Hepatocellular carcinoma risk, cirrhosis and hepatitis C
High profile public health strategy needed Related items fromOnMedica Overweight teens more likely to have severe liver disease later Scotland reveals target of halving child obesity by 2030 JCVI recommends universal HPV vaccination Lower cancer risk in people with higher vitamin D levels Public drastically underestimates cannabis risks (Source: OnMedica Blogs)
Source: OnMedica Blogs - December 3, 2018 Category: General Medicine Source Type: blogs
Immunohistochemistry in the Differential Diagnosis of Cutaneous Basal Cell Carcinoma
Basal cell carcinoma and squamous cell carcinoma are two of the most common cutaneous tumors seen by pathologists. In the large majority of cases, the distinction between these two tumors is readily made on the basis of standard H&E morphology. However, many of us see cases from time to time that for one reason or another (minuscule biopsy, mishandled specimen, crushed beyond recognition, dryed out, poorly fixed, etc., etc.), it is difficult to know for certain whether one is dealing with a squamous carcinoma or a basal cell carcinoma. This month, we discuss several immunostains that can be of utility in approaching th...
Source: Oncopathology - November 20, 2018 Category: Cancer & Oncology Source Type: blogs
Immunohistochemistry in the Differential Diagnosis of Cutaneous Basal Cell Carcinoma
Basal cell carcinoma and squamous cell carcinoma are two of the most common cutaneous tumors seen by pathologists. In the large majority of cases, the distinction between these two tumors is readily made on the basis of standard H&E morphology. However, many of us see cases from time to time that for one reason or another (minuscule biopsy, mishandled specimen, crushed beyond recognition, dryed out, poorly fixed, etc., etc.), it is difficult to know for certain whether one is dealing with a squamous carcinoma or a basal cell carcinoma. This month, we discuss several immunostains that can be of utility in approaching th...
Source: Oncopathology - November 20, 2018 Category: Cancer & Oncology Source Type: blogs
August 2010 Man of the Month: E-Patient Dave
Richard Davies deBronkart Jr , known by many as e-Patient Dave, is a cancer patient and blogger who, in 2009, became a noted activist for health care transformation through participatory medicine and personal health data rights. In 2010, he became a published author and Disruptive Women in Health Care’s August Man of the Month.
I was a middle-aged guy going through life, as involved with my own health care as I was with my car’s carburetor, which is to say, virtually not at all. And then I found out I was almost dead.
That’s how my interview with Dave started.
Dave was diagnosed in January 2007 with Stage IV, Grade 4...
Source: Disruptive Women in Health Care - September 27, 2018 Category: Consumer Health News Authors: dw at disruptivewomen.net Tags: Uncategorized Source Type: blogs
Answer to Case 512
Answer:Iodamoeba buetschliiI thought this was a fun example of a relatively common parasite seen with an uncommon preparation. It ' s nice to see that an alternative stain such as Papanicoloau still allows for morphologic identification of the intestinal amebae.The key morphologic features of this case are the small size of the organisms (primarily cysts, and possibly one trophozoite), nucleus with large karysome and lack of peripheral chromatin, and large cytoplasmic vacuole in the cytoplasm of the cyst form. As Florida Fan mentioned, the large glycogen-filled vacuole would be deeply stained with iodine if we had a wet mo...
Source: Creepy Dreadful Wonderful Parasites - September 23, 2018 Category: Parasitology Source Type: blogs
Bi-annual MRI More Effective than Annual Mammogram for Breast Cancer Detection
This study could significantly change the way we approach breast cancer screening." MRI is much more sensitive than mammography, " saidGreg Karczmar, PhD, professor of radiology at the University of Chicago. " It can find invasive breast cancers sooner than mammograms and it can rule out abnormalities that appear suspicious on a mammogram. Unfortunately, MRI is much too expensive for routine screening. " (Source: radRounds)
Source: radRounds - September 20, 2018 Category: Radiology Authors: Julie Morse Source Type: blogs
What's in a name?
From time to time I have commented on the controversies over cancer screening. Most people assume that screening is an unqualified good, that early detection of cancer saves lives. Whenever some panel proposes recommending less screening, we hear screaming and yelling from advocates who claim they are trying to " ration " health care to save money at the expense of people ' s lives.In fact,as a bunch of Australians and a Minnesotan explain in BMJ, there are a few conditions called " cancer " that you are better off not treating, or perhaps treating very conservatively. These include what is called ductal carcinoma in situ ...
