Data Simplification: Hitting the Complexity Barrier
Conclusions have no value until they are independently validated. Anyone who attempts to stay current in the sciences soon learns that much of the published literature is irreproducible (8); and that almost anything published today might be retracted tomorrow. This appalling truth applies to some of the most respected and trusted laboratories in the world (9), (10), (11), (12), (13), (14), (15), (16). Those of us who have been involved in assessing the rate of progress in disease research are painfully aware of the numerous reports indicating a general slowdown in medical progress (17), (18), (19), (20), (21), (22), (23...
Source: Specified Life - March 5, 2016 Category: Information Technology Tags: complexity computer science data analysis data repurposing data simplification data wrangling information science simplifying data taming data Source Type: blogs
Cancer Found in Naked Mole-Rats
Naked mole-rats are very long-lived in comparison to near relative species, and have a great resistance to cancer - to the point at which researchers have not characterized and reported on any incidence of cancer in their laboratory colonies, now numbering thousands of individuals, and not for lack of searching. This is a far cry from similarly-sized rodent species, all of which have a very high rate of cancer. There has been considerable interest in the research community in recent years in identifying the underlying mechanisms of cancer resistance in naked mole-rats, with an eye to seeing whether or not they can form the...
Source: Fight Aging! - February 19, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
DM / DNB Cardiology Entrance Mock Test 17
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Source: Cardiophile MD - February 16, 2016 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
It’s Time to Talk about Cancer Surgery Volume
By JENNIFER MALIN, MD
Twenty years ago as a newly trained oncologist, I faced the same challenge that many cancer patients and their families do as they try to figure out where to turn when my mother was diagnosed with ductal carcinoma in situ– or pre breast cancer. Her surgeon, who had come highly recommended by her family doctor,told her she needed to have a lymph node dissection, which can result in lifelong disability due to lymphedema or swelling of the arm. As an oncologist, I knew it was not recommended for ductal carcinoma in situ, but she resisted my suggestion to get a second opinion. Despite the fact that...
Source: The Health Care Blog - February 10, 2016 Category: Consumer Health News Authors: Simon Nath Tags: THCB Jennifer Malin Source Type: blogs
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Pathology, classification, and grading of neuroendocrine tumors arising in the digestive systemThe terminology of gastroenteropancreatic (GEP) neuroendocrine neoplasms has evolved over the past two decades to reflect a separation into two major categories:●Well-differentiated neuroendocrine tumors (NETs) show a solid, trabecular, gyriform, or glandular pattern, with fairly uniform nuclei, salt-and-pepper chromatin, and finely granular cytoplasm. These tumors were traditionally referred to as carcinoid and pancreatic neuroendocrine (islet cell) tumors. Although carcinoid tumors and pancreatic NETs may have simi...
Source: Oncopathology - January 27, 2016 Category: Cancer & Oncology Source Type: blogs
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Pathology, classification, and grading of neuroendocrine tumors arising in the digestive systemThe terminology of gastroenteropancreatic (GEP) neuroendocrine neoplasms has evolved over the past two decades to reflect a separation into two major categories:●Well-differentiated neuroendocrine tumors (NETs) show a solid, trabecular, gyriform, or glandular pattern, with fairly uniform nuclei, salt-and-pepper chromatin, and finely granular cytoplasm. These tumors were traditionally referred to as carcinoid and pancreatic neuroendocrine (islet cell) tumors. Although carcinoid tumors and pancreatic NETs may have simil...
Source: Oncopathology - January 27, 2016 Category: Cancer & Oncology Source Type: blogs
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Pathology, classification, and grading of neuroendocrine tumors arising in the digestive systemThe terminology of gastroenteropancreatic (GEP) neuroendocrine neoplasms has evolved over the past two decades to reflect a separation into two major categories:●Well-differentiated neuroendocrine tumors (NETs) show a solid, trabecular, gyriform, or glandular pattern, with fairly uniform nuclei, salt-and-pepper chromatin, and finely granular cytoplasm. These tumors were traditionally referred to as carcinoid and pancreatic neuroendocrine (islet cell) tumors. Although carcinoid tumors and pancreatic NETs may have simil...
Source: Oncopathology - January 27, 2016 Category: Cancer & Oncology Source Type: blogs
A Year in Review: FDA 2015 New Drug Approvals
The approval of first-of-a-kind drugs rose last year to forty-one, resulting in the highest level of newly approved U.S. drugs in nineteen years. The total number of new drugs approved last year was even higher at sixty-nine. The rising figures reflect an industry-wide desire to research and develop drugs for rare and hard-to-treat diseases.
The newly approved drugs serve to advance medical care and the health of patients suffering from many ailments, including various forms of cancer, heart failure, and cystic fibrosis. Additionally, more than 40% of the new therapies were approved for treatment of rare or "orphan" dise...
