TriNav System Uses Pressure to Push Drugs into Solid Tumors
TriSalus, a Denver, Colorado firm, is launching a new solid tumor infusion system to target hepatocellular carcinoma, liver metastases, and other tumors. The TriNav Infusion System features the company’s SmartValve and Pressure-Enabled Drug Delivery (PEDD) technologies to get more of the tumor killing drug inside the diseased tissue.
The treatment is delivered in a similar manner as many existing intravascular procedures, as the device is compatible with common cath lab tools (0.035-inch and 0.038-inch standard angiographic catheters) and is easy to track through the vasculature because of a single-body design.
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Source: Medgadget - January 15, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Oncology Radiology Source Type: blogs
MKSAP: 38-year-old woman with primary membranous glomerulopathy
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 38-year-old woman is evaluated during a follow-up visit for primary membranous glomerulopathy. Diagnosis was made by kidney biopsy 4 months ago, and she was found to be positive for anti–phospholipase A2 receptor (PLA2R) antibodies. Medications are furosemide, losartan, and simvastatin. […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 16, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > < /span > Tags: Conditions Nephrology renal cell renal cell carcinoma Source Type: blogs
Hyperspectral Surgical Microscope to See Cancer Cells in Real Time
Since internal cancerous tumors usually look exactly like the healthy tissues around them, frozen section analysis is used during and after surgeries to confirm that the entirety of a tumor has been removed. This is a slow process that often leads to patients requiring follow-up procedures.
Researchers at the University of Texas at Dallas have developed a hyperspectral surgical microscope that may be able to spot cancer cells in real-time during surgeries. It not only images across nearly the entire optical spectrum, from UV to infrared, but it also uses machine learning techniques to analyze the images it produces and...
Source: Medgadget - October 2, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Neurosurgery Ob/Gyn Oncology Pathology Radiology Source Type: blogs
Radiological findings :peritoneal carcinomatosis
Sharing a poster presentation done in Medcon2019 by Harika B 1styear PG& DR.ANV Prasad, Associate Professor NRI Institute of Medical Sciences CT Findings: Severe ascites seen. Multiple small enhancing nodules seen in the parietal peritoneum, visceral peritoneum and omentum with predominant pelvic distribution.Heterogeneously enhancing lesion of 3x2.1x1.8cm seen in RIF. Appendix is not seen separately from the lesion. Final Impression of Peritoneal carcinomatosis (pseudomyxoma peritoni) - likely due to mucinous adeno Ca. appendix.Peritoneal carcinomatosis(PC) is the term given to malignant tumour seeding...
Source: Sumer's Radiology Site - September 14, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Senescent Cells Increase Risk of Colon Cancer via Secretion of GDF15
In this study, we provide both correlative and functional evidence that senescent fibroblasts and an essential SASP factor, GDF15, induce physiological and molecular changes that promote the adenoma-carcinoma initiation and progression sequence in the colon.
We assessed the role of senescence and the SASP in CRC formation. Using primary human colon tissue, we found an accumulation of senescent fibroblasts in normal tissues from individuals with advanced adenomas or carcinomas in comparison with individuals with no polyps or CRC. In in vitro and ex vivo model systems, we induced senescence using oxidative stress in c...
Source: Fight Aging! - August 16, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 29th 2019
In this study we show, for the first time, significant alterations in cholesterol efflux capacity in adolescents throughout the range of BMI, a relationship between six circulating adipocyte-derived EVs microRNAs targeting ABCA1 and cholesterol efflux capacity, and in vitro alterations of cholesterol efflux in macrophages exposed to visceral adipose tissue adipocyte-derived EVs acquired from human subjects. These results suggest that adipocyte-derived EVs, and their microRNA content, may play a critical role in the early pathological development of ASCVD.
Commentary on the Developing UK Government Position on Hea...
Source: Fight Aging! - July 28, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reversing Somatic Mosaicism in Aged Tissue
In this study, we focused on p53 mutations because these are the most enriched during malignant transformation. p53 is mutated in 5%-10% of normal EE but in almost all esophageal squamous cell carcinomas (ESCCs). This argues that ESCC emerges from the p53 mutant cell population in normal epithelium and that mutation of p53 is required for cancer development.
We speculated that altering the selective pressure on mutant cell populations may cause them to expand or contract. We tested this hypothesis by examining the effect of oxidative stress from low-dose ionizing radiation (LDIR) on wild-type and p53 mutant cells in...
Source: Fight Aging! - July 26, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Tumors Grown in 3D from Cancer Patient Samples for Drug Screening
Cancerous tumors can be very inconsistent in how they respond to different therapies. While the tumor of one patient can rapidly shrink when exposed to a given medication, another patient suffering from the same kind of tumor may not get any benefit from that same drug. This phenomenon highlights why personalized medicine is such an important component of biomedical research.
