Ebstein ’ s Anomaly of Tricuspid Valve
Transcript of the video: Ebstein’s Anomaly is one of the cyanotic congenital heart disease in which survival to adult life is common. In Ebstein’s anomaly, there is downward or apical displacement of posterior and septal tricuspid leaflets. The anterior leaflet is not displaced, but is elongated to meet the other leaflets, so that when it closes, a loud sound, tricuspid sound, is produced, which is called as the sail sound. Ebstein’s anomaly may be associated with atrial septal defect or a patent foramen ovale, in about 50% of cases. The cyanosis in Ebstein’s anomaly, is usually not due to pulmonary...
Source: Cardiophile MD - March 30, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
A teenager involved in a motor vehicle collision with abnormal ECG
Written by Pendell MeyersA teenager was involved in a motor vehicle collision and presented to the Emergency Department via EMS altered and potentially critically ill. He was intubated for altered mental status. Chest trauma was suspected on initial exam. Here is his initial ECG around 1330:What do you think?The ECG shows sinus tachycardia with RBBB and LAFB, without clear additional superimposed signs of ischemia. It is very unlikely that a previously healthy teenager would have such disease of the conduction system, bringing up the possibility of blunt cardiac injury in this clinical setting.Trauma CTs showed a " mi...
Source: Dr. Smith's ECG Blog - February 6, 2024 Category: Cardiology Authors: Pendell Source Type: blogs
Fight Aging! Newsletter, February 5th 2024
In conclusion, the Immunity and Redox Clocks allow BA quantification in mice and both the ImmunolAge and RedoxAge in mice relate to lifespan.
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Senolytic CAR T Cell Therapy Improves Health in Aged Mice
https://www.fightaging.org/archives/2024/01/senolytic-car-t-cell-therapy-improves-health-in-aged-mice/
To the degree that senescent cells in a tissue exhibit distinctive surface features, one can deploy technologies such as chimeric antigen receptor T cells to selectively destroy them. T cells will destroy whatever cell binds to the chimeric antigen receptor they are equipped w...
Source: Fight Aging! - February 4, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Interactions Between Innervation, Vascular Aging, and Loss of Capillary Density in the Heart
One noted aspect of vascular aging is that the processes of angiogenesis become less effective with age, and as a consequence aged tissues lose capillary density. This harms function by reducing the supply of nutrients and oxygen to energy-hungry tissues such as muscles and brain, as well as putting stress on the remaining vasculature due to changes in the dynamics of blood flow. Accompanying this form of vascular aging is a progressive innervation, a loss of peripheral nervous system connections. These two complex processes interact strongly with one another, given the proximity of blood vessels and nerves, and signaling ...
Source: Fight Aging! - January 29, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, January 1st 2024
Discussion of What is Need to Speed the Pace at which Drugs to Treat Aging Arrive in the Clinic
Cellular Senescence in the Aging Brain, a Contributing Cause of Cognitive Decline
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Blunt Thoughts on Calculating the Revealed Value of Human Life
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
Towards Adjustment of the Gut Microbiome to Slow Aging
Gene Therapy Enhances Object Recognition Memory in Young and Old Mice
Benefits of Sem...
Source: Fight Aging! - December 31, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Taurine is a semi-essential amino acid. Dietary taurine supplementation has been shown to modestly slow aging in mice, though as for all such interventions there is always the question of whether it will prove to be less useful in humans, and also whether these results in mice will be disproved by the much more rigorous Interventions Testing Program (ITP), once that group gets around to assessing taurine supplementation. Few of the numerous interventions thought to modestly slow aging in mice on the basis of earlier research actually held up once subjected to the ITP degree of experimental rigor.
Speculatively, taur...
Source: Fight Aging! - December 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 18th 2023
In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team.
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Aged Transplant Organs Cause Harm to Younger Recipients
https://www.fightaging.org/archives/2023/12/aged-transplant-organs-cause-harm-to-younger-recipients/
Old tissues are dysfunctional in ways that young tissues are not. This has always been known in the context of organ transplants, but absent me...
Source: Fight Aging! - December 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cellular Stress Signaling in the Development of Ventricular Fibrillation
Researchers here report on a mechanism by which increased cellular stress in heart tissue can disrupt the regulation of the heartbeat, thus leading to arrhythmia and potentially fibrillation. The accumulated molecular damage of aging, of course, provides increased contributions to cell stress, whether from inflammatory signaling, mitochondrial dysfunction, increased presence of molecular waste, or other causes. When researchers characterize more of the ways in which regulatory pathways in cells can produce maladaptive reactions to this damage, they tend to then search for means to alter the response, rather than means to r...
