Lamin A K97E leads to NF- κB-mediated dysfunction of inflammatory responses in dilated cardiomyopathy

CONCLUSIONS: We report here for the first time that there is a significant downregulation of the NF-κB pathway, which has been implicated in cardio-protection elsewhere.SIGNIFICANCE: This provides a new pathophysiological explanation that correlates an LMNA mutation and dilated cardiomyopathy.PMID:38404031 | DOI:10.1111/boc.202300094
Source: Biology of the Cell - Category: Cytology Authors: Source Type: research