Source: Policy and Medicine - January 13, 2016 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs
Highly effective HCV treatment: once daily oral Sofosbuvir/Velpatasvir
The hepatitis C virus (HCV), a single-stranded RNA virus of the family Flaviviridae with six major genotypes, infects up to 150 million people worldwide. Chronic hepatitis C virus infection causes progressive liver fibrosis, which can lead to cirrhosis and hepatocellular carcinoma. There is now an effective oral regimen. New research findings are summarized in this short video from NEJM: This is a ribavirin-free single-tablet regimen. There 2 medications in the single tablet:- Sofosbuvir is a nucleotide analogue inhibitor of the HCV NS5B polymerase approved for the treatment of HCV in combination with a variety of other ag...
Source: Clinical Cases and Images - Blog - January 1, 2016 Category: Universities & Medical Training Tags: Gastroenterology NEJM Source Type: blogs
New Case – Alberta Children’s Hospital v. Mammo
On Monday, an Alberta Court will adjudicate a medical futility dispute between Alberta Children’s Hospital and the parents of 8-month-old Hermella Mammo. (Calgary Sun)
Baby Hermella's Condition
An abnormal mass in Hermella’s abdomen was diagnosed as stage IV adrenocortical carcinoma, an extremely rare form of cancer. The parents were told that there was basically no hope, and that they should give up.
The parents did not give up and pursued treatments in Calgary and Toronto. But when Hermella returned to Alberta Children’s Hospital in August, her depressed neurological functions we...
Source: blog.bioethics.net - December 6, 2015 Category: Medical Ethics Authors: Thaddeus Mason Pope Tags: Health Care medical futility blog syndicated Source Type: blogs
Is it time to update antiquated medical buzzwords?
“What is the term we use to describe the cells that help us diagnose papillary thyroid cancer?” the attending pathologist asked a room full of residents at a noon didactic.
“Orphan Annie Eyes,” they nearly all responded at once.
“And does anyone here know who Orphan Annie was?” he asked next.
It is something memorized by every medical student — the papillary thyroid carcinoma cells with cleared out nuclei are called “Orphan Annie Eyes.” And yet, the assembled pathology residents — most in their 20s and 30s, many born and raised outside the United States — had little idea why.
Continue read...
Source: Kevin, M.D. - Medical Weblog - November 10, 2015 Category: Journals (General) Authors: John Biemer, MD Tags: Physician Primary care Source Type: blogs
Nivolumab in Renal-Cell Carcinoma via Now@NEJM
Posted on infosnack. (Source: Kidney Notes)
Source: Kidney Notes - November 6, 2015 Category: Urology & Nephrology Authors: Joshua Schwimmer Source Type: blogs
Right Care Action Week – What can Radiologists do?
By SAURABH JHA, MD
The Lown Institute advocates rational use of medical resources. This is a noble goal and worthy of the attention of radiologists. This week is the right care action week. Here are five simple things any radiologist can do this week, and the following weeks. This will improve patient care by avoiding unnecessary tests.
Speak to the referring clinician, at least sometimes, if not often, perhaps twice a day. The conversation need not be adversarial. Ask before the imaging two simple questions. What will you do if the test is positive? What will you do if the test is negative? Inquire four weeks after the im...
Source: The Health Care Blog - October 20, 2015 Category: Consumer Health News Authors: Simon Nath Tags: THCB Saurabh Jha Source Type: blogs
Do cardiologists prescribe too many drugs?
One of the most common reasons people require medical care is their medical care.
This is a distinctly modern problem. In times past, doctors treated disease. Patients saw their doctor when they were sick. They had a problem; doctors offered help.
The doctor of today often improves health by removing healthcare. It’s one of my favorite tricks—stopping nonsense.
Excess healthcare happens for many reasons. Three big ones are the conflating of risk factors with disease, overdiagnosis and the one-disease-one-treatment mindset.
A high cholesterol level is not a disease but it is treated with a pill. When women acquire the d...
Source: Dr John M - September 20, 2015 Category: Cardiology Authors: Dr John Source Type: blogs
How a head CT changed everything for this patient
From her vantage point, cost had nothing to do with money. On most days, she struggled to her feet when I entered the room, greeted me effusively, and escorted me to her bedside chair, all the while chattering about the inadequacy of our hospital’s slushies, the beauty of the day outside, and the latest update on her children’s accomplishments at school. Despite her debilitating malignant small bowel obstruction from ovarian carcinoma, she still liked to play the hostess. I always tried to see her at the end of consult rounds, so that I could spend a few extra minutes chatting. Today was different.
She hunched in her c...
Source: Kevin, M.D. - Medical Weblog - September 19, 2015 Category: Journals (General) Authors: Susan A. Glod, MD Tags: Physician Cancer Source Type: blogs