Source: Stayin' Alive - August 13, 2018 Category: American Health Source Type: blogs
Fight Aging! Newsletter, August 13th 2018
We report that the disruption of excitation-contraction coupling contributes to impaired force generation in the mouse model of Sod1 deficiency. Briefly, we found a significant reduction in sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity as well as reduced expression of proteins involved in calcium release and force generation. Another potential factor involved in EC uncoupling in Sod1-/- mice is oxidative damage to proteins involved in the contractile response.
In summary, this study provides strong support for the coupling between increased oxidative stress and disruption of cellular excitation contraction mac...
Source: Fight Aging! - August 12, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Will Increased Understanding of Cellular Senescence Lead to an End to Cancer?
Selective destruction of senescent cells in old tissues offers the promise of some degree of rejuvenation, coupled with effective therapies for a range of age-related diseases that currently cannot be controlled. In the past few years, a number of companies have raised venture funding for the development of senolytic therapies, those capable of removing some portion of senescent cells with an acceptable side-effect profile. The potential market is enormous, and thus despite the many potential competitors, any new mechanism by which senescent cells can be destroyed might be the pathway to success and revenue for the individ...
Source: Fight Aging! - August 6, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Rethinking the screening mammogram
This study analyzed data from women over 40 and compared the size of breast cancers at the time of diagnosis detected in the 1970s (before mammography became common) with the size of tumors detected between 2000 and 2002, when screening mammography was routine. Treatments and rates of death due to breast cancer 10 years after the diagnosis were also analyzed. The study found that:
As more women underwent routine screening mammograms, more small breast cancers were detected. Many of these tumors were restricted to the ducts within the breast (called ductal carcinoma in situ), and even without treatment would never threaten...
Source: Harvard Health Blog - June 28, 2018 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Source Type: blogs
Fight Aging! Newsletter, June 4th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - June 3, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Commentary on Senolytic Gene Therapies to Target p16 Overexpression
This short commentary discusses the utility of Oisin Biotechnologies' initial strategy for destroying senescent cells, which is to use p16 expression as the determining sign of senescence. Oisin's implementation involves delivering dormant DNA machinery indiscriminately to all cells, and then triggering it only in cells with high levels of p16. This particular implementation is one of many possibilities in the gene therapy space, and thus various other groups are working on their own p16-based approaches as senolytic development as a treatment for aging grows in funding and popularity.
It isn't just senescence and a...
Source: Fight Aging! - May 28, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
KARL STORZ ’s Blue Light Flexible Cystoscopy Coming to U.S. for Bladder Cancer Detection
KARL STORZ is releasing its PDD (photodynamic diagnostics) Blue Light Flexible Video Cystoscopy in the United States for detection of non-muscle invasive bladder cancer. The news is a result of the FDA’s regulatory green light that allows the company’s Blue Light Cystoscopy with Cysview to also be useful with the KARL STORZ PDD Blue Light Flexible Video Cystoscope.
The regulatory approval includes an indication for use of Cysview repeatedly on the same patient to spot Carcinoma in Situ, a difficult bladder cancer to diagnose. Of note, Cysview, an optical imaging compound that’s injected and fluoresce...
Source: Medgadget - May 22, 2018 Category: Medical Devices Authors: Editors Tags: News Urology Source Type: blogs
Best Post of March 2018 - Featured Neuropathologist: Michael Punsoni, MD
The next in our " Best of the Month " series is from March 12, 2018On occasion, we profile a prominent or rising neuropathologist. In the past, we ' ve featured the likes of Craig Horbinski, Roger McLendon, Jan Leestma, and Karra Jones. Today we feature Michael Punsoni, MD, a 2016 graduate of the Brown University Neuropathology Fellowship Program and now on faculty at the University of Nebraska in Omaha. Dr. Punsoni agreed to engage in a little Q&A:1. Why did you decide to become a neuropathologist?I have always had a strong interest in science and medicine, particularly the neurosciences....
Source: neuropathology blog - May 10, 2018 Category: Radiology Tags: Best of the Month series neuropathologists Source Type: blogs
Insurance denials: the law of the land
It all started out with Malaysian methimazole, and didn’t end until two highly trained medical professionals sat on opposite ends of a telephone call, scratching their heads and wondering how two digits being transposed could lead to so many problems.
Those two transposed digits caused a thyroid uptake scan to become a bone marrow scan (whatever that is). But look at all it took to get there.
Mystery illness, mystery medicine
It started when a new patient came to see one of my colleagues with a mystery illness, and a medication in a pill bottle with a label in another language.
After figuring out what this medicine w...
Source: Kevin, M.D. - Medical Weblog - May 7, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/fred-n-pelzman" rel="tag" > Fred N. Pelzman, MD < /a > Tags: Physician Primary Care Source Type: blogs
