Rethinking the screening mammogram

This study analyzed data from women over 40 and compared the size of breast cancers at the time of diagnosis detected in the 1970s (before mammography became common) with the size of tumors detected between 2000 and 2002, when screening mammography was routine. Treatments and rates of death due to breast cancer 10 years after the diagnosis were also analyzed. The study found that: As more women underwent routine screening mammograms, more small breast cancers were detected. Many of these tumors were restricted to the ducts within the breast (called ductal carcinoma in situ), and even without treatment would never threaten the health of the woman. The detection of larger, more aggressive breast cancers was unchanged in frequency between the pre-mammogram and more recent time periods. This is important since, if screening mammograms caught these cancers earlier, in theory, the frequency of detecting these more dangerous tumors should be falling. Are there benefits of a screening mammogram? The study’s authors did not suggest that mammography is useless. They estimated that about 20% of women with small tumors that could only be detected with a mammogram received therapy that might be lifesaving. But the other 80% of women did not benefit. Similarly, estimates suggest that about two-thirds of the reduction in breast cancer deaths in recent years is due to better treatments, not better detection. Some additional reduction may be related to falling rates of post-menopausal...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Source Type: blogs

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Publication date: Available online 18 November 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Zhen Wang, Hui Gyu Park, Dong Hao Wang, Riki Kitano, Kumar S.D. Kothapalli, J. Thomas BrennaAbstractBranched chain fatty acids (BCFA) and linear chain/normal odd chain fatty acids (n-OCFA) are major fatty acids in human skin lipids, especially sebaceous gland (SG) wax esters. Skin lipids contain variable amounts of monounsaturated BCFA and n-OCFA, in some reports exceeding over 20% of total fatty acids. Fatty acid desaturase 2 (FADS2) codes for a multifunctional enzyme that catalyz...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - Category: Lipidology Source Type: research
This study evaluated outcomes associated with treatment strategies for this nonagenarian population.MethodsTreatment and overall survival for patients 90 years and older with NSCLC in the National Cancer Data Base (2004-2014) were evaluated using logistic regression, the Kaplan-Meier method, and multivariable Cox proportional hazard models.ResultsThe majority (n = 4152, 57.6%) of the 7205 patients 90 years or older with stage I-IV NSCLC did not receive any therapy. For the entire cohort, receiving treatment was associated with significantly better survival when compared with no therapy (5-year survival, 9.3% [95% confidenc...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
ConclusionsThe delay in surgical resection of StageIIIa NSCLC is not associated increased early mortality, however it is associated with worse 3-year post-resection survival.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
The objective of this work was to introduce high-intensity ultrasound (HIU) in different positions within a scraped surface heat exchanger (SSHE) and evaluate the crystallization behavior and physical properties of a low saturated, soybean-based fat. The SSHE in this study was composed of one pump (flow rate of 11 L/h), two crystallization barrels (32 °C, 344 rpm), and one pin worker (208 rpm). HIU was placed before the first crystallization step, or barrel 1 (HIU-0), between the two barrels (HIU-1), between barrels 2 and the pin worker (HIU-2) and after complete crystallization in the SSHE (HIU-3). HIU amplitu...
Source: Journal of Food Engineering - Category: Food Science Source Type: research
Publication date: Available online 18 November 2019Source: Innovative Food Science &Emerging TechnologiesAuthor(s): Oscar G. Martínez-Moreno, Luis M. Anaya-Esparza, Jorge A. Sánchez-Burgos, Libier Meza-Espinoza, Alejandro Pérez-Larios, J. Emanuel Bojorquez-Quintal, Efigenia Montalvo-GonzálezAbstractThe combined effect of vacuum, heat and ultrasound (vacuum-thermosonication, VTS) on soursop puree was investigated with regard to the viability of Escherichia coli and Staphylococcus aureus, inactivation of polyphenol oxidase and sensory quality. The VTS conditions were: vacuum (8.46, 11 and 16.9...
Source: Innovative Food Science and Emerging Technologies - Category: Food Science Source Type: research
In conventional acoustic-resolution-based photoacoustic microscopy (ARPAM), a focused ultrasound transducer is placed coaxially with the ...
Source: Applied Optics - Category: Physics Authors: Source Type: research
Authors: Membrey B, Miranda S, Lévesque H, Cailleux N, Benhamou Y, Armengol G Abstract Giant cell arteritis is the most common primary vasculitis of large-vessel occurring in subjects over 50 years of age. Many imaging techniques has been evaluated to improve the diagnosis of giant cell arteritis. Among these imaging techniques, ultrasound has shown good performances to detect inflammatory involvement of the temporal arteries as well as branches of the aorta. Several publications and recent EULAR recommendations have emhasized the place of this tool in the diagnosis of giant cell arteritis. PMID: 31...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB02245G, PaperHongmei Jiang, Xiaoyue Tang, Sihan Liu, Lian Wang, Haicheng Shen, Jiankui Yang, Huixian Wang, Qing-Wen Gui A novel, sustainable, environmentally friendly, high substrate scope, efficient, solvent-free and catalyst-free method for cross-dehydrogenative coupling (CDC) reaction between N-hydroxyphthalimide (NHPI) and benzyl/ether compounds is described. Compared to conventional heating... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
In conclusion, data presented in the current study suggest that tobacco smoking might cause alveolar tissue inflammation and vascular injury causing an immune response that elevates the white blood cells count. Another suggestion is that tobacco smoking defects the pulmonary gaseous exchange mechanism leading to the secondary polycythemia indicated by the increase in red blood cell count, hemoglobin levels, hematocrit and by the low serum erythropoietin levels.
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
In this study, we report that the dietary isoflavone genistein (GN) synergistically improved antineoplasticity of CC in breast cancer by arresting cells at G2/M phase culminating in ROS dependent apoptosis. The combination of CC plus GN caused dysregulation of Bax and Bcl-2 ratio inducing mitochondrial dysfunction, activation of Caspase-3/7, -9 and PARP cleavage. Further, combination significantly suppresses phosphorylation of PI3K/Akt/NF-κB, enhancing apoptosis. Additionally, combination markedly reduced tumor growth compared to CC and GN alone in mouse 4T1 breast tumor model.SignificanceTogether, these studies sugg...
Source: Life Sciences - Category: Biology Source Type: research
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