricio Flores-Bringas Veronica Shkolnik Alexander G Bick David Milan Pradeep Na Source Type: research
A Q-transform-based deep learning model for the classification of atrial fibrillation types
Phys Eng Sci Med. 2024 Feb 14. doi: 10.1007/s13246-024-01391-3. Online ahead of print.ABSTRACTAccording to the World Health Organization (WHO), Atrial Fibrillation (AF) is emerging as a global epidemic, which has resulted in a need for techniques to accurately diagnose AF and its various subtypes. While the classification of cardiac arrhythmias with AF is common, distinguishing between AF subtypes is not. Accurate classification of AF subtypes is important for making better clinical decisions and for timely management of the disease. AI techniques are increasingly being considered for image classification and detection in ...
Source: Health Physics - February 14, 2024 Category: Physics Authors: B Dhananjay R Pradeep Kumar Bala Chakravarthy Neelapu Kunal Pal J Sivaraman Source Type: research
The influence of cardiac arrhythmias on the detection of heartbeats in the photoplethysmogram: benchmarking open-source algorithms
Objective. Cardiac arrhythmias are a leading cause of mortality worldwide. Wearable devices based on photoplethysmography give the opportunity to screen large populations, hence allowing for an earlier detection of pathological rhythms that might reduce the risks of complications and medical costs. While most of beat detection algorithms have been evaluated on normal sinus rhythm or atrial fibrillation recordings, the performance of these algorithms in patients with other cardiac arrhythmias, such as ventricular tachycardia or bigeminy, remain unknown to date. Approach. The PPG-beats open-source framework, developed by Cha...
Source: Physiological Measurement - February 14, 2024 Category: Physiology Authors: Lo ïc Jeanningros, Mathieu Le Bloa, Cheryl Teres, Claudia Herrera Siklody, Alessandra Porretta, Patrizio Pascale, Adrian Luca, Jorge Solana Muñoz, Giulia Domenichini, Théo A Meister, Rodrigo Soria Maldonado, Hildegard Tanner, Jean-Marc Vesin, Jean-Phil Source Type: research
Sodium glucose cotransporter 2 inhibitors with cardiac arrhythmias in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized placebo-controlled trials
ConclusionSGLT2 inhibitors were associated with a reduced risk of atrial arrhythmias in patients with T2DM. Our results support the use of SGLT2 inhibitors in T2DM with high cardiovascular risk populations. We also recommend the long-term use of SGLT2 inhibitors to achieve further benefits.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 14, 2024 Category: Cardiology Source Type: research
A Q-transform-based deep learning model for the classification of atrial fibrillation types
AbstractAccording to the World Health Organization (WHO), Atrial Fibrillation (AF) is emerging as a global epidemic, which has resulted in a need for techniques to accurately diagnose AF and its various subtypes. While the classification of cardiac arrhythmias with AF is common, distinguishing between AF subtypes is not. Accurate classification of AF subtypes is important for making better clinical decisions and for timely management of the disease. AI techniques are increasingly being considered for image classification and detection in various ailments, as they have shown promising results in improving diagnosis and trea...
Source: Australasian Physical and Engineering Sciences in Medicine - February 14, 2024 Category: Biomedical Engineering Source Type: research
