Gut microbiota-dependent phenylacetylglutamine in cardiovascular disease: current knowledge and new insights
Front Med. 2024 Mar 1. doi: 10.1007/s11684-024-1055-9. Online ahead of print.ABSTRACTPhenylacetylglutamine (PAGln) is an amino acid derivate that comes from the amino acid phenylalanine. There are increasing studies showing that the level of PAGln is associated with the risk of different cardiovascular diseases. In this review, we discussed the metabolic pathway of PAGln production and the quantitative measurement methods of PAGln. We summarized the epidemiological evidence to show the role of PAGln in diagnostic and prognostic value in several cardiovascular diseases, such as heart failure, coronary heart disease/atherosc...
Source: Atherosclerosis - February 29, 2024 Category: Cardiology Authors: Yaonan Song Haoran Wei Zhitong Zhou Huiqing Wang Weijian Hang Junfang Wu Dao Wen Wang Source Type: research
Insomnia is related to long-term atrial fibrillation recurrence following radiofrequency ablation
CONCLUSION: This study establishes a significant link between insomnia and long-term AF recurrence following radiofrequency ablation. It underscores the importance of identifying and addressing insomnia in patients with AF undergoing radiofrequency ablation.PMID:38423515 | PMC:PMC10906119 | DOI:10.1080/07853890.2024.2323089 (Source: Annals of Medicine)
Source: Annals of Medicine - February 29, 2024 Category: Internal Medicine Authors: Rui-Bin Li Ji-Dong Zhang Xiao-Ran Cui Wei Cui Source Type: research
Isolated insular stroke: topography is the answer with respect to outcome and cardiac involvement
Discussion and conclusionIIS are extremely rare, representing according to our study about 2.6% ischemic strokes cases per year, and patients have peculiar clinical manifestations, such as dysautonomia and awareness deficits. Our data suggest the possibility for these patients to completely recover after acute ischemic stroke notwithstanding the pivotal role of the insula in cerebral connections and the frequent association with MCA occlusion. Moreover, given the central role of the insula in regulating autonomic functions, newly detected cardiac arrhythmias must be taken into consideration, as well as a full diagnostic wo...
Source: Frontiers in Neurology - February 29, 2024 Category: Neurology Source Type: research
Lamin A K97E leads to NF- κB-mediated dysfunction of inflammatory responses in dilated cardiomyopathy
CONCLUSIONS: We report here for the first time that there is a significant downregulation of the NF-κB pathway, which has been implicated in cardio-protection elsewhere.SIGNIFICANCE: This provides a new pathophysiological explanation that correlates an LMNA mutation and dilated cardiomyopathy.PMID:38404031 | DOI:10.1111/boc.202300094 (Source: Biology of the Cell)
Source: Biology of the Cell - February 26, 2024 Category: Cytology Authors: Duhita Sengupta Kaushik Sengupta Source Type: research
Beating the Heart Failure Odds: Long-Term Survival after Myocardial Ischemia in Juvenile Rainbow Trout
Am J Physiol Regul Integr Comp Physiol. 2024 Feb 26. doi: 10.1152/ajpregu.00005.2024. Online ahead of print.ABSTRACTSalmonid fish include some of the most valued cultured fish species worldwide. Unlike most other fish, the hearts of salmonids, including Atlantic salmon and rainbow trout, have a well-developed coronary circulation. Consequently, their hearts' reliance on oxygenation through coronary arteries leaves them prone to coronary lesions, believed to precipitate myocardial ischemia. Here, we mimicked such coronary lesions by subjecting groups of juvenile rainbow trout to coronary ligation, assessing histo-morphologi...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - February 26, 2024 Category: Physiology Authors: Lucas A Zena Andreas Tommy Ekstr öm Daniel Morgenroth Tristan McArley Michael Axelsson Henrik Sundh Anders Palmquist Ida B Johansen Albin Gr äns Erik Sandblom Source Type: research
Lamin A K97E leads to NF- κB-mediated dysfunction of inflammatory responses in dilated cardiomyopathy
CONCLUSIONS: We report here for the first time that there is a significant downregulation of the NF-κB pathway, which has been implicated in cardio-protection elsewhere.SIGNIFICANCE: This provides a new pathophysiological explanation that correlates an LMNA mutation and dilated cardiomyopathy.PMID:38404031 | DOI:10.1111/boc.202300094 (Source: Biology of the Cell)
Source: Biology of the Cell - February 26, 2024 Category: Cytology Authors: Duhita Sengupta Kaushik Sengupta Source Type: research
Beating the Heart Failure Odds: Long-Term Survival after Myocardial Ischemia in Juvenile Rainbow Trout