To help identify which therapies will work for a given tumor, researchers at University of Geneva (UNIGE) in Switzerland have developed a way of recreating tumors in 3D outside the body and then using them to test drug therapies. The technique should ...
Source: Medgadget - June 19, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Medicine Oncology Source Type: blogs
Virtual Biopsy for Skin Lesions Using Vibrational Optical Coherence Tomography
Tissue biopsies of skin lesions can be unpleasant and quite painful. Moreover, a biopsy typically doesn’t sample the whole lesion and doesn’t provide much information about a given lesion’s size and depth. Now, scientists at Rutgers University have developed and tested a new device that relies on two different mechanisms to analyze skin lesions.
The new “virtual biopsy” device relies on vibrational optical coherence tomography to analyze tissue. It delivers pulses of near-infrared light, along with sound clicks, into the target tissue. The combination technology can identify how deep a lesion ...
Source: Medgadget - June 18, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Dermatology Oncology Pathology Source Type: blogs
Index: Evolution's Clinical Guidebook
In the past few blogs, I ' ve been discussing the recent publication of my book,Evolution ’s Clinical Guidebook: Translating Ancient Genes Into Precision Medicine. The premise of this book is that modern medicine is based on an understanding of evolutionary processes. Evolution shows us the relationships between the subdisciplines of medicine that benefit directly from Precision Medicine (i.e., pathology, microbiology, clinical genetics, pharmacology, and bioinformatics). In Evolution ' s Clinical Guidebook, all of these diverse fields are brought together, under the subject of evolution. To illustrate, I have listed bel...
Source: Specified Life - May 11, 2019 Category: Information Technology Tags: bioinformatics clinical genetics evo-devo evolution precision medicine rare disease Source Type: blogs
Last Month in Oncology with Dr. Bishal Gyawali: April 2019
By BISHAL GYAWALI, MD
Keynote speech on the JAVELIN not going far enough to improve survival
The treatment landscape for metastatic renal-cell carcinoma has changed dramatically with the introduction of immunotherapies. Unfortunately though, we are promoting combinations over single agents without having much idea of added benefit of each drug. This is an important issue because when we combine two drugs, the only thing we are certain of are the added toxicities. PD-1 inhibitor nivolumab had improved OS when given in second line, however nivolumab was tested in combination with ipilimumab (not as a nivolumab monother...
Source: The Health Care Blog - May 10, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Bishal Gyawali Clinical Trials Oncology PD-1 inhibitor Source Type: blogs
MRI is a Non-Invasive Way to Detect Hypoxia in Breast Cancer Patients
Hypoxia and neovascularization in breast cancer can now be identified using magnetic resonance imaging (MRI) techniques, according to a studyrecently published inMolecular Imaging and Biology.Researchers from the Medical University of Vienna were intrigued by a couple of recently developed imaging methods that successfully analyzed hypoxia in patients with brain cancer and wanted to see if the same technology could be used to detect the condition in breast cancer patients. Advanced quantitative blood oxygenation level dependent (qBOLD) imaging can evaluate tissue oxygen and measure tumor hypoxia. Vascular architectural m...
Source: radRounds - February 1, 2019 Category: Radiology Authors: Julie Morse Source Type: blogs
Cauda equina mass: An Approach
- CLINICAL PRESENTATION&FINDINGS 57 yr male with h/o low back pain with no h/o trauma presents for MRI lumbar spine which shows – Large relatively well defined , regular, intradural, subtly& heterogeneously enhancing SOL, seen from lower L3 border to middle of body of L5 with compression of cauda equina fibers, displaying mostly soft tissue signals on all sequences / normal meningeal enhancement, with no significant hemorrhage / fat / cystic / necrosis/ MR demonstrable calcification components / sugarcoating / scalloping or enlargement of the posterior neural e...
Source: Sumer's Radiology Site - January 12, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Hepatocellular Carcinoma : Triple Phase CT
Presenting brief teaching video under the DAMS Unplugged series on HCC and imaging features.Famous Radiology Blog http://www.sumerdoc.blogspot.com
TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - December 27, 2018 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Artificial Intelligence Automatically Spots Polyps During Colonoscopies (Interview)
Artificial intelligence is making big strides in a variety of medical fields, including radiology, oncology, and even ophthalmology. Now a company called Wision AI, based in Shanghai, Cina, is adapting artificial intelligence vision software to help doctors spot polyps during a colonoscopy. The technology is meant for real-time use and the procedure itself doesn’t change much from existing colonoscopies.
We spoke with JingJia Liu, Cofounder and CEO of Wision AI about the company technology, how it works, and what it is capable of already.
Medgadget: Can you briefly describe your company’s technology and ...
Source: Medgadget - December 4, 2018 Category: Medical Devices Authors: Editors Tags: Exclusive GI Informatics Surgery Source Type: blogs