Source: Fight Aging! - December 11, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
ECG Changes in Intracranial Hemorrhage
ECG changes are fairly common in intracranial hemorrhage. Giant T inversions with QT interval prolongation may be seen in intracranial hemorrhage even without associated myocardial damage [1]. ECG changes described in subarachnoid hemorrhage include QT interval prolongation, T wave abnormalities and ST segment deviations. Mechanism is thought to be due to sustained sympathetic stimulation, probably caused by dysfunction of insular cortex resulting in reversible neurogenic damage to the myocardium which could include contraction bands and subendocardial ischemia [2].
In a study involving patients with supratentorial hemorr...
Source: Cardiophile MD - November 17, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
A woman in her 50s with chest pain and lightheadedness and " anterior subendocardial ischemia "
Written by Pendell MeyersA woman in her 50s presented with acute chest pain and lightheadedness since the past several hours. Here is her triage ECG during active symptoms:What do you think?The ED physician read this as " Normal sinus rhythm. LVH. Marked ST abnormality, possible anterior subendocardial injury. " Smith: I suspect this was a confirmation of the conventional computer interpretation. These are often wrong and lead the physician astray.This is wrong on many levels. The rhythm is some form of heart block (see Ken ' s comments at end of post) with junctional escape. The STD maximal in ...
Source: Dr. Smith's ECG Blog - July 30, 2023 Category: Cardiology Authors: Pendell Source Type: blogs
Beta-Blockers For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
In conclusion, beta-blockers serve as an indispensable tool in the realm of modern medical treatment, particularly in managing a broad range of cardiovascular conditions.
Their unique mechanism of action, which includes decreasing heart rate and blood pressure, confers a significant cardio-protective effect.
This, combined with their versatility and the extensive clinical experience with their use, has cemented beta-blockers as a first-line treatment for various conditions, from hypertension and heart failure to anxiety and migraines.
Although beta-blockers present unique benefits, it’s crucial...
Source: The EMT Spot - July 24, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Young Man with Very Fast Regular Wide Complex Tachycardia
EMS was dispatched for a 30-something male who feels his heart is racing. Sudden onset.The patient had no previous medical history.Vitals were normal except for a heart rate of 226.A prehospital 12-lead was recorded:There is a regular wide complex tachycardia. The computer diagnosed this as Ventricular Tachycardia.Is it definitely VT??The patient was given 6mg, then 12 mg, of adenosine, without a change in the rhythm.He arrived in the ED and had an immediate bedside cardiac ultrasound while this ECG was being recorded.The bedside ultrasound (video not available) reportedly showed only a slightly reduced LV func...
Source: Dr. Smith's ECG Blog - June 28, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
Causes of heart attack and cardiac arrest in teenagers
A heart attack occurs when blood flow to a part of the heart muscle stops. Heart attacks in teenagers can be caused by rare genetic diseases, such as familial homozygous hypercholesterolemia, which increases blood cholesterol levels, and some rare diseases that affect the blood vessels of the heart, such as Kawasaki disease.
Cardiac arrest means the heart stops working completely. A heart attack can lead to cardiac arrest. Inherited diseases like Congenital long QT syndrome and Brugada syndrome that cause cardiac arrhythmias and can also cause cardiac arrest in adolescents. (Source: Cardiophile MD)
Source: Cardiophile MD - June 1, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Graphene Patch Affixes to Heart for Pacemaking
Researchers at Northwestern University and the University of Texas at Austin have developed a thin and flexible graphene “tattoo” that can be affixed to the outside of the heart, and which can monitor heart rhythms and apply corrective electrical impulses to treat arrhythmias. The patch is optically clear, allowing the researchers to also use light to monitor and stimulate the heart. The technology has clear benefits over current pacemakers, which tend to include rigid components that can cause damage to soft tissue and potentially interfere with the natural motion of the heart.
Using soft materials to create med...
Source: Medgadget - May 1, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology Materials pacemaker UTAustin Source Type: blogs
A woman in her 60s with large T-waves. Are they hyperacute, hyperkalemic, or something else?
Case written by Brandon Friedman M.D., edits by MeyersA woman in her 60s with a history of chronic atrial fibrillation on Eliquis, ESRD on hemodialysis, type-II diabetes mellitus, prior CVA, hypertension, and hyperlipidemia presented to the emergency department with multiple complaints after missing dialysis. She described a feeling of general unwellness, diarrhea, right-sided abdominal pain, bilateral leg pain, bilateral leg swelling, and diffuse itching. She missed her last two dialysis appointments, with her last session occurring one week prior to presentation. On initial assessment, she was found to be tachycard...
Source: Dr. Smith's ECG Blog - May 1, 2023 Category: Cardiology Authors: Pendell Source Type: blogs