Am J Physiol Regul Integr Comp Physiol. 2024 Feb 26. doi: 10.1152/ajpregu.00005.2024. Online ahead of print.ABSTRACTSalmonid fish include some of the most valued cultured fish species worldwide. Unlike most other fish, the hearts of salmonids, including Atlantic salmon and rainbow trout, have a well-developed coronary circulation. Consequently, their hearts' reliance on oxygenation through coronary arteries leaves them prone to coronary lesions, believed to precipitate myocardial ischemia. Here, we mimicked such coronary lesions by subjecting groups of juvenile rainbow trout to coronary ligation, assessing histo-morphologi...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - February 26, 2024 Category: Physiology Authors: Lucas A Zena Andreas Tommy Ekstr öm Daniel Morgenroth Tristan McArley Michael Axelsson Henrik Sundh Anders Palmquist Ida B Johansen Albin Gr äns Erik Sandblom Source Type: research
Lamin A K97E leads to NF- κB-mediated dysfunction of inflammatory responses in dilated cardiomyopathy
CONCLUSIONS: We report here for the first time that there is a significant downregulation of the NF-κB pathway, which has been implicated in cardio-protection elsewhere.SIGNIFICANCE: This provides a new pathophysiological explanation that correlates an LMNA mutation and dilated cardiomyopathy.PMID:38404031 | DOI:10.1111/boc.202300094 (Source: Biology of the Cell)
Source: Biology of the Cell - February 26, 2024 Category: Cytology Authors: Duhita Sengupta Kaushik Sengupta Source Type: research
Beating the Heart Failure Odds: Long-Term Survival after Myocardial Ischemia in Juvenile Rainbow Trout
Am J Physiol Regul Integr Comp Physiol. 2024 Feb 26. doi: 10.1152/ajpregu.00005.2024. Online ahead of print.ABSTRACTSalmonid fish include some of the most valued cultured fish species worldwide. Unlike most other fish, the hearts of salmonids, including Atlantic salmon and rainbow trout, have a well-developed coronary circulation. Consequently, their hearts' reliance on oxygenation through coronary arteries leaves them prone to coronary lesions, believed to precipitate myocardial ischemia. Here, we mimicked such coronary lesions by subjecting groups of juvenile rainbow trout to coronary ligation, assessing histo-morphologi...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - February 26, 2024 Category: Physiology Authors: Lucas A Zena Andreas Tommy Ekstr öm Daniel Morgenroth Tristan McArley Michael Axelsson Henrik Sundh Anders Palmquist Ida B Johansen Albin Gr äns Erik Sandblom Source Type: research
Lamin A K97E leads to NF- κB-mediated dysfunction of inflammatory responses in dilated cardiomyopathy
CONCLUSIONS: We report here for the first time that there is a significant downregulation of the NF-κB pathway, which has been implicated in cardio-protection elsewhere.SIGNIFICANCE: This provides a new pathophysiological explanation that correlates an LMNA mutation and dilated cardiomyopathy.PMID:38404031 | DOI:10.1111/boc.202300094 (Source: Biology of the Cell)
Source: Biology of the Cell - February 26, 2024 Category: Cytology Authors: Duhita Sengupta Kaushik Sengupta Source Type: research
Beating the Heart Failure Odds: Long-Term Survival after Myocardial Ischemia in Juvenile Rainbow Trout
Am J Physiol Regul Integr Comp Physiol. 2024 Feb 26. doi: 10.1152/ajpregu.00005.2024. Online ahead of print.ABSTRACTSalmonid fish include some of the most valued cultured fish species worldwide. Unlike most other fish, the hearts of salmonids, including Atlantic salmon and rainbow trout, have a well-developed coronary circulation. Consequently, their hearts' reliance on oxygenation through coronary arteries leaves them prone to coronary lesions, believed to precipitate myocardial ischemia. Here, we mimicked such coronary lesions by subjecting groups of juvenile rainbow trout to coronary ligation, assessing histo-morphologi...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - February 26, 2024 Category: Physiology Authors: Lucas A Zena Andreas Tommy Ekstr öm Daniel Morgenroth Tristan McArley Michael Axelsson Henrik Sundh Anders Palmquist Ida B Johansen Albin Gr äns Erik Sandblom Source Type: research
Lamin A K97E leads to NF- κB-mediated dysfunction of inflammatory responses in dilated cardiomyopathy
CONCLUSIONS: We report here for the first time that there is a significant downregulation of the NF-κB pathway, which has been implicated in cardio-protection elsewhere.SIGNIFICANCE: This provides a new pathophysiological explanation that correlates an LMNA mutation and dilated cardiomyopathy.PMID:38404031 | DOI:10.1111/boc.202300094 (Source: Biology of the Cell)
Source: Biology of the Cell - February 26, 2024 Category: Cytology Authors: Duhita Sengupta Kaushik Sengupta Source Type: research
Lamin A K97E leads to NF- κB-mediated dysfunction of inflammatory responses in dilated cardiomyopathy
CONCLUSIONS: We report here for the first time that there is a significant downregulation of the NF-κB pathway, which has been implicated in cardio-protection elsewhere.SIGNIFICANCE: This provides a new pathophysiological explanation that correlates an LMNA mutation and dilated cardiomyopathy.PMID:38404031 | DOI:10.1111/boc.202300094 (Source: Biology of the Cell)
Source: Biology of the Cell - February 26, 2024 Category: Cytology Authors: Duhita Sengupta Kaushik Sengupta Source Type: research
