Micropapillary Carcinoma of the Breast
-Micropapillary breast carcinoma (or invasive micropapillary carcinoma IMPC) is a type of otherwise 'typical' invasive ductal carcinoma which exhibits a unique and characteristic growth pattern. -Invasive micropapillary breast carcinoma is a very aggressive form of breast cancer, with a very high rate of lymph node metastasis.(The rate of lymph node involvement is estimated at between 75% and 100%).-Skin invovlement (skin retraction) is another occassional feature of invasive micropapillary carcinoma of the breast, and is observed in about 20-23% of all cases.Histological aspects of invasive micropapillary carcinoma o...
Source: Oncopathology - October 24, 2012 Category: Cancer & Oncology Tags: breast breast cancer carcinoma micropapillary poor prognosis Source Type: blogs
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ImmunohistochemistryImmunohistochemistry in the differential diagnosis ofclear cell carcinomas from the kidney, liver, and lung Clear cell carcinoma is a common specimen seen by many surgical pathologists. Given an appropriate clinical context (for example, a patient with a large kidney mass), determining the nature and origin of a clear cell carcinoma can be very easy. However, in other situations this can be a challenging task, primarily because of the tremendous degree of overlap in the morphologic appearance of clear cell carcinomas from different primary sites. This month, we discuss the utility of a number ...
Source: Oncopathology - April 2, 2012 Category: Cancer & Oncology Source Type: blogs
Cancer on our Calendar – guest post
A dreary wet Monday after a gorgeous sunny Sunday. Being it is the second week of March though, I can’t complain. Crocous have been in bloom for weeks now. Tulips starting to bud. Trees and bushes too. It really feels like Spring. But this evening I must return to work at the clinic where it is still a cold winter for some.
Today’s breast cancer blogger hails from the UK. Yvonne has been penning her posts for a little over a year now. I decided to include her “About me” profile as it is such a succinct and well written introduction to writing about cancer. You can find Yvonne at time...
Source: Being Cancer Network - March 12, 2012 Category: Cancer Authors: admin Tags: Guest Post * Living with Cancer Breast cancer Source Type: blogs
Minimal Reporting Guidelines for the Treatment of Cancer Patients
Minimal Reporting Guidelines for the Treatment of Cancer Patients As laboratory physicians, our contribution to patient care is knowledge: this is the starting point from which all informed therapeutic intervention proceeds. How that knowledge is obtained and communicated is the art and science of our profession. These minimal diagnostic guidelines are designed to be used as an aid, not a constraint, in that process. The guidelines are presented in a specific format out of necessity, but any format that effectively communicates the necessary information in a given patho...
Source: Oncopathology - September 5, 2011 Category: Cancer & Oncology Source Type: blogs
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Protocol for Synpotic reporting of Breast excision specimen with diagnosis of Ductal Carcinoma In Situ (DCIS) of the BreastProtocol applies to DCIS without invasive carcinoma or microinvasion.The complete pathology report should include following parameters.Specimen type.___ Partial breast___ Total breast (including nipple and skin)___ Other (specify): ___ Not specified Procedure ___ Excision without wire-guided localization___ Excision with wire-guided localization___ Total mastectomy (including nipple and skin)___ Other (specify): _______________________________ Not specified Lymph Nod...
Source: Oncopathology - August 25, 2011 Category: Cancer & Oncology Tags: Protocol for Synpotic reporting of Breast excision specimen with diagnosis of Ductal Carcinoma In Situ (DCIS) of the Breast Source Type: blogs
Breast Carcinoma vs. Pulmonary Adenocarcinoma
Some authors have estimated that 4-9% of patients with breast carcinoma will eventually develop second pulmonary carcinomas. As a result, many pathologists have been faced with the problem of trying to determine whether a particular lung carcinoma represents metastatic breast carcinoma or a new primary pulmonary adenocarcinoma. This month, we will briefly review antibodies that may be useful in addressing this differential diagnostic problem.GCDFP-15(gross cystic disease fluid protein-15): This marker has good specificity for breast carcinoma, although its sensitivity is not high, as only about 50% of breast carcinomas exp...
Source: Oncopathology - December 30, 2010 Category: Cancer & Oncology Tags: Breast Carcinoma vs. Pulmonary Adenocarcinoma Source Type: blogs
Microcystic adenocarcinoma of the prostate-pseudobenign carcinoma
Reference :Microcystic Adenocarcinoma of the Prostate: A Variant of Pseudohyperplastic and Atrophic Patterns : Yaskiv, Oksana et al.The American Journal of Surgical Pathology: April 2010 - Volume 34 - Issue 4 - pp 556-561Do you see anything in this prostate that's worrisome for malignancy?dilated glands admixed with small acini in a noduleI don't, at least not at this power, and yet this is an example of"microcystic" adenocarcinoma of the prostate. Higher power will show clear-cut cytologic features of malignancy.If this doesn't concern you about the risk of scanning prostate slides at 4x, it should!Microcystic adenocarcin...
Source: Oncopathology - April 13, 2010 Category: Cancer & Oncology Tags: Microcystic adenocarcinoma of the prostate-pseudobenign carcinoma Source Type: blogs
High Grade Prostatic Intraepithelial Neoplasia (HGPIN)
:Common questions asked about HGPIN are :-How do we as pathologists make these diagnoses?-What do they mean for the patient in terms of cancer risk?-What is/are the optimal strategies for follow-up so that if cancer does eventually develop it is caught at an early, curable stage?Pathology criteria for diagnosis of HGPIN:-Architecturally benign acini/ducts lined by atypical cells.-These cells show large nuclei and prominent nucleoli (cytologic features of carcinoma).-Generally at least 10% of the luminal cells should show these features to make the diagnosis. Diagnosis of HGPIN has been shown to be reproducible. Low grade p...
Source: Oncopathology - March 2, 2010 Category: Cancer & Oncology Tags: High Grade Prostatic Intraepithelial Neoplasia (HGPIN) Source Type: blogs
Adenocarcinoma of unknown primary
What do you do when your doctors tell you that you have an adenocarcinoma of unknown primary? Did doctors use the new Pathwork Tissue of Origin test or any other more advanced test than the one used in your hospital? Janet replied in email to Gary’s (Small cell carcinoma of the lungs) post: how her […] (Source: Metastatic liver cancer)
Source: Metastatic liver cancer - June 17, 2009 Category: Cancer Authors: Daughter SK Tags: Adenocarcinoma adenocarcinoma of unknown primary Alternative CANCER TREATMENTS Cancer Prevention Health holistic cancer treatment immune system Source Type: blogs
